Solid-state structures are presented for three propionyl complexes of MoII featuring piano-stool geometries and supported by triarylphosphine ligands, showing the effects of para substitution on supramolecular structure and allowing comparison to the large class of previously reported acetyl complexes.
X-ray and computational study of cis- and trans-diketopiperazines of N-methyl-phenylalanine with the thia-pipecolic acids and thia-prolines are presented. The effect of sulfur on the geometry of diketopiperazine ring and amide bond non-planarity is discussed.
Structures of human Gcn5L2 bound to propionyl-CoA and butyryl-CoA show how the active site accommodates different acyl modifications and explain why butyryl-CoA acts as a competitive inhibitor.
In the crystal, neighboring molecules are linked into layers parallel to the (200) plane via C—HO hydrogen bonds and C—Hπ interactions. van der Waals interactions between parallel molecular layers help to strengthen the packing.
The structure of (S)-5-(3-acetyl-5-chloro-2-ethoxy-6-fluorophenyl)-2-oxazolidinone has been determined to establish its absolute configuration in efforts to synthesize an anticancer drug candidate, parsaclisib.
The molecular and crystal structures of the title hydrated oxazolidinone derivative is reported. The two carbonyl groups are oriented anti to one another. In the crystal, O—HO, C—HO and C—HF hydrogen bonds generate a three-dimensional supramolecular architecture.
Reported here are the isolation and direct observation of extremely reactive S2 and its conversion into bent-S3via a cyclo-S32+ intermediate on interactive sites in porous coordination networks.