5α,14α-Androstane (C19H32) crystallizes in two different polymorphic forms in the same vapor diffusion experiment. The major form (Form I) crystallizes as thin plates in the space group P21, with Z = 4. These plates are twinned along a long c axis of length 43 Å and readily suffer from radiation damage when diffracted. The minor form (Form II) crystallizes as fine needles in the space group P212121, Z = 3. In the minor form, 5α,14α-androstane cocrystallizes with 5α,14α-androstan-17-one, an oxidation product of 5α,14α-androstane. The presence of 5α,14α-androstan-17-one in the minor form of the crystals was confirmed by HR-MS. Form II can be crystallized as a pure form without the ketone impurity using a different solvent system. High level density functional theory (DFT) lattice free energy calculations were performed and show that both pure forms are isoergic within the estimated error of the calculations.
Supporting information
CCDC references: 2102883; 2102884; 2102885
For all structures, data collection: CrysAlis PRO (Rigaku OD, 2021); cell refinement: CrysAlis PRO (Rigaku OD, 2021); data reduction: CrysAlis PRO (Rigaku OD, 2021); program(s) used to solve structure: WinGX (Farrugia, 2012) and SHELXT2014 (Sheldrick, 2015a); program(s) used to refine structure: WinGX (Farrugia, 2012) and SHELXL2018 (Sheldrick, 2015b); molecular graphics: ORTEP-32 (Farrugia, 2012) and Mercury (Macrae et al., 2020); software used to prepare material for publication: WinGX (Farrugia, 2012).
5
α,14
α-Androstane, Form I (Form_I)
top
Crystal data top
C19H32 | F(000) = 1168 |
Mr = 260.44 | Dx = 1.095 Mg m−3 |
Monoclinic, P21 | Cu Kα radiation, λ = 1.54184 Å |
a = 7.4417 (1) Å | Cell parameters from 31493 reflections |
b = 9.8831 (1) Å | θ = 2.1–75.2° |
c = 43.0002 (6) Å | µ = 0.44 mm−1 |
β = 92.742 (1)° | T = 90 K |
V = 3158.92 (7) Å3 | Plate, colorless |
Z = 8 | 0.20 × 0.13 × 0.06 mm |
Data collection top
ROD, Synergy Custom system, HyPix diffractometer | 15656 independent reflections |
Radiation source: Rotating-anode X-ray tube | 15312 reflections with I > 2σ(I) |
Detector resolution: 10.0000 pixels mm-1 | Rint = 0.025 |
ω scans | θmax = 75.5°, θmin = 2.1° |
Absorption correction: gaussian (CrysAlis PRO; Rigaku OD, 2021) | h = −9→9 |
Tmin = 0.776, Tmax = 1.000 | k = −12→12 |
64068 measured reflections | l = −53→52 |
Refinement top
Refinement on F2 | Hydrogen site location: inferred from neighbouring sites |
Least-squares matrix: full | H-atom parameters constrained |
R[F2 > 2σ(F2)] = 0.045 | w = 1/[σ2(Fo2) + (0.0523P)2 + 2.5739P] where P = (Fo2 + 2Fc2)/3 |
wR(F2) = 0.133 | (Δ/σ)max = 0.001 |
S = 1.09 | Δρmax = 0.31 e Å−3 |
15656 reflections | Δρmin = −0.21 e Å−3 |
695 parameters | Extinction correction: SHELXL2018 (Sheldrick, 2015b), Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4 |
1 restraint | Extinction coefficient: 0.0006 (2) |
Primary atom site location: iterative | Absolute structure: Flack x determined using 5698 quotients [(I+)-(I-)]/[(I+)+(I-)]
(Parsons et al., 2013) |
Secondary atom site location: difference Fourier map | Absolute structure parameter: 0.0 (5) |
Special details top
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes)
are estimated using the full covariance matrix. The cell esds are taken
into account individually in the estimation of esds in distances, angles
and torsion angles; correlations between esds in cell parameters are only
used when they are defined by crystal symmetry. An approximate (isotropic)
treatment of cell esds is used for estimating esds involving l.s. planes. |
Refinement. Refined as a 2-component twin Data were integrated and
scaled using CrysAlis PRO (Rigaku OD, 2021). WinGX (Farrugia, 2012) was used
for the solution and refinement of the crystal structures.
Solution by intrinsic phasing (SHELXT2014; Sheldrick, 2015a) produced
a complete heavy-atom phasing model. All non-H atoms were refined
anisotropically by full-matrix least-squares (SHELXL2018; Sheldrick,
2015b). |
Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top | x | y | z | Uiso*/Ueq | |
C1 | 1.1169 (6) | 0.7345 (5) | 0.81549 (9) | 0.0201 (9) | |
H1A | 1.214915 | 0.679497 | 0.807196 | 0.024* | |
H1B | 1.151996 | 0.830878 | 0.814033 | 0.024* | |
C2 | 1.0973 (7) | 0.6982 (5) | 0.84980 (9) | 0.0238 (10) | |
H2A | 1.078475 | 0.599437 | 0.851672 | 0.029* | |
H2B | 1.209828 | 0.721660 | 0.861800 | 0.029* | |
C3 | 0.9395 (7) | 0.7729 (5) | 0.86366 (9) | 0.0242 (10) | |
H3A | 0.922241 | 0.738711 | 0.884956 | 0.029* | |
H3B | 0.967826 | 0.870625 | 0.865189 | 0.029* | |
C4 | 0.7657 (6) | 0.7537 (5) | 0.84382 (9) | 0.0201 (9) | |
H4A | 0.669682 | 0.810288 | 0.852253 | 0.024* | |
H4B | 0.727358 | 0.657914 | 0.844882 | 0.024* | |
C5 | 0.7907 (6) | 0.7925 (4) | 0.80970 (9) | 0.0187 (9) | |
H5 | 0.829102 | 0.889465 | 0.809821 | 0.022* | |
C6 | 0.6148 (6) | 0.7860 (5) | 0.79032 (10) | 0.0221 (9) | |
H6A | 0.523145 | 0.841779 | 0.800279 | 0.027* | |
H6B | 0.571054 | 0.691387 | 0.789497 | 0.027* | |
C7 | 0.6392 (6) | 0.8372 (5) | 0.75724 (9) | 0.0220 (9) | |
H7A | 0.668026 | 0.934993 | 0.757960 | 0.026* | |
H7B | 0.524942 | 0.825778 | 0.744758 | 0.026* | |
C8 | 0.7892 (6) | 0.7616 (4) | 0.74145 (9) | 0.0187 (9) | |
H8 | 0.752512 | 0.664734 | 0.738811 | 0.022* | |
C9 | 0.9663 (6) | 0.7669 (4) | 0.76164 (9) | 0.0153 (8) | |
H9 | 0.997063 | 0.864951 | 0.764078 | 0.018* | |
C10 | 0.9444 (6) | 0.7113 (4) | 0.79523 (9) | 0.0174 (8) | |
C11 | 1.1224 (6) | 0.7024 (5) | 0.74492 (9) | 0.0217 (9) | |
H11A | 1.102650 | 0.603481 | 0.743565 | 0.026* | |
H11B | 1.235601 | 0.717873 | 0.757465 | 0.026* | |
C12 | 1.1436 (7) | 0.7589 (5) | 0.71185 (10) | 0.0237 (10) | |
H12A | 1.180945 | 0.854943 | 0.713268 | 0.028* | |
H12B | 1.239178 | 0.708044 | 0.701671 | 0.028* | |
C13 | 0.9694 (7) | 0.7482 (4) | 0.69218 (9) | 0.0208 (9) | |
C14 | 0.8203 (6) | 0.8208 (4) | 0.70944 (9) | 0.0187 (9) | |
H14 | 0.862475 | 0.915810 | 0.713002 | 0.022* | |
C15 | 0.6621 (7) | 0.8284 (5) | 0.68530 (9) | 0.0246 (10) | |
H15A | 0.580708 | 0.904360 | 0.689843 | 0.030* | |
H15B | 0.592476 | 0.743036 | 0.684646 | 0.030* | |
C16 | 0.7565 (7) | 0.8521 (6) | 0.65422 (10) | 0.0299 (11) | |
H16A | 0.735304 | 0.945704 | 0.646713 | 0.036* | |
H16B | 0.709466 | 0.788384 | 0.638035 | 0.036* | |
C17 | 0.9618 (7) | 0.8274 (5) | 0.66145 (10) | 0.0265 (10) | |
H17A | 1.014709 | 0.774077 | 0.644673 | 0.032* | |
H17B | 1.027391 | 0.914233 | 0.663793 | 0.032* | |
C18 | 0.9012 (6) | 0.5583 (4) | 0.79400 (9) | 0.0187 (8) | |
H18A | 1.002852 | 0.509220 | 0.785723 | 0.028* | |
H18B | 0.793310 | 0.543117 | 0.780474 | 0.028* | |
H18C | 0.879925 | 0.525624 | 0.815026 | 0.028* | |
C19 | 0.9256 (7) | 0.5987 (5) | 0.68504 (10) | 0.0255 (10) | |
H19A | 1.024054 | 0.558133 | 0.673912 | 0.038* | |
H19B | 0.813841 | 0.593109 | 0.672080 | 0.038* | |
H19C | 0.910893 | 0.549794 | 0.704578 | 0.038* | |
C20 | −0.4513 (7) | 0.1102 (5) | 0.44527 (9) | 0.0215 (9) | |
H20A | −0.556822 | 0.089018 | 0.457569 | 0.026* | |
H20B | −0.422194 | 0.207135 | 0.448402 | 0.026* | |
C21 | −0.5006 (7) | 0.0855 (5) | 0.41054 (10) | 0.0241 (10) | |
H21A | −0.544590 | −0.008501 | 0.407735 | 0.029* | |
H21B | −0.599329 | 0.147386 | 0.403695 | 0.029* | |
C22 | −0.3414 (8) | 0.1077 (5) | 0.39039 (9) | 0.0282 (11) | |
H22A | −0.308996 | 0.204889 | 0.390644 | 0.034* | |
H22B | −0.375504 | 0.082245 | 0.368634 | 0.034* | |
C23 | −0.1775 (6) | 0.0237 (5) | 0.40193 (10) | 0.0226 (10) | |
H23A | −0.203092 | −0.073638 | 0.398589 | 0.027* | |
H23B | −0.072385 | 0.047980 | 0.389813 | 0.027* | |
C24 | −0.1336 (6) | 0.0495 (4) | 0.43646 (9) | 0.0178 (9) | |
H24 | −0.105272 | 0.148108 | 0.438400 | 0.021* | |
C25 | 0.0415 (6) | −0.0272 (5) | 0.44742 (9) | 0.0205 (9) | |
H25A | 0.021412 | −0.125985 | 0.445763 | 0.025* | |
H25B | 0.140215 | −0.002754 | 0.433839 | 0.025* | |
C26 | 0.0941 (6) | 0.0099 (5) | 0.48101 (9) | 0.0197 (9) | |
H26A | 0.197261 | −0.047030 | 0.488251 | 0.024* | |
H26B | 0.134259 | 0.105378 | 0.481719 | 0.024* | |
C27 | −0.0562 (6) | −0.0078 (4) | 0.50315 (9) | 0.0160 (8) | |
H27 | −0.084281 | −0.106458 | 0.504619 | 0.019* | |
C28 | −0.2312 (6) | 0.0683 (4) | 0.49122 (9) | 0.0157 (8) | |
H28 | −0.196929 | 0.165866 | 0.489691 | 0.019* | |
C29 | −0.2888 (6) | 0.0234 (4) | 0.45754 (9) | 0.0156 (8) | |
C30 | −0.3775 (6) | 0.0624 (5) | 0.51479 (9) | 0.0179 (9) | |
H30A | −0.421792 | −0.031818 | 0.516116 | 0.022* | |
H30B | −0.479719 | 0.119816 | 0.507344 | 0.022* | |
C31 | −0.3120 (6) | 0.1099 (5) | 0.54762 (9) | 0.0200 (9) | |
H31A | −0.280468 | 0.207172 | 0.546903 | 0.024* | |
H31B | −0.410335 | 0.098976 | 0.562125 | 0.024* | |
C32 | −0.1497 (6) | 0.0298 (4) | 0.55949 (9) | 0.0179 (9) | |
C33 | −0.0019 (6) | 0.0438 (4) | 0.53568 (9) | 0.0182 (9) | |
H33 | 0.020066 | 0.143071 | 0.533438 | 0.022* | |
C34 | 0.1657 (6) | −0.0134 (5) | 0.55255 (10) | 0.0210 (9) | |
H34A | 0.276031 | 0.024297 | 0.543925 | 0.025* | |
H34B | 0.168808 | −0.113268 | 0.550858 | 0.025* | |
C35 | 0.1483 (7) | 0.0313 (5) | 0.58687 (10) | 0.0255 (10) | |
H35A | 0.236460 | 0.103397 | 0.592469 | 0.031* | |
H35B | 0.169653 | −0.046174 | 0.601166 | 0.031* | |
C36 | −0.0472 (6) | 0.0850 (5) | 0.58888 (9) | 0.0205 (9) | |
H36A | −0.101748 | 0.051406 | 0.607960 | 0.025* | |
H36B | −0.048884 | 0.185124 | 0.589061 | 0.025* | |
C37 | −0.3478 (6) | −0.1268 (4) | 0.45731 (9) | 0.0197 (9) | |
H37A | −0.368464 | −0.157338 | 0.435752 | 0.030* | |
H37B | −0.459117 | −0.136103 | 0.468404 | 0.030* | |
H37C | −0.253134 | −0.181951 | 0.467620 | 0.030* | |
C38 | −0.2011 (7) | −0.1177 (5) | 0.56571 (10) | 0.0235 (10) | |
H38A | −0.300969 | −0.120135 | 0.579743 | 0.035* | |
H38B | −0.097274 | −0.165434 | 0.575360 | 0.035* | |
H38C | −0.237743 | −0.161816 | 0.546005 | 0.035* | |
C39 | 0.6365 (7) | 0.2470 (5) | 0.69536 (10) | 0.0233 (10) | |
H39A | 0.731389 | 0.299791 | 0.706825 | 0.028* | |
H39B | 0.664819 | 0.149889 | 0.698326 | 0.028* | |
C40 | 0.6407 (7) | 0.2810 (5) | 0.66050 (10) | 0.0272 (10) | |
H40A | 0.630497 | 0.380187 | 0.657699 | 0.033* | |
H40B | 0.757415 | 0.252034 | 0.652613 | 0.033* | |
C41 | 0.4873 (7) | 0.2112 (5) | 0.64152 (9) | 0.0260 (10) | |
H41A | 0.485956 | 0.243588 | 0.619727 | 0.031* | |
H41B | 0.508598 | 0.112295 | 0.641404 | 0.031* | |
C42 | 0.3050 (7) | 0.2402 (5) | 0.65512 (9) | 0.0243 (10) | |
H42A | 0.210060 | 0.188004 | 0.643523 | 0.029* | |
H42B | 0.276303 | 0.337599 | 0.652780 | 0.029* | |
C43 | 0.3076 (6) | 0.2015 (4) | 0.68963 (9) | 0.0185 (9) | |
H43 | 0.339828 | 0.103372 | 0.690830 | 0.022* | |
C44 | 0.1207 (6) | 0.2148 (5) | 0.70262 (9) | 0.0221 (9) | |
H44A | 0.082251 | 0.310674 | 0.701630 | 0.027* | |
H44B | 0.033382 | 0.161037 | 0.689657 | 0.027* | |
C45 | 0.1205 (6) | 0.1657 (4) | 0.73621 (9) | 0.0185 (8) | |
H45A | 0.141402 | 0.066741 | 0.736696 | 0.022* | |
H45B | 0.000775 | 0.182978 | 0.744492 | 0.022* | |
C46 | 0.2643 (6) | 0.2353 (4) | 0.75715 (9) | 0.0149 (8) | |
H46 | 0.234116 | 0.333635 | 0.758478 | 0.018* | |
C47 | 0.4521 (6) | 0.2211 (5) | 0.74321 (9) | 0.0181 (9) | |
H47 | 0.475188 | 0.121789 | 0.741543 | 0.022* | |
C48 | 0.4528 (6) | 0.2775 (4) | 0.70952 (9) | 0.0175 (8) | |
C49 | 0.6021 (6) | 0.2773 (5) | 0.76537 (10) | 0.0250 (10) | |
H49A | 0.591348 | 0.377073 | 0.766124 | 0.030* | |
H49B | 0.719950 | 0.255387 | 0.756896 | 0.030* | |
C50 | 0.5977 (6) | 0.2212 (5) | 0.79871 (10) | 0.0252 (10) | |
H50A | 0.626072 | 0.123390 | 0.798592 | 0.030* | |
H50B | 0.690515 | 0.267346 | 0.812146 | 0.030* | |
C51 | 0.4145 (7) | 0.2424 (4) | 0.81191 (9) | 0.0209 (9) | |
C52 | 0.2699 (6) | 0.1756 (4) | 0.78997 (9) | 0.0177 (8) | |
H52 | 0.306190 | 0.078751 | 0.787866 | 0.021* | |
C53 | 0.1014 (7) | 0.1757 (5) | 0.80849 (10) | 0.0232 (10) | |
H53A | 0.020117 | 0.100762 | 0.801832 | 0.028* | |
H53B | 0.035833 | 0.262460 | 0.805895 | 0.028* | |
C54 | 0.1721 (8) | 0.1563 (5) | 0.84273 (10) | 0.0300 (11) | |
H54A | 0.123537 | 0.227434 | 0.856203 | 0.036* | |
H54B | 0.135994 | 0.066780 | 0.850636 | 0.036* | |
C55 | 0.3794 (7) | 0.1669 (5) | 0.84232 (10) | 0.0259 (10) | |
H55A | 0.428477 | 0.218031 | 0.860605 | 0.031* | |
H55B | 0.434957 | 0.075834 | 0.842387 | 0.031* | |
C56 | 0.4224 (7) | 0.4317 (4) | 0.70900 (10) | 0.0228 (9) | |
H56A | 0.522944 | 0.476686 | 0.720363 | 0.034* | |
H56B | 0.309970 | 0.453007 | 0.718913 | 0.034* | |
H56C | 0.415108 | 0.463644 | 0.687398 | 0.034* | |
C57 | 0.3797 (7) | 0.3943 (5) | 0.81721 (9) | 0.0239 (10) | |
H57A | 0.377414 | 0.441879 | 0.797196 | 0.036* | |
H57B | 0.475817 | 0.431649 | 0.831029 | 0.036* | |
H57C | 0.263762 | 0.405883 | 0.826762 | 0.036* | |
C58 | 0.0786 (6) | 0.8877 (5) | 1.05343 (9) | 0.0183 (8) | |
H58A | −0.034470 | 0.906386 | 1.041108 | 0.022* | |
H58B | 0.109236 | 0.791197 | 1.050439 | 0.022* | |
C59 | 0.0479 (7) | 0.9126 (5) | 1.08796 (9) | 0.0225 (10) | |
H59A | 0.005323 | 1.006500 | 1.090728 | 0.027* | |
H59B | −0.046793 | 0.850521 | 1.094826 | 0.027* | |
C60 | 0.2197 (7) | 0.8904 (5) | 1.10815 (9) | 0.0239 (9) | |
H60A | 0.197345 | 0.914331 | 1.129992 | 0.029* | |
H60B | 0.253520 | 0.793617 | 1.107578 | 0.029* | |
C61 | 0.3743 (7) | 0.9760 (5) | 1.09693 (9) | 0.0239 (10) | |
H61A | 0.486011 | 0.953485 | 1.109267 | 0.029* | |
H61B | 0.347704 | 1.072965 | 1.100219 | 0.029* | |
C62 | 0.4028 (6) | 0.9511 (4) | 1.06234 (9) | 0.0177 (9) | |
H62 | 0.431783 | 0.852745 | 1.060319 | 0.021* | |
C63 | 0.5643 (6) | 1.0279 (5) | 1.05121 (9) | 0.0186 (9) | |
H63A | 0.670434 | 1.007890 | 1.065210 | 0.022* | |
H63B | 0.540318 | 1.126249 | 1.052291 | 0.022* | |
C64 | 0.6062 (7) | 0.9901 (5) | 1.01788 (9) | 0.0211 (9) | |
H64A | 0.705044 | 1.048120 | 1.010937 | 0.025* | |
H64B | 0.647399 | 0.894960 | 1.017384 | 0.025* | |
C65 | 0.4423 (6) | 1.0070 (4) | 0.99550 (9) | 0.0154 (8) | |
H65 | 0.412822 | 1.105601 | 0.993912 | 0.018* | |
C66 | 0.2773 (6) | 0.9320 (4) | 1.00757 (9) | 0.0171 (9) | |
H66 | 0.312722 | 0.834564 | 1.009233 | 0.020* | |
C67 | 0.2305 (6) | 0.9766 (4) | 1.04105 (9) | 0.0149 (8) | |
C68 | 0.1146 (6) | 0.9374 (5) | 0.98373 (9) | 0.0175 (9) | |
H68A | 0.017050 | 0.879613 | 0.991256 | 0.021* | |
H68B | 0.068922 | 1.031415 | 0.982397 | 0.021* | |
C69 | 0.1616 (6) | 0.8900 (5) | 0.95102 (9) | 0.0189 (9) | |
H69A | 0.192217 | 0.792484 | 0.951709 | 0.023* | |
H69B | 0.055488 | 0.901719 | 0.936496 | 0.023* | |
C70 | 0.3187 (6) | 0.9688 (4) | 0.93907 (9) | 0.0162 (8) | |
C71 | 0.4774 (6) | 0.9547 (4) | 0.96312 (9) | 0.0161 (8) | |
H71 | 0.498854 | 0.855260 | 0.965538 | 0.019* | |
C72 | 0.6400 (6) | 1.0101 (5) | 0.94636 (9) | 0.0182 (9) | |
H72A | 0.753917 | 0.971203 | 0.955216 | 0.022* | |
H72B | 0.646169 | 1.109970 | 0.947840 | 0.022* | |
C73 | 0.6032 (7) | 0.9640 (5) | 0.91226 (9) | 0.0245 (10) | |
H73A | 0.686896 | 0.890655 | 0.906921 | 0.029* | |
H73B | 0.618746 | 1.040571 | 0.897781 | 0.029* | |
C74 | 0.4042 (7) | 0.9122 (4) | 0.91003 (9) | 0.0208 (9) | |
H74A | 0.340555 | 0.946124 | 0.890843 | 0.025* | |
H74B | 0.400410 | 0.812109 | 0.909952 | 0.025* | |
C75 | 0.1725 (6) | 1.1254 (4) | 1.04120 (9) | 0.0191 (9) | |
H75A | 0.261536 | 1.180403 | 1.030860 | 0.029* | |
H75B | 0.163748 | 1.156237 | 1.062739 | 0.029* | |
H75C | 0.055029 | 1.134793 | 1.030096 | 0.029* | |
C76 | 0.2670 (7) | 1.1172 (4) | 0.93268 (9) | 0.0220 (9) | |
H76A | 0.159642 | 1.120717 | 0.918600 | 0.033* | |
H76B | 0.366675 | 1.163536 | 0.923039 | 0.033* | |
H76C | 0.241919 | 1.162038 | 0.952336 | 0.033* | |
Atomic displacement parameters (Å2) top | U11 | U22 | U33 | U12 | U13 | U23 |
C1 | 0.014 (2) | 0.022 (2) | 0.0242 (19) | −0.0018 (18) | 0.0021 (17) | −0.0019 (16) |
C2 | 0.021 (2) | 0.028 (2) | 0.0227 (19) | 0.001 (2) | −0.0026 (18) | −0.0012 (17) |
C3 | 0.029 (3) | 0.024 (2) | 0.0195 (19) | −0.001 (2) | 0.0017 (18) | −0.0015 (16) |
C4 | 0.016 (2) | 0.020 (2) | 0.0243 (19) | 0.0008 (19) | 0.0050 (17) | −0.0017 (16) |
C5 | 0.016 (2) | 0.016 (2) | 0.0238 (19) | −0.0006 (18) | 0.0026 (18) | −0.0008 (15) |
C6 | 0.016 (2) | 0.024 (2) | 0.027 (2) | 0.001 (2) | 0.0044 (18) | 0.0016 (17) |
C7 | 0.016 (2) | 0.027 (2) | 0.0233 (19) | 0.004 (2) | 0.0015 (17) | 0.0016 (17) |
C8 | 0.020 (2) | 0.015 (2) | 0.0205 (18) | 0.0003 (18) | 0.0009 (18) | 0.0001 (15) |
C9 | 0.008 (2) | 0.0150 (19) | 0.0234 (18) | −0.0033 (17) | 0.0026 (15) | −0.0031 (15) |
C10 | 0.017 (2) | 0.015 (2) | 0.0211 (18) | 0.0020 (18) | 0.0007 (17) | 0.0001 (15) |
C11 | 0.017 (2) | 0.024 (2) | 0.0241 (19) | 0.0046 (19) | 0.0016 (18) | 0.0004 (17) |
C12 | 0.022 (2) | 0.021 (2) | 0.029 (2) | 0.002 (2) | 0.0106 (19) | −0.0013 (18) |
C13 | 0.025 (2) | 0.017 (2) | 0.0210 (19) | −0.001 (2) | 0.0048 (18) | −0.0007 (16) |
C14 | 0.020 (2) | 0.016 (2) | 0.0210 (18) | −0.0026 (18) | 0.0023 (18) | −0.0012 (15) |
C15 | 0.026 (3) | 0.025 (2) | 0.0227 (19) | 0.001 (2) | 0.0002 (19) | 0.0019 (17) |
C16 | 0.024 (3) | 0.039 (3) | 0.027 (2) | 0.004 (2) | 0.002 (2) | 0.0053 (19) |
C17 | 0.030 (3) | 0.025 (2) | 0.025 (2) | 0.001 (2) | 0.005 (2) | 0.0017 (17) |
C18 | 0.015 (2) | 0.016 (2) | 0.0244 (19) | 0.0016 (17) | 0.0002 (16) | −0.0014 (15) |
C19 | 0.029 (3) | 0.019 (2) | 0.028 (2) | 0.000 (2) | 0.0044 (19) | −0.0046 (17) |
C20 | 0.022 (2) | 0.018 (2) | 0.025 (2) | 0.0012 (19) | 0.0019 (18) | −0.0018 (17) |
C21 | 0.017 (2) | 0.025 (2) | 0.029 (2) | 0.003 (2) | −0.0013 (19) | 0.0001 (17) |
C22 | 0.034 (3) | 0.030 (2) | 0.0202 (19) | 0.003 (2) | −0.0012 (19) | 0.0016 (18) |
C23 | 0.018 (2) | 0.026 (2) | 0.024 (2) | 0.002 (2) | 0.0046 (18) | −0.0012 (17) |
C24 | 0.013 (2) | 0.016 (2) | 0.0245 (19) | −0.0026 (18) | 0.0035 (17) | −0.0005 (16) |
C25 | 0.015 (2) | 0.022 (2) | 0.025 (2) | 0.0014 (19) | 0.0046 (18) | −0.0035 (17) |
C26 | 0.009 (2) | 0.023 (2) | 0.028 (2) | −0.0014 (18) | 0.0041 (17) | −0.0007 (16) |
C27 | 0.010 (2) | 0.018 (2) | 0.0206 (18) | 0.0009 (17) | 0.0025 (16) | −0.0008 (15) |
C28 | 0.011 (2) | 0.015 (2) | 0.0211 (18) | 0.0021 (17) | 0.0021 (16) | −0.0002 (15) |
C29 | 0.009 (2) | 0.013 (2) | 0.0242 (19) | −0.0019 (17) | 0.0014 (16) | −0.0004 (15) |
C30 | 0.0070 (19) | 0.022 (2) | 0.0248 (19) | −0.0012 (18) | 0.0042 (16) | −0.0016 (16) |
C31 | 0.018 (2) | 0.020 (2) | 0.0215 (19) | −0.0011 (19) | 0.0047 (17) | −0.0021 (16) |
C32 | 0.016 (2) | 0.015 (2) | 0.0233 (18) | −0.0051 (18) | 0.0049 (17) | 0.0002 (16) |
C33 | 0.018 (2) | 0.014 (2) | 0.0236 (19) | −0.0037 (18) | 0.0056 (18) | −0.0005 (15) |
C34 | 0.012 (2) | 0.025 (2) | 0.026 (2) | −0.0003 (19) | −0.0001 (17) | 0.0016 (17) |
C35 | 0.018 (2) | 0.036 (3) | 0.022 (2) | 0.000 (2) | 0.0000 (18) | 0.0010 (18) |
C36 | 0.017 (2) | 0.023 (2) | 0.0212 (18) | −0.0028 (19) | 0.0010 (17) | −0.0014 (16) |
C37 | 0.019 (2) | 0.017 (2) | 0.0234 (18) | −0.0036 (19) | 0.0002 (17) | −0.0011 (15) |
C38 | 0.024 (3) | 0.021 (2) | 0.027 (2) | −0.004 (2) | 0.0067 (18) | 0.0014 (17) |
C39 | 0.021 (2) | 0.023 (2) | 0.025 (2) | −0.001 (2) | −0.0005 (18) | −0.0005 (17) |
C40 | 0.021 (2) | 0.035 (3) | 0.025 (2) | −0.003 (2) | 0.0055 (19) | 0.0012 (19) |
C41 | 0.027 (3) | 0.032 (3) | 0.0196 (18) | 0.002 (2) | 0.0044 (18) | −0.0030 (18) |
C42 | 0.022 (2) | 0.031 (3) | 0.0198 (19) | 0.001 (2) | 0.0012 (18) | −0.0023 (17) |
C43 | 0.018 (2) | 0.016 (2) | 0.0214 (19) | 0.0039 (18) | 0.0001 (17) | −0.0020 (15) |
C44 | 0.020 (2) | 0.022 (2) | 0.025 (2) | 0.0005 (19) | −0.0010 (19) | −0.0020 (17) |
C45 | 0.0054 (19) | 0.023 (2) | 0.027 (2) | 0.0013 (18) | 0.0014 (16) | −0.0028 (17) |
C46 | 0.0090 (19) | 0.016 (2) | 0.0203 (17) | 0.0027 (16) | 0.0028 (15) | −0.0009 (15) |
C47 | 0.015 (2) | 0.020 (2) | 0.0200 (18) | 0.0009 (18) | 0.0014 (16) | −0.0028 (16) |
C48 | 0.013 (2) | 0.019 (2) | 0.0214 (18) | 0.0006 (18) | 0.0023 (16) | 0.0000 (16) |
C49 | 0.012 (2) | 0.037 (3) | 0.025 (2) | −0.006 (2) | −0.0010 (18) | −0.0064 (19) |
C50 | 0.016 (2) | 0.035 (3) | 0.023 (2) | 0.002 (2) | −0.0046 (18) | −0.0025 (19) |
C51 | 0.027 (3) | 0.018 (2) | 0.0176 (18) | 0.004 (2) | −0.0012 (17) | −0.0001 (16) |
C52 | 0.015 (2) | 0.014 (2) | 0.0237 (18) | 0.0007 (17) | 0.0013 (17) | 0.0013 (15) |
C53 | 0.022 (2) | 0.020 (2) | 0.027 (2) | 0.000 (2) | 0.0037 (19) | 0.0014 (17) |
C54 | 0.037 (3) | 0.029 (3) | 0.024 (2) | −0.006 (2) | 0.004 (2) | 0.0028 (18) |
C55 | 0.027 (3) | 0.027 (3) | 0.023 (2) | 0.004 (2) | 0.0006 (19) | 0.0040 (18) |
C56 | 0.022 (2) | 0.019 (2) | 0.027 (2) | −0.0013 (19) | 0.0029 (18) | −0.0017 (16) |
C57 | 0.026 (2) | 0.022 (2) | 0.0241 (19) | −0.001 (2) | 0.0012 (18) | −0.0039 (17) |
C58 | 0.016 (2) | 0.017 (2) | 0.0219 (18) | −0.0008 (18) | −0.0001 (17) | 0.0003 (16) |
C59 | 0.023 (3) | 0.021 (2) | 0.0231 (19) | −0.001 (2) | −0.0007 (19) | 0.0022 (16) |
C60 | 0.022 (2) | 0.030 (2) | 0.0202 (18) | 0.000 (2) | 0.0016 (18) | 0.0031 (17) |
C61 | 0.030 (3) | 0.025 (2) | 0.0167 (18) | −0.003 (2) | −0.0028 (18) | 0.0012 (16) |
C62 | 0.018 (2) | 0.014 (2) | 0.0215 (19) | 0.0036 (18) | −0.0002 (17) | −0.0014 (15) |
C63 | 0.011 (2) | 0.024 (2) | 0.0208 (19) | 0.0011 (18) | −0.0049 (16) | −0.0009 (16) |
C64 | 0.023 (2) | 0.018 (2) | 0.0211 (19) | 0.000 (2) | −0.0033 (18) | 0.0000 (15) |
C65 | 0.013 (2) | 0.014 (2) | 0.0183 (17) | −0.0004 (17) | −0.0001 (16) | −0.0019 (15) |
C66 | 0.023 (2) | 0.012 (2) | 0.0156 (17) | −0.0002 (18) | −0.0014 (17) | 0.0003 (14) |
C67 | 0.011 (2) | 0.014 (2) | 0.0196 (17) | −0.0011 (17) | −0.0007 (16) | 0.0005 (15) |
C68 | 0.0078 (19) | 0.022 (2) | 0.0230 (19) | −0.0021 (18) | 0.0008 (16) | −0.0008 (16) |
C69 | 0.018 (2) | 0.020 (2) | 0.0187 (17) | −0.0041 (19) | −0.0014 (16) | −0.0027 (16) |
C70 | 0.014 (2) | 0.017 (2) | 0.0181 (17) | 0.0002 (17) | 0.0012 (16) | 0.0002 (15) |
C71 | 0.012 (2) | 0.016 (2) | 0.0196 (18) | 0.0016 (17) | 0.0014 (16) | −0.0008 (15) |
C72 | 0.008 (2) | 0.023 (2) | 0.0234 (19) | −0.0002 (18) | 0.0028 (16) | 0.0000 (16) |
C73 | 0.022 (2) | 0.031 (3) | 0.0207 (19) | 0.003 (2) | 0.0044 (18) | 0.0028 (18) |
C74 | 0.027 (3) | 0.017 (2) | 0.0185 (18) | 0.0041 (19) | −0.0004 (18) | 0.0001 (15) |
C75 | 0.022 (2) | 0.015 (2) | 0.0204 (18) | 0.0056 (18) | 0.0019 (17) | −0.0008 (15) |
C76 | 0.027 (3) | 0.017 (2) | 0.0219 (18) | 0.0009 (19) | 0.0015 (19) | 0.0027 (16) |
Geometric parameters (Å, º) top
C1—C2 | 1.532 (6) | C39—C40 | 1.538 (6) |
C1—C10 | 1.534 (6) | C39—C48 | 1.552 (6) |
C1—H1A | 0.9900 | C39—H39A | 0.9900 |
C1—H1B | 0.9900 | C39—H39B | 0.9900 |
C2—C3 | 1.532 (6) | C40—C41 | 1.535 (7) |
C2—H2A | 0.9900 | C40—H40A | 0.9900 |
C2—H2B | 0.9900 | C40—H40B | 0.9900 |
C3—C4 | 1.527 (6) | C41—C42 | 1.531 (6) |
C3—H3A | 0.9900 | C41—H41A | 0.9900 |
C3—H3B | 0.9900 | C41—H41B | 0.9900 |
C4—C5 | 1.536 (5) | C42—C43 | 1.531 (5) |
C4—H4A | 0.9900 | C42—H42A | 0.9900 |
C4—H4B | 0.9900 | C42—H42B | 0.9900 |
C5—C6 | 1.519 (6) | C43—C44 | 1.530 (6) |
C5—C10 | 1.551 (6) | C43—C48 | 1.540 (6) |
C5—H5 | 1.0000 | C43—H43 | 1.0000 |
C6—C7 | 1.529 (5) | C44—C45 | 1.524 (5) |
C6—H6A | 0.9900 | C44—H44A | 0.9900 |
C6—H6B | 0.9900 | C44—H44B | 0.9900 |
C7—C8 | 1.529 (6) | C45—C46 | 1.529 (6) |
C7—H7A | 0.9900 | C45—H45A | 0.9900 |
C7—H7B | 0.9900 | C45—H45B | 0.9900 |
C8—C14 | 1.523 (5) | C46—C52 | 1.528 (5) |
C8—C9 | 1.544 (5) | C46—C47 | 1.553 (6) |
C8—H8 | 1.0000 | C46—H46 | 1.0000 |
C9—C11 | 1.534 (6) | C47—C49 | 1.536 (6) |
C9—C10 | 1.561 (5) | C47—C48 | 1.552 (5) |
C9—H9 | 1.0000 | C47—H47 | 1.0000 |
C10—C18 | 1.547 (6) | C48—C56 | 1.541 (6) |
C11—C12 | 1.543 (6) | C49—C50 | 1.539 (6) |
C11—H11A | 0.9900 | C49—H49A | 0.9900 |
C11—H11B | 0.9900 | C49—H49B | 0.9900 |
C12—C13 | 1.517 (6) | C50—C51 | 1.516 (7) |
C12—H12A | 0.9900 | C50—H50A | 0.9900 |
C12—H12B | 0.9900 | C50—H50B | 0.9900 |
C13—C17 | 1.534 (6) | C51—C55 | 1.539 (6) |
C13—C14 | 1.541 (6) | C51—C57 | 1.542 (6) |
C13—C19 | 1.541 (6) | C51—C52 | 1.545 (6) |
C14—C15 | 1.533 (6) | C52—C53 | 1.517 (6) |
C14—H14 | 1.0000 | C52—H52 | 1.0000 |
C15—C16 | 1.556 (6) | C53—C54 | 1.551 (6) |
C15—H15A | 0.9900 | C53—H53A | 0.9900 |
C15—H15B | 0.9900 | C53—H53B | 0.9900 |
C16—C17 | 1.564 (7) | C54—C55 | 1.547 (7) |
C16—H16A | 0.9900 | C54—H54A | 0.9900 |
C16—H16B | 0.9900 | C54—H54B | 0.9900 |
C17—H17A | 0.9900 | C55—H55A | 0.9900 |
C17—H17B | 0.9900 | C55—H55B | 0.9900 |
C18—H18A | 0.9800 | C56—H56A | 0.9800 |
C18—H18B | 0.9800 | C56—H56B | 0.9800 |
C18—H18C | 0.9800 | C56—H56C | 0.9800 |
C19—H19A | 0.9800 | C57—H57A | 0.9800 |
C19—H19B | 0.9800 | C57—H57B | 0.9800 |
C19—H19C | 0.9800 | C57—H57C | 0.9800 |
C20—C21 | 1.540 (6) | C58—C59 | 1.533 (5) |
C20—C29 | 1.554 (6) | C58—C67 | 1.546 (6) |
C20—H20A | 0.9900 | C58—H58A | 0.9900 |
C20—H20B | 0.9900 | C58—H58B | 0.9900 |
C21—C22 | 1.517 (7) | C59—C60 | 1.526 (6) |
C21—H21A | 0.9900 | C59—H59A | 0.9900 |
C21—H21B | 0.9900 | C59—H59B | 0.9900 |
C22—C23 | 1.538 (7) | C60—C61 | 1.525 (7) |
C22—H22A | 0.9900 | C60—H60A | 0.9900 |
C22—H22B | 0.9900 | C60—H60B | 0.9900 |
C23—C24 | 1.526 (5) | C61—C62 | 1.532 (5) |
C23—H23A | 0.9900 | C61—H61A | 0.9900 |
C23—H23B | 0.9900 | C61—H61B | 0.9900 |
C24—C29 | 1.523 (6) | C62—C63 | 1.518 (6) |
C24—C25 | 1.560 (6) | C62—C67 | 1.560 (6) |
C24—H24 | 1.0000 | C62—H62 | 1.0000 |
C25—C26 | 1.523 (6) | C63—C64 | 1.527 (5) |
C25—H25A | 0.9900 | C63—H63A | 0.9900 |
C25—H25B | 0.9900 | C63—H63B | 0.9900 |
C26—C27 | 1.513 (6) | C64—C65 | 1.526 (6) |
C26—H26A | 0.9900 | C64—H64A | 0.9900 |
C26—H26B | 0.9900 | C64—H64B | 0.9900 |
C27—C33 | 1.525 (5) | C65—C71 | 1.520 (5) |
C27—C28 | 1.569 (6) | C65—C66 | 1.545 (6) |
C27—H27 | 1.0000 | C65—H65 | 1.0000 |
C28—C30 | 1.524 (5) | C66—C68 | 1.550 (6) |
C28—C29 | 1.555 (5) | C66—C67 | 1.561 (5) |
C28—H28 | 1.0000 | C66—H66 | 1.0000 |
C29—C37 | 1.548 (6) | C67—C75 | 1.533 (6) |
C30—C31 | 1.544 (5) | C68—C69 | 1.539 (5) |
C30—H30A | 0.9900 | C68—H68A | 0.9900 |
C30—H30B | 0.9900 | C68—H68B | 0.9900 |
C31—C32 | 1.513 (6) | C69—C70 | 1.515 (6) |
C31—H31A | 0.9900 | C69—H69A | 0.9900 |
C31—H31B | 0.9900 | C69—H69B | 0.9900 |
C32—C38 | 1.534 (6) | C70—C74 | 1.534 (6) |
C32—C36 | 1.544 (6) | C70—C76 | 1.538 (6) |
C32—C33 | 1.544 (6) | C70—C71 | 1.538 (6) |
C33—C34 | 1.521 (6) | C71—C72 | 1.539 (6) |
C33—H33 | 1.0000 | C71—H71 | 1.0000 |
C34—C35 | 1.552 (6) | C72—C73 | 1.548 (5) |
C34—H34A | 0.9900 | C72—H72A | 0.9900 |
C34—H34B | 0.9900 | C72—H72B | 0.9900 |
C35—C36 | 1.555 (6) | C73—C74 | 1.565 (7) |
C35—H35A | 0.9900 | C73—H73A | 0.9900 |
C35—H35B | 0.9900 | C73—H73B | 0.9900 |
C36—H36A | 0.9900 | C74—H74A | 0.9900 |
C36—H36B | 0.9900 | C74—H74B | 0.9900 |
C37—H37A | 0.9800 | C75—H75A | 0.9800 |
C37—H37B | 0.9800 | C75—H75B | 0.9800 |
C37—H37C | 0.9800 | C75—H75C | 0.9800 |
C38—H38A | 0.9800 | C76—H76A | 0.9800 |
C38—H38B | 0.9800 | C76—H76B | 0.9800 |
C38—H38C | 0.9800 | C76—H76C | 0.9800 |
| | | |
C2—C1—C10 | 113.3 (4) | C40—C39—C48 | 113.5 (4) |
C2—C1—H1A | 108.9 | C40—C39—H39A | 108.9 |
C10—C1—H1A | 108.9 | C48—C39—H39A | 108.9 |
C2—C1—H1B | 108.9 | C40—C39—H39B | 108.9 |
C10—C1—H1B | 108.9 | C48—C39—H39B | 108.9 |
H1A—C1—H1B | 107.7 | H39A—C39—H39B | 107.7 |
C3—C2—C1 | 111.8 (4) | C41—C40—C39 | 111.8 (4) |
C3—C2—H2A | 109.2 | C41—C40—H40A | 109.3 |
C1—C2—H2A | 109.2 | C39—C40—H40A | 109.3 |
C3—C2—H2B | 109.2 | C41—C40—H40B | 109.3 |
C1—C2—H2B | 109.2 | C39—C40—H40B | 109.3 |
H2A—C2—H2B | 107.9 | H40A—C40—H40B | 107.9 |
C4—C3—C2 | 111.5 (3) | C42—C41—C40 | 111.3 (4) |
C4—C3—H3A | 109.3 | C42—C41—H41A | 109.4 |
C2—C3—H3A | 109.3 | C40—C41—H41A | 109.4 |
C4—C3—H3B | 109.3 | C42—C41—H41B | 109.4 |
C2—C3—H3B | 109.3 | C40—C41—H41B | 109.4 |
H3A—C3—H3B | 108.0 | H41A—C41—H41B | 108.0 |
C3—C4—C5 | 111.4 (4) | C41—C42—C43 | 110.7 (4) |
C3—C4—H4A | 109.4 | C41—C42—H42A | 109.5 |
C5—C4—H4A | 109.4 | C43—C42—H42A | 109.5 |
C3—C4—H4B | 109.4 | C41—C42—H42B | 109.5 |
C5—C4—H4B | 109.4 | C43—C42—H42B | 109.5 |
H4A—C4—H4B | 108.0 | H42A—C42—H42B | 108.1 |
C6—C5—C4 | 111.9 (4) | C44—C43—C42 | 111.2 (4) |
C6—C5—C10 | 113.0 (3) | C44—C43—C48 | 112.4 (3) |
C4—C5—C10 | 112.3 (3) | C42—C43—C48 | 113.1 (4) |
C6—C5—H5 | 106.4 | C44—C43—H43 | 106.5 |
C4—C5—H5 | 106.4 | C42—C43—H43 | 106.5 |
C10—C5—H5 | 106.4 | C48—C43—H43 | 106.5 |
C5—C6—C7 | 111.0 (4) | C45—C44—C43 | 111.1 (4) |
C5—C6—H6A | 109.4 | C45—C44—H44A | 109.4 |
C7—C6—H6A | 109.4 | C43—C44—H44A | 109.4 |
C5—C6—H6B | 109.4 | C45—C44—H44B | 109.4 |
C7—C6—H6B | 109.4 | C43—C44—H44B | 109.4 |
H6A—C6—H6B | 108.0 | H44A—C44—H44B | 108.0 |
C6—C7—C8 | 111.9 (4) | C44—C45—C46 | 112.5 (4) |
C6—C7—H7A | 109.2 | C44—C45—H45A | 109.1 |
C8—C7—H7A | 109.2 | C46—C45—H45A | 109.1 |
C6—C7—H7B | 109.2 | C44—C45—H45B | 109.1 |
C8—C7—H7B | 109.2 | C46—C45—H45B | 109.1 |
H7A—C7—H7B | 107.9 | H45A—C45—H45B | 107.8 |
C14—C8—C7 | 111.0 (4) | C52—C46—C45 | 111.0 (4) |
C14—C8—C9 | 109.4 (4) | C52—C46—C47 | 109.6 (3) |
C7—C8—C9 | 110.8 (3) | C45—C46—C47 | 110.5 (3) |
C14—C8—H8 | 108.5 | C52—C46—H46 | 108.6 |
C7—C8—H8 | 108.5 | C45—C46—H46 | 108.6 |
C9—C8—H8 | 108.5 | C47—C46—H46 | 108.6 |
C11—C9—C8 | 111.6 (3) | C49—C47—C48 | 114.5 (4) |
C11—C9—C10 | 113.7 (3) | C49—C47—C46 | 111.6 (3) |
C8—C9—C10 | 112.6 (3) | C48—C47—C46 | 111.8 (3) |
C11—C9—H9 | 106.1 | C49—C47—H47 | 106.1 |
C8—C9—H9 | 106.1 | C48—C47—H47 | 106.1 |
C10—C9—H9 | 106.1 | C46—C47—H47 | 106.1 |
C1—C10—C18 | 109.4 (3) | C43—C48—C56 | 112.1 (4) |
C1—C10—C5 | 107.9 (3) | C43—C48—C47 | 108.1 (3) |
C18—C10—C5 | 111.3 (4) | C56—C48—C47 | 111.2 (3) |
C1—C10—C9 | 110.6 (4) | C43—C48—C39 | 107.2 (3) |
C18—C10—C9 | 110.1 (3) | C56—C48—C39 | 108.5 (4) |
C5—C10—C9 | 107.5 (3) | C47—C48—C39 | 109.8 (4) |
C9—C11—C12 | 113.2 (4) | C47—C49—C50 | 113.6 (4) |
C9—C11—H11A | 108.9 | C47—C49—H49A | 108.8 |
C12—C11—H11A | 108.9 | C50—C49—H49A | 108.8 |
C9—C11—H11B | 108.9 | C47—C49—H49B | 108.8 |
C12—C11—H11B | 108.9 | C50—C49—H49B | 108.8 |
H11A—C11—H11B | 107.7 | H49A—C49—H49B | 107.7 |
C13—C12—C11 | 111.5 (4) | C51—C50—C49 | 111.0 (4) |
C13—C12—H12A | 109.3 | C51—C50—H50A | 109.4 |
C11—C12—H12A | 109.3 | C49—C50—H50A | 109.4 |
C13—C12—H12B | 109.3 | C51—C50—H50B | 109.4 |
C11—C12—H12B | 109.3 | C49—C50—H50B | 109.4 |
H12A—C12—H12B | 108.0 | H50A—C50—H50B | 108.0 |
C12—C13—C17 | 116.1 (4) | C50—C51—C55 | 116.3 (4) |
C12—C13—C14 | 108.4 (3) | C50—C51—C57 | 110.5 (4) |
C17—C13—C14 | 100.4 (4) | C55—C51—C57 | 108.1 (4) |
C12—C13—C19 | 110.2 (4) | C50—C51—C52 | 109.0 (3) |
C17—C13—C19 | 108.6 (4) | C55—C51—C52 | 99.8 (4) |
C14—C13—C19 | 113.0 (4) | C57—C51—C52 | 112.9 (4) |
C8—C14—C15 | 119.1 (4) | C53—C52—C46 | 119.8 (4) |
C8—C14—C13 | 113.6 (4) | C53—C52—C51 | 104.4 (3) |
C15—C14—C13 | 104.1 (3) | C46—C52—C51 | 112.7 (4) |
C8—C14—H14 | 106.4 | C53—C52—H52 | 106.3 |
C15—C14—H14 | 106.4 | C46—C52—H52 | 106.3 |
C13—C14—H14 | 106.4 | C51—C52—H52 | 106.3 |
C14—C15—C16 | 103.0 (4) | C52—C53—C54 | 104.3 (4) |
C14—C15—H15A | 111.2 | C52—C53—H53A | 110.9 |
C16—C15—H15A | 111.2 | C54—C53—H53A | 110.9 |
C14—C15—H15B | 111.2 | C52—C53—H53B | 110.9 |
C16—C15—H15B | 111.2 | C54—C53—H53B | 110.9 |
H15A—C15—H15B | 109.1 | H53A—C53—H53B | 108.9 |
C15—C16—C17 | 106.4 (4) | C55—C54—C53 | 105.9 (4) |
C15—C16—H16A | 110.4 | C55—C54—H54A | 110.6 |
C17—C16—H16A | 110.4 | C53—C54—H54A | 110.6 |
C15—C16—H16B | 110.4 | C55—C54—H54B | 110.6 |
C17—C16—H16B | 110.4 | C53—C54—H54B | 110.6 |
H16A—C16—H16B | 108.6 | H54A—C54—H54B | 108.7 |
C13—C17—C16 | 104.3 (4) | C51—C55—C54 | 104.6 (4) |
C13—C17—H17A | 110.9 | C51—C55—H55A | 110.8 |
C16—C17—H17A | 110.9 | C54—C55—H55A | 110.8 |
C13—C17—H17B | 110.9 | C51—C55—H55B | 110.8 |
C16—C17—H17B | 110.9 | C54—C55—H55B | 110.8 |
H17A—C17—H17B | 108.9 | H55A—C55—H55B | 108.9 |
C10—C18—H18A | 109.5 | C48—C56—H56A | 109.5 |
C10—C18—H18B | 109.5 | C48—C56—H56B | 109.5 |
H18A—C18—H18B | 109.5 | H56A—C56—H56B | 109.5 |
C10—C18—H18C | 109.5 | C48—C56—H56C | 109.5 |
H18A—C18—H18C | 109.5 | H56A—C56—H56C | 109.5 |
H18B—C18—H18C | 109.5 | H56B—C56—H56C | 109.5 |
C13—C19—H19A | 109.5 | C51—C57—H57A | 109.5 |
C13—C19—H19B | 109.5 | C51—C57—H57B | 109.5 |
H19A—C19—H19B | 109.5 | H57A—C57—H57B | 109.5 |
C13—C19—H19C | 109.5 | C51—C57—H57C | 109.5 |
H19A—C19—H19C | 109.5 | H57A—C57—H57C | 109.5 |
H19B—C19—H19C | 109.5 | H57B—C57—H57C | 109.5 |
C21—C20—C29 | 112.8 (4) | C59—C58—C67 | 112.8 (4) |
C21—C20—H20A | 109.0 | C59—C58—H58A | 109.0 |
C29—C20—H20A | 109.0 | C67—C58—H58A | 109.0 |
C21—C20—H20B | 109.0 | C59—C58—H58B | 109.0 |
C29—C20—H20B | 109.0 | C67—C58—H58B | 109.0 |
H20A—C20—H20B | 107.8 | H58A—C58—H58B | 107.8 |
C22—C21—C20 | 112.0 (4) | C60—C59—C58 | 111.6 (4) |
C22—C21—H21A | 109.2 | C60—C59—H59A | 109.3 |
C20—C21—H21A | 109.2 | C58—C59—H59A | 109.3 |
C22—C21—H21B | 109.2 | C60—C59—H59B | 109.3 |
C20—C21—H21B | 109.2 | C58—C59—H59B | 109.3 |
H21A—C21—H21B | 107.9 | H59A—C59—H59B | 108.0 |
C21—C22—C23 | 111.5 (4) | C61—C60—C59 | 111.4 (4) |
C21—C22—H22A | 109.3 | C61—C60—H60A | 109.4 |
C23—C22—H22A | 109.3 | C59—C60—H60A | 109.4 |
C21—C22—H22B | 109.3 | C61—C60—H60B | 109.4 |
C23—C22—H22B | 109.3 | C59—C60—H60B | 109.4 |
H22A—C22—H22B | 108.0 | H60A—C60—H60B | 108.0 |
C24—C23—C22 | 110.7 (4) | C60—C61—C62 | 111.1 (4) |
C24—C23—H23A | 109.5 | C60—C61—H61A | 109.4 |
C22—C23—H23A | 109.5 | C62—C61—H61A | 109.4 |
C24—C23—H23B | 109.5 | C60—C61—H61B | 109.4 |
C22—C23—H23B | 109.5 | C62—C61—H61B | 109.4 |
H23A—C23—H23B | 108.1 | H61A—C61—H61B | 108.0 |
C29—C24—C23 | 114.7 (4) | C63—C62—C61 | 112.0 (4) |
C29—C24—C25 | 112.6 (3) | C63—C62—C67 | 112.0 (3) |
C23—C24—C25 | 110.5 (4) | C61—C62—C67 | 113.3 (4) |
C29—C24—H24 | 106.1 | C63—C62—H62 | 106.3 |
C23—C24—H24 | 106.1 | C61—C62—H62 | 106.3 |
C25—C24—H24 | 106.1 | C67—C62—H62 | 106.3 |
C26—C25—C24 | 110.0 (3) | C62—C63—C64 | 112.0 (4) |
C26—C25—H25A | 109.7 | C62—C63—H63A | 109.2 |
C24—C25—H25A | 109.7 | C64—C63—H63A | 109.2 |
C26—C25—H25B | 109.7 | C62—C63—H63B | 109.2 |
C24—C25—H25B | 109.7 | C64—C63—H63B | 109.2 |
H25A—C25—H25B | 108.2 | H63A—C63—H63B | 107.9 |
C27—C26—C25 | 113.9 (4) | C65—C64—C63 | 111.8 (4) |
C27—C26—H26A | 108.8 | C65—C64—H64A | 109.2 |
C25—C26—H26A | 108.8 | C63—C64—H64A | 109.2 |
C27—C26—H26B | 108.8 | C65—C64—H64B | 109.2 |
C25—C26—H26B | 108.8 | C63—C64—H64B | 109.2 |
H26A—C26—H26B | 107.7 | H64A—C64—H64B | 107.9 |
C26—C27—C33 | 111.5 (4) | C71—C65—C64 | 111.9 (4) |
C26—C27—C28 | 111.4 (3) | C71—C65—C66 | 108.6 (3) |
C33—C27—C28 | 108.6 (3) | C64—C65—C66 | 111.1 (3) |
C26—C27—H27 | 108.4 | C71—C65—H65 | 108.4 |
C33—C27—H27 | 108.4 | C64—C65—H65 | 108.4 |
C28—C27—H27 | 108.4 | C66—C65—H65 | 108.4 |
C30—C28—C29 | 115.7 (4) | C65—C66—C68 | 111.7 (3) |
C30—C28—C27 | 111.9 (3) | C65—C66—C67 | 113.0 (3) |
C29—C28—C27 | 110.8 (3) | C68—C66—C67 | 113.5 (4) |
C30—C28—H28 | 105.9 | C65—C66—H66 | 106.0 |
C29—C28—H28 | 105.9 | C68—C66—H66 | 106.0 |
C27—C28—H28 | 105.9 | C67—C66—H66 | 106.0 |
C24—C29—C37 | 112.4 (3) | C75—C67—C58 | 109.5 (4) |
C24—C29—C20 | 107.7 (3) | C75—C67—C62 | 112.1 (3) |
C37—C29—C20 | 108.1 (4) | C58—C67—C62 | 107.5 (3) |
C24—C29—C28 | 108.8 (3) | C75—C67—C66 | 110.5 (3) |
C37—C29—C28 | 110.2 (3) | C58—C67—C66 | 110.8 (3) |
C20—C29—C28 | 109.5 (3) | C62—C67—C66 | 106.4 (3) |
C28—C30—C31 | 113.1 (3) | C69—C68—C66 | 112.9 (4) |
C28—C30—H30A | 109.0 | C69—C68—H68A | 109.0 |
C31—C30—H30A | 109.0 | C66—C68—H68A | 109.0 |
C28—C30—H30B | 109.0 | C69—C68—H68B | 109.0 |
C31—C30—H30B | 109.0 | C66—C68—H68B | 109.0 |
H30A—C30—H30B | 107.8 | H68A—C68—H68B | 107.8 |
C32—C31—C30 | 111.2 (4) | C70—C69—C68 | 111.5 (3) |
C32—C31—H31A | 109.4 | C70—C69—H69A | 109.3 |
C30—C31—H31A | 109.4 | C68—C69—H69A | 109.3 |
C32—C31—H31B | 109.4 | C70—C69—H69B | 109.3 |
C30—C31—H31B | 109.4 | C68—C69—H69B | 109.3 |
H31A—C31—H31B | 108.0 | H69A—C69—H69B | 108.0 |
C31—C32—C38 | 110.8 (4) | C69—C70—C74 | 116.4 (4) |
C31—C32—C36 | 116.5 (4) | C69—C70—C76 | 111.2 (4) |
C38—C32—C36 | 108.1 (3) | C74—C70—C76 | 108.2 (3) |
C31—C32—C33 | 108.2 (3) | C69—C70—C71 | 107.8 (3) |
C38—C32—C33 | 113.1 (4) | C74—C70—C71 | 100.3 (3) |
C36—C32—C33 | 99.8 (3) | C76—C70—C71 | 112.6 (3) |
C34—C33—C27 | 119.2 (4) | C65—C71—C70 | 115.1 (4) |
C34—C33—C32 | 104.1 (3) | C65—C71—C72 | 118.8 (4) |
C27—C33—C32 | 114.3 (4) | C70—C71—C72 | 104.4 (3) |
C34—C33—H33 | 106.1 | C65—C71—H71 | 105.8 |
C27—C33—H33 | 106.1 | C70—C71—H71 | 105.8 |
C32—C33—H33 | 106.1 | C72—C71—H71 | 105.8 |
C33—C34—C35 | 104.1 (4) | C71—C72—C73 | 103.4 (3) |
C33—C34—H34A | 110.9 | C71—C72—H72A | 111.1 |
C35—C34—H34A | 110.9 | C73—C72—H72A | 111.1 |
C33—C34—H34B | 110.9 | C71—C72—H72B | 111.1 |
C35—C34—H34B | 110.9 | C73—C72—H72B | 111.1 |
H34A—C34—H34B | 108.9 | H72A—C72—H72B | 109.1 |
C34—C35—C36 | 105.7 (3) | C72—C73—C74 | 106.2 (3) |
C34—C35—H35A | 110.6 | C72—C73—H73A | 110.5 |
C36—C35—H35A | 110.6 | C74—C73—H73A | 110.5 |
C34—C35—H35B | 110.6 | C72—C73—H73B | 110.5 |
C36—C35—H35B | 110.6 | C74—C73—H73B | 110.5 |
H35A—C35—H35B | 108.7 | H73A—C73—H73B | 108.7 |
C32—C36—C35 | 105.1 (3) | C70—C74—C73 | 105.0 (3) |
C32—C36—H36A | 110.7 | C70—C74—H74A | 110.7 |
C35—C36—H36A | 110.7 | C73—C74—H74A | 110.7 |
C32—C36—H36B | 110.7 | C70—C74—H74B | 110.7 |
C35—C36—H36B | 110.7 | C73—C74—H74B | 110.7 |
H36A—C36—H36B | 108.8 | H74A—C74—H74B | 108.8 |
C29—C37—H37A | 109.5 | C67—C75—H75A | 109.5 |
C29—C37—H37B | 109.5 | C67—C75—H75B | 109.5 |
H37A—C37—H37B | 109.5 | H75A—C75—H75B | 109.5 |
C29—C37—H37C | 109.5 | C67—C75—H75C | 109.5 |
H37A—C37—H37C | 109.5 | H75A—C75—H75C | 109.5 |
H37B—C37—H37C | 109.5 | H75B—C75—H75C | 109.5 |
C32—C38—H38A | 109.5 | C70—C76—H76A | 109.5 |
C32—C38—H38B | 109.5 | C70—C76—H76B | 109.5 |
H38A—C38—H38B | 109.5 | H76A—C76—H76B | 109.5 |
C32—C38—H38C | 109.5 | C70—C76—H76C | 109.5 |
H38A—C38—H38C | 109.5 | H76A—C76—H76C | 109.5 |
H38B—C38—H38C | 109.5 | H76B—C76—H76C | 109.5 |
| | | |
C10—C1—C2—C3 | −54.9 (5) | C48—C39—C40—C41 | −54.1 (5) |
C1—C2—C3—C4 | 52.3 (5) | C39—C40—C41—C42 | 52.6 (6) |
C2—C3—C4—C5 | −53.5 (5) | C40—C41—C42—C43 | −54.5 (5) |
C3—C4—C5—C6 | −174.8 (4) | C41—C42—C43—C44 | −173.6 (4) |
C3—C4—C5—C10 | 56.9 (5) | C41—C42—C43—C48 | 58.8 (5) |
C4—C5—C6—C7 | 174.8 (4) | C42—C43—C44—C45 | 175.5 (4) |
C10—C5—C6—C7 | −57.3 (5) | C48—C43—C44—C45 | −56.5 (5) |
C5—C6—C7—C8 | 54.9 (5) | C43—C44—C45—C46 | 53.9 (5) |
C6—C7—C8—C14 | −176.0 (4) | C44—C45—C46—C52 | −175.5 (4) |
C6—C7—C8—C9 | −54.2 (5) | C44—C45—C46—C47 | −53.7 (5) |
C14—C8—C9—C11 | −52.2 (5) | C52—C46—C47—C49 | −51.5 (5) |
C7—C8—C9—C11 | −175.0 (4) | C45—C46—C47—C49 | −174.1 (4) |
C14—C8—C9—C10 | 178.5 (3) | C52—C46—C47—C48 | 178.8 (3) |
C7—C8—C9—C10 | 55.7 (5) | C45—C46—C47—C48 | 56.2 (5) |
C2—C1—C10—C18 | −65.6 (5) | C44—C43—C48—C56 | −65.3 (5) |
C2—C1—C10—C5 | 55.6 (5) | C42—C43—C48—C56 | 61.7 (5) |
C2—C1—C10—C9 | 173.0 (4) | C44—C43—C48—C47 | 57.5 (5) |
C6—C5—C10—C1 | 175.8 (4) | C42—C43—C48—C47 | −175.4 (4) |
C4—C5—C10—C1 | −56.5 (5) | C44—C43—C48—C39 | 175.8 (3) |
C6—C5—C10—C18 | −64.1 (5) | C42—C43—C48—C39 | −57.1 (5) |
C4—C5—C10—C18 | 63.6 (5) | C49—C47—C48—C43 | 174.5 (4) |
C6—C5—C10—C9 | 56.5 (5) | C46—C47—C48—C43 | −57.3 (5) |
C4—C5—C10—C9 | −175.8 (3) | C49—C47—C48—C56 | −62.1 (5) |
C11—C9—C10—C1 | 58.7 (5) | C46—C47—C48—C56 | 66.1 (5) |
C8—C9—C10—C1 | −173.1 (3) | C49—C47—C48—C39 | 57.9 (5) |
C11—C9—C10—C18 | −62.3 (5) | C46—C47—C48—C39 | −173.9 (3) |
C8—C9—C10—C18 | 65.8 (5) | C40—C39—C48—C43 | 54.7 (5) |
C11—C9—C10—C5 | 176.3 (4) | C40—C39—C48—C56 | −66.5 (5) |
C8—C9—C10—C5 | −55.5 (4) | C40—C39—C48—C47 | 171.8 (4) |
C8—C9—C11—C12 | 51.8 (5) | C48—C47—C49—C50 | 179.4 (4) |
C10—C9—C11—C12 | −179.6 (4) | C46—C47—C49—C50 | 51.1 (5) |
C9—C11—C12—C13 | −54.2 (5) | C47—C49—C50—C51 | −54.1 (5) |
C11—C12—C13—C17 | 167.6 (4) | C49—C50—C51—C55 | 168.3 (4) |
C11—C12—C13—C14 | 55.6 (5) | C49—C50—C51—C57 | −68.0 (5) |
C11—C12—C13—C19 | −68.5 (5) | C49—C50—C51—C52 | 56.6 (5) |
C7—C8—C14—C15 | −56.5 (5) | C45—C46—C52—C53 | −57.0 (5) |
C9—C8—C14—C15 | −179.1 (4) | C47—C46—C52—C53 | −179.3 (4) |
C7—C8—C14—C13 | −179.7 (4) | C45—C46—C52—C51 | 179.6 (3) |
C9—C8—C14—C13 | 57.7 (5) | C47—C46—C52—C51 | 57.3 (5) |
C12—C13—C14—C8 | −59.6 (5) | C50—C51—C52—C53 | 168.1 (4) |
C17—C13—C14—C8 | 178.3 (4) | C55—C51—C52—C53 | 45.8 (4) |
C19—C13—C14—C8 | 62.9 (5) | C57—C51—C52—C53 | −68.7 (4) |
C12—C13—C14—C15 | 169.4 (4) | C50—C51—C52—C46 | −60.3 (5) |
C17—C13—C14—C15 | 47.2 (4) | C55—C51—C52—C46 | 177.4 (4) |
C19—C13—C14—C15 | −68.2 (4) | C57—C51—C52—C46 | 62.9 (5) |
C8—C14—C15—C16 | −163.9 (4) | C46—C52—C53—C54 | −160.9 (4) |
C13—C14—C15—C16 | −36.1 (4) | C51—C52—C53—C54 | −33.5 (5) |
C14—C15—C16—C17 | 11.2 (5) | C52—C53—C54—C55 | 7.9 (5) |
C12—C13—C17—C16 | −155.5 (4) | C50—C51—C55—C54 | −156.9 (4) |
C14—C13—C17—C16 | −39.0 (4) | C57—C51—C55—C54 | 78.1 (5) |
C19—C13—C17—C16 | 79.7 (5) | C52—C51—C55—C54 | −40.0 (5) |
C15—C16—C17—C13 | 17.7 (5) | C53—C54—C55—C51 | 20.5 (5) |
C29—C20—C21—C22 | −55.3 (5) | C67—C58—C59—C60 | −56.6 (5) |
C20—C21—C22—C23 | 53.5 (5) | C58—C59—C60—C61 | 54.6 (5) |
C21—C22—C23—C24 | −53.0 (5) | C59—C60—C61—C62 | −54.1 (5) |
C22—C23—C24—C29 | 55.9 (5) | C60—C61—C62—C63 | −176.0 (4) |
C22—C23—C24—C25 | −175.6 (4) | C60—C61—C62—C67 | 56.1 (5) |
C29—C24—C25—C26 | −55.8 (5) | C61—C62—C63—C64 | 173.2 (4) |
C23—C24—C25—C26 | 174.6 (4) | C67—C62—C63—C64 | −58.3 (5) |
C24—C25—C26—C27 | 52.4 (5) | C62—C63—C64—C65 | 54.0 (5) |
C25—C26—C27—C33 | −174.4 (4) | C63—C64—C65—C71 | −173.6 (4) |
C25—C26—C27—C28 | −52.8 (5) | C63—C64—C65—C66 | −52.0 (5) |
C26—C27—C28—C30 | −174.6 (4) | C71—C65—C66—C68 | −51.5 (4) |
C33—C27—C28—C30 | −51.3 (5) | C64—C65—C66—C68 | −174.9 (3) |
C26—C27—C28—C29 | 54.6 (5) | C71—C65—C66—C67 | 179.2 (3) |
C33—C27—C28—C29 | 177.9 (3) | C64—C65—C66—C67 | 55.7 (5) |
C23—C24—C29—C37 | 63.7 (5) | C59—C58—C67—C75 | −66.8 (5) |
C25—C24—C29—C37 | −63.8 (4) | C59—C58—C67—C62 | 55.2 (5) |
C23—C24—C29—C20 | −55.3 (5) | C59—C58—C67—C66 | 171.0 (4) |
C25—C24—C29—C20 | 177.2 (3) | C63—C62—C67—C75 | −62.8 (4) |
C23—C24—C29—C28 | −174.0 (3) | C61—C62—C67—C75 | 65.0 (5) |
C25—C24—C29—C28 | 58.6 (5) | C63—C62—C67—C58 | 176.8 (3) |
C21—C20—C29—C24 | 54.1 (5) | C61—C62—C67—C58 | −55.3 (5) |
C21—C20—C29—C37 | −67.6 (5) | C63—C62—C67—C66 | 58.1 (4) |
C21—C20—C29—C28 | 172.3 (4) | C61—C62—C67—C66 | −174.1 (4) |
C30—C28—C29—C24 | 174.1 (3) | C65—C66—C67—C75 | 64.8 (5) |
C27—C28—C29—C24 | −57.1 (4) | C68—C66—C67—C75 | −63.7 (5) |
C30—C28—C29—C37 | −62.2 (5) | C65—C66—C67—C58 | −173.7 (3) |
C27—C28—C29—C37 | 66.5 (4) | C68—C66—C67—C58 | 57.9 (5) |
C30—C28—C29—C20 | 56.6 (5) | C65—C66—C67—C62 | −57.1 (4) |
C27—C28—C29—C20 | −174.7 (3) | C68—C66—C67—C62 | 174.4 (3) |
C29—C28—C30—C31 | −179.3 (4) | C65—C66—C68—C69 | 52.3 (5) |
C27—C28—C30—C31 | 52.5 (5) | C67—C66—C68—C69 | −178.6 (4) |
C28—C30—C31—C32 | −55.9 (5) | C66—C68—C69—C70 | −55.0 (5) |
C30—C31—C32—C38 | −67.9 (4) | C68—C69—C70—C74 | 167.5 (4) |
C30—C31—C32—C36 | 168.0 (4) | C68—C69—C70—C76 | −68.0 (4) |
C30—C31—C32—C33 | 56.6 (5) | C68—C69—C70—C71 | 55.9 (4) |
C26—C27—C33—C34 | −56.3 (5) | C64—C65—C71—C70 | −179.7 (3) |
C28—C27—C33—C34 | −179.6 (4) | C66—C65—C71—C70 | 57.4 (5) |
C26—C27—C33—C32 | 179.6 (4) | C64—C65—C71—C72 | −54.8 (5) |
C28—C27—C33—C32 | 56.4 (5) | C66—C65—C71—C72 | −177.8 (4) |
C31—C32—C33—C34 | 168.4 (4) | C69—C70—C71—C65 | −59.8 (5) |
C38—C32—C33—C34 | −68.5 (4) | C74—C70—C71—C65 | 178.0 (4) |
C36—C32—C33—C34 | 46.1 (4) | C76—C70—C71—C65 | 63.2 (5) |
C31—C32—C33—C27 | −59.8 (5) | C69—C70—C71—C72 | 168.2 (3) |
C38—C32—C33—C27 | 63.3 (5) | C74—C70—C71—C72 | 46.0 (4) |
C36—C32—C33—C27 | 177.9 (4) | C76—C70—C71—C72 | −68.8 (4) |
C27—C33—C34—C35 | −165.1 (4) | C65—C71—C72—C73 | −165.8 (4) |
C32—C33—C34—C35 | −36.2 (4) | C70—C71—C72—C73 | −35.9 (4) |
C33—C34—C35—C36 | 11.7 (5) | C71—C72—C73—C74 | 11.6 (5) |
C31—C32—C36—C35 | −154.2 (4) | C69—C70—C74—C73 | −153.7 (4) |
C38—C32—C36—C35 | 80.3 (4) | C76—C70—C74—C73 | 80.3 (4) |
C33—C32—C36—C35 | −38.1 (4) | C71—C70—C74—C73 | −37.8 (4) |
C34—C35—C36—C32 | 16.9 (5) | C72—C73—C74—C70 | 16.6 (4) |
5
α,14
α-Androstane, Form II w/ impurity (Form_II_impure)
top
Crystal data top
2C19H31O0.50·C19H32 | Dx = 1.114 Mg m−3 |
Mr = 795.32 | Cu Kα radiation, λ = 1.54184 Å |
Orthorhombic, P212121 | Cell parameters from 31747 reflections |
a = 7.1699 (1) Å | θ = 2.0–74.8° |
b = 22.1480 (3) Å | µ = 0.46 mm−1 |
c = 29.8734 (5) Å | T = 90 K |
V = 4743.86 (12) Å3 | Needle, colorless |
Z = 4 | 0.19 × 0.06 × 0.03 mm |
F(000) = 1776 | |
Data collection top
ROD, Synergy Custom system, HyPix diffractometer | 9113 independent reflections |
Radiation source: Rotating-anode X-ray tube | 8487 reflections with I > 2σ(I) |
Detector resolution: 10.0000 pixels mm-1 | Rint = 0.059 |
ω scans | θmax = 75.1°, θmin = 2.5° |
Absorption correction: gaussian (CrysAlis PRO; Rigaku OD, 2021) | h = −8→7 |
Tmin = 0.757, Tmax = 1.000 | k = −26→27 |
59898 measured reflections | l = −36→34 |
Refinement top
Refinement on F2 | Hydrogen site location: inferred from neighbouring sites |
Least-squares matrix: full | H-atom parameters constrained |
R[F2 > 2σ(F2)] = 0.045 | w = 1/[σ2(Fo2) + (0.0541P)2 + 1.8106P] where P = (Fo2 + 2Fc2)/3 |
wR(F2) = 0.112 | (Δ/σ)max < 0.001 |
S = 1.03 | Δρmax = 0.24 e Å−3 |
9113 reflections | Δρmin = −0.34 e Å−3 |
539 parameters | Extinction correction: SHELXL2018 (Sheldrick, 2015b), Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4 |
0 restraints | Extinction coefficient: 0.00062 (10) |
Primary atom site location: iterative | Absolute structure: Flack x determined using 3326 quotients [(I+)-(I-)]/[(I+)+(I-)]
(Parsons et al., 2013) |
Secondary atom site location: difference Fourier map | Absolute structure parameter: 0.0 (2) |
Special details top
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes)
are estimated using the full covariance matrix. The cell esds are taken
into account individually in the estimation of esds in distances, angles
and torsion angles; correlations between esds in cell parameters are only
used when they are defined by crystal symmetry. An approximate (isotropic)
treatment of cell esds is used for estimating esds involving l.s. planes. |
Refinement. Data were integrated and
scaled using CrysAlis PRO (Rigaku OD, 2021). WinGX (Farrugia, 2012) was used
for the solution and refinement of the crystal structures.
Solution by intrinsic phasing (SHELXT2014; Sheldrick, 2015a) produced
a complete heavy-atom phasing model. All non-H atoms were refined
anisotropically by full-matrix least-squares (SHELXL2018; Sheldrick,
2015b). |
Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top | x | y | z | Uiso*/Ueq | Occ. (<1) |
C1 | 0.3096 (3) | 0.69774 (11) | 0.46259 (9) | 0.0256 (5) | |
H1A | 0.429224 | 0.716861 | 0.454056 | 0.031* | |
H1B | 0.264300 | 0.717920 | 0.490091 | 0.031* | |
C2 | 0.3441 (4) | 0.63099 (12) | 0.47277 (9) | 0.0303 (6) | |
H2A | 0.401442 | 0.611506 | 0.446307 | 0.036* | |
H2B | 0.432906 | 0.627557 | 0.498019 | 0.036* | |
C3 | 0.1641 (4) | 0.59809 (12) | 0.48469 (10) | 0.0327 (6) | |
H3A | 0.115443 | 0.613690 | 0.513466 | 0.039* | |
H3B | 0.189902 | 0.554452 | 0.488358 | 0.039* | |
C4 | 0.0181 (4) | 0.60706 (12) | 0.44811 (9) | 0.0303 (6) | |
H4A | −0.100861 | 0.588437 | 0.457729 | 0.036* | |
H4B | 0.059683 | 0.586276 | 0.420522 | 0.036* | |
C5 | −0.0148 (3) | 0.67409 (12) | 0.43780 (8) | 0.0246 (5) | |
H5 | −0.059826 | 0.692943 | 0.466233 | 0.030* | |
C6 | −0.1690 (3) | 0.68352 (12) | 0.40326 (9) | 0.0267 (5) | |
H6A | −0.282637 | 0.661773 | 0.412981 | 0.032* | |
H6B | −0.129108 | 0.666382 | 0.374186 | 0.032* | |
C7 | −0.2144 (4) | 0.75054 (12) | 0.39730 (9) | 0.0263 (5) | |
H7A | −0.304438 | 0.755148 | 0.372413 | 0.032* | |
H7B | −0.274598 | 0.765758 | 0.424899 | 0.032* | |
C8 | −0.0416 (3) | 0.78878 (11) | 0.38739 (8) | 0.0222 (5) | |
H8 | 0.004952 | 0.778308 | 0.356802 | 0.027* | |
C9 | 0.1160 (3) | 0.77643 (11) | 0.42159 (8) | 0.0223 (5) | |
H9 | 0.064183 | 0.787692 | 0.451519 | 0.027* | |
C10 | 0.1666 (3) | 0.70791 (12) | 0.42473 (8) | 0.0236 (5) | |
C11 | 0.2840 (3) | 0.81831 (12) | 0.41387 (9) | 0.0263 (5) | |
H11A | 0.343411 | 0.807794 | 0.384991 | 0.032* | |
H11B | 0.376854 | 0.811457 | 0.437866 | 0.032* | |
C12 | 0.2300 (3) | 0.88577 (11) | 0.41327 (9) | 0.0263 (5) | |
H12A | 0.185016 | 0.897870 | 0.443295 | 0.032* | |
H12B | 0.341247 | 0.910384 | 0.406080 | 0.032* | |
C13 | 0.0777 (3) | 0.89781 (11) | 0.37867 (8) | 0.0249 (5) | |
C14 | −0.0884 (3) | 0.85607 (11) | 0.38845 (8) | 0.0237 (5) | |
H14 | −0.127463 | 0.865077 | 0.419882 | 0.028* | |
C15 | −0.2436 (4) | 0.88051 (12) | 0.35853 (9) | 0.0280 (6) | |
H15A | −0.367894 | 0.870314 | 0.370796 | 0.034* | |
H15B | −0.233363 | 0.864062 | 0.327811 | 0.034* | |
C16 | −0.2110 (4) | 0.94973 (13) | 0.35886 (10) | 0.0338 (6) | |
H16A | −0.210189 | 0.965804 | 0.327941 | 0.041* | |
H16B | −0.310653 | 0.970332 | 0.375977 | 0.041* | |
C17 | −0.0189 (4) | 0.95970 (12) | 0.38149 (9) | 0.0297 (6) | |
H17A | 0.054016 | 0.990819 | 0.365373 | 0.036* | |
H17B | −0.034348 | 0.972421 | 0.413044 | 0.036* | |
C18 | 0.2495 (4) | 0.68511 (12) | 0.38036 (9) | 0.0274 (5) | |
H18A | 0.264547 | 0.641175 | 0.381702 | 0.041* | |
H18B | 0.371231 | 0.704074 | 0.375411 | 0.041* | |
H18C | 0.165392 | 0.695568 | 0.355679 | 0.041* | |
C19 | 0.1557 (4) | 0.89004 (13) | 0.33101 (9) | 0.0318 (6) | |
H19A | 0.195832 | 0.848141 | 0.326730 | 0.048* | |
H19B | 0.262342 | 0.917115 | 0.326819 | 0.048* | |
H19C | 0.058448 | 0.899913 | 0.309144 | 0.048* | |
C20 | 0.4793 (3) | 0.82137 (11) | 0.24893 (8) | 0.0230 (5) | |
H20A | 0.360295 | 0.798781 | 0.250223 | 0.028* | |
H20B | 0.521855 | 0.828052 | 0.280065 | 0.028* | |
C21 | 0.4442 (4) | 0.88292 (11) | 0.22671 (9) | 0.0267 (5) | |
H21A | 0.386836 | 0.876610 | 0.196923 | 0.032* | |
H21B | 0.355488 | 0.906431 | 0.245182 | 0.032* | |
C22 | 0.6247 (4) | 0.91862 (11) | 0.22134 (9) | 0.0287 (6) | |
H22A | 0.599183 | 0.956319 | 0.204618 | 0.034* | |
H22B | 0.673331 | 0.929774 | 0.251234 | 0.034* | |
C23 | 0.7706 (4) | 0.88177 (11) | 0.19644 (9) | 0.0266 (5) | |
H23A | 0.888696 | 0.904848 | 0.195083 | 0.032* | |
H23B | 0.727838 | 0.874649 | 0.165372 | 0.032* | |
C24 | 0.8057 (3) | 0.82099 (11) | 0.21944 (8) | 0.0224 (5) | |
H24 | 0.847208 | 0.830638 | 0.250586 | 0.027* | |
C25 | 0.9643 (3) | 0.78534 (12) | 0.19809 (8) | 0.0250 (5) | |
H25A | 1.076921 | 0.811078 | 0.196261 | 0.030* | |
H25B | 0.928754 | 0.773583 | 0.167278 | 0.030* | |
C26 | 1.0082 (3) | 0.72878 (11) | 0.22538 (9) | 0.0259 (5) | |
H26A | 1.057084 | 0.740862 | 0.255051 | 0.031* | |
H26B | 1.106435 | 0.705277 | 0.209934 | 0.031* | |
C27 | 0.8361 (3) | 0.68892 (11) | 0.23182 (8) | 0.0210 (5) | |
H27 | 0.795289 | 0.673894 | 0.201808 | 0.025* | |
C28 | 0.6737 (3) | 0.72582 (11) | 0.25266 (8) | 0.0201 (5) | |
H28 | 0.720740 | 0.741176 | 0.282052 | 0.024* | |
C29 | 0.6253 (3) | 0.78271 (11) | 0.22425 (8) | 0.0203 (5) | |
C30 | 0.5042 (3) | 0.68561 (11) | 0.26348 (8) | 0.0230 (5) | |
H30A | 0.410944 | 0.709839 | 0.280057 | 0.028* | |
H30B | 0.445974 | 0.672352 | 0.235084 | 0.028* | |
C31 | 0.5544 (3) | 0.62957 (11) | 0.29141 (8) | 0.0244 (5) | |
H31A | 0.596563 | 0.642376 | 0.321503 | 0.029* | |
H31B | 0.442251 | 0.603984 | 0.295142 | 0.029* | |
C32 | 0.7077 (3) | 0.59312 (11) | 0.26888 (9) | 0.0240 (5) | |
C33 | 0.8774 (3) | 0.63460 (11) | 0.26148 (9) | 0.0242 (5) | |
H33 | 0.910985 | 0.651153 | 0.291564 | 0.029* | |
C34 | 1.0338 (4) | 0.59056 (13) | 0.24873 (11) | 0.0351 (6) | |
H34A | 1.158057 | 0.608208 | 0.254900 | 0.042* | |
H34B | 1.026471 | 0.579338 | 0.216703 | 0.042* | |
C35 | 0.9958 (4) | 0.53525 (14) | 0.27926 (13) | 0.0454 (8) | |
H35A | 1.005634 | 0.497250 | 0.261971 | 0.054* | |
H35B | 1.086292 | 0.533907 | 0.304268 | 0.054* | |
C36 | 0.7968 (4) | 0.54379 (12) | 0.29705 (9) | 0.0261 (5) | 0.5 |
H36A | 0.725233 | 0.505747 | 0.294302 | 0.031* | 0.5 |
H36B | 0.799535 | 0.555813 | 0.328962 | 0.031* | 0.5 |
C36A | 0.7968 (4) | 0.54379 (12) | 0.29705 (9) | 0.0261 (5) | 0.5 |
C37 | 0.5469 (3) | 0.76430 (11) | 0.17819 (8) | 0.0236 (5) | |
H37A | 0.422338 | 0.746845 | 0.181987 | 0.035* | |
H37B | 0.629631 | 0.734365 | 0.164411 | 0.035* | |
H37C | 0.539014 | 0.799975 | 0.158878 | 0.035* | |
C38 | 0.6357 (4) | 0.56397 (12) | 0.22526 (9) | 0.0292 (6) | |
H38A | 0.735771 | 0.540175 | 0.211536 | 0.044* | |
H38B | 0.595868 | 0.595661 | 0.204461 | 0.044* | |
H38C | 0.529795 | 0.537561 | 0.232081 | 0.044* | |
C39 | 1.3496 (4) | 0.33732 (13) | 0.53750 (10) | 0.0322 (6) | |
H39A | 1.354491 | 0.305355 | 0.514364 | 0.039* | |
H39B | 1.419921 | 0.372544 | 0.526052 | 0.039* | |
C40 | 1.4440 (4) | 0.31436 (13) | 0.57959 (10) | 0.0342 (6) | |
H40A | 1.575956 | 0.304757 | 0.572880 | 0.041* | |
H40B | 1.382107 | 0.276720 | 0.589533 | 0.041* | |
C41 | 1.4359 (4) | 0.36074 (13) | 0.61707 (10) | 0.0326 (6) | |
H41A | 1.508589 | 0.396918 | 0.608444 | 0.039* | |
H41B | 1.492303 | 0.343594 | 0.644518 | 0.039* | |
C42 | 1.2337 (4) | 0.37879 (13) | 0.62647 (9) | 0.0295 (6) | |
H42A | 1.164734 | 0.343472 | 0.638261 | 0.035* | |
H42B | 1.231230 | 0.410816 | 0.649581 | 0.035* | |
C43 | 1.1377 (3) | 0.40169 (11) | 0.58407 (8) | 0.0232 (5) | |
H43 | 1.211205 | 0.437565 | 0.573979 | 0.028* | |
C44 | 0.9406 (4) | 0.42460 (12) | 0.59292 (8) | 0.0256 (5) | |
H44A | 0.942864 | 0.453809 | 0.618004 | 0.031* | |
H44B | 0.859726 | 0.390357 | 0.601676 | 0.031* | |
C45 | 0.8606 (4) | 0.45509 (12) | 0.55128 (8) | 0.0252 (5) | |
H45A | 0.930991 | 0.492699 | 0.545348 | 0.030* | |
H45B | 0.729117 | 0.466316 | 0.557086 | 0.030* | |
C46 | 0.8689 (4) | 0.41484 (11) | 0.50980 (8) | 0.0230 (5) | |
H46 | 0.780431 | 0.380378 | 0.513921 | 0.028* | |
C47 | 1.0676 (3) | 0.38923 (11) | 0.50277 (8) | 0.0247 (5) | |
H47 | 1.150666 | 0.424978 | 0.498202 | 0.030* | |
C48 | 1.1434 (3) | 0.35606 (11) | 0.54478 (9) | 0.0246 (5) | |
C49 | 1.0793 (4) | 0.35205 (15) | 0.45941 (10) | 0.0381 (7) | |
H49A | 1.001705 | 0.315340 | 0.462667 | 0.046* | |
H49B | 1.209939 | 0.339008 | 0.454747 | 0.046* | |
C50 | 1.0134 (4) | 0.38759 (16) | 0.41800 (9) | 0.0418 (7) | |
H50A | 1.099747 | 0.421646 | 0.412395 | 0.050* | |
H50B | 1.015593 | 0.360872 | 0.391436 | 0.050* | |
C51 | 0.8163 (4) | 0.41186 (13) | 0.42490 (9) | 0.0316 (6) | |
C52 | 0.8128 (4) | 0.44977 (11) | 0.46790 (8) | 0.0248 (5) | |
H52 | 0.909730 | 0.481792 | 0.463866 | 0.030* | |
C53 | 0.6238 (4) | 0.48232 (12) | 0.46601 (9) | 0.0309 (6) | |
H53A | 0.625754 | 0.519753 | 0.484115 | 0.037* | |
H53B | 0.522073 | 0.455880 | 0.476851 | 0.037* | |
C54 | 0.6004 (4) | 0.49676 (14) | 0.41545 (10) | 0.0374 (7) | |
H54A | 0.473588 | 0.485916 | 0.405120 | 0.045* | |
H54B | 0.621387 | 0.540259 | 0.409713 | 0.045* | |
C55 | 0.7472 (4) | 0.45863 (13) | 0.39143 (9) | 0.0363 (7) | 0.5 |
H55A | 0.691789 | 0.438468 | 0.365012 | 0.044* | 0.5 |
H55B | 0.851740 | 0.484382 | 0.381241 | 0.044* | 0.5 |
C55A | 0.7472 (4) | 0.45863 (13) | 0.39143 (9) | 0.0363 (7) | 0.5 |
C56 | 1.0282 (4) | 0.29894 (12) | 0.55494 (10) | 0.0310 (6) | |
H56A | 1.048451 | 0.269021 | 0.531264 | 0.047* | |
H56B | 0.895506 | 0.309431 | 0.556259 | 0.047* | |
H56C | 1.067317 | 0.282028 | 0.583765 | 0.047* | |
C57 | 0.6750 (5) | 0.35999 (13) | 0.42512 (11) | 0.0407 (7) | |
H57A | 0.549272 | 0.376264 | 0.429547 | 0.061* | |
H57B | 0.704870 | 0.331989 | 0.449488 | 0.061* | |
H57C | 0.680537 | 0.338536 | 0.396458 | 0.061* | |
O1 | 0.6982 (6) | 0.5160 (2) | 0.32882 (14) | 0.0440 (10) | 0.5 |
O2 | 0.7997 (6) | 0.4697 (2) | 0.35179 (15) | 0.0447 (11) | 0.5 |
Atomic displacement parameters (Å2) top | U11 | U22 | U33 | U12 | U13 | U23 |
C1 | 0.0206 (12) | 0.0274 (13) | 0.0287 (13) | −0.0001 (10) | −0.0014 (10) | −0.0025 (10) |
C2 | 0.0270 (14) | 0.0313 (14) | 0.0326 (14) | 0.0024 (11) | −0.0036 (11) | −0.0007 (11) |
C3 | 0.0343 (15) | 0.0279 (13) | 0.0360 (15) | 0.0000 (12) | −0.0023 (12) | 0.0066 (11) |
C4 | 0.0259 (13) | 0.0266 (13) | 0.0385 (15) | −0.0043 (11) | −0.0001 (11) | 0.0011 (11) |
C5 | 0.0200 (12) | 0.0266 (13) | 0.0272 (12) | −0.0040 (10) | 0.0005 (10) | −0.0007 (10) |
C6 | 0.0191 (12) | 0.0290 (13) | 0.0320 (13) | −0.0048 (10) | −0.0012 (10) | −0.0013 (11) |
C7 | 0.0189 (12) | 0.0301 (14) | 0.0299 (14) | −0.0012 (10) | −0.0011 (10) | −0.0004 (11) |
C8 | 0.0175 (11) | 0.0251 (12) | 0.0241 (12) | −0.0016 (9) | 0.0006 (9) | −0.0006 (10) |
C9 | 0.0184 (11) | 0.0254 (12) | 0.0232 (12) | −0.0008 (10) | 0.0006 (9) | −0.0027 (10) |
C10 | 0.0180 (11) | 0.0279 (13) | 0.0249 (12) | −0.0037 (10) | −0.0006 (10) | −0.0016 (10) |
C11 | 0.0159 (12) | 0.0264 (13) | 0.0366 (14) | −0.0013 (10) | −0.0004 (10) | 0.0000 (11) |
C12 | 0.0203 (12) | 0.0250 (13) | 0.0337 (14) | −0.0012 (10) | 0.0003 (10) | −0.0013 (11) |
C13 | 0.0226 (12) | 0.0226 (12) | 0.0294 (13) | −0.0021 (10) | 0.0015 (10) | −0.0021 (10) |
C14 | 0.0201 (12) | 0.0287 (13) | 0.0224 (12) | −0.0009 (10) | 0.0008 (9) | −0.0031 (10) |
C15 | 0.0229 (13) | 0.0310 (14) | 0.0300 (14) | 0.0023 (11) | −0.0029 (10) | −0.0001 (11) |
C16 | 0.0299 (15) | 0.0308 (15) | 0.0406 (16) | 0.0030 (12) | −0.0070 (12) | −0.0030 (12) |
C17 | 0.0291 (14) | 0.0242 (13) | 0.0357 (14) | 0.0014 (11) | −0.0014 (11) | −0.0033 (11) |
C18 | 0.0234 (12) | 0.0291 (13) | 0.0298 (13) | 0.0022 (11) | 0.0003 (10) | −0.0020 (11) |
C19 | 0.0307 (14) | 0.0318 (14) | 0.0329 (14) | −0.0013 (12) | 0.0051 (11) | 0.0022 (12) |
C20 | 0.0188 (12) | 0.0244 (12) | 0.0259 (12) | 0.0004 (10) | 0.0018 (9) | −0.0005 (10) |
C21 | 0.0259 (13) | 0.0245 (13) | 0.0298 (13) | 0.0028 (10) | 0.0026 (10) | 0.0002 (10) |
C22 | 0.0292 (14) | 0.0209 (12) | 0.0361 (14) | 0.0003 (11) | 0.0021 (11) | 0.0008 (11) |
C23 | 0.0250 (13) | 0.0226 (12) | 0.0321 (14) | −0.0033 (10) | 0.0028 (10) | 0.0001 (11) |
C24 | 0.0193 (12) | 0.0229 (12) | 0.0249 (12) | −0.0031 (10) | 0.0009 (9) | −0.0021 (10) |
C25 | 0.0197 (12) | 0.0258 (13) | 0.0296 (13) | −0.0043 (10) | 0.0045 (10) | 0.0019 (10) |
C26 | 0.0174 (12) | 0.0273 (13) | 0.0330 (13) | −0.0004 (10) | 0.0011 (10) | 0.0006 (11) |
C27 | 0.0151 (11) | 0.0232 (12) | 0.0247 (12) | −0.0007 (9) | 0.0009 (9) | 0.0003 (10) |
C28 | 0.0174 (11) | 0.0218 (12) | 0.0212 (11) | −0.0015 (9) | −0.0008 (9) | −0.0003 (9) |
C29 | 0.0165 (11) | 0.0221 (11) | 0.0222 (12) | 0.0000 (9) | 0.0004 (9) | −0.0009 (10) |
C30 | 0.0160 (11) | 0.0251 (12) | 0.0280 (12) | −0.0010 (10) | 0.0012 (9) | 0.0047 (10) |
C31 | 0.0201 (12) | 0.0262 (13) | 0.0268 (13) | −0.0011 (10) | 0.0008 (10) | 0.0046 (10) |
C32 | 0.0217 (12) | 0.0229 (12) | 0.0274 (13) | −0.0001 (10) | −0.0004 (10) | 0.0035 (10) |
C33 | 0.0180 (12) | 0.0258 (13) | 0.0289 (13) | 0.0001 (10) | −0.0017 (10) | 0.0010 (10) |
C34 | 0.0210 (13) | 0.0319 (15) | 0.0523 (17) | 0.0031 (11) | 0.0030 (12) | 0.0039 (13) |
C35 | 0.0277 (15) | 0.0312 (16) | 0.077 (2) | 0.0058 (13) | 0.0025 (15) | 0.0134 (15) |
C36 | 0.0282 (14) | 0.0227 (12) | 0.0275 (13) | 0.0000 (11) | −0.0025 (11) | 0.0023 (10) |
C36A | 0.0282 (14) | 0.0227 (12) | 0.0275 (13) | 0.0000 (11) | −0.0025 (11) | 0.0023 (10) |
C37 | 0.0219 (12) | 0.0241 (12) | 0.0249 (12) | −0.0029 (10) | −0.0025 (10) | 0.0010 (10) |
C38 | 0.0299 (14) | 0.0248 (13) | 0.0330 (14) | −0.0006 (11) | −0.0012 (11) | 0.0008 (11) |
C39 | 0.0216 (13) | 0.0359 (15) | 0.0392 (15) | 0.0047 (11) | 0.0043 (12) | −0.0033 (12) |
C40 | 0.0195 (13) | 0.0337 (15) | 0.0493 (17) | 0.0044 (11) | −0.0019 (12) | 0.0042 (13) |
C41 | 0.0232 (13) | 0.0349 (15) | 0.0398 (15) | −0.0029 (11) | −0.0064 (12) | 0.0086 (12) |
C42 | 0.0259 (13) | 0.0323 (14) | 0.0304 (14) | −0.0027 (11) | −0.0029 (11) | 0.0061 (11) |
C43 | 0.0189 (12) | 0.0239 (12) | 0.0270 (13) | −0.0014 (10) | 0.0022 (10) | 0.0031 (10) |
C44 | 0.0248 (13) | 0.0305 (13) | 0.0216 (12) | 0.0029 (10) | 0.0023 (10) | 0.0016 (10) |
C45 | 0.0240 (12) | 0.0277 (13) | 0.0239 (12) | 0.0062 (11) | 0.0015 (10) | 0.0012 (10) |
C46 | 0.0212 (12) | 0.0227 (12) | 0.0249 (12) | −0.0015 (10) | 0.0015 (10) | 0.0010 (10) |
C47 | 0.0225 (12) | 0.0254 (12) | 0.0264 (13) | −0.0015 (10) | 0.0031 (10) | −0.0022 (10) |
C48 | 0.0189 (12) | 0.0225 (12) | 0.0325 (13) | −0.0013 (10) | 0.0018 (10) | −0.0012 (10) |
C49 | 0.0344 (15) | 0.0457 (17) | 0.0341 (15) | 0.0107 (13) | −0.0007 (12) | −0.0129 (13) |
C50 | 0.0414 (17) | 0.058 (2) | 0.0256 (14) | 0.0078 (15) | 0.0003 (12) | −0.0127 (14) |
C51 | 0.0338 (15) | 0.0344 (14) | 0.0266 (13) | −0.0026 (12) | −0.0036 (11) | −0.0016 (11) |
C52 | 0.0266 (13) | 0.0231 (12) | 0.0247 (12) | −0.0040 (10) | 0.0006 (10) | 0.0012 (10) |
C53 | 0.0329 (14) | 0.0270 (13) | 0.0326 (14) | 0.0014 (11) | −0.0049 (12) | 0.0023 (11) |
C54 | 0.0362 (16) | 0.0412 (16) | 0.0346 (16) | −0.0032 (13) | −0.0098 (12) | 0.0098 (13) |
C55 | 0.0448 (17) | 0.0390 (16) | 0.0252 (14) | −0.0120 (14) | −0.0073 (12) | 0.0045 (12) |
C55A | 0.0448 (17) | 0.0390 (16) | 0.0252 (14) | −0.0120 (14) | −0.0073 (12) | 0.0045 (12) |
C56 | 0.0239 (13) | 0.0227 (13) | 0.0464 (16) | −0.0026 (11) | −0.0055 (12) | 0.0030 (11) |
C57 | 0.0468 (18) | 0.0307 (15) | 0.0445 (17) | −0.0054 (13) | −0.0164 (14) | −0.0064 (13) |
O1 | 0.048 (3) | 0.041 (2) | 0.042 (2) | 0.000 (2) | −0.006 (2) | 0.0053 (19) |
O2 | 0.048 (3) | 0.043 (2) | 0.043 (2) | 0.004 (2) | −0.002 (2) | 0.003 (2) |
Geometric parameters (Å, º) top
C1—C2 | 1.530 (4) | C30—H30A | 0.9900 |
C1—C10 | 1.543 (3) | C30—H30B | 0.9900 |
C1—H1A | 0.9900 | C31—C32 | 1.521 (4) |
C1—H1B | 0.9900 | C31—H31A | 0.9900 |
C2—C3 | 1.524 (4) | C31—H31B | 0.9900 |
C2—H2A | 0.9900 | C32—C36A | 1.520 (3) |
C2—H2B | 0.9900 | C32—C36 | 1.520 (3) |
C3—C4 | 1.526 (4) | C32—C33 | 1.540 (3) |
C3—H3A | 0.9900 | C32—C38 | 1.543 (4) |
C3—H3B | 0.9900 | C33—C34 | 1.534 (4) |
C4—C5 | 1.535 (4) | C33—H33 | 1.0000 |
C4—H4A | 0.9900 | C34—C35 | 1.551 (4) |
C4—H4B | 0.9900 | C34—H34A | 0.9900 |
C5—C6 | 1.527 (3) | C34—H34B | 0.9900 |
C5—C10 | 1.551 (3) | C35—C36A | 1.534 (4) |
C5—H5 | 1.0000 | C35—C36 | 1.534 (4) |
C6—C7 | 1.530 (4) | C35—H35A | 0.9900 |
C6—H6A | 0.9900 | C35—H35B | 0.9900 |
C6—H6B | 0.9900 | C36—H36A | 0.9900 |
C7—C8 | 1.530 (3) | C36—H36B | 0.9900 |
C7—H7A | 0.9900 | C36A—O1 | 1.335 (5) |
C7—H7B | 0.9900 | C37—H37A | 0.9800 |
C8—C14 | 1.528 (3) | C37—H37B | 0.9800 |
C8—C9 | 1.548 (3) | C37—H37C | 0.9800 |
C8—H8 | 1.0000 | C38—H38A | 0.9800 |
C9—C11 | 1.538 (3) | C38—H38B | 0.9800 |
C9—C10 | 1.563 (3) | C38—H38C | 0.9800 |
C9—H9 | 1.0000 | C39—C40 | 1.516 (4) |
C10—C18 | 1.538 (4) | C39—C48 | 1.551 (3) |
C11—C12 | 1.544 (4) | C39—H39A | 0.9900 |
C11—H11A | 0.9900 | C39—H39B | 0.9900 |
C11—H11B | 0.9900 | C40—C41 | 1.520 (4) |
C12—C13 | 1.527 (4) | C40—H40A | 0.9900 |
C12—H12A | 0.9900 | C40—H40B | 0.9900 |
C12—H12B | 0.9900 | C41—C42 | 1.530 (4) |
C13—C14 | 1.536 (3) | C41—H41A | 0.9900 |
C13—C17 | 1.538 (3) | C41—H41B | 0.9900 |
C13—C19 | 1.539 (4) | C42—C43 | 1.528 (3) |
C14—C15 | 1.526 (3) | C42—H42A | 0.9900 |
C14—H14 | 1.0000 | C42—H42B | 0.9900 |
C15—C16 | 1.551 (4) | C43—C44 | 1.525 (3) |
C15—H15A | 0.9900 | C43—C48 | 1.549 (3) |
C15—H15B | 0.9900 | C43—H43 | 1.0000 |
C16—C17 | 1.550 (4) | C44—C45 | 1.527 (3) |
C16—H16A | 0.9900 | C44—H44A | 0.9900 |
C16—H16B | 0.9900 | C44—H44B | 0.9900 |
C17—H17A | 0.9900 | C45—C46 | 1.528 (3) |
C17—H17B | 0.9900 | C45—H45A | 0.9900 |
C18—H18A | 0.9800 | C45—H45B | 0.9900 |
C18—H18B | 0.9800 | C46—C52 | 1.525 (3) |
C18—H18C | 0.9800 | C46—C47 | 1.548 (3) |
C19—H19A | 0.9800 | C46—H46 | 1.0000 |
C19—H19B | 0.9800 | C47—C49 | 1.537 (4) |
C19—H19C | 0.9800 | C47—C48 | 1.552 (4) |
C20—C21 | 1.537 (3) | C47—H47 | 1.0000 |
C20—C29 | 1.540 (3) | C48—C56 | 1.541 (3) |
C20—H20A | 0.9900 | C49—C50 | 1.540 (4) |
C20—H20B | 0.9900 | C49—H49A | 0.9900 |
C21—C22 | 1.525 (4) | C49—H49B | 0.9900 |
C21—H21A | 0.9900 | C50—C51 | 1.526 (4) |
C21—H21B | 0.9900 | C50—H50A | 0.9900 |
C22—C23 | 1.521 (4) | C50—H50B | 0.9900 |
C22—H22A | 0.9900 | C51—C55A | 1.523 (4) |
C22—H22B | 0.9900 | C51—C55 | 1.523 (4) |
C23—C24 | 1.532 (3) | C51—C57 | 1.532 (4) |
C23—H23A | 0.9900 | C51—C52 | 1.535 (4) |
C23—H23B | 0.9900 | C52—C53 | 1.536 (4) |
C24—C25 | 1.524 (3) | C52—H52 | 1.0000 |
C24—C29 | 1.553 (3) | C53—C54 | 1.553 (4) |
C24—H24 | 1.0000 | C53—H53A | 0.9900 |
C25—C26 | 1.527 (4) | C53—H53B | 0.9900 |
C25—H25A | 0.9900 | C54—C55A | 1.528 (4) |
C25—H25B | 0.9900 | C54—C55 | 1.528 (4) |
C26—C27 | 1.529 (3) | C54—H54A | 0.9900 |
C26—H26A | 0.9900 | C54—H54B | 0.9900 |
C26—H26B | 0.9900 | C55—H55A | 0.9900 |
C27—C33 | 1.523 (3) | C55—H55B | 0.9900 |
C27—C28 | 1.553 (3) | C55A—O2 | 1.267 (5) |
C27—H27 | 1.0000 | C56—H56A | 0.9800 |
C28—C30 | 1.541 (3) | C56—H56B | 0.9800 |
C28—C29 | 1.558 (3) | C56—H56C | 0.9800 |
C28—H28 | 1.0000 | C57—H57A | 0.9800 |
C29—C37 | 1.541 (3) | C57—H57B | 0.9800 |
C30—C31 | 1.538 (3) | C57—H57C | 0.9800 |
| | | |
C2—C1—C10 | 113.2 (2) | C28—C30—H30B | 108.9 |
C2—C1—H1A | 108.9 | H30A—C30—H30B | 107.7 |
C10—C1—H1A | 108.9 | C32—C31—C30 | 111.0 (2) |
C2—C1—H1B | 108.9 | C32—C31—H31A | 109.4 |
C10—C1—H1B | 108.9 | C30—C31—H31A | 109.4 |
H1A—C1—H1B | 107.7 | C32—C31—H31B | 109.4 |
C3—C2—C1 | 111.8 (2) | C30—C31—H31B | 109.4 |
C3—C2—H2A | 109.3 | H31A—C31—H31B | 108.0 |
C1—C2—H2A | 109.3 | C36A—C32—C31 | 116.1 (2) |
C3—C2—H2B | 109.3 | C36—C32—C31 | 116.1 (2) |
C1—C2—H2B | 109.3 | C36A—C32—C33 | 100.2 (2) |
H2A—C2—H2B | 107.9 | C36—C32—C33 | 100.2 (2) |
C2—C3—C4 | 110.6 (2) | C31—C32—C33 | 108.5 (2) |
C2—C3—H3A | 109.5 | C36A—C32—C38 | 107.9 (2) |
C4—C3—H3A | 109.5 | C36—C32—C38 | 107.9 (2) |
C2—C3—H3B | 109.5 | C31—C32—C38 | 110.7 (2) |
C4—C3—H3B | 109.5 | C33—C32—C38 | 113.1 (2) |
H3A—C3—H3B | 108.1 | C27—C33—C34 | 120.0 (2) |
C3—C4—C5 | 112.0 (2) | C27—C33—C32 | 113.6 (2) |
C3—C4—H4A | 109.2 | C34—C33—C32 | 103.5 (2) |
C5—C4—H4A | 109.2 | C27—C33—H33 | 106.3 |
C3—C4—H4B | 109.2 | C34—C33—H33 | 106.3 |
C5—C4—H4B | 109.2 | C32—C33—H33 | 106.3 |
H4A—C4—H4B | 107.9 | C33—C34—C35 | 103.1 (2) |
C6—C5—C4 | 112.3 (2) | C33—C34—H34A | 111.1 |
C6—C5—C10 | 111.8 (2) | C35—C34—H34A | 111.1 |
C4—C5—C10 | 112.9 (2) | C33—C34—H34B | 111.1 |
C6—C5—H5 | 106.4 | C35—C34—H34B | 111.1 |
C4—C5—H5 | 106.4 | H34A—C34—H34B | 109.1 |
C10—C5—H5 | 106.4 | C36A—C35—C34 | 105.6 (2) |
C5—C6—C7 | 111.4 (2) | C36—C35—C34 | 105.6 (2) |
C5—C6—H6A | 109.3 | C36—C35—H35A | 110.6 |
C7—C6—H6A | 109.3 | C34—C35—H35A | 110.6 |
C5—C6—H6B | 109.3 | C36—C35—H35B | 110.6 |
C7—C6—H6B | 109.3 | C34—C35—H35B | 110.6 |
H6A—C6—H6B | 108.0 | H35A—C35—H35B | 108.7 |
C8—C7—C6 | 112.8 (2) | C32—C36—C35 | 106.7 (2) |
C8—C7—H7A | 109.0 | C32—C36—H36A | 110.4 |
C6—C7—H7A | 109.0 | C35—C36—H36A | 110.4 |
C8—C7—H7B | 109.0 | C32—C36—H36B | 110.4 |
C6—C7—H7B | 109.0 | C35—C36—H36B | 110.4 |
H7A—C7—H7B | 107.8 | H36A—C36—H36B | 108.6 |
C14—C8—C7 | 111.0 (2) | O1—C36A—C32 | 120.2 (3) |
C14—C8—C9 | 108.62 (19) | O1—C36A—C35 | 133.0 (3) |
C7—C8—C9 | 111.5 (2) | C32—C36A—C35 | 106.7 (2) |
C14—C8—H8 | 108.6 | C29—C37—H37A | 109.5 |
C7—C8—H8 | 108.6 | C29—C37—H37B | 109.5 |
C9—C8—H8 | 108.6 | H37A—C37—H37B | 109.5 |
C11—C9—C8 | 111.5 (2) | C29—C37—H37C | 109.5 |
C11—C9—C10 | 114.4 (2) | H37A—C37—H37C | 109.5 |
C8—C9—C10 | 112.38 (19) | H37B—C37—H37C | 109.5 |
C11—C9—H9 | 105.9 | C32—C38—H38A | 109.5 |
C8—C9—H9 | 105.9 | C32—C38—H38B | 109.5 |
C10—C9—H9 | 105.9 | H38A—C38—H38B | 109.5 |
C18—C10—C1 | 109.1 (2) | C32—C38—H38C | 109.5 |
C18—C10—C5 | 112.5 (2) | H38A—C38—H38C | 109.5 |
C1—C10—C5 | 107.6 (2) | H38B—C38—H38C | 109.5 |
C18—C10—C9 | 110.9 (2) | C40—C39—C48 | 113.5 (2) |
C1—C10—C9 | 109.9 (2) | C40—C39—H39A | 108.9 |
C5—C10—C9 | 106.8 (2) | C48—C39—H39A | 108.9 |
C9—C11—C12 | 112.9 (2) | C40—C39—H39B | 108.9 |
C9—C11—H11A | 109.0 | C48—C39—H39B | 108.9 |
C12—C11—H11A | 109.0 | H39A—C39—H39B | 107.7 |
C9—C11—H11B | 109.0 | C39—C40—C41 | 111.5 (2) |
C12—C11—H11B | 109.0 | C39—C40—H40A | 109.3 |
H11A—C11—H11B | 107.8 | C41—C40—H40A | 109.3 |
C13—C12—C11 | 110.9 (2) | C39—C40—H40B | 109.3 |
C13—C12—H12A | 109.5 | C41—C40—H40B | 109.3 |
C11—C12—H12A | 109.5 | H40A—C40—H40B | 108.0 |
C13—C12—H12B | 109.5 | C40—C41—C42 | 110.4 (2) |
C11—C12—H12B | 109.5 | C40—C41—H41A | 109.6 |
H12A—C12—H12B | 108.1 | C42—C41—H41A | 109.6 |
C12—C13—C14 | 108.7 (2) | C40—C41—H41B | 109.6 |
C12—C13—C17 | 116.1 (2) | C42—C41—H41B | 109.6 |
C14—C13—C17 | 100.2 (2) | H41A—C41—H41B | 108.1 |
C12—C13—C19 | 110.3 (2) | C43—C42—C41 | 111.2 (2) |
C14—C13—C19 | 113.0 (2) | C43—C42—H42A | 109.4 |
C17—C13—C19 | 108.3 (2) | C41—C42—H42A | 109.4 |
C15—C14—C8 | 119.6 (2) | C43—C42—H42B | 109.4 |
C15—C14—C13 | 103.9 (2) | C41—C42—H42B | 109.4 |
C8—C14—C13 | 114.4 (2) | H42A—C42—H42B | 108.0 |
C15—C14—H14 | 106.0 | C44—C43—C42 | 112.6 (2) |
C8—C14—H14 | 106.0 | C44—C43—C48 | 111.9 (2) |
C13—C14—H14 | 106.0 | C42—C43—C48 | 113.6 (2) |
C14—C15—C16 | 103.7 (2) | C44—C43—H43 | 106.0 |
C14—C15—H15A | 111.0 | C42—C43—H43 | 106.0 |
C16—C15—H15A | 111.0 | C48—C43—H43 | 106.0 |
C14—C15—H15B | 111.0 | C43—C44—C45 | 110.7 (2) |
C16—C15—H15B | 111.0 | C43—C44—H44A | 109.5 |
H15A—C15—H15B | 109.0 | C45—C44—H44A | 109.5 |
C17—C16—C15 | 106.1 (2) | C43—C44—H44B | 109.5 |
C17—C16—H16A | 110.5 | C45—C44—H44B | 109.5 |
C15—C16—H16A | 110.5 | H44A—C44—H44B | 108.1 |
C17—C16—H16B | 110.5 | C44—C45—C46 | 112.8 (2) |
C15—C16—H16B | 110.5 | C44—C45—H45A | 109.0 |
H16A—C16—H16B | 108.7 | C46—C45—H45A | 109.0 |
C13—C17—C16 | 104.4 (2) | C44—C45—H45B | 109.0 |
C13—C17—H17A | 110.9 | C46—C45—H45B | 109.0 |
C16—C17—H17A | 110.9 | H45A—C45—H45B | 107.8 |
C13—C17—H17B | 110.9 | C52—C46—C45 | 111.1 (2) |
C16—C17—H17B | 110.9 | C52—C46—C47 | 108.5 (2) |
H17A—C17—H17B | 108.9 | C45—C46—C47 | 111.1 (2) |
C10—C18—H18A | 109.5 | C52—C46—H46 | 108.7 |
C10—C18—H18B | 109.5 | C45—C46—H46 | 108.7 |
H18A—C18—H18B | 109.5 | C47—C46—H46 | 108.7 |
C10—C18—H18C | 109.5 | C49—C47—C46 | 111.2 (2) |
H18A—C18—H18C | 109.5 | C49—C47—C48 | 114.1 (2) |
H18B—C18—H18C | 109.5 | C46—C47—C48 | 112.7 (2) |
C13—C19—H19A | 109.5 | C49—C47—H47 | 106.1 |
C13—C19—H19B | 109.5 | C46—C47—H47 | 106.1 |
H19A—C19—H19B | 109.5 | C48—C47—H47 | 106.1 |
C13—C19—H19C | 109.5 | C56—C48—C43 | 111.9 (2) |
H19A—C19—H19C | 109.5 | C56—C48—C39 | 108.6 (2) |
H19B—C19—H19C | 109.5 | C43—C48—C39 | 107.8 (2) |
C21—C20—C29 | 113.4 (2) | C56—C48—C47 | 111.1 (2) |
C21—C20—H20A | 108.9 | C43—C48—C47 | 107.13 (19) |
C29—C20—H20A | 108.9 | C39—C48—C47 | 110.3 (2) |
C21—C20—H20B | 108.9 | C47—C49—C50 | 112.7 (2) |
C29—C20—H20B | 108.9 | C47—C49—H49A | 109.0 |
H20A—C20—H20B | 107.7 | C50—C49—H49A | 109.0 |
C22—C21—C20 | 111.5 (2) | C47—C49—H49B | 109.0 |
C22—C21—H21A | 109.3 | C50—C49—H49B | 109.0 |
C20—C21—H21A | 109.3 | H49A—C49—H49B | 107.8 |
C22—C21—H21B | 109.3 | C51—C50—C49 | 110.8 (2) |
C20—C21—H21B | 109.3 | C51—C50—H50A | 109.5 |
H21A—C21—H21B | 108.0 | C49—C50—H50A | 109.5 |
C23—C22—C21 | 110.9 (2) | C51—C50—H50B | 109.5 |
C23—C22—H22A | 109.5 | C49—C50—H50B | 109.5 |
C21—C22—H22A | 109.5 | H50A—C50—H50B | 108.1 |
C23—C22—H22B | 109.5 | C55A—C51—C50 | 116.9 (3) |
C21—C22—H22B | 109.5 | C55—C51—C50 | 116.9 (3) |
H22A—C22—H22B | 108.0 | C55A—C51—C57 | 107.3 (2) |
C22—C23—C24 | 111.4 (2) | C55—C51—C57 | 107.3 (2) |
C22—C23—H23A | 109.3 | C50—C51—C57 | 110.4 (3) |
C24—C23—H23A | 109.3 | C55A—C51—C52 | 99.9 (2) |
C22—C23—H23B | 109.3 | C55—C51—C52 | 99.9 (2) |
C24—C23—H23B | 109.3 | C50—C51—C52 | 108.7 (2) |
H23A—C23—H23B | 108.0 | C57—C51—C52 | 113.3 (2) |
C25—C24—C23 | 113.0 (2) | C46—C52—C51 | 113.9 (2) |
C25—C24—C29 | 112.2 (2) | C46—C52—C53 | 120.1 (2) |
C23—C24—C29 | 112.6 (2) | C51—C52—C53 | 103.9 (2) |
C25—C24—H24 | 106.2 | C46—C52—H52 | 106.0 |
C23—C24—H24 | 106.2 | C51—C52—H52 | 106.0 |
C29—C24—H24 | 106.2 | C53—C52—H52 | 106.0 |
C24—C25—C26 | 110.8 (2) | C52—C53—C54 | 103.2 (2) |
C24—C25—H25A | 109.5 | C52—C53—H53A | 111.1 |
C26—C25—H25A | 109.5 | C54—C53—H53A | 111.1 |
C24—C25—H25B | 109.5 | C52—C53—H53B | 111.1 |
C26—C25—H25B | 109.5 | C54—C53—H53B | 111.1 |
H25A—C25—H25B | 108.1 | H53A—C53—H53B | 109.1 |
C25—C26—C27 | 112.0 (2) | C55A—C54—C53 | 105.6 (2) |
C25—C26—H26A | 109.2 | C55—C54—C53 | 105.6 (2) |
C27—C26—H26A | 109.2 | C55—C54—H54A | 110.6 |
C25—C26—H26B | 109.2 | C53—C54—H54A | 110.6 |
C27—C26—H26B | 109.2 | C55—C54—H54B | 110.6 |
H26A—C26—H26B | 107.9 | C53—C54—H54B | 110.6 |
C33—C27—C26 | 111.9 (2) | H54A—C54—H54B | 108.8 |
C33—C27—C28 | 109.15 (19) | C51—C55—C54 | 107.0 (2) |
C26—C27—C28 | 110.58 (19) | C51—C55—H55A | 110.3 |
C33—C27—H27 | 108.4 | C54—C55—H55A | 110.3 |
C26—C27—H27 | 108.4 | C51—C55—H55B | 110.3 |
C28—C27—H27 | 108.4 | C54—C55—H55B | 110.3 |
C30—C28—C27 | 111.80 (19) | H55A—C55—H55B | 108.6 |
C30—C28—C29 | 113.94 (19) | O2—C55A—C51 | 130.5 (3) |
C27—C28—C29 | 111.96 (19) | O2—C55A—C54 | 122.4 (3) |
C30—C28—H28 | 106.2 | C51—C55A—C54 | 107.0 (2) |
C27—C28—H28 | 106.2 | C48—C56—H56A | 109.5 |
C29—C28—H28 | 106.2 | C48—C56—H56B | 109.5 |
C20—C29—C37 | 109.07 (19) | H56A—C56—H56B | 109.5 |
C20—C29—C24 | 107.87 (19) | C48—C56—H56C | 109.5 |
C37—C29—C24 | 111.4 (2) | H56A—C56—H56C | 109.5 |
C20—C29—C28 | 109.88 (19) | H56B—C56—H56C | 109.5 |
C37—C29—C28 | 110.71 (19) | C51—C57—H57A | 109.5 |
C24—C29—C28 | 107.83 (19) | C51—C57—H57B | 109.5 |
C31—C30—C28 | 113.3 (2) | H57A—C57—H57B | 109.5 |
C31—C30—H30A | 108.9 | C51—C57—H57C | 109.5 |
C28—C30—H30A | 108.9 | H57A—C57—H57C | 109.5 |
C31—C30—H30B | 108.9 | H57B—C57—H57C | 109.5 |
| | | |
C10—C1—C2—C3 | −56.7 (3) | C26—C27—C33—C32 | −180.0 (2) |
C1—C2—C3—C4 | 54.1 (3) | C28—C27—C33—C32 | 57.3 (3) |
C2—C3—C4—C5 | −53.9 (3) | C36A—C32—C33—C27 | 177.5 (2) |
C3—C4—C5—C6 | −176.6 (2) | C36—C32—C33—C27 | 177.5 (2) |
C3—C4—C5—C10 | 56.0 (3) | C31—C32—C33—C27 | −60.3 (3) |
C4—C5—C6—C7 | 173.7 (2) | C38—C32—C33—C27 | 62.9 (3) |
C10—C5—C6—C7 | −58.2 (3) | C36A—C32—C33—C34 | 45.7 (2) |
C5—C6—C7—C8 | 52.6 (3) | C36—C32—C33—C34 | 45.7 (2) |
C6—C7—C8—C14 | −171.7 (2) | C31—C32—C33—C34 | 167.9 (2) |
C6—C7—C8—C9 | −50.5 (3) | C38—C32—C33—C34 | −68.8 (3) |
C14—C8—C9—C11 | −53.0 (3) | C27—C33—C34—C35 | −165.8 (2) |
C7—C8—C9—C11 | −175.6 (2) | C32—C33—C34—C35 | −37.9 (3) |
C14—C8—C9—C10 | 177.0 (2) | C33—C34—C35—C36A | 15.0 (3) |
C7—C8—C9—C10 | 54.4 (3) | C33—C34—C35—C36 | 15.0 (3) |
C2—C1—C10—C18 | −67.1 (3) | C31—C32—C36—C35 | −152.7 (2) |
C2—C1—C10—C5 | 55.2 (3) | C33—C32—C36—C35 | −36.1 (3) |
C2—C1—C10—C9 | 171.1 (2) | C38—C32—C36—C35 | 82.3 (3) |
C6—C5—C10—C18 | −62.2 (3) | C34—C35—C36—C32 | 13.5 (3) |
C4—C5—C10—C18 | 65.5 (3) | C31—C32—C36A—O1 | 29.7 (4) |
C6—C5—C10—C1 | 177.6 (2) | C33—C32—C36A—O1 | 146.3 (3) |
C4—C5—C10—C1 | −54.7 (3) | C38—C32—C36A—O1 | −95.3 (3) |
C6—C5—C10—C9 | 59.7 (3) | C31—C32—C36A—C35 | −152.7 (2) |
C4—C5—C10—C9 | −172.6 (2) | C33—C32—C36A—C35 | −36.1 (3) |
C11—C9—C10—C18 | −63.4 (3) | C38—C32—C36A—C35 | 82.3 (3) |
C8—C9—C10—C18 | 65.0 (3) | C34—C35—C36A—O1 | −169.4 (4) |
C11—C9—C10—C1 | 57.3 (3) | C34—C35—C36A—C32 | 13.5 (3) |
C8—C9—C10—C1 | −174.3 (2) | C48—C39—C40—C41 | −56.8 (3) |
C11—C9—C10—C5 | 173.7 (2) | C39—C40—C41—C42 | 56.1 (3) |
C8—C9—C10—C5 | −57.8 (3) | C40—C41—C42—C43 | −55.5 (3) |
C8—C9—C11—C12 | 53.9 (3) | C41—C42—C43—C44 | −175.6 (2) |
C10—C9—C11—C12 | −177.2 (2) | C41—C42—C43—C48 | 55.9 (3) |
C9—C11—C12—C13 | −55.1 (3) | C42—C43—C44—C45 | 172.0 (2) |
C11—C12—C13—C14 | 55.2 (3) | C48—C43—C44—C45 | −58.7 (3) |
C11—C12—C13—C17 | 167.2 (2) | C43—C44—C45—C46 | 53.8 (3) |
C11—C12—C13—C19 | −69.1 (3) | C44—C45—C46—C52 | −172.2 (2) |
C7—C8—C14—C15 | −55.7 (3) | C44—C45—C46—C47 | −51.4 (3) |
C9—C8—C14—C15 | −178.6 (2) | C52—C46—C47—C49 | −54.0 (3) |
C7—C8—C14—C13 | −179.8 (2) | C45—C46—C47—C49 | −176.3 (2) |
C9—C8—C14—C13 | 57.3 (3) | C52—C46—C47—C48 | 176.4 (2) |
C12—C13—C14—C15 | 169.0 (2) | C45—C46—C47—C48 | 54.1 (3) |
C17—C13—C14—C15 | 46.7 (2) | C44—C43—C48—C56 | −62.6 (3) |
C19—C13—C14—C15 | −68.2 (3) | C42—C43—C48—C56 | 66.2 (3) |
C12—C13—C14—C8 | −58.9 (3) | C44—C43—C48—C39 | 178.1 (2) |
C17—C13—C14—C8 | 178.9 (2) | C42—C43—C48—C39 | −53.1 (3) |
C19—C13—C14—C8 | 63.9 (3) | C44—C43—C48—C47 | 59.4 (3) |
C8—C14—C15—C16 | −164.5 (2) | C42—C43—C48—C47 | −171.8 (2) |
C13—C14—C15—C16 | −35.5 (3) | C40—C39—C48—C56 | −67.9 (3) |
C14—C15—C16—C17 | 10.3 (3) | C40—C39—C48—C43 | 53.4 (3) |
C12—C13—C17—C16 | −156.3 (2) | C40—C39—C48—C47 | 170.1 (2) |
C14—C13—C17—C16 | −39.4 (3) | C49—C47—C48—C56 | −62.6 (3) |
C19—C13—C17—C16 | 79.0 (3) | C46—C47—C48—C56 | 65.4 (3) |
C15—C16—C17—C13 | 18.4 (3) | C49—C47—C48—C43 | 174.9 (2) |
C29—C20—C21—C22 | −55.4 (3) | C46—C47—C48—C43 | −57.0 (3) |
C20—C21—C22—C23 | 54.2 (3) | C49—C47—C48—C39 | 57.9 (3) |
C21—C22—C23—C24 | −55.4 (3) | C46—C47—C48—C39 | −174.1 (2) |
C22—C23—C24—C25 | −174.5 (2) | C46—C47—C49—C50 | 54.5 (3) |
C22—C23—C24—C29 | 57.2 (3) | C48—C47—C49—C50 | −176.7 (2) |
C23—C24—C25—C26 | 173.5 (2) | C47—C49—C50—C51 | −55.3 (3) |
C29—C24—C25—C26 | −58.0 (3) | C49—C50—C51—C55A | 167.6 (3) |
C24—C25—C26—C27 | 55.7 (3) | C49—C50—C51—C55 | 167.6 (3) |
C25—C26—C27—C33 | −176.4 (2) | C49—C50—C51—C57 | −69.4 (3) |
C25—C26—C27—C28 | −54.5 (3) | C49—C50—C51—C52 | 55.5 (3) |
C33—C27—C28—C30 | −51.4 (3) | C45—C46—C52—C51 | −179.5 (2) |
C26—C27—C28—C30 | −174.88 (19) | C47—C46—C52—C51 | 58.2 (3) |
C33—C27—C28—C29 | 179.34 (19) | C45—C46—C52—C53 | −55.4 (3) |
C26—C27—C28—C29 | 55.9 (3) | C47—C46—C52—C53 | −177.8 (2) |
C21—C20—C29—C37 | −66.9 (3) | C55A—C51—C52—C46 | 177.7 (2) |
C21—C20—C29—C24 | 54.3 (3) | C55—C51—C52—C46 | 177.7 (2) |
C21—C20—C29—C28 | 171.6 (2) | C50—C51—C52—C46 | −59.3 (3) |
C25—C24—C29—C20 | 176.21 (19) | C57—C51—C52—C46 | 63.9 (3) |
C23—C24—C29—C20 | −55.1 (3) | C55A—C51—C52—C53 | 45.3 (3) |
C25—C24—C29—C37 | −64.1 (3) | C55—C51—C52—C53 | 45.3 (3) |
C23—C24—C29—C37 | 64.6 (3) | C50—C51—C52—C53 | 168.3 (2) |
C25—C24—C29—C28 | 57.6 (3) | C57—C51—C52—C53 | −68.5 (3) |
C23—C24—C29—C28 | −173.67 (19) | C46—C52—C53—C54 | −165.8 (2) |
C30—C28—C29—C20 | 58.2 (3) | C51—C52—C53—C54 | −37.1 (3) |
C27—C28—C29—C20 | −173.71 (19) | C52—C53—C54—C55A | 13.9 (3) |
C30—C28—C29—C37 | −62.3 (3) | C52—C53—C54—C55 | 13.9 (3) |
C27—C28—C29—C37 | 65.8 (2) | C50—C51—C55—C54 | −153.6 (2) |
C30—C28—C29—C24 | 175.51 (19) | C57—C51—C55—C54 | 81.8 (3) |
C27—C28—C29—C24 | −56.4 (2) | C52—C51—C55—C54 | −36.6 (3) |
C27—C28—C30—C31 | 51.6 (3) | C53—C54—C55—C51 | 14.4 (3) |
C29—C28—C30—C31 | 179.8 (2) | C50—C51—C55A—O2 | 22.5 (5) |
C28—C30—C31—C32 | −54.6 (3) | C57—C51—C55A—O2 | −102.1 (4) |
C30—C31—C32—C36A | 168.4 (2) | C52—C51—C55A—O2 | 139.5 (4) |
C30—C31—C32—C36 | 168.4 (2) | C50—C51—C55A—C54 | −153.6 (2) |
C30—C31—C32—C33 | 56.6 (3) | C57—C51—C55A—C54 | 81.8 (3) |
C30—C31—C32—C38 | −68.1 (3) | C52—C51—C55A—C54 | −36.6 (3) |
C26—C27—C33—C34 | −56.8 (3) | C53—C54—C55A—O2 | −162.0 (3) |
C28—C27—C33—C34 | −179.5 (2) | C53—C54—C55A—C51 | 14.4 (3) |
5
α,14
α-Androstane (Form_II)
top
Crystal data top
C19H32 | Dx = 1.088 Mg m−3 |
Mr = 260.44 | Cu Kα radiation, λ = 1.54184 Å |
Orthorhombic, P212121 | Cell parameters from 86352 reflections |
a = 7.1465 (1) Å | θ = 2.5–74.7° |
b = 22.2064 (1) Å | µ = 0.44 mm−1 |
c = 30.0679 (1) Å | T = 90 K |
V = 4771.72 (7) Å3 | Rod, colorless |
Z = 12 | 0.16 × 0.14 × 0.07 mm |
F(000) = 1752 | |
Data collection top
ROD, Synergy Custom system, HyPix diffractometer | 9535 independent reflections |
Radiation source: Rotating-anode X-ray tube | 9414 reflections with I > 2σ(I) |
Detector resolution: 10.0000 pixels mm-1 | Rint = 0.030 |
ω scans | θmax = 75.3°, θmin = 2.5° |
Absorption correction: gaussian (CrysAlis PRO; Rigaku OD, 2021) | h = −8→8 |
Tmin = 0.798, Tmax = 1.000 | k = −27→27 |
116227 measured reflections | l = −36→37 |
Refinement top
Refinement on F2 | Hydrogen site location: inferred from neighbouring sites |
Least-squares matrix: full | H-atom parameters constrained |
R[F2 > 2σ(F2)] = 0.030 | w = 1/[σ2(Fo2) + (0.0474P)2 + 0.9086P] where P = (Fo2 + 2Fc2)/3 |
wR(F2) = 0.080 | (Δ/σ)max = 0.001 |
S = 1.03 | Δρmax = 0.29 e Å−3 |
9535 reflections | Δρmin = −0.14 e Å−3 |
521 parameters | Extinction correction: SHELXL2018 (Sheldrick, 2015b), Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4 |
0 restraints | Extinction coefficient: 0.00036 (8) |
Primary atom site location: iterative | Absolute structure: Flack x determined using 4010 quotients [(I+)-(I-)]/[(I+)+(I-)]
(Parsons et al., 2013) |
Secondary atom site location: difference Fourier map | Absolute structure parameter: −0.16 (12) |
Special details top
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes)
are estimated using the full covariance matrix. The cell esds are taken
into account individually in the estimation of esds in distances, angles
and torsion angles; correlations between esds in cell parameters are only
used when they are defined by crystal symmetry. An approximate (isotropic)
treatment of cell esds is used for estimating esds involving l.s. planes. |
Refinement. Data were integrated and
scaled using CrysAlis PRO (Rigaku OD, 2021). WinGX (Farrugia, 2012) was used
for the solution and refinement of the crystal structures.
Solution by intrinsic phasing (SHELXT2014; Sheldrick, 2015a) produced
a complete heavy-atom phasing model. All non-H atoms were refined
anisotropically by full-matrix least-squares (SHELXL2018; Sheldrick,
2015b). |
Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top | x | y | z | Uiso*/Ueq | |
C1 | 0.3130 (2) | 0.69729 (7) | 0.46329 (5) | 0.0210 (3) | |
H1A | 0.433221 | 0.716740 | 0.455461 | 0.025* | |
H1B | 0.264658 | 0.717135 | 0.490441 | 0.025* | |
C2 | 0.3486 (2) | 0.63075 (7) | 0.47338 (5) | 0.0252 (3) | |
H2A | 0.409089 | 0.611630 | 0.447348 | 0.030* | |
H2B | 0.435303 | 0.627429 | 0.498935 | 0.030* | |
C3 | 0.1679 (2) | 0.59747 (7) | 0.48413 (6) | 0.0278 (3) | |
H3A | 0.115985 | 0.612818 | 0.512474 | 0.033* | |
H3B | 0.194644 | 0.554026 | 0.487873 | 0.033* | |
C4 | 0.0237 (2) | 0.60598 (7) | 0.44700 (6) | 0.0259 (3) | |
H4A | 0.068292 | 0.585514 | 0.419733 | 0.031* | |
H4B | −0.095931 | 0.587027 | 0.455950 | 0.031* | |
C5 | −0.0098 (2) | 0.67267 (7) | 0.43691 (5) | 0.0198 (3) | |
H5 | −0.057370 | 0.691020 | 0.465098 | 0.024* | |
C6 | −0.1628 (2) | 0.68212 (7) | 0.40223 (5) | 0.0224 (3) | |
H6A | −0.277149 | 0.660367 | 0.411560 | 0.027* | |
H6B | −0.121351 | 0.665130 | 0.373432 | 0.027* | |
C7 | −0.2082 (2) | 0.74884 (7) | 0.39630 (5) | 0.0207 (3) | |
H7A | −0.270397 | 0.763828 | 0.423556 | 0.025* | |
H7B | −0.297322 | 0.753404 | 0.371314 | 0.025* | |
C8 | −0.0350 (2) | 0.78750 (6) | 0.38705 (5) | 0.0170 (3) | |
H8 | 0.013737 | 0.777186 | 0.356816 | 0.020* | |
C9 | 0.1214 (2) | 0.77534 (6) | 0.42159 (5) | 0.0174 (3) | |
H9 | 0.067340 | 0.786519 | 0.451139 | 0.021* | |
C10 | 0.1724 (2) | 0.70732 (6) | 0.42494 (5) | 0.0176 (3) | |
C11 | 0.2896 (2) | 0.81756 (7) | 0.41450 (5) | 0.0208 (3) | |
H11A | 0.381202 | 0.811024 | 0.438735 | 0.025* | |
H11B | 0.351551 | 0.807051 | 0.386088 | 0.025* | |
C12 | 0.2347 (2) | 0.88440 (7) | 0.41350 (5) | 0.0210 (3) | |
H12A | 0.187663 | 0.896517 | 0.443152 | 0.025* | |
H12B | 0.346531 | 0.909048 | 0.406729 | 0.025* | |
C13 | 0.0839 (2) | 0.89643 (6) | 0.37861 (5) | 0.0197 (3) | |
C14 | −0.0832 (2) | 0.85457 (6) | 0.38797 (5) | 0.0180 (3) | |
H14 | −0.124535 | 0.863605 | 0.419033 | 0.022* | |
C15 | −0.2369 (2) | 0.87856 (7) | 0.35744 (5) | 0.0231 (3) | |
H15A | −0.362445 | 0.868250 | 0.369071 | 0.028* | |
H15B | −0.223884 | 0.862053 | 0.327010 | 0.028* | |
C16 | −0.2051 (3) | 0.94772 (7) | 0.35780 (6) | 0.0292 (4) | |
H16A | −0.306188 | 0.968161 | 0.374495 | 0.035* | |
H16B | −0.203004 | 0.963699 | 0.327060 | 0.035* | |
C17 | −0.0132 (2) | 0.95806 (7) | 0.38084 (5) | 0.0246 (3) | |
H17A | 0.060552 | 0.988998 | 0.364887 | 0.030* | |
H17B | −0.030440 | 0.971016 | 0.412079 | 0.030* | |
C18 | 0.2589 (2) | 0.68474 (7) | 0.38108 (5) | 0.0215 (3) | |
H18A | 0.276597 | 0.641035 | 0.382643 | 0.032* | |
H18B | 0.380082 | 0.704380 | 0.376387 | 0.032* | |
H18C | 0.174985 | 0.694454 | 0.356318 | 0.032* | |
C19 | 0.1650 (2) | 0.88863 (7) | 0.33150 (5) | 0.0262 (3) | |
H19A | 0.204687 | 0.846773 | 0.327324 | 0.039* | |
H19B | 0.272822 | 0.915420 | 0.327749 | 0.039* | |
H19C | 0.069028 | 0.898749 | 0.309446 | 0.039* | |
C20 | 0.4800 (2) | 0.82160 (6) | 0.24857 (5) | 0.0162 (3) | |
H20A | 0.360901 | 0.798972 | 0.250375 | 0.019* | |
H20B | 0.524297 | 0.828724 | 0.279322 | 0.019* | |
C21 | 0.4433 (2) | 0.88242 (7) | 0.22618 (5) | 0.0203 (3) | |
H21A | 0.384695 | 0.875593 | 0.196774 | 0.024* | |
H21B | 0.354576 | 0.905952 | 0.244543 | 0.024* | |
C22 | 0.6235 (2) | 0.91851 (6) | 0.22009 (5) | 0.0225 (3) | |
H22A | 0.596176 | 0.955641 | 0.203059 | 0.027* | |
H22B | 0.672668 | 0.930478 | 0.249571 | 0.027* | |
C23 | 0.7712 (2) | 0.88161 (6) | 0.19548 (5) | 0.0198 (3) | |
H23A | 0.889479 | 0.904746 | 0.194137 | 0.024* | |
H23B | 0.728810 | 0.874251 | 0.164605 | 0.024* | |
C24 | 0.80678 (19) | 0.82109 (6) | 0.21863 (5) | 0.0156 (3) | |
H24 | 0.849291 | 0.830925 | 0.249468 | 0.019* | |
C25 | 0.9655 (2) | 0.78552 (7) | 0.19715 (5) | 0.0188 (3) | |
H25A | 1.078461 | 0.811199 | 0.195174 | 0.023* | |
H25B | 0.929100 | 0.773794 | 0.166591 | 0.023* | |
C26 | 1.0103 (2) | 0.72907 (6) | 0.22422 (5) | 0.0188 (3) | |
H26A | 1.108354 | 0.705590 | 0.208699 | 0.023* | |
H26B | 1.060370 | 0.741112 | 0.253606 | 0.023* | |
C27 | 0.83791 (19) | 0.68941 (6) | 0.23092 (4) | 0.0147 (3) | |
H27 | 0.795759 | 0.674617 | 0.201149 | 0.018* | |
C28 | 0.67619 (19) | 0.72620 (6) | 0.25199 (4) | 0.0138 (3) | |
H28 | 0.724676 | 0.741616 | 0.281034 | 0.017* | |
C29 | 0.62593 (19) | 0.78284 (6) | 0.22377 (4) | 0.0133 (3) | |
C30 | 0.5066 (2) | 0.68603 (6) | 0.26323 (5) | 0.0169 (3) | |
H30A | 0.414007 | 0.710141 | 0.280028 | 0.020* | |
H30B | 0.446680 | 0.672852 | 0.235192 | 0.020* | |
C31 | 0.5588 (2) | 0.63008 (6) | 0.29076 (5) | 0.0176 (3) | |
H31A | 0.603190 | 0.642837 | 0.320489 | 0.021* | |
H31B | 0.446399 | 0.604633 | 0.294915 | 0.021* | |
C32 | 0.7117 (2) | 0.59336 (6) | 0.26774 (5) | 0.0168 (3) | |
C33 | 0.8808 (2) | 0.63499 (6) | 0.26001 (5) | 0.0168 (3) | |
H33 | 0.916568 | 0.651190 | 0.289854 | 0.020* | |
C34 | 1.0371 (2) | 0.59147 (7) | 0.24633 (6) | 0.0248 (3) | |
H34A | 1.161797 | 0.608529 | 0.253195 | 0.030* | |
H34B | 1.030575 | 0.582208 | 0.214162 | 0.030* | |
C35 | 0.9982 (2) | 0.53429 (7) | 0.27474 (6) | 0.0280 (3) | |
H35A | 0.997943 | 0.497858 | 0.255767 | 0.034* | |
H35B | 1.095142 | 0.529492 | 0.298004 | 0.034* | |
C36 | 0.8028 (2) | 0.54404 (7) | 0.29616 (5) | 0.0216 (3) | |
H36A | 0.728125 | 0.506520 | 0.295235 | 0.026* | |
H36B | 0.815122 | 0.557247 | 0.327475 | 0.026* | |
C37 | 0.5454 (2) | 0.76431 (6) | 0.17816 (4) | 0.0166 (3) | |
H37A | 0.420595 | 0.746892 | 0.182247 | 0.025* | |
H37B | 0.627883 | 0.734430 | 0.164338 | 0.025* | |
H37C | 0.536642 | 0.799836 | 0.158942 | 0.025* | |
C38 | 0.6365 (2) | 0.56492 (7) | 0.22461 (5) | 0.0222 (3) | |
H38A | 0.734724 | 0.540339 | 0.210893 | 0.033* | |
H38B | 0.598734 | 0.596820 | 0.203959 | 0.033* | |
H38C | 0.528298 | 0.539481 | 0.231513 | 0.033* | |
C39 | 1.3354 (2) | 0.33356 (7) | 0.53877 (5) | 0.0220 (3) | |
H39A | 1.333065 | 0.300154 | 0.516978 | 0.026* | |
H39B | 1.409367 | 0.366802 | 0.525655 | 0.026* | |
C40 | 1.4330 (2) | 0.31189 (7) | 0.58108 (5) | 0.0246 (3) | |
H40A | 1.367606 | 0.275855 | 0.592684 | 0.030* | |
H40B | 1.563354 | 0.300291 | 0.574008 | 0.030* | |
C41 | 1.4338 (2) | 0.36102 (7) | 0.61665 (6) | 0.0246 (3) | |
H41A | 1.491366 | 0.345214 | 0.644231 | 0.030* | |
H41B | 1.509749 | 0.395558 | 0.606276 | 0.030* | |
C42 | 1.2345 (2) | 0.38205 (7) | 0.62642 (5) | 0.0202 (3) | |
H42A | 1.237921 | 0.415133 | 0.648474 | 0.024* | |
H42B | 1.162001 | 0.348370 | 0.639384 | 0.024* | |
C43 | 1.1379 (2) | 0.40402 (6) | 0.58402 (4) | 0.0152 (3) | |
H43 | 1.215549 | 0.438032 | 0.572430 | 0.018* | |
C44 | 0.9436 (2) | 0.43000 (6) | 0.59295 (4) | 0.0174 (3) | |
H44A | 0.951505 | 0.460420 | 0.616954 | 0.021* | |
H44B | 0.858844 | 0.397470 | 0.603002 | 0.021* | |
C45 | 0.8642 (2) | 0.45918 (6) | 0.55097 (4) | 0.0176 (3) | |
H45A | 0.939885 | 0.495090 | 0.543451 | 0.021* | |
H45B | 0.734660 | 0.472799 | 0.556942 | 0.021* | |
C46 | 0.8629 (2) | 0.41622 (6) | 0.51122 (4) | 0.0151 (3) | |
H46 | 0.769754 | 0.383570 | 0.517058 | 0.018* | |
C47 | 1.0576 (2) | 0.38699 (6) | 0.50394 (4) | 0.0162 (3) | |
H47 | 1.145624 | 0.420900 | 0.497553 | 0.019* | |
C48 | 1.1331 (2) | 0.35570 (6) | 0.54652 (5) | 0.0156 (3) | |
C49 | 1.0594 (2) | 0.34663 (7) | 0.46228 (5) | 0.0228 (3) | |
H49A | 1.188109 | 0.331617 | 0.457278 | 0.027* | |
H49B | 0.977521 | 0.311360 | 0.467459 | 0.027* | |
C50 | 0.9925 (3) | 0.38011 (7) | 0.42040 (5) | 0.0266 (3) | |
H50A | 1.082954 | 0.412316 | 0.412939 | 0.032* | |
H50B | 0.987751 | 0.351655 | 0.395083 | 0.032* | |
C51 | 0.7995 (2) | 0.40773 (7) | 0.42735 (5) | 0.0237 (3) | |
C52 | 0.8074 (2) | 0.44885 (6) | 0.46850 (5) | 0.0183 (3) | |
H52 | 0.908952 | 0.478769 | 0.462555 | 0.022* | |
C53 | 0.6228 (2) | 0.48422 (7) | 0.46669 (5) | 0.0245 (3) | |
H53A | 0.634517 | 0.523406 | 0.482138 | 0.029* | |
H53B | 0.519383 | 0.460999 | 0.480314 | 0.029* | |
C54 | 0.5900 (3) | 0.49321 (8) | 0.41579 (6) | 0.0328 (4) | |
H54A | 0.461831 | 0.480609 | 0.407462 | 0.039* | |
H54B | 0.606839 | 0.536028 | 0.407524 | 0.039* | |
C55 | 0.7370 (3) | 0.45342 (7) | 0.39211 (5) | 0.0319 (4) | |
H55A | 0.681152 | 0.432698 | 0.366154 | 0.038* | |
H55B | 0.844274 | 0.477988 | 0.381852 | 0.038* | |
C56 | 1.0103 (2) | 0.30139 (6) | 0.55920 (5) | 0.0193 (3) | |
H56A | 1.020154 | 0.270413 | 0.536101 | 0.029* | |
H56B | 0.879678 | 0.314351 | 0.561888 | 0.029* | |
H56C | 1.052787 | 0.284832 | 0.587668 | 0.029* | |
C57 | 0.6499 (3) | 0.35826 (7) | 0.43114 (6) | 0.0297 (4) | |
H57A | 0.526197 | 0.376847 | 0.434189 | 0.045* | |
H57B | 0.675743 | 0.333272 | 0.457292 | 0.045* | |
H57C | 0.652443 | 0.333128 | 0.404357 | 0.045* | |
Atomic displacement parameters (Å2) top | U11 | U22 | U33 | U12 | U13 | U23 |
C1 | 0.0202 (7) | 0.0206 (7) | 0.0222 (7) | −0.0001 (6) | −0.0025 (6) | −0.0011 (6) |
C2 | 0.0255 (8) | 0.0230 (7) | 0.0270 (8) | 0.0026 (6) | −0.0044 (6) | 0.0007 (6) |
C3 | 0.0326 (9) | 0.0203 (7) | 0.0307 (8) | 0.0012 (7) | 0.0001 (7) | 0.0067 (6) |
C4 | 0.0234 (8) | 0.0186 (7) | 0.0357 (8) | −0.0037 (6) | −0.0003 (7) | 0.0021 (6) |
C5 | 0.0179 (7) | 0.0196 (7) | 0.0218 (7) | −0.0029 (6) | 0.0013 (6) | −0.0002 (5) |
C6 | 0.0166 (7) | 0.0202 (7) | 0.0305 (8) | −0.0049 (6) | −0.0014 (6) | −0.0025 (6) |
C7 | 0.0156 (7) | 0.0219 (7) | 0.0246 (7) | −0.0037 (6) | −0.0015 (6) | −0.0001 (6) |
C8 | 0.0140 (6) | 0.0174 (6) | 0.0194 (6) | −0.0013 (5) | 0.0011 (5) | −0.0026 (5) |
C9 | 0.0156 (6) | 0.0185 (7) | 0.0181 (6) | −0.0017 (5) | 0.0008 (5) | −0.0024 (5) |
C10 | 0.0154 (6) | 0.0184 (7) | 0.0190 (6) | −0.0016 (5) | 0.0006 (6) | −0.0014 (5) |
C11 | 0.0140 (7) | 0.0188 (7) | 0.0297 (8) | −0.0009 (6) | −0.0013 (6) | −0.0006 (6) |
C12 | 0.0179 (7) | 0.0174 (7) | 0.0276 (7) | −0.0033 (6) | −0.0005 (6) | −0.0006 (6) |
C13 | 0.0195 (7) | 0.0172 (7) | 0.0224 (7) | −0.0013 (6) | 0.0014 (6) | −0.0019 (5) |
C14 | 0.0166 (7) | 0.0189 (7) | 0.0185 (6) | −0.0005 (6) | 0.0002 (5) | −0.0017 (5) |
C15 | 0.0204 (7) | 0.0228 (7) | 0.0260 (7) | 0.0002 (6) | −0.0026 (6) | −0.0010 (6) |
C16 | 0.0294 (9) | 0.0222 (8) | 0.0359 (9) | 0.0035 (7) | −0.0085 (7) | 0.0001 (6) |
C17 | 0.0254 (8) | 0.0171 (7) | 0.0314 (8) | 0.0010 (6) | −0.0015 (6) | −0.0022 (6) |
C18 | 0.0200 (7) | 0.0209 (7) | 0.0236 (7) | 0.0012 (6) | 0.0020 (6) | −0.0032 (6) |
C19 | 0.0267 (8) | 0.0266 (8) | 0.0253 (8) | −0.0029 (7) | 0.0058 (6) | 0.0012 (6) |
C20 | 0.0147 (6) | 0.0161 (6) | 0.0176 (6) | 0.0005 (5) | 0.0017 (5) | 0.0005 (5) |
C21 | 0.0190 (7) | 0.0169 (7) | 0.0249 (7) | 0.0035 (6) | 0.0032 (6) | 0.0012 (6) |
C22 | 0.0228 (7) | 0.0148 (7) | 0.0300 (8) | 0.0009 (6) | 0.0016 (6) | 0.0007 (6) |
C23 | 0.0191 (7) | 0.0145 (6) | 0.0256 (7) | −0.0024 (6) | 0.0032 (6) | 0.0024 (5) |
C24 | 0.0135 (6) | 0.0152 (6) | 0.0181 (6) | −0.0021 (5) | 0.0006 (5) | 0.0006 (5) |
C25 | 0.0143 (7) | 0.0178 (7) | 0.0244 (7) | −0.0015 (5) | 0.0040 (6) | 0.0042 (5) |
C26 | 0.0124 (6) | 0.0176 (7) | 0.0265 (7) | 0.0000 (5) | 0.0019 (6) | 0.0042 (5) |
C27 | 0.0120 (6) | 0.0155 (6) | 0.0167 (6) | −0.0007 (5) | 0.0007 (5) | 0.0025 (5) |
C28 | 0.0135 (6) | 0.0150 (6) | 0.0128 (6) | −0.0008 (5) | −0.0005 (5) | 0.0014 (5) |
C29 | 0.0122 (6) | 0.0136 (6) | 0.0141 (6) | −0.0003 (5) | 0.0010 (5) | 0.0009 (5) |
C30 | 0.0129 (6) | 0.0178 (7) | 0.0201 (6) | −0.0002 (5) | 0.0017 (5) | 0.0043 (5) |
C31 | 0.0165 (7) | 0.0185 (7) | 0.0179 (6) | −0.0015 (5) | 0.0027 (5) | 0.0048 (5) |
C32 | 0.0172 (7) | 0.0157 (6) | 0.0176 (6) | −0.0015 (6) | −0.0006 (5) | 0.0034 (5) |
C33 | 0.0133 (6) | 0.0172 (7) | 0.0198 (7) | −0.0004 (5) | −0.0008 (5) | 0.0032 (5) |
C34 | 0.0173 (7) | 0.0203 (7) | 0.0368 (8) | 0.0034 (6) | 0.0043 (6) | 0.0080 (6) |
C35 | 0.0249 (8) | 0.0210 (7) | 0.0382 (9) | 0.0045 (6) | 0.0021 (7) | 0.0092 (7) |
C36 | 0.0236 (8) | 0.0175 (7) | 0.0236 (7) | −0.0007 (6) | −0.0015 (6) | 0.0061 (6) |
C37 | 0.0171 (7) | 0.0167 (6) | 0.0159 (6) | −0.0020 (5) | −0.0023 (5) | 0.0011 (5) |
C38 | 0.0267 (8) | 0.0185 (7) | 0.0212 (7) | −0.0038 (6) | −0.0023 (6) | 0.0002 (5) |
C39 | 0.0182 (7) | 0.0209 (7) | 0.0269 (7) | 0.0035 (6) | 0.0037 (6) | 0.0002 (6) |
C40 | 0.0156 (7) | 0.0226 (7) | 0.0356 (8) | 0.0045 (6) | −0.0005 (6) | 0.0036 (6) |
C41 | 0.0177 (7) | 0.0241 (7) | 0.0320 (8) | −0.0010 (6) | −0.0070 (6) | 0.0043 (6) |
C42 | 0.0192 (7) | 0.0213 (7) | 0.0201 (7) | −0.0006 (6) | −0.0039 (6) | 0.0021 (6) |
C43 | 0.0148 (6) | 0.0145 (6) | 0.0165 (6) | −0.0013 (5) | −0.0003 (5) | 0.0013 (5) |
C44 | 0.0181 (7) | 0.0203 (7) | 0.0139 (6) | 0.0022 (6) | 0.0010 (5) | −0.0017 (5) |
C45 | 0.0181 (7) | 0.0170 (6) | 0.0176 (6) | 0.0042 (6) | −0.0002 (5) | −0.0009 (5) |
C46 | 0.0166 (6) | 0.0136 (6) | 0.0152 (6) | −0.0009 (5) | 0.0000 (5) | 0.0006 (5) |
C47 | 0.0197 (7) | 0.0136 (6) | 0.0152 (6) | −0.0007 (5) | 0.0025 (5) | 0.0003 (5) |
C48 | 0.0150 (6) | 0.0137 (6) | 0.0181 (6) | −0.0009 (5) | 0.0011 (5) | 0.0004 (5) |
C49 | 0.0314 (8) | 0.0186 (7) | 0.0183 (7) | 0.0039 (6) | 0.0026 (6) | −0.0028 (5) |
C50 | 0.0444 (10) | 0.0217 (7) | 0.0137 (6) | 0.0003 (7) | 0.0028 (7) | −0.0023 (6) |
C51 | 0.0379 (9) | 0.0169 (7) | 0.0162 (6) | −0.0044 (7) | −0.0050 (6) | 0.0016 (5) |
C52 | 0.0244 (7) | 0.0133 (6) | 0.0172 (6) | −0.0017 (5) | −0.0024 (6) | 0.0012 (5) |
C53 | 0.0270 (8) | 0.0209 (7) | 0.0256 (7) | 0.0012 (6) | −0.0083 (6) | 0.0041 (6) |
C54 | 0.0456 (10) | 0.0246 (8) | 0.0283 (8) | 0.0000 (7) | −0.0170 (8) | 0.0060 (6) |
C55 | 0.0539 (11) | 0.0225 (7) | 0.0192 (7) | −0.0033 (8) | −0.0112 (7) | 0.0045 (6) |
C56 | 0.0206 (7) | 0.0149 (6) | 0.0225 (7) | −0.0030 (6) | −0.0019 (6) | 0.0035 (5) |
C57 | 0.0435 (10) | 0.0188 (7) | 0.0268 (8) | −0.0073 (7) | −0.0134 (7) | 0.0006 (6) |
Geometric parameters (Å, º) top
C1—C2 | 1.530 (2) | C28—H28 | 1.0000 |
C1—C10 | 1.546 (2) | C29—C37 | 1.5430 (18) |
C1—H1A | 0.9900 | C30—C31 | 1.5385 (18) |
C1—H1B | 0.9900 | C30—H30A | 0.9900 |
C2—C3 | 1.523 (2) | C30—H30B | 0.9900 |
C2—H2A | 0.9900 | C31—C32 | 1.529 (2) |
C2—H2B | 0.9900 | C31—H31A | 0.9900 |
C3—C4 | 1.531 (2) | C31—H31B | 0.9900 |
C3—H3A | 0.9900 | C32—C36 | 1.5344 (19) |
C3—H3B | 0.9900 | C32—C38 | 1.539 (2) |
C4—C5 | 1.531 (2) | C32—C33 | 1.5394 (19) |
C4—H4A | 0.9900 | C33—C34 | 1.533 (2) |
C4—H4B | 0.9900 | C33—H33 | 1.0000 |
C5—C6 | 1.525 (2) | C34—C35 | 1.555 (2) |
C5—C10 | 1.554 (2) | C34—H34A | 0.9900 |
C5—H5 | 1.0000 | C34—H34B | 0.9900 |
C6—C7 | 1.527 (2) | C35—C36 | 1.553 (2) |
C6—H6A | 0.9900 | C35—H35A | 0.9900 |
C6—H6B | 0.9900 | C35—H35B | 0.9900 |
C7—C8 | 1.532 (2) | C36—H36A | 0.9900 |
C7—H7A | 0.9900 | C36—H36B | 0.9900 |
C7—H7B | 0.9900 | C37—H37A | 0.9800 |
C8—C14 | 1.5289 (19) | C37—H37B | 0.9800 |
C8—C9 | 1.550 (2) | C37—H37C | 0.9800 |
C8—H8 | 1.0000 | C38—H38A | 0.9800 |
C9—C11 | 1.539 (2) | C38—H38B | 0.9800 |
C9—C10 | 1.557 (2) | C38—H38C | 0.9800 |
C9—H9 | 1.0000 | C39—C40 | 1.528 (2) |
C10—C18 | 1.540 (2) | C39—C48 | 1.5446 (19) |
C11—C12 | 1.536 (2) | C39—H39A | 0.9900 |
C11—H11A | 0.9900 | C39—H39B | 0.9900 |
C11—H11B | 0.9900 | C40—C41 | 1.528 (2) |
C12—C13 | 1.527 (2) | C40—H40A | 0.9900 |
C12—H12A | 0.9900 | C40—H40B | 0.9900 |
C12—H12B | 0.9900 | C41—C42 | 1.527 (2) |
C13—C17 | 1.536 (2) | C41—H41A | 0.9900 |
C13—C14 | 1.539 (2) | C41—H41B | 0.9900 |
C13—C19 | 1.540 (2) | C42—C43 | 1.5298 (19) |
C14—C15 | 1.527 (2) | C42—H42A | 0.9900 |
C14—H14 | 1.0000 | C42—H42B | 0.9900 |
C15—C16 | 1.553 (2) | C43—C44 | 1.5274 (19) |
C15—H15A | 0.9900 | C43—C48 | 1.5568 (19) |
C15—H15B | 0.9900 | C43—H43 | 1.0000 |
C16—C17 | 1.553 (2) | C44—C45 | 1.5282 (19) |
C16—H16A | 0.9900 | C44—H44A | 0.9900 |
C16—H16B | 0.9900 | C44—H44B | 0.9900 |
C17—H17A | 0.9900 | C45—C46 | 1.5294 (18) |
C17—H17B | 0.9900 | C45—H45A | 0.9900 |
C18—H18A | 0.9800 | C45—H45B | 0.9900 |
C18—H18B | 0.9800 | C46—C52 | 1.5270 (18) |
C18—H18C | 0.9800 | C46—C47 | 1.5503 (19) |
C19—H19A | 0.9800 | C46—H46 | 1.0000 |
C19—H19B | 0.9800 | C47—C49 | 1.5404 (19) |
C19—H19C | 0.9800 | C47—C48 | 1.5535 (18) |
C20—C21 | 1.5319 (19) | C47—H47 | 1.0000 |
C20—C29 | 1.5440 (19) | C48—C56 | 1.5395 (19) |
C20—H20A | 0.9900 | C49—C50 | 1.538 (2) |
C20—H20B | 0.9900 | C49—H49A | 0.9900 |
C21—C22 | 1.528 (2) | C49—H49B | 0.9900 |
C21—H21A | 0.9900 | C50—C51 | 1.524 (2) |
C21—H21B | 0.9900 | C50—H50A | 0.9900 |
C22—C23 | 1.527 (2) | C50—H50B | 0.9900 |
C22—H22A | 0.9900 | C51—C55 | 1.533 (2) |
C22—H22B | 0.9900 | C51—C57 | 1.537 (2) |
C23—C24 | 1.5348 (19) | C51—C52 | 1.539 (2) |
C23—H23A | 0.9900 | C52—C53 | 1.536 (2) |
C23—H23B | 0.9900 | C52—H52 | 1.0000 |
C24—C25 | 1.526 (2) | C53—C54 | 1.561 (2) |
C24—C29 | 1.5543 (18) | C53—H53A | 0.9900 |
C24—H24 | 1.0000 | C53—H53B | 0.9900 |
C25—C26 | 1.5286 (19) | C54—C55 | 1.547 (3) |
C25—H25A | 0.9900 | C54—H54A | 0.9900 |
C25—H25B | 0.9900 | C54—H54B | 0.9900 |
C26—C27 | 1.5280 (19) | C55—H55A | 0.9900 |
C26—H26A | 0.9900 | C55—H55B | 0.9900 |
C26—H26B | 0.9900 | C56—H56A | 0.9800 |
C27—C33 | 1.5229 (18) | C56—H56B | 0.9800 |
C27—C28 | 1.5507 (18) | C56—H56C | 0.9800 |
C27—H27 | 1.0000 | C57—H57A | 0.9800 |
C28—C30 | 1.5421 (19) | C57—H57B | 0.9800 |
C28—C29 | 1.5591 (18) | C57—H57C | 0.9800 |
| | | |
C2—C1—C10 | 113.28 (12) | C37—C29—C28 | 110.75 (11) |
C2—C1—H1A | 108.9 | C20—C29—C28 | 110.03 (11) |
C10—C1—H1A | 108.9 | C24—C29—C28 | 107.67 (11) |
C2—C1—H1B | 108.9 | C31—C30—C28 | 113.25 (12) |
C10—C1—H1B | 108.9 | C31—C30—H30A | 108.9 |
H1A—C1—H1B | 107.7 | C28—C30—H30A | 108.9 |
C3—C2—C1 | 111.72 (13) | C31—C30—H30B | 108.9 |
C3—C2—H2A | 109.3 | C28—C30—H30B | 108.9 |
C1—C2—H2A | 109.3 | H30A—C30—H30B | 107.7 |
C3—C2—H2B | 109.3 | C32—C31—C30 | 111.11 (11) |
C1—C2—H2B | 109.3 | C32—C31—H31A | 109.4 |
H2A—C2—H2B | 107.9 | C30—C31—H31A | 109.4 |
C2—C3—C4 | 110.87 (13) | C32—C31—H31B | 109.4 |
C2—C3—H3A | 109.5 | C30—C31—H31B | 109.4 |
C4—C3—H3A | 109.5 | H31A—C31—H31B | 108.0 |
C2—C3—H3B | 109.5 | C31—C32—C36 | 115.59 (12) |
C4—C3—H3B | 109.5 | C31—C32—C38 | 110.55 (12) |
H3A—C3—H3B | 108.1 | C36—C32—C38 | 108.94 (12) |
C5—C4—C3 | 111.65 (13) | C31—C32—C33 | 108.01 (11) |
C5—C4—H4A | 109.3 | C36—C32—C33 | 100.32 (11) |
C3—C4—H4A | 109.3 | C38—C32—C33 | 113.15 (12) |
C5—C4—H4B | 109.3 | C27—C33—C34 | 119.52 (12) |
C3—C4—H4B | 109.3 | C27—C33—C32 | 113.90 (11) |
H4A—C4—H4B | 108.0 | C34—C33—C32 | 103.54 (11) |
C6—C5—C4 | 112.36 (12) | C27—C33—H33 | 106.3 |
C6—C5—C10 | 111.96 (12) | C34—C33—H33 | 106.3 |
C4—C5—C10 | 113.21 (13) | C32—C33—H33 | 106.3 |
C6—C5—H5 | 106.2 | C33—C34—C35 | 103.71 (12) |
C4—C5—H5 | 106.2 | C33—C34—H34A | 111.0 |
C10—C5—H5 | 106.2 | C35—C34—H34A | 111.0 |
C5—C6—C7 | 111.45 (12) | C33—C34—H34B | 111.0 |
C5—C6—H6A | 109.3 | C35—C34—H34B | 111.0 |
C7—C6—H6A | 109.3 | H34A—C34—H34B | 109.0 |
C5—C6—H6B | 109.3 | C36—C35—C34 | 105.94 (12) |
C7—C6—H6B | 109.3 | C36—C35—H35A | 110.5 |
H6A—C6—H6B | 108.0 | C34—C35—H35A | 110.5 |
C6—C7—C8 | 113.15 (12) | C36—C35—H35B | 110.5 |
C6—C7—H7A | 108.9 | C34—C35—H35B | 110.5 |
C8—C7—H7A | 108.9 | H35A—C35—H35B | 108.7 |
C6—C7—H7B | 108.9 | C32—C36—C35 | 104.50 (12) |
C8—C7—H7B | 108.9 | C32—C36—H36A | 110.9 |
H7A—C7—H7B | 107.8 | C35—C36—H36A | 110.9 |
C14—C8—C7 | 111.15 (12) | C32—C36—H36B | 110.9 |
C14—C8—C9 | 108.66 (11) | C35—C36—H36B | 110.9 |
C7—C8—C9 | 111.31 (12) | H36A—C36—H36B | 108.9 |
C14—C8—H8 | 108.5 | C29—C37—H37A | 109.5 |
C7—C8—H8 | 108.5 | C29—C37—H37B | 109.5 |
C9—C8—H8 | 108.5 | H37A—C37—H37B | 109.5 |
C11—C9—C8 | 111.37 (12) | C29—C37—H37C | 109.5 |
C11—C9—C10 | 114.64 (12) | H37A—C37—H37C | 109.5 |
C8—C9—C10 | 112.40 (11) | H37B—C37—H37C | 109.5 |
C11—C9—H9 | 105.9 | C32—C38—H38A | 109.5 |
C8—C9—H9 | 105.9 | C32—C38—H38B | 109.5 |
C10—C9—H9 | 105.9 | H38A—C38—H38B | 109.5 |
C18—C10—C1 | 109.31 (12) | C32—C38—H38C | 109.5 |
C18—C10—C5 | 111.92 (12) | H38A—C38—H38C | 109.5 |
C1—C10—C5 | 107.49 (12) | H38B—C38—H38C | 109.5 |
C18—C10—C9 | 110.75 (12) | C40—C39—C48 | 113.68 (12) |
C1—C10—C9 | 109.88 (11) | C40—C39—H39A | 108.8 |
C5—C10—C9 | 107.42 (11) | C48—C39—H39A | 108.8 |
C12—C11—C9 | 113.04 (12) | C40—C39—H39B | 108.8 |
C12—C11—H11A | 109.0 | C48—C39—H39B | 108.8 |
C9—C11—H11A | 109.0 | H39A—C39—H39B | 107.7 |
C12—C11—H11B | 109.0 | C41—C40—C39 | 111.08 (12) |
C9—C11—H11B | 109.0 | C41—C40—H40A | 109.4 |
H11A—C11—H11B | 107.8 | C39—C40—H40A | 109.4 |
C13—C12—C11 | 111.28 (12) | C41—C40—H40B | 109.4 |
C13—C12—H12A | 109.4 | C39—C40—H40B | 109.4 |
C11—C12—H12A | 109.4 | H40A—C40—H40B | 108.0 |
C13—C12—H12B | 109.4 | C42—C41—C40 | 110.44 (12) |
C11—C12—H12B | 109.4 | C42—C41—H41A | 109.6 |
H12A—C12—H12B | 108.0 | C40—C41—H41A | 109.6 |
C12—C13—C17 | 116.41 (12) | C42—C41—H41B | 109.6 |
C12—C13—C14 | 108.43 (12) | C40—C41—H41B | 109.6 |
C17—C13—C14 | 100.34 (12) | H41A—C41—H41B | 108.1 |
C12—C13—C19 | 110.29 (13) | C41—C42—C43 | 111.00 (12) |
C17—C13—C19 | 108.07 (12) | C41—C42—H42A | 109.4 |
C14—C13—C19 | 113.08 (12) | C43—C42—H42A | 109.4 |
C15—C14—C8 | 119.39 (12) | C41—C42—H42B | 109.4 |
C15—C14—C13 | 103.74 (12) | C43—C42—H42B | 109.4 |
C8—C14—C13 | 114.22 (12) | H42A—C42—H42B | 108.0 |
C15—C14—H14 | 106.2 | C44—C43—C42 | 112.60 (11) |
C8—C14—H14 | 106.2 | C44—C43—C48 | 111.59 (11) |
C13—C14—H14 | 106.2 | C42—C43—C48 | 113.18 (11) |
C14—C15—C16 | 103.63 (12) | C44—C43—H43 | 106.3 |
C14—C15—H15A | 111.0 | C42—C43—H43 | 106.3 |
C16—C15—H15A | 111.0 | C48—C43—H43 | 106.3 |
C14—C15—H15B | 111.0 | C43—C44—C45 | 110.64 (11) |
C16—C15—H15B | 111.0 | C43—C44—H44A | 109.5 |
H15A—C15—H15B | 109.0 | C45—C44—H44A | 109.5 |
C15—C16—C17 | 106.16 (13) | C43—C44—H44B | 109.5 |
C15—C16—H16A | 110.5 | C45—C44—H44B | 109.5 |
C17—C16—H16A | 110.5 | H44A—C44—H44B | 108.1 |
C15—C16—H16B | 110.5 | C44—C45—C46 | 112.54 (11) |
C17—C16—H16B | 110.5 | C44—C45—H45A | 109.1 |
H16A—C16—H16B | 108.7 | C46—C45—H45A | 109.1 |
C13—C17—C16 | 104.35 (12) | C44—C45—H45B | 109.1 |
C13—C17—H17A | 110.9 | C46—C45—H45B | 109.1 |
C16—C17—H17A | 110.9 | H45A—C45—H45B | 107.8 |
C13—C17—H17B | 110.9 | C52—C46—C45 | 111.27 (11) |
C16—C17—H17B | 110.9 | C52—C46—C47 | 108.25 (11) |
H17A—C17—H17B | 108.9 | C45—C46—C47 | 111.49 (11) |
C10—C18—H18A | 109.5 | C52—C46—H46 | 108.6 |
C10—C18—H18B | 109.5 | C45—C46—H46 | 108.6 |
H18A—C18—H18B | 109.5 | C47—C46—H46 | 108.6 |
C10—C18—H18C | 109.5 | C49—C47—C46 | 111.46 (12) |
H18A—C18—H18C | 109.5 | C49—C47—C48 | 114.02 (11) |
H18B—C18—H18C | 109.5 | C46—C47—C48 | 112.51 (11) |
C13—C19—H19A | 109.5 | C49—C47—H47 | 106.1 |
C13—C19—H19B | 109.5 | C46—C47—H47 | 106.1 |
H19A—C19—H19B | 109.5 | C48—C47—H47 | 106.1 |
C13—C19—H19C | 109.5 | C56—C48—C39 | 108.76 (11) |
H19A—C19—H19C | 109.5 | C56—C48—C47 | 110.87 (12) |
H19B—C19—H19C | 109.5 | C39—C48—C47 | 110.08 (12) |
C21—C20—C29 | 113.26 (11) | C56—C48—C43 | 111.91 (11) |
C21—C20—H20A | 108.9 | C39—C48—C43 | 107.94 (11) |
C29—C20—H20A | 108.9 | C47—C48—C43 | 107.22 (10) |
C21—C20—H20B | 108.9 | C50—C49—C47 | 112.45 (12) |
C29—C20—H20B | 108.9 | C50—C49—H49A | 109.1 |
H20A—C20—H20B | 107.7 | C47—C49—H49A | 109.1 |
C22—C21—C20 | 111.77 (12) | C50—C49—H49B | 109.1 |
C22—C21—H21A | 109.3 | C47—C49—H49B | 109.1 |
C20—C21—H21A | 109.3 | H49A—C49—H49B | 107.8 |
C22—C21—H21B | 109.3 | C51—C50—C49 | 111.33 (13) |
C20—C21—H21B | 109.3 | C51—C50—H50A | 109.4 |
H21A—C21—H21B | 107.9 | C49—C50—H50A | 109.4 |
C23—C22—C21 | 111.05 (12) | C51—C50—H50B | 109.4 |
C23—C22—H22A | 109.4 | C49—C50—H50B | 109.4 |
C21—C22—H22A | 109.4 | H50A—C50—H50B | 108.0 |
C23—C22—H22B | 109.4 | C50—C51—C55 | 115.79 (14) |
C21—C22—H22B | 109.4 | C50—C51—C57 | 110.60 (13) |
H22A—C22—H22B | 108.0 | C55—C51—C57 | 108.77 (14) |
C22—C23—C24 | 111.38 (12) | C50—C51—C52 | 108.40 (13) |
C22—C23—H23A | 109.4 | C55—C51—C52 | 100.01 (12) |
C24—C23—H23A | 109.4 | C57—C51—C52 | 112.96 (13) |
C22—C23—H23B | 109.4 | C46—C52—C53 | 119.71 (13) |
C24—C23—H23B | 109.4 | C46—C52—C51 | 113.85 (11) |
H23A—C23—H23B | 108.0 | C53—C52—C51 | 104.07 (12) |
C25—C24—C23 | 112.62 (11) | C46—C52—H52 | 106.1 |
C25—C24—C29 | 112.18 (11) | C53—C52—H52 | 106.1 |
C23—C24—C29 | 112.70 (11) | C51—C52—H52 | 106.1 |
C25—C24—H24 | 106.2 | C52—C53—C54 | 103.25 (13) |
C23—C24—H24 | 106.2 | C52—C53—H53A | 111.1 |
C29—C24—H24 | 106.2 | C54—C53—H53A | 111.1 |
C24—C25—C26 | 110.80 (11) | C52—C53—H53B | 111.1 |
C24—C25—H25A | 109.5 | C54—C53—H53B | 111.1 |
C26—C25—H25A | 109.5 | H53A—C53—H53B | 109.1 |
C24—C25—H25B | 109.5 | C55—C54—C53 | 106.03 (13) |
C26—C25—H25B | 109.5 | C55—C54—H54A | 110.5 |
H25A—C25—H25B | 108.1 | C53—C54—H54A | 110.5 |
C27—C26—C25 | 111.96 (12) | C55—C54—H54B | 110.5 |
C27—C26—H26A | 109.2 | C53—C54—H54B | 110.5 |
C25—C26—H26A | 109.2 | H54A—C54—H54B | 108.7 |
C27—C26—H26B | 109.2 | C51—C55—C54 | 104.93 (13) |
C25—C26—H26B | 109.2 | C51—C55—H55A | 110.8 |
H26A—C26—H26B | 107.9 | C54—C55—H55A | 110.8 |
C33—C27—C26 | 111.76 (11) | C51—C55—H55B | 110.8 |
C33—C27—C28 | 109.48 (11) | C54—C55—H55B | 110.8 |
C26—C27—C28 | 110.57 (11) | H55A—C55—H55B | 108.8 |
C33—C27—H27 | 108.3 | C48—C56—H56A | 109.5 |
C26—C27—H27 | 108.3 | C48—C56—H56B | 109.5 |
C28—C27—H27 | 108.3 | H56A—C56—H56B | 109.5 |
C30—C28—C27 | 111.74 (11) | C48—C56—H56C | 109.5 |
C30—C28—C29 | 113.89 (11) | H56A—C56—H56C | 109.5 |
C27—C28—C29 | 111.99 (11) | H56B—C56—H56C | 109.5 |
C30—C28—H28 | 106.2 | C51—C57—H57A | 109.5 |
C27—C28—H28 | 106.2 | C51—C57—H57B | 109.5 |
C29—C28—H28 | 106.2 | H57A—C57—H57B | 109.5 |
C37—C29—C20 | 109.03 (11) | C51—C57—H57C | 109.5 |
C37—C29—C24 | 111.55 (11) | H57A—C57—H57C | 109.5 |
C20—C29—C24 | 107.76 (11) | H57B—C57—H57C | 109.5 |
| | | |
C10—C1—C2—C3 | −56.62 (18) | C27—C28—C29—C20 | −173.80 (11) |
C1—C2—C3—C4 | 54.22 (18) | C30—C28—C29—C24 | 175.38 (11) |
C2—C3—C4—C5 | −53.98 (18) | C27—C28—C29—C24 | −56.61 (14) |
C3—C4—C5—C6 | −176.07 (13) | C27—C28—C30—C31 | 51.40 (15) |
C3—C4—C5—C10 | 55.88 (17) | C29—C28—C30—C31 | 179.54 (11) |
C4—C5—C6—C7 | 173.97 (13) | C28—C30—C31—C32 | −54.78 (16) |
C10—C5—C6—C7 | −57.32 (17) | C30—C31—C32—C36 | 168.07 (12) |
C5—C6—C7—C8 | 52.42 (17) | C30—C31—C32—C38 | −67.60 (15) |
C6—C7—C8—C14 | −171.88 (12) | C30—C31—C32—C33 | 56.69 (15) |
C6—C7—C8—C9 | −50.60 (16) | C26—C27—C33—C34 | −56.81 (17) |
C14—C8—C9—C11 | −52.96 (15) | C28—C27—C33—C34 | −179.67 (12) |
C7—C8—C9—C11 | −175.68 (12) | C26—C27—C33—C32 | −179.85 (11) |
C14—C8—C9—C10 | 176.82 (11) | C28—C27—C33—C32 | 57.30 (15) |
C7—C8—C9—C10 | 54.11 (15) | C31—C32—C33—C27 | −60.18 (15) |
C2—C1—C10—C18 | −66.77 (16) | C36—C32—C33—C27 | 178.42 (12) |
C2—C1—C10—C5 | 54.90 (16) | C38—C32—C33—C27 | 62.53 (16) |
C2—C1—C10—C9 | 171.50 (12) | C31—C32—C33—C34 | 168.44 (11) |
C6—C5—C10—C18 | −62.88 (16) | C36—C32—C33—C34 | 47.04 (14) |
C4—C5—C10—C18 | 65.38 (16) | C38—C32—C33—C34 | −68.85 (15) |
C6—C5—C10—C1 | 177.09 (12) | C27—C33—C34—C35 | −163.47 (13) |
C4—C5—C10—C1 | −54.65 (15) | C32—C33—C34—C35 | −35.51 (16) |
C6—C5—C10—C9 | 58.89 (15) | C33—C34—C35—C36 | 10.22 (17) |
C4—C5—C10—C9 | −172.85 (12) | C31—C32—C36—C35 | −155.81 (13) |
C11—C9—C10—C18 | −63.32 (16) | C38—C32—C36—C35 | 79.03 (15) |
C8—C9—C10—C18 | 65.20 (15) | C33—C32—C36—C35 | −39.98 (14) |
C11—C9—C10—C1 | 57.55 (16) | C34—C35—C36—C32 | 18.76 (16) |
C8—C9—C10—C1 | −173.93 (12) | C48—C39—C40—C41 | −56.35 (17) |
C11—C9—C10—C5 | 174.19 (12) | C39—C40—C41—C42 | 56.13 (17) |
C8—C9—C10—C5 | −57.29 (15) | C40—C41—C42—C43 | −56.52 (16) |
C8—C9—C11—C12 | 53.58 (16) | C41—C42—C43—C44 | −175.54 (12) |
C10—C9—C11—C12 | −177.39 (12) | C41—C42—C43—C48 | 56.75 (16) |
C9—C11—C12—C13 | −55.03 (17) | C42—C43—C44—C45 | 172.12 (12) |
C11—C12—C13—C17 | 167.40 (13) | C48—C43—C44—C45 | −59.33 (15) |
C11—C12—C13—C14 | 55.27 (16) | C43—C44—C45—C46 | 54.40 (16) |
C11—C12—C13—C19 | −69.04 (16) | C44—C45—C46—C52 | −172.49 (12) |
C7—C8—C14—C15 | −56.08 (17) | C44—C45—C46—C47 | −51.53 (15) |
C9—C8—C14—C15 | −178.89 (13) | C52—C46—C47—C49 | −53.94 (14) |
C7—C8—C14—C13 | −179.60 (12) | C45—C46—C47—C49 | −176.65 (11) |
C9—C8—C14—C13 | 57.58 (15) | C52—C46—C47—C48 | 176.55 (11) |
C12—C13—C14—C15 | 169.46 (12) | C45—C46—C47—C48 | 53.84 (14) |
C17—C13—C14—C15 | 46.96 (14) | C40—C39—C48—C56 | −68.22 (15) |
C19—C13—C14—C15 | −67.90 (15) | C40—C39—C48—C47 | 170.12 (12) |
C12—C13—C14—C8 | −58.93 (15) | C40—C39—C48—C43 | 53.40 (15) |
C17—C13—C14—C8 | 178.57 (12) | C49—C47—C48—C56 | −62.46 (16) |
C19—C13—C14—C8 | 63.70 (16) | C46—C47—C48—C56 | 65.73 (14) |
C8—C14—C15—C16 | −164.31 (13) | C49—C47—C48—C39 | 57.93 (16) |
C13—C14—C15—C16 | −35.81 (15) | C46—C47—C48—C39 | −173.88 (11) |
C14—C15—C16—C17 | 10.78 (17) | C49—C47—C48—C43 | 175.10 (12) |
C12—C13—C17—C16 | −156.05 (14) | C46—C47—C48—C43 | −56.71 (14) |
C14—C13—C17—C16 | −39.35 (15) | C44—C43—C48—C56 | −62.14 (15) |
C19—C13—C17—C16 | 79.25 (15) | C42—C43—C48—C56 | 66.10 (15) |
C15—C16—C17—C13 | 18.08 (17) | C44—C43—C48—C39 | 178.21 (11) |
C29—C20—C21—C22 | −55.67 (16) | C42—C43—C48—C39 | −53.55 (15) |
C20—C21—C22—C23 | 53.82 (17) | C44—C43—C48—C47 | 59.65 (14) |
C21—C22—C23—C24 | −54.47 (17) | C42—C43—C48—C47 | −172.11 (12) |
C22—C23—C24—C25 | −175.05 (12) | C46—C47—C49—C50 | 54.01 (17) |
C22—C23—C24—C29 | 56.80 (16) | C48—C47—C49—C50 | −177.28 (13) |
C23—C24—C25—C26 | 173.76 (12) | C47—C49—C50—C51 | −55.13 (18) |
C29—C24—C25—C26 | −57.82 (15) | C49—C50—C51—C55 | 167.09 (13) |
C24—C25—C26—C27 | 55.59 (16) | C49—C50—C51—C57 | −68.62 (16) |
C25—C26—C27—C33 | −176.90 (12) | C49—C50—C51—C52 | 55.73 (16) |
C25—C26—C27—C28 | −54.66 (15) | C45—C46—C52—C53 | −54.84 (17) |
C33—C27—C28—C30 | −51.06 (15) | C47—C46—C52—C53 | −177.68 (12) |
C26—C27—C28—C30 | −174.63 (11) | C45—C46—C52—C51 | −178.77 (13) |
C33—C27—C28—C29 | 179.79 (11) | C47—C46—C52—C51 | 58.39 (16) |
C26—C27—C28—C29 | 56.23 (15) | C50—C51—C52—C46 | −59.64 (16) |
C21—C20—C29—C37 | −66.37 (15) | C55—C51—C52—C46 | 178.74 (14) |
C21—C20—C29—C24 | 54.86 (15) | C57—C51—C52—C46 | 63.29 (18) |
C21—C20—C29—C28 | 171.98 (11) | C50—C51—C52—C53 | 168.33 (12) |
C25—C24—C29—C37 | −64.15 (15) | C55—C51—C52—C53 | 46.71 (16) |
C23—C24—C29—C37 | 64.23 (15) | C57—C51—C52—C53 | −68.74 (16) |
C25—C24—C29—C20 | 176.21 (11) | C46—C52—C53—C54 | −163.51 (13) |
C23—C24—C29—C20 | −55.41 (14) | C51—C52—C53—C54 | −34.98 (15) |
C25—C24—C29—C28 | 57.56 (14) | C52—C53—C54—C55 | 9.59 (17) |
C23—C24—C29—C28 | −174.06 (11) | C50—C51—C55—C54 | −156.18 (14) |
C30—C28—C29—C37 | −62.42 (14) | C57—C51—C55—C54 | 78.58 (16) |
C27—C28—C29—C37 | 65.59 (14) | C52—C51—C55—C54 | −40.00 (17) |
C30—C28—C29—C20 | 58.20 (14) | C53—C54—C55—C51 | 19.21 (18) |
Maximum deviation (and RMSD, Å) between crystallograpically independent
molecule overlays of Form I topRing definitions: (#1) C1–C19, (#2) C20–C38, (#3) C39–C57, and
(#4) C58–C76. |
| #2 | #3 | #4 |
#1 | 0.0651 (0.0336) | 0.0597 (0.0220) | 0.0635 (0.0318) |
#2 | - | 0.0764 (0.0359) | 0.0321 (0.0196) |
#3 | - | - | 0.0943 (0.0407) |