Structure of ribose 5-phosphate isomerase from Plasmodium falciparum

Holmes, M.A.; Buckner, F.S.; Van Voorhis, W.C.; Verlinde, C.L.M.J.; Mehlin, C.; Boni, E.; DeTitta, G.; Luft, J.; Lauricella, A.; Anderson, L.; Kalyuzhniy, O.; Zucker, F.; Schoenfeld, L.W.; Earnest, T.N.; Hol, W.G.J.; Merritt, E.A.

doi:10.1107/S1744309106010876

Structure of ribose 5-phosphate isomerase from Plasmodium falciparum

M. A. Holmes, F. S. Buckner, W. C. Van Voorhis, C. L. M. J. Verlinde, C. Mehlin, E. Boni, G. DeTitta, J. Luft, A. Lauricella, L. Anderson, O. Kalyuzhniy, F. Zucker, L. W. Schoenfeld, T. N. Earnest, W. G. J. Hol and E. A. Merritt

The structure of ribose 5-phosphate isomerase from Plasmodium falciparum, PFE0730c, has been determined by molecular replacement at 2.09 Å resolution. The enzyme, which catalyzes the isomerization reaction that interconverts ribose 5-phosphate and ribulose 5-phosphate, is a member of the pentose phosphate pathway. The P. falciparum enzyme belongs to the ribose 5-phosphate isomerase A family, Pfam family PF06562 (DUF1124), and is structurally similar to other members of the family.

Keywords: ribose 5-phosphate isomerase.

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Supporting information

PDB reference: ribose 5-phosphate isomerase, 2f8m, r2f8msf

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