2',3'-Dideoxy-3'-nitrothymidine and 2'-Propoxy-3'-nitrothymidine

The crystal structures of 2',3'-dideoxy-3'-nitrothymidine, C₁₀H₁₃N₃O₆ and 2'-propoxy-3'-nitrothymidine, C₁₃H₁₉N₃O₇, are reported. Both compounds are analogous to the anti-HIV nucleoside 3'-azido-2',3'-dideoxythymidine (AZT). The replacement of the azido group in AZT by the nitro group in these two compounds has resulted in a sugar pucker preference of C2'-endo type, as observed in both structures, AZT itself and several of its derivatives.

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