3-Ethoxycarbonyl-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)pyridinium Nitrate, Dineopentyl 2,6-Dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate and Dihexyl 2,6-Dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

The single-crystal X-ray structures of three oxidation products of 4-(3-nitrophenyl)-1,4-dihydropyridine, namely, 3-ethoxycarbonyl-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)pyridinium nitrate, C₁₈H₁₉N₂O₆⁺.NO₃^-, dineopentyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate, C₂₅H₃₂N₂O₆, and dihexyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate, C₂₇H₃₆N₂O₆, suggest that their decreased calcium-blocking activity arises from incompatibility of the phenyl ring and ester conformation with the receptor site.

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