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Fun30 (Function unknown now 30) is a chromatin remodeller belonging to the Snf2 family. It has previously been reported to be a regulator of several cellular activities, including DNA repair, gene silencing and maintenance of chromatin structure. Here, the crystal structure of the Fun30 ATPase-C domain (the C-lobe of the ATPase domain) is reported at 1.95 Å resolution. Although the structure displays overall similarities to those of other Snf2 family members, a new structural module was found to be specific to the Fun30 subfamily. Fun30 ATPase-C was shown be monomeric in solution and showed no detectable affinity for dsDNA.

Supporting information

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Portable Document Format (PDF) file https://doi.org/10.1107/S2053230X16019269/no5111sup1.pdf
Supplementary Figure S1.

PDB reference: C-terminal part of Fun30 ATPase domain, 5gn1


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