X-ray Structure Investigations of Potential β-Blockers. III

X-ray studies of 6,7-dihydroxy-1-phenyl-1,2,3,4-tetrahydroisoquinolinium chloride hydrate (C₁₅H₁₆NO₂⁺.Cl⁻.H₂O), 6,7-dihydroxy-1-(2-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolinium chloride (C₁₆H₁₈NO₃⁺.Cl⁻) and 6,7-dihydroxy-1-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinolinium chloride (C₁₅H₁₅N₂O₄⁺.Cl⁻) show that the saturated parts of the rings have deformed half-chair conformations, with equatorially attached phenyl rings. All three structures are ionic, and hydrogen bonds are observed.

-1