Supporting information
Crystallographic Information File (CIF) https://doi.org/10.1107/S1600536807026062/lw2023sup1.cif | |
Structure factor file (CIF format) https://doi.org/10.1107/S1600536807026062/lw2023Isup2.hkl |
CCDC reference: 616164
The title compound was prepared according to the literature method (Jayalakshmi & Gowda, 2004). The purity of the compound was checked by determining its melting point. It was characterized by recording its infrared and NMR spectra (Jayalakshmi & Gowda, 2004). Single crystals of the title compound were obtained from a slow evaporation of its ethanolic solution and used for X-ray diffraction studied at room temperature.
The H atom of the NH group was located in a diffrerence map and its position refined. The carbon-bound H atoms were positioned with idealized geometry and refined using a riding model with C—H = 0.93 Å (CH aromatic) or 0.96 Å (CH3). Isotropic displacement parameters for all H atoms were set equal to 1.2 Ueq (parent atom).
The structural studies of sulfonanilides are of interest due to their biological activity. In the present work, the structure of N-(2,4-dichlorophenyl)-methanesulfonamide (24DCPMSA) has been determined to explore the substituent effects on the solid state structures of sulfonanilides (Gowda et al., 2007a-l). The structure of 24DCPMSA (Fig. 1) resembles those of N-(phenyl)-methanesulfonamide (PMSA) (Klug, 1968), N-(2-chlorophenyl)-methanesulfonamide (2CPMSA) (Gowda et al., 2007l), N-(2,3-dichlorophenyl)- methanesulfonamide (23DCPMSA)(Gowda et al., 2007k), N-(2,4-dimethylphenyl)-methanesulfonamide (24DMPMSA)(Gowda et al., 2007i) and other methylsulfonanilides (Gowda et al., 2007a-h). The conformation of the N—H bond in 24DCPMSA is nearly syn to the ortho-chloro substituent, similar to the syn conformation observed for 24DMPMSA (Gowda et al., 2007i). The ortho substitution of either a chloro or methyl group in PMSA changes its space group from monoclinic P21/c to triclinic P-1. But the substitution of an additional chloro group in the para position of 2CPMSA to produce 24DCPMSA does not further alter the space group, in contrast to the change over from triclinic P-1 to monoclinic P21/n on substitution of an additional methyl group at the para position in N-(2-methylphenyl)- methanesulfonamide (2MPMSA) (Gowda et al., 2007d) to form 24DMPMSA and monoclinic P21/c space group observed for 23DCPMSA (Gowda et al., 2007k). The geometric parameters in 24DCPMSA are similar to those in PMSA, 2CPMSA, 23DCPMSA, 24DMPMSA and other methanesulfonanilides except for some difference in the bond and torsional angles. The amide hydrogen is readily available to a receptor molecule during its biological activity as it sits alone on one side of the plane of the phenyl group similar to those in other N-(aryl)-methanesulfonamides. The molecules in 24DCPMSA are packed into chains in the direction of b axis (Fig. 2) through both N—H···O and N—H···Cl hydrogen bonds (Table 1).
For related literature, see:
Gowda et al. (2007a,b,c,d,e,f,g,h,i,j,k,l); Jayalakshmi & Gowda (2004); Klug (1968).
Data collection: CAD-4-PC (Enraf–Nonius, 1996); cell refinement: CAD-4-PC; data reduction: REDU4 (Stoe & Cie, 1987); program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: PLATON (Spek, 2003); software used to prepare material for publication: SHELXL97.
C7H7Cl2NO2S | Z = 2 |
Mr = 240.10 | F(000) = 244 |
Triclinic, P1 | Dx = 1.660 Mg m−3 |
Hall symbol: -P 1 | Cu Kα radiation, λ = 1.54180 Å |
a = 7.580 (1) Å | Cell parameters from 25 reflections |
b = 8.269 (1) Å | θ = 6.8–25.8° |
c = 8.285 (1) Å | µ = 7.85 mm−1 |
α = 83.70 (1)° | T = 299 K |
β = 87.95 (1)° | Prism, colourless |
γ = 68.57 (1)° | 0.52 × 0.32 × 0.15 mm |
V = 480.47 (10) Å3 |
Enraf–Nonius CAD-4 diffractometer | 1601 reflections with I > 2σ(I) |
Radiation source: fine-focus sealed tube | Rint = 0.048 |
Graphite monochromator | θmax = 66.9°, θmin = 5.4° |
ω/2θ scans | h = −9→9 |
Absorption correction: ψ scan (North et al., 1968) | k = −9→9 |
Tmin = 0.042, Tmax = 0.307 | l = −9→0 |
1831 measured reflections | 3 standard reflections every 120 min |
1701 independent reflections | intensity decay: 5.0% |
Refinement on F2 | Secondary atom site location: difference Fourier map |
Least-squares matrix: full | Hydrogen site location: inferred from neighbouring sites |
R[F2 > 2σ(F2)] = 0.095 | H-atom parameters constrained |
wR(F2) = 0.277 | w = 1/[σ2(Fo2) + (0.2P)2] where P = (Fo2 + 2Fc2)/3 |
S = 1.37 | (Δ/σ)max < 0.001 |
1701 reflections | Δρmax = 0.84 e Å−3 |
119 parameters | Δρmin = −1.65 e Å−3 |
0 restraints | Extinction correction: SHELXL97 (Sheldrick, 1997), Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4 |
Primary atom site location: structure-invariant direct methods | Extinction coefficient: 0.130 (17) |
C7H7Cl2NO2S | γ = 68.57 (1)° |
Mr = 240.10 | V = 480.47 (10) Å3 |
Triclinic, P1 | Z = 2 |
a = 7.580 (1) Å | Cu Kα radiation |
b = 8.269 (1) Å | µ = 7.85 mm−1 |
c = 8.285 (1) Å | T = 299 K |
α = 83.70 (1)° | 0.52 × 0.32 × 0.15 mm |
β = 87.95 (1)° |
Enraf–Nonius CAD-4 diffractometer | 1601 reflections with I > 2σ(I) |
Absorption correction: ψ scan (North et al., 1968) | Rint = 0.048 |
Tmin = 0.042, Tmax = 0.307 | 3 standard reflections every 120 min |
1831 measured reflections | intensity decay: 5.0% |
1701 independent reflections |
R[F2 > 2σ(F2)] = 0.095 | 0 restraints |
wR(F2) = 0.277 | H-atom parameters constrained |
S = 1.37 | Δρmax = 0.84 e Å−3 |
1701 reflections | Δρmin = −1.65 e Å−3 |
119 parameters |
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | ||
C1 | 0.3441 (5) | 0.4168 (5) | 0.2568 (4) | 0.0353 (9) | |
C2 | 0.2920 (5) | 0.3970 (5) | 0.1016 (4) | 0.0366 (9) | |
C3 | 0.2380 (5) | 0.5343 (5) | −0.0203 (5) | 0.0402 (10) | |
H3 | 0.2052 | 0.5185 | −0.1229 | 0.048* | |
C4 | 0.2337 (5) | 0.6943 (5) | 0.0135 (5) | 0.0402 (10) | |
C5 | 0.2829 (6) | 0.7203 (5) | 0.1657 (5) | 0.0435 (10) | |
H5 | 0.2785 | 0.8298 | 0.1870 | 0.052* | |
C6 | 0.3382 (6) | 0.5817 (5) | 0.2844 (5) | 0.0423 (10) | |
H6 | 0.3727 | 0.5986 | 0.3860 | 0.051* | |
C7 | 0.1136 (6) | 0.1897 (7) | 0.4902 (7) | 0.0582 (12) | |
H7A | 0.1653 | 0.0805 | 0.4440 | 0.070* | |
H7B | 0.0322 | 0.2772 | 0.4122 | 0.070* | |
H7C | 0.0421 | 0.1765 | 0.5853 | 0.070* | |
N1 | 0.4140 (4) | 0.2726 (4) | 0.3754 (4) | 0.0402 (9) | |
H1N | 0.5211 | 0.1917 | 0.3592 | 0.048* | |
O1 | 0.4295 (5) | 0.1117 (4) | 0.6438 (4) | 0.0533 (9) | |
O2 | 0.2194 (5) | 0.4216 (4) | 0.6006 (4) | 0.0528 (9) | |
S1 | 0.29870 (12) | 0.25352 (12) | 0.54332 (10) | 0.0385 (6) | |
Cl1 | 0.29909 (18) | 0.19478 (13) | 0.05738 (13) | 0.0544 (6) | |
Cl2 | 0.17636 (15) | 0.86631 (14) | −0.14033 (13) | 0.0542 (6) |
U11 | U22 | U33 | U12 | U13 | U23 | |
C1 | 0.0286 (16) | 0.0312 (19) | 0.0447 (18) | −0.0097 (14) | 0.0020 (13) | −0.0028 (15) |
C2 | 0.0343 (17) | 0.032 (2) | 0.0433 (18) | −0.0125 (15) | 0.0027 (14) | −0.0051 (16) |
C3 | 0.0344 (18) | 0.038 (2) | 0.0462 (19) | −0.0111 (16) | 0.0006 (15) | −0.0033 (17) |
C4 | 0.0333 (18) | 0.034 (2) | 0.052 (2) | −0.0125 (16) | 0.0045 (15) | 0.0008 (17) |
C5 | 0.046 (2) | 0.0310 (19) | 0.055 (2) | −0.0157 (16) | 0.0037 (17) | −0.0058 (17) |
C6 | 0.0416 (19) | 0.038 (2) | 0.0489 (19) | −0.0161 (16) | −0.0034 (16) | −0.0044 (17) |
C7 | 0.044 (2) | 0.055 (3) | 0.080 (3) | −0.023 (2) | 0.005 (2) | −0.008 (2) |
N1 | 0.0335 (15) | 0.0297 (16) | 0.0499 (18) | −0.0041 (12) | 0.0024 (13) | −0.0001 (14) |
O1 | 0.062 (2) | 0.0393 (17) | 0.0464 (15) | −0.0057 (14) | −0.0051 (13) | 0.0036 (13) |
O2 | 0.0627 (19) | 0.0360 (17) | 0.0491 (16) | −0.0054 (14) | 0.0043 (14) | −0.0063 (14) |
S1 | 0.0398 (8) | 0.0281 (8) | 0.0423 (8) | −0.0068 (5) | 0.0007 (5) | −0.0011 (5) |
Cl1 | 0.0720 (9) | 0.0341 (9) | 0.0594 (9) | −0.0207 (6) | −0.0036 (6) | −0.0081 (5) |
Cl2 | 0.0552 (9) | 0.0405 (9) | 0.0583 (9) | −0.0121 (6) | 0.0016 (6) | 0.0120 (5) |
C1—C6 | 1.392 (5) | C5—H5 | 0.9300 |
C1—C2 | 1.402 (5) | C6—H6 | 0.9300 |
C1—N1 | 1.409 (5) | C7—S1 | 1.754 (4) |
C2—C3 | 1.384 (6) | C7—H7A | 0.9600 |
C2—Cl1 | 1.732 (4) | C7—H7B | 0.9600 |
C3—C4 | 1.371 (6) | C7—H7C | 0.9600 |
C3—H3 | 0.9300 | N1—S1 | 1.640 (3) |
C4—C5 | 1.388 (6) | N1—H1N | 0.8600 |
C4—Cl2 | 1.739 (4) | O1—S1 | 1.431 (3) |
C5—C6 | 1.374 (6) | O2—S1 | 1.426 (3) |
C6—C1—C2 | 117.2 (4) | C1—C6—H6 | 119.1 |
C6—C1—N1 | 121.4 (3) | S1—C7—H7A | 109.5 |
C2—C1—N1 | 121.2 (3) | S1—C7—H7B | 109.5 |
C3—C2—C1 | 121.9 (4) | H7A—C7—H7B | 109.5 |
C3—C2—Cl1 | 118.3 (3) | S1—C7—H7C | 109.5 |
C1—C2—Cl1 | 119.8 (3) | H7A—C7—H7C | 109.5 |
C4—C3—C2 | 118.6 (4) | H7B—C7—H7C | 109.5 |
C4—C3—H3 | 120.7 | C1—N1—S1 | 122.4 (2) |
C2—C3—H3 | 120.7 | C1—N1—H1N | 118.8 |
C3—C4—C5 | 121.5 (4) | S1—N1—H1N | 118.8 |
C3—C4—Cl2 | 119.3 (3) | O2—S1—O1 | 119.49 (19) |
C5—C4—Cl2 | 119.1 (3) | O2—S1—N1 | 107.84 (18) |
C6—C5—C4 | 119.0 (3) | O1—S1—N1 | 105.42 (18) |
C6—C5—H5 | 120.5 | O2—S1—C7 | 108.8 (2) |
C4—C5—H5 | 120.5 | O1—S1—C7 | 108.1 (2) |
C5—C6—C1 | 121.9 (3) | N1—S1—C7 | 106.5 (2) |
C5—C6—H6 | 119.1 | ||
C6—C1—C2—C3 | 0.4 (5) | Cl2—C4—C5—C6 | −176.5 (3) |
N1—C1—C2—C3 | −174.6 (3) | C4—C5—C6—C1 | −0.8 (6) |
C6—C1—C2—Cl1 | 179.1 (3) | C2—C1—C6—C5 | 0.4 (6) |
N1—C1—C2—Cl1 | 4.1 (5) | N1—C1—C6—C5 | 175.3 (3) |
C1—C2—C3—C4 | −0.7 (6) | C6—C1—N1—S1 | 70.8 (4) |
Cl1—C2—C3—C4 | −179.4 (3) | C2—C1—N1—S1 | −114.4 (3) |
C2—C3—C4—C5 | 0.3 (6) | C1—N1—S1—O2 | −40.3 (3) |
C2—C3—C4—Cl2 | 177.2 (3) | C1—N1—S1—O1 | −169.0 (3) |
C3—C4—C5—C6 | 0.4 (6) | C1—N1—S1—C7 | 76.4 (3) |
D—H···A | D—H | H···A | D···A | D—H···A |
N1—H1N···O1i | 0.86 | 2.40 | 2.979 (5) | 125 |
N1—H1N···Cl2ii | 0.86 | 2.80 | 3.494 (3) | 138 |
Symmetry codes: (i) −x+1, −y, −z+1; (ii) −x+1, −y+1, −z. |
Experimental details
Crystal data | |
Chemical formula | C7H7Cl2NO2S |
Mr | 240.10 |
Crystal system, space group | Triclinic, P1 |
Temperature (K) | 299 |
a, b, c (Å) | 7.580 (1), 8.269 (1), 8.285 (1) |
α, β, γ (°) | 83.70 (1), 87.95 (1), 68.57 (1) |
V (Å3) | 480.47 (10) |
Z | 2 |
Radiation type | Cu Kα |
µ (mm−1) | 7.85 |
Crystal size (mm) | 0.52 × 0.32 × 0.15 |
Data collection | |
Diffractometer | Enraf–Nonius CAD-4 |
Absorption correction | ψ scan (North et al., 1968) |
Tmin, Tmax | 0.042, 0.307 |
No. of measured, independent and observed [I > 2σ(I)] reflections | 1831, 1701, 1601 |
Rint | 0.048 |
(sin θ/λ)max (Å−1) | 0.597 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.095, 0.277, 1.37 |
No. of reflections | 1701 |
No. of parameters | 119 |
H-atom treatment | H-atom parameters constrained |
Δρmax, Δρmin (e Å−3) | 0.84, −1.65 |
Computer programs: CAD-4-PC (Enraf–Nonius, 1996), CAD-4-PC, REDU4 (Stoe & Cie, 1987), SHELXS97 (Sheldrick, 1997), SHELXL97 (Sheldrick, 1997), PLATON (Spek, 2003), SHELXL97.
D—H···A | D—H | H···A | D···A | D—H···A |
N1—H1N···O1i | 0.86 | 2.40 | 2.979 (5) | 125.1 |
N1—H1N···Cl2ii | 0.86 | 2.80 | 3.494 (3) | 138.3 |
Symmetry codes: (i) −x+1, −y, −z+1; (ii) −x+1, −y+1, −z. |
The structural studies of sulfonanilides are of interest due to their biological activity. In the present work, the structure of N-(2,4-dichlorophenyl)-methanesulfonamide (24DCPMSA) has been determined to explore the substituent effects on the solid state structures of sulfonanilides (Gowda et al., 2007a-l). The structure of 24DCPMSA (Fig. 1) resembles those of N-(phenyl)-methanesulfonamide (PMSA) (Klug, 1968), N-(2-chlorophenyl)-methanesulfonamide (2CPMSA) (Gowda et al., 2007l), N-(2,3-dichlorophenyl)- methanesulfonamide (23DCPMSA)(Gowda et al., 2007k), N-(2,4-dimethylphenyl)-methanesulfonamide (24DMPMSA)(Gowda et al., 2007i) and other methylsulfonanilides (Gowda et al., 2007a-h). The conformation of the N—H bond in 24DCPMSA is nearly syn to the ortho-chloro substituent, similar to the syn conformation observed for 24DMPMSA (Gowda et al., 2007i). The ortho substitution of either a chloro or methyl group in PMSA changes its space group from monoclinic P21/c to triclinic P-1. But the substitution of an additional chloro group in the para position of 2CPMSA to produce 24DCPMSA does not further alter the space group, in contrast to the change over from triclinic P-1 to monoclinic P21/n on substitution of an additional methyl group at the para position in N-(2-methylphenyl)- methanesulfonamide (2MPMSA) (Gowda et al., 2007d) to form 24DMPMSA and monoclinic P21/c space group observed for 23DCPMSA (Gowda et al., 2007k). The geometric parameters in 24DCPMSA are similar to those in PMSA, 2CPMSA, 23DCPMSA, 24DMPMSA and other methanesulfonanilides except for some difference in the bond and torsional angles. The amide hydrogen is readily available to a receptor molecule during its biological activity as it sits alone on one side of the plane of the phenyl group similar to those in other N-(aryl)-methanesulfonamides. The molecules in 24DCPMSA are packed into chains in the direction of b axis (Fig. 2) through both N—H···O and N—H···Cl hydrogen bonds (Table 1).