Supporting information
Crystallographic Information File (CIF) https://doi.org/10.1107/S1600536807032369/kp2116sup1.cif | |
Structure factor file (CIF format) https://doi.org/10.1107/S1600536807032369/kp2116Isup2.hkl |
CCDC reference: 657755
Methanesulfonyl chloride (1.26 g, 11 mmol) was added into a mixture of 3-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester (1.87 g, 10 mmol) and triethylamine (1.21 g, 12 mmol) in dichloromethane (20 ml) with stirring in an ice bath. The mixture was stirred at 273 K for 1 h, and then warmed to room temperature, stirred for additional 8 h, then partitioned between ethyl acetate (3×15 ml) and water (15 ml). The organic phase was dried and concentrated to give 3-(methylsulfonyloxy)pyrrolidine-1-carboxylic acid tert-butyl ester 2.44 g (yield 92%) that was added into a mixture of 4-bromothiophenol (2.27 g, 12 mmol) and potassium carbonate (2.21 g, 16 mmol) in acetonitrile (20 ml), and the resulting slurry was heated at reflux for 24 h. After cooling to room temperature, the reaction mixture was partitioned between water and dichloromethane. The organic phase was washed with brine, dried, and concentrated to give 3-(4-bromobenzene)thiopyrrolidine-1-carboxylic acid tert-butyl ester 2.40 g (yield 67%) and then dissolved in 10 ml of methanol; potassium peroxymonosulfate (18.54 g, 30 mmol) was added to a methanol solution. After stirring over 24 h, the solvent was evaporated. The residue was partitioned between chloroform and water. The organic phase was dried and concentrated to give the aimed product as a white solid 2.49 g (yield 92%). Single crystals suitable for X-ray diffraction were obtained by slow evaporation of a dichloromethane solution at room temperature.
H atoms were found in difference Fourier maps and refined as riding, with C—H distance of 0.93 (aromatic), 0.98 (CH), 0.97 (CH2) and 0.96 Å (CH3), and with Uiso(H) =kUeq(C,N), where k=1.5 for the methyl groups and k=1.2 for all other H atoms.
The title compound, (I), is an intermediate in potential drug synthesis. The pyrrolidine ring adopts an envelope conformation (Fig. 1) with the atom C8 as the flap atom whereas the four atoms are coplanar. The crystal structure is stabilized by C—H···O hydrogen bonds (Fig. 2 and Table 1) and Br···O van der Waals interactions with the distance of 3.126 Å which is shorter than the sum of radii (3.37 Å).
The preparation of a similar compound, 4-(4-bromobenzene)sulfonylpiperidine-1-carboxylic acid tert-butyl ester, was reported by Fletcher et al. (2002).
Data collection: SMART (Bruker, 1998); cell refinement: SAINT (Bruker, 2003); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: SHELXTL (Bruker, 1997); software used to prepare material for publication: SHELXTL.
C15H20BrNO4S | Dx = 1.511 Mg m−3 |
Mr = 390.29 | Mo Kα radiation, λ = 0.71073 Å |
Tetragonal, P421c | Cell parameters from 5667 reflections |
a = 18.424 (1) Å | θ = 2.3–23.3° |
c = 10.1082 (11) Å | µ = 2.53 mm−1 |
V = 3431.2 (5) Å3 | T = 293 K |
Z = 8 | Block, colourless |
F(000) = 1600 | 0.33 × 0.26 × 0.15 mm |
Bruker SMART CCD area-detector diffractometer | 3390 independent reflections |
Radiation source: fine-focus sealed tube | 2760 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.056 |
φ and ω scans | θmax = 26.1°, θmin = 1.6° |
Absorption correction: multi-scan (SADABS; Sheldrick, 2002) | h = −22→12 |
Tmin = 0.493, Tmax = 0.707 | k = −20→22 |
18794 measured reflections | l = −12→12 |
Refinement on F2 | Secondary atom site location: difference Fourier map |
Least-squares matrix: full | Hydrogen site location: inferred from neighbouring sites |
R[F2 > 2σ(F2)] = 0.033 | H-atom parameters constrained |
wR(F2) = 0.073 | w = 1/[σ2(Fo2) + (0.0351P)2] where P = (Fo2 + 2Fc2)/3 |
S = 1.00 | (Δ/σ)max = 0.001 |
3390 reflections | Δρmax = 0.42 e Å−3 |
202 parameters | Δρmin = −0.17 e Å−3 |
0 restraints | Absolute structure: Flack (1983), 1482 Friedel pairs |
Primary atom site location: structure-invariant direct methods | Absolute structure parameter: −0.021 (8) |
C15H20BrNO4S | Z = 8 |
Mr = 390.29 | Mo Kα radiation |
Tetragonal, P421c | µ = 2.53 mm−1 |
a = 18.424 (1) Å | T = 293 K |
c = 10.1082 (11) Å | 0.33 × 0.26 × 0.15 mm |
V = 3431.2 (5) Å3 |
Bruker SMART CCD area-detector diffractometer | 3390 independent reflections |
Absorption correction: multi-scan (SADABS; Sheldrick, 2002) | 2760 reflections with I > 2σ(I) |
Tmin = 0.493, Tmax = 0.707 | Rint = 0.056 |
18794 measured reflections |
R[F2 > 2σ(F2)] = 0.033 | H-atom parameters constrained |
wR(F2) = 0.073 | Δρmax = 0.42 e Å−3 |
S = 1.00 | Δρmin = −0.17 e Å−3 |
3390 reflections | Absolute structure: Flack (1983), 1482 Friedel pairs |
202 parameters | Absolute structure parameter: −0.021 (8) |
0 restraints |
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | ||
Br1 | 0.620575 (19) | 0.59671 (2) | −0.04350 (4) | 0.06539 (13) | |
S | 0.66889 (4) | 0.63796 (4) | 0.57777 (8) | 0.0515 (2) | |
C1 | 0.63226 (15) | 0.60962 (17) | 0.1410 (3) | 0.0468 (7) | |
O1 | 0.61910 (12) | 0.59169 (13) | 0.6474 (2) | 0.0652 (6) | |
O3 | 0.83317 (15) | 0.59393 (12) | 0.9922 (2) | 0.0746 (7) | |
C3 | 0.68573 (17) | 0.67391 (17) | 0.3186 (3) | 0.0510 (8) | |
H3 | 0.7146 | 0.7115 | 0.3502 | 0.061* | |
O2 | 0.66995 (16) | 0.71375 (13) | 0.6072 (2) | 0.0772 (7) | |
O4 | 0.80675 (12) | 0.47438 (10) | 0.9672 (2) | 0.0591 (6) | |
C9 | 0.75873 (19) | 0.49303 (17) | 0.7196 (3) | 0.0564 (8) | |
H9A | 0.7084 | 0.4848 | 0.7434 | 0.068* | |
H9B | 0.7854 | 0.4479 | 0.7282 | 0.068* | |
C4 | 0.65312 (15) | 0.62685 (16) | 0.4064 (3) | 0.0459 (7) | |
N1 | 0.79046 (14) | 0.54924 (13) | 0.7999 (3) | 0.0508 (6) | |
C6 | 0.59860 (17) | 0.56282 (18) | 0.2270 (3) | 0.0538 (8) | |
H6 | 0.5690 | 0.5258 | 0.1952 | 0.065* | |
C5 | 0.60938 (17) | 0.57141 (16) | 0.3618 (3) | 0.0513 (8) | |
H5 | 0.5873 | 0.5400 | 0.4216 | 0.062* | |
C8 | 0.7650 (2) | 0.52323 (18) | 0.5805 (3) | 0.0630 (9) | |
H8A | 0.8112 | 0.5102 | 0.5411 | 0.076* | |
H8B | 0.7261 | 0.5051 | 0.5248 | 0.076* | |
C12 | 0.83221 (17) | 0.45220 (17) | 1.0991 (3) | 0.0534 (8) | |
C11 | 0.81189 (17) | 0.54343 (16) | 0.9263 (3) | 0.0527 (8) | |
C7 | 0.75911 (16) | 0.60457 (18) | 0.5981 (3) | 0.0534 (8) | |
H7 | 0.7910 | 0.6286 | 0.5339 | 0.064* | |
C10 | 0.78683 (18) | 0.62034 (18) | 0.7381 (3) | 0.0562 (8) | |
H10A | 0.8343 | 0.6430 | 0.7356 | 0.067* | |
H10B | 0.7536 | 0.6519 | 0.7854 | 0.067* | |
C2 | 0.67588 (17) | 0.66560 (17) | 0.1851 (3) | 0.0512 (8) | |
H2 | 0.6981 | 0.6970 | 0.1255 | 0.061* | |
C14 | 0.8185 (2) | 0.37114 (18) | 1.0985 (4) | 0.0701 (10) | |
H14A | 0.7677 | 0.3621 | 1.0850 | 0.105* | |
H14B | 0.8333 | 0.3508 | 1.1817 | 0.105* | |
H14C | 0.8459 | 0.3491 | 1.0284 | 0.105* | |
C13 | 0.7871 (2) | 0.4881 (2) | 1.2038 (4) | 0.0810 (11) | |
H13A | 0.8001 | 0.5385 | 1.2097 | 0.121* | |
H13B | 0.7957 | 0.4650 | 1.2874 | 0.121* | |
H13C | 0.7367 | 0.4839 | 1.1812 | 0.121* | |
C15 | 0.9123 (2) | 0.4685 (3) | 1.1138 (5) | 0.0936 (14) | |
H15A | 0.9379 | 0.4509 | 1.0374 | 0.140* | |
H15B | 0.9306 | 0.4448 | 1.1916 | 0.140* | |
H15C | 0.9192 | 0.5199 | 1.1216 | 0.140* |
U11 | U22 | U33 | U12 | U13 | U23 | |
Br1 | 0.0659 (2) | 0.0847 (3) | 0.04548 (16) | 0.00603 (17) | −0.00009 (17) | 0.00048 (18) |
S | 0.0526 (5) | 0.0572 (5) | 0.0447 (4) | 0.0067 (4) | 0.0066 (4) | −0.0020 (3) |
C1 | 0.0444 (17) | 0.0557 (19) | 0.0402 (14) | 0.0114 (16) | 0.0003 (13) | 0.0023 (14) |
O1 | 0.0509 (12) | 0.0935 (17) | 0.0512 (12) | 0.0015 (15) | 0.0106 (11) | 0.0073 (12) |
O3 | 0.1084 (18) | 0.0532 (13) | 0.0621 (15) | −0.0231 (14) | −0.0227 (13) | 0.0004 (11) |
C3 | 0.0526 (18) | 0.0429 (17) | 0.0577 (19) | 0.0007 (15) | 0.0012 (15) | 0.0030 (16) |
O2 | 0.105 (2) | 0.0596 (15) | 0.0674 (16) | 0.0173 (15) | −0.0021 (15) | −0.0141 (12) |
O4 | 0.0740 (15) | 0.0450 (12) | 0.0584 (14) | −0.0080 (10) | −0.0145 (12) | 0.0049 (11) |
C9 | 0.068 (2) | 0.0424 (16) | 0.0587 (19) | 0.0013 (16) | −0.0070 (17) | −0.0107 (16) |
C4 | 0.0426 (17) | 0.0482 (18) | 0.0468 (16) | 0.0082 (15) | 0.0050 (13) | 0.0002 (14) |
N1 | 0.0574 (15) | 0.0424 (13) | 0.0526 (15) | −0.0097 (12) | −0.0044 (13) | 0.0019 (12) |
C6 | 0.0514 (19) | 0.0591 (19) | 0.0510 (18) | −0.0020 (16) | 0.0006 (15) | −0.0031 (15) |
C5 | 0.0499 (19) | 0.0507 (18) | 0.0534 (18) | −0.0031 (15) | 0.0074 (15) | 0.0090 (14) |
C8 | 0.061 (2) | 0.071 (2) | 0.056 (2) | 0.0140 (17) | −0.0035 (16) | −0.0140 (17) |
C12 | 0.0533 (19) | 0.0502 (18) | 0.0566 (19) | 0.0048 (16) | −0.0085 (15) | 0.0051 (15) |
C11 | 0.0588 (19) | 0.0431 (17) | 0.056 (2) | −0.0081 (15) | −0.0050 (16) | −0.0003 (15) |
C7 | 0.0474 (17) | 0.065 (2) | 0.0472 (16) | −0.0050 (16) | 0.0070 (14) | 0.0041 (15) |
C10 | 0.0614 (19) | 0.0516 (18) | 0.0556 (19) | −0.0159 (17) | −0.0039 (15) | 0.0101 (16) |
C2 | 0.0493 (17) | 0.0537 (18) | 0.0506 (18) | 0.0014 (16) | 0.0062 (15) | 0.0129 (15) |
C14 | 0.080 (2) | 0.050 (2) | 0.080 (3) | 0.0036 (19) | −0.017 (2) | 0.0083 (17) |
C13 | 0.099 (3) | 0.074 (2) | 0.070 (2) | 0.016 (2) | 0.015 (2) | 0.010 (2) |
C15 | 0.054 (2) | 0.102 (3) | 0.125 (4) | −0.004 (2) | −0.022 (2) | 0.013 (3) |
Br1—C1 | 1.893 (3) | C5—H5 | 0.9300 |
S—O2 | 1.428 (2) | C8—C7 | 1.513 (5) |
S—O1 | 1.437 (2) | C8—H8A | 0.9700 |
S—C4 | 1.768 (3) | C8—H8B | 0.9700 |
S—C7 | 1.784 (3) | C12—C13 | 1.499 (5) |
C1—C6 | 1.372 (4) | C12—C15 | 1.513 (5) |
C1—C2 | 1.381 (4) | C12—C14 | 1.515 (5) |
O3—C11 | 1.210 (4) | C7—C10 | 1.533 (4) |
C3—C2 | 1.370 (5) | C7—H7 | 0.9800 |
C3—C4 | 1.378 (4) | C10—H10A | 0.9700 |
C3—H3 | 0.9300 | C10—H10B | 0.9700 |
O4—C11 | 1.341 (4) | C2—H2 | 0.9300 |
O4—C12 | 1.472 (4) | C14—H14A | 0.9600 |
C9—N1 | 1.440 (4) | C14—H14B | 0.9600 |
C9—C8 | 1.516 (4) | C14—H14C | 0.9600 |
C9—H9A | 0.9700 | C13—H13A | 0.9600 |
C9—H9B | 0.9700 | C13—H13B | 0.9600 |
C4—C5 | 1.377 (4) | C13—H13C | 0.9600 |
N1—C11 | 1.342 (4) | C15—H15A | 0.9600 |
N1—C10 | 1.452 (4) | C15—H15B | 0.9600 |
C6—C5 | 1.386 (4) | C15—H15C | 0.9600 |
C6—H6 | 0.9300 | ||
O2—S—O1 | 119.13 (16) | O4—C12—C14 | 102.5 (3) |
O2—S—C4 | 108.65 (15) | C13—C12—C14 | 110.2 (3) |
O1—S—C4 | 107.84 (14) | C15—C12—C14 | 111.0 (3) |
O2—S—C7 | 107.49 (17) | O3—C11—O4 | 125.7 (3) |
O1—S—C7 | 109.51 (14) | O3—C11—N1 | 123.9 (3) |
C4—S—C7 | 103.05 (13) | O4—C11—N1 | 110.4 (3) |
C6—C1—C2 | 121.9 (3) | C8—C7—C10 | 105.8 (3) |
C6—C1—Br1 | 119.6 (2) | C8—C7—S | 113.2 (2) |
C2—C1—Br1 | 118.6 (2) | C10—C7—S | 110.6 (2) |
C2—C3—C4 | 120.4 (3) | C8—C7—H7 | 109.0 |
C2—C3—H3 | 119.8 | C10—C7—H7 | 109.0 |
C4—C3—H3 | 119.8 | S—C7—H7 | 109.0 |
C11—O4—C12 | 121.4 (2) | N1—C10—C7 | 104.0 (3) |
N1—C9—C8 | 103.2 (3) | N1—C10—H10A | 111.0 |
N1—C9—H9A | 111.1 | C7—C10—H10A | 111.0 |
C8—C9—H9A | 111.1 | N1—C10—H10B | 111.0 |
N1—C9—H9B | 111.1 | C7—C10—H10B | 111.0 |
C8—C9—H9B | 111.1 | H10A—C10—H10B | 109.0 |
H9A—C9—H9B | 109.1 | C3—C2—C1 | 118.6 (3) |
C5—C4—C3 | 120.7 (3) | C3—C2—H2 | 120.7 |
C5—C4—S | 120.2 (2) | C1—C2—H2 | 120.7 |
C3—C4—S | 119.1 (2) | C12—C14—H14A | 109.5 |
C11—N1—C9 | 126.8 (3) | C12—C14—H14B | 109.5 |
C11—N1—C10 | 119.6 (3) | H14A—C14—H14B | 109.5 |
C9—N1—C10 | 112.8 (3) | C12—C14—H14C | 109.5 |
C1—C6—C5 | 119.1 (3) | H14A—C14—H14C | 109.5 |
C1—C6—H6 | 120.5 | H14B—C14—H14C | 109.5 |
C5—C6—H6 | 120.5 | C12—C13—H13A | 109.5 |
C4—C5—C6 | 119.4 (3) | C12—C13—H13B | 109.5 |
C4—C5—H5 | 120.3 | H13A—C13—H13B | 109.5 |
C6—C5—H5 | 120.3 | C12—C13—H13C | 109.5 |
C7—C8—C9 | 104.4 (3) | H13A—C13—H13C | 109.5 |
C7—C8—H8A | 110.9 | H13B—C13—H13C | 109.5 |
C9—C8—H8A | 110.9 | C12—C15—H15A | 109.5 |
C7—C8—H8B | 110.9 | C12—C15—H15B | 109.5 |
C9—C8—H8B | 110.9 | H15A—C15—H15B | 109.5 |
H8A—C8—H8B | 108.9 | C12—C15—H15C | 109.5 |
O4—C12—C13 | 109.9 (3) | H15A—C15—H15C | 109.5 |
O4—C12—C15 | 110.2 (3) | H15B—C15—H15C | 109.5 |
C13—C12—C15 | 112.6 (3) |
D—H···A | D—H | H···A | D···A | D—H···A |
C5—H5···O1 | 0.93 | 2.54 | 2.916 (3) | 105 |
C7—H7···O3i | 0.98 | 2.27 | 3.129 (3) | 145 |
C13—H13A···O3 | 0.96 | 2.50 | 3.016 (4) | 114 |
C15—H15C···O3 | 0.96 | 2.47 | 2.996 (6) | 115 |
Symmetry code: (i) −y+3/2, −x+3/2, z−1/2. |
Experimental details
Crystal data | |
Chemical formula | C15H20BrNO4S |
Mr | 390.29 |
Crystal system, space group | Tetragonal, P421c |
Temperature (K) | 293 |
a, c (Å) | 18.424 (1), 10.1082 (11) |
V (Å3) | 3431.2 (5) |
Z | 8 |
Radiation type | Mo Kα |
µ (mm−1) | 2.53 |
Crystal size (mm) | 0.33 × 0.26 × 0.15 |
Data collection | |
Diffractometer | Bruker SMART CCD area-detector |
Absorption correction | Multi-scan (SADABS; Sheldrick, 2002) |
Tmin, Tmax | 0.493, 0.707 |
No. of measured, independent and observed [I > 2σ(I)] reflections | 18794, 3390, 2760 |
Rint | 0.056 |
(sin θ/λ)max (Å−1) | 0.618 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.033, 0.073, 1.00 |
No. of reflections | 3390 |
No. of parameters | 202 |
H-atom treatment | H-atom parameters constrained |
Δρmax, Δρmin (e Å−3) | 0.42, −0.17 |
Absolute structure | Flack (1983), 1482 Friedel pairs |
Absolute structure parameter | −0.021 (8) |
Computer programs: SMART (Bruker, 1998), SAINT (Bruker, 2003), SAINT, SHELXS97 (Sheldrick, 1997), SHELXL97 (Sheldrick, 1997), SHELXTL (Bruker, 1997), SHELXTL.
D—H···A | D—H | H···A | D···A | D—H···A |
C5—H5···O1 | 0.93 | 2.54 | 2.916 (3) | 104.45 |
C7—H7···O3i | 0.98 | 2.27 | 3.129 (3) | 145.19 |
C13—H13A···O3 | 0.96 | 2.50 | 3.016 (4) | 113.64 |
C15—H15C···O3 | 0.96 | 2.47 | 2.996 (6) | 114.67 |
Symmetry code: (i) −y+3/2, −x+3/2, z−1/2. |
The title compound, (I), is an intermediate in potential drug synthesis. The pyrrolidine ring adopts an envelope conformation (Fig. 1) with the atom C8 as the flap atom whereas the four atoms are coplanar. The crystal structure is stabilized by C—H···O hydrogen bonds (Fig. 2 and Table 1) and Br···O van der Waals interactions with the distance of 3.126 Å which is shorter than the sum of radii (3.37 Å).