RESTRAIN: restrained structure-factor least-squares refinement program for macromolecular structures

A complete description of the current version of RESTRAIN, a program primarily for the least-squares refinement of macromolecular structures, is presented. This description announces the version that will be released to the academic community. The additional features present in this version are described in detail. The program is compared with two other macromolecular refinement programs. Finally information about documentation and availability is presented.