Dimethyl 2,6-Dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate, Diethyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and Diethyl 2,6-Dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

The crystal structure of diethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, C₁₉H₂₂N₂O₆ (FR7534), a member of the 1,4-dihydropyridine class of calcium blockers, and the crystal structures of diethyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate, C₁₉H₂₀N₂O₆, (III) and dimethyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate, C₁₇H₁₆N₂O₆, decomposition products of FR7534 and dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, respectively, reveal that the decomposition products display conformational features associated with activity according to structure-activity relationships.

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