Supporting information
Crystallographic Information File (CIF) https://doi.org/10.1107/S1600536807043280/dn2226sup1.cif | |
Structure factor file (CIF format) https://doi.org/10.1107/S1600536807043280/dn2226Isup2.hkl |
CCDC reference: 659488
To a solution of 4-methoxybenzaldehyde (5 mmol, 0.68 g) and diethyl phosphonate (5 mmol, 0.69 g) in tetrahydrofuran (5 ml) at 0 \%C was added aqueous ammonia (25%, 1.6 ml). The mixture was left to stand at ambient temperature for 2 h, during which time a precipitate separated. The precipitate was filtered off and washed rapidly with cold diethyl ether (Martine et al., 1995). Single crystals were obtained by crystallization of a dichloromethane/ petroleum ether (v/v = 1/4) solution (Fig. 1). CHN analysis, calculated for C~12~H~19Õ~5~P: C, 52.55%; H, 6.98%; Found: C, 52.41%; H, 6.96%.
All H atoms were placed in geometrically idealized positions and treated as riding on their parent atoms, with C—H = 0.93 (aromatic), 0.96 (CH3), 0.97 (CH2) or 0.98 (CH), O—H = 0.82 \%A and Uiso(H) = 1.2Ueq (aromatic C, CH and CH2) or 1.5Ueq (methyl C and O).
In recent years \a-hydroxyphosphonic acids esters have attracted much attention due to their wide biological activity (Stowasser et al., 1992) and pharmaceutical interest (Chen et al., 1995). They are useful reagents for the synthesis of enol ethers and \a-ketophosphonates (Babak et al., 2001). Bond lengths and angles in the title compound, (I), are in agreement with the values reported for related compounds (Smaardijk et al., 1985). Intermolecular O—H···O hydrogen bond between the phosphoryl O atom and the hydroxy group results in the formation of an infinite chain connecting the molecules along the b axis (Table 1 and Fig. 3).
For related literature, see: Babak & Rahman (2001); Chen et al. (1995); Martine et al. (1995); Smaardijk et al. (1985); Stowasser et al. (1992).
Data collection: SMART (Bruker, 2001); cell refinement: SAINT (Bruker, 2001); data reduction: SAINT (Bruker, 2001); program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: ORTEP-3 for Windows (Farrugia, 1997) and PLATON (Spek, 2003); software used to prepare material for publication: SHELXL97.
C12H19O5P | F(000) = 584 |
Mr = 274.24 | Dx = 1.294 Mg m−3 |
Monoclinic, P21/n | Mo Kα radiation, λ = 0.71073 Å |
Hall symbol: -P 2yn | Cell parameters from 1884 reflections |
a = 10.454 (4) Å | θ = 2.6–25.1° |
b = 7.745 (3) Å | µ = 0.21 mm−1 |
c = 18.021 (7) Å | T = 273 K |
β = 105.228 (7)° | Block, colourless |
V = 1407.8 (9) Å3 | 0.30 × 0.20 × 0.18 mm |
Z = 4 |
Bruker APEX area-detector diffractometer | 2891 independent reflections |
Radiation source: fine-focus sealed tube | 1818 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.068 |
φ and ω scan | θmax = 26.5°, θmin = 2.1° |
Absorption correction: multi-scan (SADABS; Bruker, 2001) | h = −12→13 |
Tmin = 0.941, Tmax = 0.964 | k = −9→9 |
7612 measured reflections | l = −18→22 |
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.065 | Hydrogen site location: inferred from neighbouring sites |
wR(F2) = 0.159 | H-atom parameters constrained |
S = 1.06 | w = 1/[σ2(Fo2) + (0.0544P)2 + 0.210P] where P = (Fo2 + 2Fc2)/3 |
2891 reflections | (Δ/σ)max < 0.001 |
163 parameters | Δρmax = 0.34 e Å−3 |
0 restraints | Δρmin = −0.23 e Å−3 |
C12H19O5P | V = 1407.8 (9) Å3 |
Mr = 274.24 | Z = 4 |
Monoclinic, P21/n | Mo Kα radiation |
a = 10.454 (4) Å | µ = 0.21 mm−1 |
b = 7.745 (3) Å | T = 273 K |
c = 18.021 (7) Å | 0.30 × 0.20 × 0.18 mm |
β = 105.228 (7)° |
Bruker APEX area-detector diffractometer | 2891 independent reflections |
Absorption correction: multi-scan (SADABS; Bruker, 2001) | 1818 reflections with I > 2σ(I) |
Tmin = 0.941, Tmax = 0.964 | Rint = 0.068 |
7612 measured reflections |
R[F2 > 2σ(F2)] = 0.065 | 0 restraints |
wR(F2) = 0.159 | H-atom parameters constrained |
S = 1.06 | Δρmax = 0.34 e Å−3 |
2891 reflections | Δρmin = −0.23 e Å−3 |
163 parameters |
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | ||
P1 | 0.14301 (7) | 0.22551 (10) | 0.12858 (4) | 0.0579 (3) | |
C1 | 0.1690 (2) | 0.3440 (4) | 0.21623 (17) | 0.0585 (8) | |
H1A | 0.1783 | 0.4665 | 0.2051 | 0.070* | |
O1 | 0.29092 (16) | 0.2847 (3) | 0.26315 (12) | 0.0686 (6) | |
H1B | 0.3220 | 0.3574 | 0.2960 | 0.103* | |
C2 | 0.0569 (2) | 0.3249 (3) | 0.25236 (16) | 0.0538 (7) | |
O2 | 0.12622 (17) | 0.0406 (2) | 0.13491 (10) | 0.0610 (5) | |
O3 | 0.2581 (2) | 0.2753 (3) | 0.09399 (13) | 0.0794 (7) | |
C3 | 0.0574 (3) | 0.2032 (4) | 0.30721 (17) | 0.0631 (8) | |
H3A | 0.1283 | 0.1268 | 0.3217 | 0.076* | |
O4 | 0.0233 (2) | 0.3229 (3) | 0.07794 (13) | 0.0766 (6) | |
C4 | −0.0443 (3) | 0.1923 (4) | 0.34103 (18) | 0.0711 (9) | |
H4A | −0.0413 | 0.1103 | 0.3792 | 0.085* | |
O5 | −0.2459 (2) | 0.2769 (3) | 0.35739 (14) | 0.0913 (8) | |
C5 | −0.1500 (3) | 0.2997 (4) | 0.31971 (18) | 0.0643 (8) | |
C6 | −0.1545 (3) | 0.4176 (5) | 0.2642 (2) | 0.0738 (9) | |
H6A | −0.2276 | 0.4898 | 0.2483 | 0.089* | |
C7 | −0.0514 (3) | 0.4306 (4) | 0.23163 (19) | 0.0683 (8) | |
H7A | −0.0547 | 0.5139 | 0.1940 | 0.082* | |
C8 | 0.3671 (5) | 0.1724 (7) | 0.0963 (4) | 0.154 (2) | |
H8A | 0.4157 | 0.1605 | 0.1499 | 0.185* | |
H8B | 0.3342 | 0.0585 | 0.0785 | 0.185* | |
C9 | −0.0663 (4) | 0.2564 (5) | 0.0107 (2) | 0.1039 (13) | |
H9A | −0.0628 | 0.1312 | 0.0115 | 0.125* | |
H9B | −0.0407 | 0.2960 | −0.0344 | 0.125* | |
C10 | 0.4525 (5) | 0.2167 (7) | 0.0581 (3) | 0.143 (2) | |
H10B | 0.5230 | 0.1335 | 0.0672 | 0.215* | |
H10C | 0.4883 | 0.3284 | 0.0750 | 0.215* | |
H10D | 0.4089 | 0.2206 | 0.0042 | 0.215* | |
C11 | −0.1979 (4) | 0.3120 (7) | 0.0065 (3) | 0.142 (2) | |
H11A | −0.2576 | 0.2658 | −0.0390 | 0.214* | |
H11B | −0.2016 | 0.4359 | 0.0048 | 0.214* | |
H11C | −0.2233 | 0.2719 | 0.0510 | 0.214* | |
C12 | −0.3571 (3) | 0.3881 (6) | 0.3378 (3) | 0.1105 (14) | |
H12A | −0.4172 | 0.3592 | 0.3681 | 0.166* | |
H12B | −0.4012 | 0.3751 | 0.2842 | 0.166* | |
H12C | −0.3283 | 0.5055 | 0.3479 | 0.166* |
U11 | U22 | U33 | U12 | U13 | U23 | |
P1 | 0.0565 (5) | 0.0514 (5) | 0.0661 (5) | 0.0027 (4) | 0.0168 (4) | 0.0044 (4) |
C1 | 0.0453 (15) | 0.0469 (17) | 0.081 (2) | −0.0007 (13) | 0.0119 (14) | −0.0014 (14) |
O1 | 0.0438 (11) | 0.0669 (14) | 0.0886 (15) | 0.0018 (9) | 0.0057 (10) | −0.0180 (11) |
C2 | 0.0452 (15) | 0.0466 (17) | 0.0645 (18) | 0.0029 (12) | 0.0056 (13) | −0.0098 (13) |
O2 | 0.0687 (12) | 0.0461 (12) | 0.0671 (13) | −0.0026 (9) | 0.0157 (10) | −0.0039 (9) |
O3 | 0.0787 (14) | 0.0681 (15) | 0.1036 (18) | 0.0080 (12) | 0.0456 (13) | 0.0170 (12) |
C3 | 0.0542 (17) | 0.067 (2) | 0.0642 (19) | 0.0183 (15) | 0.0087 (15) | −0.0023 (15) |
O4 | 0.0772 (14) | 0.0683 (16) | 0.0764 (15) | 0.0111 (11) | 0.0065 (12) | 0.0024 (11) |
C4 | 0.0676 (19) | 0.078 (2) | 0.070 (2) | 0.0145 (17) | 0.0220 (17) | 0.0075 (16) |
O5 | 0.0689 (14) | 0.116 (2) | 0.0976 (18) | 0.0117 (14) | 0.0382 (13) | −0.0108 (14) |
C5 | 0.0498 (17) | 0.077 (2) | 0.066 (2) | 0.0040 (16) | 0.0162 (15) | −0.0154 (17) |
C6 | 0.0543 (17) | 0.075 (2) | 0.090 (2) | 0.0214 (16) | 0.0157 (17) | −0.0023 (19) |
C7 | 0.0574 (17) | 0.057 (2) | 0.090 (2) | 0.0149 (15) | 0.0186 (16) | 0.0101 (16) |
C8 | 0.111 (3) | 0.140 (5) | 0.249 (7) | 0.039 (3) | 0.114 (4) | 0.073 (4) |
C9 | 0.109 (3) | 0.098 (3) | 0.086 (3) | 0.014 (2) | −0.009 (2) | −0.010 (2) |
C10 | 0.126 (4) | 0.155 (5) | 0.172 (5) | 0.025 (4) | 0.082 (4) | 0.017 (4) |
C11 | 0.089 (3) | 0.140 (5) | 0.163 (5) | 0.002 (3) | −0.030 (3) | 0.025 (4) |
C12 | 0.067 (2) | 0.129 (4) | 0.147 (4) | 0.020 (2) | 0.049 (2) | −0.025 (3) |
P1—O2 | 1.451 (2) | C6—C7 | 1.359 (4) |
P1—O4 | 1.539 (2) | C6—H6A | 0.9300 |
P1—O3 | 1.543 (2) | C7—H7A | 0.9300 |
P1—C1 | 1.785 (3) | C8—C10 | 1.308 (5) |
C1—O1 | 1.408 (3) | C8—H8A | 0.9700 |
C1—C2 | 1.490 (4) | C8—H8B | 0.9700 |
C1—H1A | 0.9800 | C9—C11 | 1.425 (5) |
O1—H1B | 0.8200 | C9—H9A | 0.9700 |
C2—C3 | 1.364 (4) | C9—H9B | 0.9700 |
C2—C7 | 1.367 (4) | C10—H10B | 0.9600 |
O3—C8 | 1.382 (4) | C10—H10C | 0.9600 |
C3—C4 | 1.360 (4) | C10—H10D | 0.9600 |
C3—H3A | 0.9300 | C11—H11A | 0.9600 |
O4—C9 | 1.420 (4) | C11—H11B | 0.9600 |
C4—C5 | 1.356 (4) | C11—H11C | 0.9600 |
C4—H4A | 0.9300 | C12—H12A | 0.9600 |
O5—C5 | 1.362 (3) | C12—H12B | 0.9600 |
O5—C12 | 1.415 (4) | C12—H12C | 0.9600 |
C5—C6 | 1.346 (5) | ||
O2—P1—O4 | 115.73 (12) | C6—C7—H7A | 119.0 |
O2—P1—O3 | 113.70 (12) | C2—C7—H7A | 119.0 |
O4—P1—O3 | 103.71 (13) | C10—C8—O3 | 120.3 (4) |
O2—P1—C1 | 115.56 (13) | C10—C8—H8A | 107.3 |
O4—P1—C1 | 100.60 (13) | O3—C8—H8A | 107.3 |
O3—P1—C1 | 105.98 (13) | C10—C8—H8B | 107.3 |
O1—C1—C2 | 113.4 (2) | O3—C8—H8B | 107.3 |
O1—C1—P1 | 105.49 (18) | H8A—C8—H8B | 106.9 |
C2—C1—P1 | 112.39 (18) | O4—C9—C11 | 110.3 (3) |
O1—C1—H1A | 108.5 | O4—C9—H9A | 109.6 |
C2—C1—H1A | 108.5 | C11—C9—H9A | 109.6 |
P1—C1—H1A | 108.5 | O4—C9—H9B | 109.6 |
C1—O1—H1B | 109.5 | C11—C9—H9B | 109.6 |
C3—C2—C7 | 117.2 (3) | H9A—C9—H9B | 108.1 |
C3—C2—C1 | 122.1 (2) | C8—C10—H10B | 109.5 |
C7—C2—C1 | 120.7 (3) | C8—C10—H10C | 109.5 |
C8—O3—P1 | 124.6 (2) | H10B—C10—H10C | 109.5 |
C4—C3—C2 | 120.8 (3) | C8—C10—H10D | 109.5 |
C4—C3—H3A | 119.6 | H10B—C10—H10D | 109.5 |
C2—C3—H3A | 119.6 | H10C—C10—H10D | 109.5 |
C9—O4—P1 | 125.4 (2) | C9—C11—H11A | 109.5 |
C5—C4—C3 | 120.6 (3) | C9—C11—H11B | 109.5 |
C5—C4—H4A | 119.7 | H11A—C11—H11B | 109.5 |
C3—C4—H4A | 119.7 | C9—C11—H11C | 109.5 |
C5—O5—C12 | 117.4 (3) | H11A—C11—H11C | 109.5 |
C6—C5—C4 | 119.6 (3) | H11B—C11—H11C | 109.5 |
C6—C5—O5 | 124.9 (3) | O5—C12—H12A | 109.5 |
C4—C5—O5 | 115.5 (3) | O5—C12—H12B | 109.5 |
C5—C6—C7 | 119.6 (3) | H12A—C12—H12B | 109.5 |
C5—C6—H6A | 120.2 | O5—C12—H12C | 109.5 |
C7—C6—H6A | 120.2 | H12A—C12—H12C | 109.5 |
C6—C7—C2 | 122.1 (3) | H12B—C12—H12C | 109.5 |
O2—P1—C1—O1 | 64.4 (2) | O2—P1—O4—C9 | −33.9 (3) |
O4—P1—C1—O1 | −170.20 (17) | O3—P1—O4—C9 | 91.3 (3) |
O3—P1—C1—O1 | −62.5 (2) | C1—P1—O4—C9 | −159.2 (3) |
O2—P1—C1—C2 | −59.6 (2) | C2—C3—C4—C5 | 1.5 (5) |
O4—P1—C1—C2 | 65.8 (2) | C3—C4—C5—C6 | 0.4 (5) |
O3—P1—C1—C2 | 173.50 (19) | C3—C4—C5—O5 | 179.9 (3) |
O1—C1—C2—C3 | −25.5 (4) | C12—O5—C5—C6 | −1.5 (5) |
P1—C1—C2—C3 | 94.0 (3) | C12—O5—C5—C4 | 179.0 (3) |
O1—C1—C2—C7 | 154.2 (3) | C4—C5—C6—C7 | −1.7 (5) |
P1—C1—C2—C7 | −86.3 (3) | O5—C5—C6—C7 | 178.8 (3) |
O2—P1—O3—C8 | −24.8 (4) | C5—C6—C7—C2 | 1.2 (5) |
O4—P1—O3—C8 | −151.3 (4) | C3—C2—C7—C6 | 0.6 (4) |
C1—P1—O3—C8 | 103.2 (4) | C1—C2—C7—C6 | −179.2 (3) |
C7—C2—C3—C4 | −1.9 (4) | P1—O3—C8—C10 | 172.4 (4) |
C1—C2—C3—C4 | 177.8 (3) | P1—O4—C9—C11 | 142.0 (3) |
D—H···A | D—H | H···A | D···A | D—H···A |
O1—H1B···O2i | 0.82 | 1.87 | 2.687 (3) | 173 |
Symmetry code: (i) −x+1/2, y+1/2, −z+1/2. |
Experimental details
Crystal data | |
Chemical formula | C12H19O5P |
Mr | 274.24 |
Crystal system, space group | Monoclinic, P21/n |
Temperature (K) | 273 |
a, b, c (Å) | 10.454 (4), 7.745 (3), 18.021 (7) |
β (°) | 105.228 (7) |
V (Å3) | 1407.8 (9) |
Z | 4 |
Radiation type | Mo Kα |
µ (mm−1) | 0.21 |
Crystal size (mm) | 0.30 × 0.20 × 0.18 |
Data collection | |
Diffractometer | Bruker APEX area-detector diffractometer |
Absorption correction | Multi-scan (SADABS; Bruker, 2001) |
Tmin, Tmax | 0.941, 0.964 |
No. of measured, independent and observed [I > 2σ(I)] reflections | 7612, 2891, 1818 |
Rint | 0.068 |
(sin θ/λ)max (Å−1) | 0.628 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.065, 0.159, 1.06 |
No. of reflections | 2891 |
No. of parameters | 163 |
H-atom treatment | H-atom parameters constrained |
Δρmax, Δρmin (e Å−3) | 0.34, −0.23 |
Computer programs: SMART (Bruker, 2001), SAINT (Bruker, 2001), SHELXS97 (Sheldrick, 1997), SHELXL97 (Sheldrick, 1997), ORTEP-3 for Windows (Farrugia, 1997) and PLATON (Spek, 2003), SHELXL97.
D—H···A | D—H | H···A | D···A | D—H···A |
O1—H1B···O2i | 0.82 | 1.87 | 2.687 (3) | 172.7 |
Symmetry code: (i) −x+1/2, y+1/2, −z+1/2. |
In recent years \a-hydroxyphosphonic acids esters have attracted much attention due to their wide biological activity (Stowasser et al., 1992) and pharmaceutical interest (Chen et al., 1995). They are useful reagents for the synthesis of enol ethers and \a-ketophosphonates (Babak et al., 2001). Bond lengths and angles in the title compound, (I), are in agreement with the values reported for related compounds (Smaardijk et al., 1985). Intermolecular O—H···O hydrogen bond between the phosphoryl O atom and the hydroxy group results in the formation of an infinite chain connecting the molecules along the b axis (Table 1 and Fig. 3).