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crystallization communications
The serine protease thrombin plays a major role in thrombosis and haemostasis. This has driven interest in thrombin inhibitors as potential antithrombotic drugs. Here, the crystallization and preliminary crystallographic analysis of human α-thrombin in complex with three noncovalent peptide inhibitors of the general sequence D-Phe-Pro-D-Arg-P1′-CONH2 are reported. The crystals belonged to the orthorhombic space group P212121 and diffracted to beyond 1.3 Å resolution.