Supporting information
Crystallographic Information File (CIF) https://doi.org/10.1107/S1600536807019204/sj2284sup1.cif | |
Structure factor file (CIF format) https://doi.org/10.1107/S1600536807019204/sj2284Isup2.hkl |
CCDC reference: 647701
Key indicators
- Single-crystal X-ray study
- T = 299 K
- Mean (C-C) = 0.005 Å
- R factor = 0.052
- wR factor = 0.117
- Data-to-parameter ratio = 9.7
checkCIF/PLATON results
No syntax errors found
Alert level C PLAT220_ALERT_2_C Large Non-Solvent C Ueq(max)/Ueq(min) ... 2.95 Ratio PLAT222_ALERT_3_C Large Non-Solvent H Ueq(max)/Ueq(min) ... 3.71 Ratio PLAT242_ALERT_2_C Check Low Ueq as Compared to Neighbors for C13 PLAT340_ALERT_3_C Low Bond Precision on C-C bonds (x 1000) Ang ... 5 PLAT480_ALERT_4_C Long H...A H-Bond Reported H10C .. O3 .. 2.69 Ang.
Alert level G REFLT03_ALERT_4_G Please check that the estimate of the number of Friedel pairs is correct. If it is not, please give the correct count in the _publ_section_exptl_refinement section of the submitted CIF. From the CIF: _diffrn_reflns_theta_max 25.97 From the CIF: _reflns_number_total 1648 Count of symmetry unique reflns 1655 Completeness (_total/calc) 99.58% TEST3: Check Friedels for noncentro structure Estimate of Friedel pairs measured 0 Fraction of Friedel pairs measured 0.000 Are heavy atom types Z>Si present no PLAT791_ALERT_1_G Confirm the Absolute Configuration of C1 = . R PLAT791_ALERT_1_G Confirm the Absolute Configuration of C6 = . S PLAT791_ALERT_1_G Confirm the Absolute Configuration of C8 = . S
0 ALERT level A = In general: serious problem 0 ALERT level B = Potentially serious problem 5 ALERT level C = Check and explain 4 ALERT level G = General alerts; check 3 ALERT type 1 CIF construction/syntax error, inconsistent or missing data 2 ALERT type 2 Indicator that the structure model may be wrong or deficient 2 ALERT type 3 Indicator that the structure quality may be low 2 ALERT type 4 Improvement, methodology, query or suggestion 0 ALERT type 5 Informative message, check
Angelica polymorpha is described by Mi et al. (2003) and the bioactivity of the title compound is described by Mi et al. (1992) and Mi (1995). For related literature, see: Cremer & Pople (1975).
The roots of Angelica polymorpha Maxim (1.0 kg) were extracted four times, each for 1.5 h, with refluxing ethyl acetate. After the removal of solvent under reduced pressure, the extract was obtained. Chromatography on silica gel eluting with petroleum ether - EtOAc (4:1 v/v) yielded 46 50 ml fractions. The title compound, (I), was obtained from fractions 11–15 and was recrystallized from methanol.
In the absence of significant anomalous scattering effects, 1164 Friedel pairs were merged. The OH proton H2 was located in a difference Fourier map and refined isotropically with Ueq = 1.5 Ueq(O). All other H-atoms were positioned geometrically and refined using a riding model with d(C—H) = 0.93 Å, Uiso=1.2Ueq (C) for aromatic 0.98 Å, Uiso = 1.2Ueq (C) for CH, 0.97 Å, Uiso = 1.2Ueq (C) for CH2, 0.96 Å, Uiso = 1.5Ueq (C) for CH3 atoms.
Angelica polymorpha, belongs to parsley family, and is a species Chinese medicinal herb and has been widely used in folk medicine for the treatment of stomach ache, abdominal pain and rheumatism (Mi et al., 1995). It contains coumarin, terpenoids and volatile oils (Mi et al., 2003). Angelica polymorpha belongs to the same family as A. pubescens, A. silvesrtis and A. koreana. It was first obtained from Angelica polymorpha and shown to have strong antifeedant properties against insects (Mi et al., 1992). We present here the crystal structure of the title compound, (I), a constituent of Angelica polymorpha (Fig. 1).
Within the molecule of (I), the bond lengths and angles present no unusual features. The penta-1,3,diene fragment is essentially planar and the planarity extends to the adjacent C and O atoms of the benzofuran system. The maximum deviation from the meanplane through atoms O3, C9, C11, C12, C13, C14 is -0.036 (2)Å for atom C12. The six-membered ring, C1/C2/C3/C4/C5/C6, has a total puckering amplitude of 0.327 (1) %A (Cremer & Pople, 1975) and a distorted chair conformation [θ = 51.9 (4)° and φ= 3.3 (4)°]. In the crystal structure, intermolecular O2—H2···O1 hydrogen bonds form zigzag rows along b and weak C10—H10c···O3 interactions further stabilize the structure, Fig 2. Table 1.
Angelica polymorpha is described by Mi et al. (2003) and the bioactivity of the title compound is described by Mi et al. (1992) and Mi (1995). For related literature, see: Cremer & Pople (1975).
Data collection: SMART (Bruker, 2001); cell refinement: SAINT (Bruker, 2001); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: PLATON (Spek, 2003); software used to prepare material for publication: SHELXTL (Sheldrick, 2001).
C15H20O3 | F(000) = 536 |
Mr = 248.31 | Dx = 1.147 Mg m−3 |
Orthorhombic, P212121 | Mo Kα radiation, λ = 0.71073 Å |
Hall symbol: P 2ac 2ab | Cell parameters from 1719 reflections |
a = 6.9797 (11) Å | θ = 2.4–19.1° |
b = 9.0174 (14) Å | µ = 0.08 mm−1 |
c = 22.840 (4) Å | T = 299 K |
V = 1437.5 (4) Å3 | Plate, colorless |
Z = 4 | 0.20 × 0.20 × 0.06 mm |
Bruker SMART 4K CCD area-detector diffractometer | 1251 reflections with I > 2σ(I) |
Radiation source: fine-focus sealed tube | Rint = 0.063 |
Graphite monochromator | θmax = 26.0°, θmin = 1.8° |
φ and ω scans | h = −8→8 |
12406 measured reflections | k = −10→11 |
1648 independent reflections | l = −27→27 |
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.052 | Hydrogen site location: inferred from neighbouring sites |
wR(F2) = 0.117 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.07 | w = 1/[σ2(Fo2) + (0.0518P)2 + 0.1864P] where P = (Fo2 + 2Fc2)/3 |
1648 reflections | (Δ/σ)max < 0.001 |
170 parameters | Δρmax = 0.17 e Å−3 |
0 restraints | Δρmin = −0.13 e Å−3 |
C15H20O3 | V = 1437.5 (4) Å3 |
Mr = 248.31 | Z = 4 |
Orthorhombic, P212121 | Mo Kα radiation |
a = 6.9797 (11) Å | µ = 0.08 mm−1 |
b = 9.0174 (14) Å | T = 299 K |
c = 22.840 (4) Å | 0.20 × 0.20 × 0.06 mm |
Bruker SMART 4K CCD area-detector diffractometer | 1251 reflections with I > 2σ(I) |
12406 measured reflections | Rint = 0.063 |
1648 independent reflections |
R[F2 > 2σ(F2)] = 0.052 | 0 restraints |
wR(F2) = 0.117 | H atoms treated by a mixture of independent and constrained refinement |
S = 1.07 | Δρmax = 0.17 e Å−3 |
1648 reflections | Δρmin = −0.13 e Å−3 |
170 parameters |
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | ||
C1 | 0.9568 (4) | 0.6484 (4) | 0.22512 (13) | 0.0481 (8) | |
H1 | 1.0231 | 0.5594 | 0.2112 | 0.058* | |
C2 | 1.0072 (5) | 0.7777 (4) | 0.18612 (16) | 0.0633 (9) | |
H2A | 0.9919 | 0.8686 | 0.2084 | 0.076* | |
H2B | 1.1412 | 0.7698 | 0.1754 | 0.076* | |
C3 | 0.8915 (6) | 0.7897 (4) | 0.13172 (15) | 0.0621 (9) | |
C4 | 0.7185 (5) | 0.7263 (4) | 0.12712 (14) | 0.0610 (9) | |
H4 | 0.6499 | 0.7400 | 0.0926 | 0.073* | |
C5 | 0.6334 (5) | 0.6381 (3) | 0.17280 (13) | 0.0504 (8) | |
C6 | 0.7421 (4) | 0.6173 (3) | 0.22880 (12) | 0.0410 (7) | |
H6 | 0.7243 | 0.5148 | 0.2419 | 0.049* | |
C7 | 0.9765 (7) | 0.8828 (5) | 0.08408 (19) | 0.1009 (16) | |
H7A | 0.8968 | 0.8774 | 0.0499 | 0.151* | |
H7B | 1.1023 | 0.8469 | 0.0748 | 0.151* | |
H7C | 0.9848 | 0.9839 | 0.0970 | 0.151* | |
C8 | 0.6780 (4) | 0.7213 (4) | 0.27827 (13) | 0.0453 (8) | |
C9 | 0.8597 (4) | 0.7356 (3) | 0.31434 (13) | 0.0426 (7) | |
C10 | 0.5086 (4) | 0.6627 (5) | 0.31343 (17) | 0.0761 (12) | |
H10A | 0.4841 | 0.7276 | 0.3459 | 0.114* | |
H10B | 0.5377 | 0.5651 | 0.3277 | 0.114* | |
H10C | 0.3973 | 0.6583 | 0.2888 | 0.114* | |
C11 | 0.8786 (5) | 0.8000 (4) | 0.36580 (13) | 0.0513 (8) | |
H11 | 0.7680 | 0.8346 | 0.3839 | 0.062* | |
C12 | 1.0591 (5) | 0.8210 (4) | 0.39641 (14) | 0.0592 (9) | |
H12 | 1.1666 | 0.7778 | 0.3794 | 0.071* | |
C13 | 1.0875 (6) | 0.8944 (5) | 0.44550 (16) | 0.0733 (12) | |
C14 | 1.2835 (7) | 0.9062 (6) | 0.47239 (19) | 0.115 (2) | |
H14A | 1.3730 | 0.8494 | 0.4497 | 0.173* | |
H14B | 1.2800 | 0.8686 | 0.5117 | 0.173* | |
H14C | 1.3228 | 1.0082 | 0.4730 | 0.173* | |
C15 | 0.9326 (9) | 0.9748 (6) | 0.4781 (2) | 0.121 (2) | |
H15A | 0.8143 | 0.9670 | 0.4569 | 0.182* | |
H15B | 0.9669 | 1.0774 | 0.4821 | 0.182* | |
H15C | 0.9175 | 0.9316 | 0.5163 | 0.182* | |
O1 | 0.4750 (3) | 0.5810 (3) | 0.16660 (10) | 0.0689 (7) | |
O2 | 0.6331 (4) | 0.8598 (3) | 0.25136 (10) | 0.0624 (7) | |
H2 | 0.611 (7) | 0.928 (5) | 0.2772 (16) | 0.094* | |
O3 | 1.0125 (3) | 0.6779 (3) | 0.28456 (9) | 0.0586 (7) |
U11 | U22 | U33 | U12 | U13 | U23 | |
C1 | 0.0400 (16) | 0.0488 (19) | 0.0555 (18) | 0.0054 (15) | 0.0016 (14) | −0.0070 (15) |
C2 | 0.0491 (18) | 0.065 (2) | 0.076 (2) | −0.0119 (19) | 0.0105 (18) | −0.0034 (18) |
C3 | 0.077 (2) | 0.045 (2) | 0.065 (2) | −0.0107 (19) | 0.012 (2) | −0.0007 (16) |
C4 | 0.076 (2) | 0.055 (2) | 0.0519 (18) | −0.008 (2) | −0.0079 (18) | 0.0064 (17) |
C5 | 0.0547 (19) | 0.0372 (17) | 0.0594 (19) | −0.0026 (17) | −0.0058 (17) | −0.0043 (15) |
C6 | 0.0439 (16) | 0.0312 (15) | 0.0480 (16) | 0.0012 (14) | −0.0015 (14) | 0.0017 (13) |
C7 | 0.112 (4) | 0.097 (4) | 0.093 (3) | −0.026 (3) | 0.018 (3) | 0.025 (3) |
C8 | 0.0384 (16) | 0.0442 (18) | 0.0535 (17) | 0.0015 (14) | −0.0019 (13) | −0.0022 (14) |
C9 | 0.0379 (15) | 0.0402 (17) | 0.0495 (17) | 0.0023 (15) | 0.0020 (14) | 0.0016 (14) |
C10 | 0.0425 (18) | 0.106 (3) | 0.079 (2) | −0.012 (2) | 0.0075 (19) | −0.024 (2) |
C11 | 0.0470 (17) | 0.055 (2) | 0.0514 (17) | 0.0028 (17) | 0.0028 (15) | −0.0028 (16) |
C12 | 0.061 (2) | 0.063 (2) | 0.0534 (19) | −0.0045 (19) | −0.0076 (16) | −0.0009 (17) |
C13 | 0.099 (3) | 0.068 (3) | 0.053 (2) | −0.016 (2) | −0.014 (2) | 0.0022 (19) |
C14 | 0.140 (5) | 0.119 (4) | 0.088 (3) | −0.039 (4) | −0.059 (3) | 0.005 (3) |
C15 | 0.173 (6) | 0.102 (4) | 0.088 (3) | −0.003 (4) | 0.006 (4) | −0.034 (3) |
O1 | 0.0621 (16) | 0.0666 (17) | 0.0780 (16) | −0.0244 (14) | −0.0229 (13) | 0.0106 (13) |
O2 | 0.0681 (15) | 0.0475 (14) | 0.0717 (15) | 0.0215 (12) | −0.0140 (13) | −0.0070 (12) |
O3 | 0.0374 (11) | 0.0802 (17) | 0.0583 (13) | 0.0118 (12) | −0.0056 (10) | −0.0134 (12) |
C1—O3 | 1.437 (4) | C8—C10 | 1.524 (4) |
C1—C2 | 1.509 (5) | C9—C11 | 1.318 (4) |
C1—C6 | 1.527 (4) | C9—O3 | 1.368 (3) |
C1—H1 | 0.9800 | C10—H10A | 0.9600 |
C2—C3 | 1.485 (5) | C10—H10B | 0.9600 |
C2—H2A | 0.9700 | C10—H10C | 0.9600 |
C2—H2B | 0.9700 | C11—C12 | 1.454 (4) |
C3—C4 | 1.340 (5) | C11—H11 | 0.9300 |
C3—C7 | 1.497 (5) | C12—C13 | 1.317 (5) |
C4—C5 | 1.441 (4) | C12—H12 | 0.9300 |
C4—H4 | 0.9300 | C13—C15 | 1.500 (7) |
C5—O1 | 1.228 (4) | C13—C14 | 1.503 (6) |
C5—C6 | 1.499 (4) | C14—H14A | 0.9600 |
C6—C8 | 1.535 (4) | C14—H14B | 0.9600 |
C6—H6 | 0.9800 | C14—H14C | 0.9600 |
C7—H7A | 0.9600 | C15—H15A | 0.9600 |
C7—H7B | 0.9600 | C15—H15B | 0.9600 |
C7—H7C | 0.9600 | C15—H15C | 0.9600 |
C8—O2 | 1.426 (4) | O2—H2 | 0.86 (4) |
C8—C9 | 1.517 (4) | ||
O3—C1—C2 | 110.6 (3) | O2—C8—C6 | 106.4 (2) |
O3—C1—C6 | 104.4 (2) | C9—C8—C6 | 102.0 (2) |
C2—C1—C6 | 113.8 (3) | C10—C8—C6 | 113.7 (3) |
O3—C1—H1 | 109.3 | C11—C9—O3 | 122.2 (3) |
C2—C1—H1 | 109.3 | C11—C9—C8 | 127.2 (3) |
C6—C1—H1 | 109.3 | O3—C9—C8 | 110.5 (2) |
C3—C2—C1 | 115.0 (3) | C8—C10—H10A | 109.5 |
C3—C2—H2A | 108.5 | C8—C10—H10B | 109.5 |
C1—C2—H2A | 108.5 | H10A—C10—H10B | 109.5 |
C3—C2—H2B | 108.5 | C8—C10—H10C | 109.5 |
C1—C2—H2B | 108.5 | H10A—C10—H10C | 109.5 |
H2A—C2—H2B | 107.5 | H10B—C10—H10C | 109.5 |
C4—C3—C2 | 121.6 (3) | C9—C11—C12 | 125.0 (3) |
C4—C3—C7 | 122.6 (4) | C9—C11—H11 | 117.5 |
C2—C3—C7 | 115.7 (3) | C12—C11—H11 | 117.5 |
C3—C4—C5 | 123.4 (3) | C13—C12—C11 | 127.3 (4) |
C3—C4—H4 | 118.3 | C13—C12—H12 | 116.4 |
C5—C4—H4 | 118.3 | C11—C12—H12 | 116.4 |
O1—C5—C4 | 121.3 (3) | C12—C13—C15 | 123.9 (4) |
O1—C5—C6 | 120.1 (3) | C12—C13—C14 | 121.4 (4) |
C4—C5—C6 | 118.6 (3) | C15—C13—C14 | 114.7 (4) |
C5—C6—C1 | 115.3 (3) | C13—C14—H14A | 109.5 |
C5—C6—C8 | 113.8 (2) | C13—C14—H14B | 109.5 |
C1—C6—C8 | 102.4 (2) | H14A—C14—H14B | 109.5 |
C5—C6—H6 | 108.3 | C13—C14—H14C | 109.5 |
C1—C6—H6 | 108.3 | H14A—C14—H14C | 109.5 |
C8—C6—H6 | 108.3 | H14B—C14—H14C | 109.5 |
C3—C7—H7A | 109.5 | C13—C15—H15A | 109.5 |
C3—C7—H7B | 109.5 | C13—C15—H15B | 109.5 |
H7A—C7—H7B | 109.5 | H15A—C15—H15B | 109.5 |
C3—C7—H7C | 109.5 | C13—C15—H15C | 109.5 |
H7A—C7—H7C | 109.5 | H15A—C15—H15C | 109.5 |
H7B—C7—H7C | 109.5 | H15B—C15—H15C | 109.5 |
O2—C8—C9 | 110.1 (2) | C8—O2—H2 | 111 (3) |
O2—C8—C10 | 111.1 (3) | C9—O3—C1 | 109.2 (2) |
C9—C8—C10 | 113.0 (3) | ||
O3—C1—C2—C3 | −156.0 (3) | C1—C6—C8—C9 | −27.2 (3) |
C6—C1—C2—C3 | −39.0 (4) | C5—C6—C8—C10 | 85.7 (3) |
C1—C2—C3—C4 | 22.0 (5) | C1—C6—C8—C10 | −149.2 (3) |
C1—C2—C3—C7 | −160.9 (3) | O2—C8—C9—C11 | 75.5 (4) |
C2—C3—C4—C5 | −2.3 (5) | C10—C8—C9—C11 | −49.4 (5) |
C7—C3—C4—C5 | −179.1 (4) | C6—C8—C9—C11 | −171.9 (3) |
C3—C4—C5—O1 | −179.4 (3) | O2—C8—C9—O3 | −101.1 (3) |
C3—C4—C5—C6 | 0.8 (5) | C10—C8—C9—O3 | 133.9 (3) |
O1—C5—C6—C1 | 161.2 (3) | C6—C8—C9—O3 | 11.5 (3) |
C4—C5—C6—C1 | −19.1 (4) | O3—C9—C11—C12 | 1.5 (5) |
O1—C5—C6—C8 | −81.0 (4) | C8—C9—C11—C12 | −174.8 (3) |
C4—C5—C6—C8 | 98.8 (3) | C9—C11—C12—C13 | 174.3 (4) |
O3—C1—C6—C5 | 158.4 (2) | C11—C12—C13—C15 | −1.8 (6) |
C2—C1—C6—C5 | 37.7 (4) | C11—C12—C13—C14 | 179.7 (4) |
O3—C1—C6—C8 | 34.2 (3) | C11—C9—O3—C1 | −166.2 (3) |
C2—C1—C6—C8 | −86.4 (3) | C8—C9—O3—C1 | 10.6 (3) |
C5—C6—C8—O2 | −36.9 (3) | C2—C1—O3—C9 | 94.3 (3) |
C1—C6—C8—O2 | 88.2 (3) | C6—C1—O3—C9 | −28.5 (3) |
C5—C6—C8—C9 | −152.2 (2) |
D—H···A | D—H | H···A | D···A | D—H···A |
O2—H2···O1i | 0.86 (4) | 1.98 (5) | 2.839 (3) | 173 (4) |
C10—H10C···O3ii | 0.96 | 2.69 | 3.528 (4) | 146 |
Symmetry codes: (i) −x+1, y+1/2, −z+1/2; (ii) x−1, y, z. |
Experimental details
Crystal data | |
Chemical formula | C15H20O3 |
Mr | 248.31 |
Crystal system, space group | Orthorhombic, P212121 |
Temperature (K) | 299 |
a, b, c (Å) | 6.9797 (11), 9.0174 (14), 22.840 (4) |
V (Å3) | 1437.5 (4) |
Z | 4 |
Radiation type | Mo Kα |
µ (mm−1) | 0.08 |
Crystal size (mm) | 0.20 × 0.20 × 0.06 |
Data collection | |
Diffractometer | Bruker SMART 4K CCD area-detector |
Absorption correction | – |
No. of measured, independent and observed [I > 2σ(I)] reflections | 12406, 1648, 1251 |
Rint | 0.063 |
(sin θ/λ)max (Å−1) | 0.616 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.052, 0.117, 1.07 |
No. of reflections | 1648 |
No. of parameters | 170 |
H-atom treatment | H atoms treated by a mixture of independent and constrained refinement |
Δρmax, Δρmin (e Å−3) | 0.17, −0.13 |
Computer programs: SMART (Bruker, 2001), SAINT (Bruker, 2001), SAINT, SHELXS97 (Sheldrick, 1997), SHELXL97 (Sheldrick, 1997), PLATON (Spek, 2003), SHELXTL (Sheldrick, 2001).
D—H···A | D—H | H···A | D···A | D—H···A |
O2—H2···O1i | 0.86 (4) | 1.98 (5) | 2.839 (3) | 173 (4) |
C10—H10C···O3ii | 0.96 | 2.693 | 3.528 (4) | 145.6 |
Symmetry codes: (i) −x+1, y+1/2, −z+1/2; (ii) x−1, y, z. |
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Angelica polymorpha, belongs to parsley family, and is a species Chinese medicinal herb and has been widely used in folk medicine for the treatment of stomach ache, abdominal pain and rheumatism (Mi et al., 1995). It contains coumarin, terpenoids and volatile oils (Mi et al., 2003). Angelica polymorpha belongs to the same family as A. pubescens, A. silvesrtis and A. koreana. It was first obtained from Angelica polymorpha and shown to have strong antifeedant properties against insects (Mi et al., 1992). We present here the crystal structure of the title compound, (I), a constituent of Angelica polymorpha (Fig. 1).
Within the molecule of (I), the bond lengths and angles present no unusual features. The penta-1,3,diene fragment is essentially planar and the planarity extends to the adjacent C and O atoms of the benzofuran system. The maximum deviation from the meanplane through atoms O3, C9, C11, C12, C13, C14 is -0.036 (2)Å for atom C12. The six-membered ring, C1/C2/C3/C4/C5/C6, has a total puckering amplitude of 0.327 (1) %A (Cremer & Pople, 1975) and a distorted chair conformation [θ = 51.9 (4)° and φ= 3.3 (4)°]. In the crystal structure, intermolecular O2—H2···O1 hydrogen bonds form zigzag rows along b and weak C10—H10c···O3 interactions further stabilize the structure, Fig 2. Table 1.