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The solid-state structure of the title enaminone, C
15H
17N
1O
7, the C adduct obtained from the reaction of 4-aminopent-3-en-2-one with methoxymethylene Meldrum's acid, has been investigated by X-ray diffraction, and several structural features are different from the previously described structure of the corresponding N adduct. The carbonyl group of the enaminone moiety of the C adduct is not coplanar with the enamine fragment. One bifurcated intramolecular N—H
O hydrogen bond [2.688 (2) and 2.668 (2) Å] and two intermolecular C—H
O hydrogen bonds [3.339 (3) and 3.379 (3) Å] are observed. The structure packs in a linear fashion along the [100] direction.
Supporting information
CCDC reference: 259853
Key indicators
- Single-crystal X-ray study
- T = 293 K
- Mean (C-C) = 0.003 Å
- R factor = 0.056
- wR factor = 0.162
- Data-to-parameter ratio = 12.9
checkCIF/PLATON results
No syntax errors found
No errors found in this datablock
Data collection: CAD-4-PC (Enraf–Nonius, 1993); cell refinement: CAD-4-PC; data reduction: XCAD4 (Harms & Wocadlo, 1995); program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: ORTEP-3 for Windows (Farrugia, 1997); software used to prepare material for publication: WinGX (Farrugia, 1999).
ethyl [(
Z)-2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidenemethyl)-
1-methyl-3-oxo-but-1-enylamino]acetate
top
Crystal data top
C16H21NO7 | F(000) = 720 |
Mr = 339.34 | Dx = 1.355 Mg m−3 |
Monoclinic, P21/c | Melting point = 412–415 K |
Hall symbol: -P 2ybc | Cu Kα radiation, λ = 1.54180 Å |
a = 16.324 (2) Å | Cell parameters from 25 reflections |
b = 9.478 (1) Å | θ = 13.1–28.7° |
c = 11.062 (2) Å | µ = 0.90 mm−1 |
β = 103.69 (1)° | T = 293 K |
V = 1662.9 (4) Å3 | Prism, yellow |
Z = 4 | 0.33 × 0.18 × 0.15 mm |
Data collection top
Enraf–Nonius CAD-4 diffractometer | Rint = 0.044 |
Radiation source: fine-focus sealed tube | θmax = 67.2°, θmin = 2.8° |
Graphite monochromator | h = 0→19 |
ω–2θ scans | k = −11→0 |
3072 measured reflections | l = −13→12 |
2978 independent reflections | 2 standard reflections every 129 min |
2304 reflections with I > 2σ(I) | intensity decay: <1.0% |
Refinement top
Refinement on F2 | Secondary atom site location: difference Fourier map |
Least-squares matrix: full | Hydrogen site location: inferred from neighbouring sites |
R[F2 > 2σ(F2)] = 0.056 | H atoms treated by a mixture of independent and constrained refinement |
wR(F2) = 0.163 | w = 1/[σ2(Fo2) + (0.1046P)2 + 0.187P] where P = (Fo2 + 2Fc2)/3 |
S = 1.07 | (Δ/σ)max = 0.001 |
2978 reflections | Δρmax = 0.27 e Å−3 |
230 parameters | Δρmin = −0.27 e Å−3 |
0 restraints | Extinction correction: SHELXL97, Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4 |
Primary atom site location: structure-invariant direct methods | Extinction coefficient: 0.010 (1) |
Special details top
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes)
are estimated using the full covariance matrix. The cell e.s.d.'s are taken
into account individually in the estimation of e.s.d.'s in distances, angles
and torsion angles; correlations between e.s.d.'s in cell parameters are only
used when they are defined by crystal symmetry. An approximate (isotropic)
treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s.
planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor
wR and goodness of fit S are based on F2, conventional
R-factors R are based on F, with F set to zero for
negative F2. The threshold expression of F2 >
σ(F2) is used only for calculating R-factors(gt) etc.
and is not relevant to the choice of reflections for refinement.
R-factors based on F2 are statistically about twice as large
as those based on F, and R- factors based on ALL data will be
even larger. |
Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top | x | y | z | Uiso*/Ueq | Occ. (<1) |
O1 | 1.21481 (9) | 0.13425 (17) | 0.81314 (15) | 0.0618 (4) | |
O2 | 1.17075 (11) | 0.23360 (19) | 0.97006 (17) | 0.0721 (5) | |
O3 | 0.97068 (10) | 0.31469 (18) | 1.04251 (16) | 0.0705 (5) | |
O4 | 0.62670 (10) | 0.00513 (18) | 0.79400 (16) | 0.0682 (5) | |
O5 | 0.57765 (9) | 0.12099 (17) | 0.93399 (15) | 0.0613 (4) | |
O6 | 0.66828 (9) | 0.21696 (17) | 1.11133 (13) | 0.0582 (4) | |
O7 | 0.80650 (9) | 0.21545 (18) | 1.14054 (13) | 0.0585 (4) | |
N1 | 1.01424 (11) | 0.13006 (18) | 0.88673 (16) | 0.0485 (4) | |
C1 | 1.15935 (13) | 0.1589 (2) | 0.8805 (2) | 0.0510 (5) | |
C2 | 1.07866 (13) | 0.0797 (2) | 0.8275 (2) | 0.0496 (5) | |
C3 | 0.93473 (12) | 0.0870 (2) | 0.86241 (17) | 0.0447 (5) | |
C4 | 0.87499 (12) | 0.1570 (2) | 0.91528 (17) | 0.0440 (5) | |
C5 | 0.79115 (12) | 0.1080 (2) | 0.88807 (18) | 0.0458 (5) | |
C6 | 0.72613 (12) | 0.1370 (2) | 0.94445 (19) | 0.0465 (5) | |
C7 | 0.64266 (13) | 0.0821 (2) | 0.8832 (2) | 0.0520 (5) | |
C8 | 0.59025 (13) | 0.2359 (2) | 1.0217 (2) | 0.0561 (5) | |
C9 | 0.73911 (12) | 0.1949 (2) | 1.06886 (18) | 0.0471 (5) | |
C10 | 0.58963 (16) | 0.3753 (3) | 0.9549 (3) | 0.0713 (7) | |
H10A | 0.5979 | 0.4508 | 1.0144 | 0.107* | |
H10B | 0.5364 | 0.3872 | 0.8963 | 0.107* | |
H10C | 0.6342 | 0.3763 | 0.9118 | 0.107* | |
C11 | 0.52173 (16) | 0.2241 (3) | 1.0912 (3) | 0.0770 (8) | |
H11A | 0.5274 | 0.2992 | 1.1509 | 0.115* | |
H11B | 0.5263 | 0.1350 | 1.1335 | 0.115* | |
H11C | 0.4677 | 0.2306 | 1.0336 | 0.115* | |
C12 | 0.89942 (13) | 0.2943 (2) | 0.97843 (18) | 0.0488 (5) | |
C13 | 0.84012 (15) | 0.4166 (2) | 0.9466 (2) | 0.0595 (6) | |
H13A | 0.8641 | 0.4976 | 0.9941 | 0.089* | 0.50 |
H13B | 0.7874 | 0.3933 | 0.9658 | 0.089* | 0.50 |
H13C | 0.8309 | 0.4372 | 0.8594 | 0.089* | 0.50 |
H13D | 0.7908 | 0.3878 | 0.8855 | 0.089* | 0.50 |
H13E | 0.8675 | 0.4921 | 0.9137 | 0.089* | 0.50 |
H13F | 0.8240 | 0.4482 | 1.0201 | 0.089* | 0.50 |
C14 | 0.91296 (14) | −0.0379 (2) | 0.7780 (2) | 0.0583 (6) | |
H14A | 0.9191 | −0.0134 | 0.6964 | 0.087* | |
H14B | 0.8557 | −0.0656 | 0.7734 | 0.087* | |
H14C | 0.9501 | −0.1147 | 0.8100 | 0.087* | |
C15 | 1.29647 (15) | 0.2029 (3) | 0.8509 (3) | 0.0718 (7) | |
H15A | 1.3245 | 0.1753 | 0.9349 | 0.086* | |
H15B | 1.2898 | 0.3046 | 0.8486 | 0.086* | |
C16 | 1.34631 (18) | 0.1577 (4) | 0.7624 (3) | 0.0877 (9) | |
H16A | 1.4012 | 0.2002 | 0.7848 | 0.132* | |
H16B | 1.3182 | 0.1866 | 0.6798 | 0.132* | |
H16C | 1.3520 | 0.0568 | 0.7649 | 0.132* | |
H1N | 1.028 (2) | 0.200 (4) | 0.936 (3) | 0.105* | |
H2A | 1.0900 (18) | −0.018 (4) | 0.844 (3) | 0.105* | |
H2B | 1.0627 (19) | 0.093 (4) | 0.741 (3) | 0.105* | |
H5 | 0.7706 (19) | 0.048 (4) | 0.818 (3) | 0.105* | |
Atomic displacement parameters (Å2) top | U11 | U22 | U33 | U12 | U13 | U23 |
O1 | 0.0530 (8) | 0.0632 (9) | 0.0718 (10) | −0.0059 (7) | 0.0198 (7) | −0.0073 (8) |
O2 | 0.0664 (10) | 0.0702 (11) | 0.0792 (11) | −0.0044 (8) | 0.0162 (8) | −0.0247 (9) |
O3 | 0.0565 (9) | 0.0678 (10) | 0.0803 (11) | 0.0008 (8) | 0.0025 (8) | −0.0294 (9) |
O4 | 0.0630 (10) | 0.0634 (10) | 0.0757 (11) | −0.0103 (8) | 0.0113 (8) | −0.0238 (9) |
O5 | 0.0491 (8) | 0.0620 (9) | 0.0737 (10) | −0.0064 (7) | 0.0163 (7) | −0.0126 (8) |
O6 | 0.0526 (8) | 0.0691 (10) | 0.0544 (8) | 0.0031 (7) | 0.0158 (7) | −0.0040 (7) |
O7 | 0.0529 (8) | 0.0715 (10) | 0.0486 (8) | 0.0039 (7) | 0.0069 (7) | −0.0057 (7) |
N1 | 0.0492 (9) | 0.0456 (9) | 0.0507 (9) | 0.0039 (7) | 0.0116 (7) | −0.0026 (7) |
C1 | 0.0533 (11) | 0.0425 (10) | 0.0558 (12) | 0.0072 (8) | 0.0100 (9) | 0.0052 (9) |
C2 | 0.0505 (11) | 0.0465 (10) | 0.0518 (11) | 0.0062 (9) | 0.0125 (9) | 0.0008 (9) |
C3 | 0.0523 (11) | 0.0388 (9) | 0.0415 (9) | 0.0029 (8) | 0.0081 (8) | 0.0038 (8) |
C4 | 0.0500 (10) | 0.0385 (9) | 0.0416 (10) | 0.0039 (8) | 0.0074 (8) | −0.0003 (7) |
C5 | 0.0515 (11) | 0.0391 (10) | 0.0445 (10) | 0.0032 (8) | 0.0068 (8) | −0.0001 (7) |
C6 | 0.0495 (11) | 0.0388 (9) | 0.0499 (10) | 0.0018 (8) | 0.0092 (8) | 0.0000 (8) |
C7 | 0.0536 (11) | 0.0433 (10) | 0.0576 (11) | −0.0018 (9) | 0.0105 (9) | −0.0026 (9) |
C8 | 0.0500 (11) | 0.0574 (12) | 0.0606 (12) | 0.0010 (9) | 0.0124 (10) | −0.0073 (10) |
C9 | 0.0507 (11) | 0.0419 (10) | 0.0490 (10) | 0.0025 (8) | 0.0127 (9) | 0.0026 (8) |
C10 | 0.0669 (14) | 0.0587 (14) | 0.0871 (18) | 0.0134 (11) | 0.0160 (13) | 0.0042 (12) |
C11 | 0.0581 (14) | 0.095 (2) | 0.0835 (17) | −0.0045 (13) | 0.0278 (13) | −0.0140 (15) |
C12 | 0.0539 (11) | 0.0461 (11) | 0.0464 (10) | 0.0003 (9) | 0.0116 (9) | −0.0051 (8) |
C13 | 0.0745 (14) | 0.0394 (10) | 0.0636 (13) | 0.0039 (10) | 0.0146 (11) | −0.0010 (9) |
C14 | 0.0644 (13) | 0.0492 (12) | 0.0626 (13) | −0.0021 (9) | 0.0177 (10) | −0.0141 (10) |
C15 | 0.0557 (13) | 0.0682 (15) | 0.0916 (18) | −0.0107 (11) | 0.0175 (12) | −0.0069 (14) |
C16 | 0.0669 (16) | 0.094 (2) | 0.110 (2) | −0.0112 (15) | 0.0381 (15) | −0.0024 (18) |
Geometric parameters (Å, º) top
O1—C1 | 1.322 (3) | C8—C11 | 1.504 (3) |
O1—C15 | 1.453 (3) | C8—C10 | 1.512 (3) |
O2—C1 | 1.196 (3) | C10—H10A | 0.9600 |
O3—C12 | 1.226 (2) | C10—H10B | 0.9600 |
O4—C7 | 1.205 (3) | C10—H10C | 0.9600 |
O5—C7 | 1.364 (3) | C11—H11A | 0.9600 |
O5—C8 | 1.441 (3) | C11—H11B | 0.9600 |
O6—C9 | 1.363 (2) | C11—H11C | 0.9600 |
O6—C8 | 1.428 (3) | C12—C13 | 1.498 (3) |
O7—C9 | 1.210 (2) | C13—H13A | 0.9600 |
N1—C3 | 1.326 (3) | C13—H13B | 0.9600 |
N1—C2 | 1.445 (3) | C13—H13C | 0.9600 |
N1—H1N | 0.85 (3) | C13—H13D | 0.9600 |
C1—C2 | 1.509 (3) | C13—H13E | 0.9600 |
C2—H2A | 0.95 (4) | C13—H13F | 0.9600 |
C2—H2B | 0.93 (3) | C14—H14A | 0.9600 |
C3—C4 | 1.415 (3) | C14—H14B | 0.9600 |
C3—C14 | 1.497 (3) | C14—H14C | 0.9600 |
C4—C5 | 1.409 (3) | C15—C16 | 1.477 (4) |
C4—C12 | 1.486 (3) | C15—H15A | 0.9700 |
C5—C6 | 1.380 (3) | C15—H15B | 0.9700 |
C5—H5 | 0.96 (3) | C16—H16A | 0.9600 |
C6—C9 | 1.450 (3) | C16—H16B | 0.9600 |
C6—C7 | 1.466 (3) | C16—H16C | 0.9600 |
| | | |
C1—O1—C15 | 117.58 (18) | H11A—C11—H11B | 109.5 |
C7—O5—C8 | 118.74 (16) | C8—C11—H11C | 109.5 |
C9—O6—C8 | 118.04 (16) | H11A—C11—H11C | 109.5 |
C3—N1—C2 | 126.06 (18) | H11B—C11—H11C | 109.5 |
C3—N1—H1N | 118 (2) | O3—C12—C4 | 121.49 (18) |
C2—N1—H1N | 116 (2) | O3—C12—C13 | 119.08 (19) |
O2—C1—O1 | 125.3 (2) | C4—C12—C13 | 118.71 (18) |
O2—C1—C2 | 124.5 (2) | C12—C13—H13A | 109.5 |
O1—C1—C2 | 110.18 (18) | C12—C13—H13B | 109.5 |
N1—C2—C1 | 108.78 (17) | H13A—C13—H13B | 109.5 |
N1—C2—H2A | 111.5 (19) | C12—C13—H13C | 109.5 |
C1—C2—H2A | 107.3 (18) | H13A—C13—H13C | 109.5 |
N1—C2—H2B | 111.0 (19) | H13B—C13—H13C | 109.5 |
C1—C2—H2B | 109 (2) | C12—C13—H13D | 109.5 |
H2A—C2—H2B | 109 (3) | H13A—C13—H13D | 141.1 |
N1—C3—C4 | 120.59 (18) | H13B—C13—H13D | 56.3 |
N1—C3—C14 | 116.51 (18) | H13C—C13—H13D | 56.3 |
C4—C3—C14 | 122.91 (18) | C12—C13—H13E | 109.5 |
C5—C4—C3 | 119.13 (18) | H13A—C13—H13E | 56.3 |
C5—C4—C12 | 121.87 (17) | H13B—C13—H13E | 141.1 |
C3—C4—C12 | 118.06 (17) | H13C—C13—H13E | 56.3 |
C6—C5—C4 | 130.56 (19) | H13D—C13—H13E | 109.5 |
C6—C5—H5 | 108.9 (19) | C12—C13—H13F | 109.5 |
C4—C5—H5 | 120.5 (19) | H13A—C13—H13F | 56.3 |
C5—C6—C9 | 123.31 (18) | H13B—C13—H13F | 56.3 |
C5—C6—C7 | 116.78 (18) | H13C—C13—H13F | 141.1 |
C9—C6—C7 | 118.95 (18) | H13D—C13—H13F | 109.5 |
O4—C7—O5 | 117.54 (18) | H13E—C13—H13F | 109.5 |
O4—C7—C6 | 126.2 (2) | C3—C14—H14A | 109.5 |
O5—C7—C6 | 116.25 (18) | C3—C14—H14B | 109.5 |
O6—C8—O5 | 109.52 (16) | H14A—C14—H14B | 109.5 |
O6—C8—C11 | 106.56 (19) | C3—C14—H14C | 109.5 |
O5—C8—C11 | 106.45 (19) | H14A—C14—H14C | 109.5 |
O6—C8—C10 | 110.52 (19) | H14B—C14—H14C | 109.5 |
O5—C8—C10 | 110.36 (19) | O1—C15—C16 | 106.9 (2) |
C11—C8—C10 | 113.3 (2) | O1—C15—H15A | 110.3 |
O7—C9—O6 | 117.60 (18) | C16—C15—H15A | 110.3 |
O7—C9—C6 | 126.08 (18) | O1—C15—H15B | 110.3 |
O6—C9—C6 | 116.10 (17) | C16—C15—H15B | 110.3 |
C8—C10—H10A | 109.5 | H15A—C15—H15B | 108.6 |
C8—C10—H10B | 109.5 | C15—C16—H16A | 109.5 |
H10A—C10—H10B | 109.5 | C15—C16—H16B | 109.5 |
C8—C10—H10C | 109.5 | H16A—C16—H16B | 109.5 |
H10A—C10—H10C | 109.5 | C15—C16—H16C | 109.5 |
H10B—C10—H10C | 109.5 | H16A—C16—H16C | 109.5 |
C8—C11—H11A | 109.5 | H16B—C16—H16C | 109.5 |
C8—C11—H11B | 109.5 | | |
| | | |
C15—O1—C1—O2 | 0.2 (3) | C5—C6—C7—O5 | −174.84 (18) |
C15—O1—C1—C2 | 179.80 (19) | C9—C6—C7—O5 | 16.0 (3) |
C3—N1—C2—C1 | 178.66 (18) | C9—O6—C8—O5 | 52.4 (2) |
O2—C1—C2—N1 | 10.9 (3) | C9—O6—C8—C11 | 167.15 (19) |
O1—C1—C2—N1 | −168.64 (16) | C9—O6—C8—C10 | −69.4 (2) |
C2—N1—C3—C4 | −171.90 (18) | C7—O5—C8—O6 | −47.2 (3) |
C2—N1—C3—C14 | 8.4 (3) | C7—O5—C8—C11 | −162.0 (2) |
N1—C3—C4—C5 | −179.64 (17) | C7—O5—C8—C10 | 74.7 (2) |
C14—C3—C4—C5 | 0.0 (3) | C8—O6—C9—O7 | 161.10 (19) |
N1—C3—C4—C12 | 11.3 (3) | C8—O6—C9—C6 | −24.0 (3) |
C14—C3—C4—C12 | −169.07 (18) | C5—C6—C9—O7 | −5.4 (3) |
C3—C4—C5—C6 | 165.4 (2) | C7—C6—C9—O7 | 163.0 (2) |
C12—C4—C5—C6 | −25.9 (3) | C5—C6—C9—O6 | −179.76 (18) |
C4—C5—C6—C9 | −18.9 (3) | C7—C6—C9—O6 | −11.4 (3) |
C4—C5—C6—C7 | 172.49 (19) | C5—C4—C12—O3 | 152.2 (2) |
C8—O5—C7—O4 | −166.4 (2) | C3—C4—C12—O3 | −39.0 (3) |
C8—O5—C7—C6 | 14.5 (3) | C5—C4—C12—C13 | −37.6 (3) |
C5—C6—C7—O4 | 6.2 (3) | C3—C4—C12—C13 | 131.2 (2) |
C9—C6—C7—O4 | −163.0 (2) | C1—O1—C15—C16 | 179.5 (2) |
Hydrogen-bond geometry (Å, º) top
D—H···A | D—H | H···A | D···A | D—H···A |
N1—H1N···O2 | 0.85 (3) | 2.29 (3) | 2.688 (2) | 109 (3) |
N1—H1N···O3 | 0.85 (3) | 1.99 (3) | 2.668 (2) | 135 (3) |
C5—H5···O4 | 0.96 (3) | 2.34 (3) | 2.814 (3) | 110 (2) |
C2—H2A···O7i | 0.95 (4) | 2.50 (3) | 3.339 (3) | 147 (3) |
C2—H2B···O3ii | 0.93 (3) | 2.51 (3) | 3.379 (3) | 155 (3) |
Symmetry codes: (i) −x+2, −y, −z+2; (ii) x, −y+1/2, z−1/2. |
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