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research papers
AMP-activated kinase (AMPK) is central to sensing energy status in eukaryotic cells via binding of AMP and ATP to CBS (cystathionine β-synthase) domains in the regulatory γ subunit. The structure of a CBS-domain pair from human AMPK γ1 in complex with the physiological activator AMP and the pharmacological activator ZMP (AICAR) is presented.