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The crystal structure of an acidic phospholipase A2 from the venom of Echis carinatus (saw-scaled viper; scPLA2) has been determined at 2.6 Å resolution and refined to a crystallographic R factor of 0.192. Although the overall structure of scPLA2 is essentially similar to those of other group II acidic PLA2s from different species, it shows unique features in several parts. Particularly noteworthy is the C-terminal part, which folds differently to those of other group II PLA2s. This part is considered to be responsible for inhibition of the platelet-aggregation activity. The calcium-binding loop is tightly organized with sevenfold coordination. Another striking feature of scPLA2 is the involvement of Asn79 Oδ1 of a symmetry-related molecule in a coordination linkage with Ca2+ of the calcium-binding loop. This is the first observation of an internal metal ion participating in an intermolecular interaction. The β-wing of a molecule is deeply inserted into the hydrophobic channel of another molecule and forms several intermolecular interactions. This results in the formation of an infinite chain of molecules. These chains are stacked in an antiparallel arrangement in the crystals.

Supporting information

PDB reference: phospholipase A2, 1oz6


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