Supporting information
Crystallographic Information File (CIF) https://doi.org/10.1107/S1600536803018397/cv6223sup1.cif | |
Structure factor file (CIF format) https://doi.org/10.1107/S1600536803018397/cv6223IIsup2.hkl |
CCDC reference: 222899
Key indicators
- Single-crystal X-ray study
- T = 173 K
- Mean (C-C) = 0.005 Å
- R factor = 0.046
- wR factor = 0.094
- Data-to-parameter ratio = 8.0
checkCIF/PLATON results
No syntax errors found
Alert level C PLAT024_ALERT_4_C Merging of Friedel Data Preferred for Z<=Si .... ! PLAT340_ALERT_3_C Low Bond Precision on C-C bonds (x 1000) Ang ... 5
Alert level G REFLT03_ALERT_4_G Please check that the estimate of the number of Friedel pairs is correct. If it is not, please give the correct count in the _publ_section_exptl_refinement section of the submitted CIF. From the CIF: _diffrn_reflns_theta_max 25.90 From the CIF: _reflns_number_total 1504 Count of symmetry unique reflns 1489 Completeness (_total/calc) 101.01% TEST3: Check Friedels for noncentro structure Estimate of Friedel pairs measured 15 Fraction of Friedel pairs measured 0.010 Are heavy atom types Z>Si present no
0 ALERT level A = In general: serious problem 0 ALERT level B = Potentially serious problem 2 ALERT level C = Check and explain 1 ALERT level G = General alerts; check 0 ALERT type 1 CIF construction/syntax error, inconsistent or missing data 0 ALERT type 2 Indicator that the structure model may be wrong or deficient 1 ALERT type 3 Indicator that the structure quality may be low 2 ALERT type 4 Improvement, methodology, query or suggestion
A suspension of deoxynojirimycin (50 mg, 0.31 mmol), potassium carbonate (100 mg) and 2-bromobenzoyl chloride (200 µl) in water (1 ml) was sonicated for 15 min and then stirred at room temperature overnight. The solvent was removed under reduced pressure and the residue was chromatographed on a column of silica gel eluted with CH2Cl2/CH3OH/NH4OH (5:8:2) to give first deoxynojirimycin, (I), and then the title compound as an oil that gave suitable crystals on standing.
All H atoms were constrained to ride on their parent atoms, with Uiso values of 1.2Ueq of the parent atoms.
Data collection: SHELXTL (Siemens, 1983); cell refinement: SHELXTL; data reduction: SHELXTL; program(s) used to solve structure: SHELXS86 (Sheldrick, 1990); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: ORTEP-3 for Windows (Farrugia, 1997); software used to prepare material for publication: SHELXL97.
Fig. 1. ORTEP-3 (Farrugia, 1997) view of (II), showing the atom-numbering scheme and displacement ellipsoids at the 50% probability level. H atoms are shown as circles of arbitrary radii. |
C12H22N2O6 | F(000) = 624 |
Mr = 290.32 | Dx = 1.475 Mg m−3 |
Orthorhombic, P212121 | Mo Kα radiation, λ = 0.71073 Å |
Hall symbol: P 2ac 2ab | Cell parameters from 24 reflections |
a = 6.702 (2) Å | θ = 4.8–23.8° |
b = 13.099 (5) Å | µ = 0.12 mm−1 |
c = 14.893 (3) Å | T = 173 K |
V = 1307.5 (7) Å3 | Needle, colourless |
Z = 4 | 0.42 × 0.30 × 0.15 mm |
Siemens/Nicolet R3m 4-circle diffractometer | Rint = 0.039 |
Radiation source: fine-focus sealed tube | θmax = 25.9°, θmin = 2.1° |
Graphite monochromator | h = 0→8 |
ω scan | k = 0→16 |
1608 measured reflections | l = 0→18 |
1504 independent reflections | 3 standard reflections every 97 reflections |
1146 reflections with I > 2σ(I) | intensity decay: 0.0% |
Refinement on F2 | Primary atom site location: structure-invariant direct methods |
Least-squares matrix: full | Secondary atom site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.046 | Hydrogen site location: inferred from neighbouring sites |
wR(F2) = 0.094 | H-atom parameters constrained |
S = 0.98 | w = 1/[σ2(Fo2) + (0.0441P)2] where P = (Fo2 + 2Fc2)/3 |
1504 reflections | (Δ/σ)max < 0.001 |
187 parameters | Δρmax = 0.23 e Å−3 |
0 restraints | Δρmin = −0.24 e Å−3 |
C12H22N2O6 | V = 1307.5 (7) Å3 |
Mr = 290.32 | Z = 4 |
Orthorhombic, P212121 | Mo Kα radiation |
a = 6.702 (2) Å | µ = 0.12 mm−1 |
b = 13.099 (5) Å | T = 173 K |
c = 14.893 (3) Å | 0.42 × 0.30 × 0.15 mm |
Siemens/Nicolet R3m 4-circle diffractometer | Rint = 0.039 |
1608 measured reflections | 3 standard reflections every 97 reflections |
1504 independent reflections | intensity decay: 0.0% |
1146 reflections with I > 2σ(I) |
R[F2 > 2σ(F2)] = 0.046 | 0 restraints |
wR(F2) = 0.094 | H-atom parameters constrained |
S = 0.98 | Δρmax = 0.23 e Å−3 |
1504 reflections | Δρmin = −0.24 e Å−3 |
187 parameters |
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | ||
O1 | −0.2909 (4) | 0.54689 (19) | 0.40930 (17) | 0.0200 (6) | |
H1O | −0.3155 | 0.5005 | 0.3720 | 0.024* | |
O2 | 0.0882 (4) | 0.57543 (17) | 0.32248 (15) | 0.0171 (6) | |
H2O | 0.1564 | 0.6215 | 0.2980 | 0.021* | |
O3 | 0.3816 (4) | 0.67349 (18) | 0.43697 (18) | 0.0210 (6) | |
H3O | 0.4911 | 0.6466 | 0.4232 | 0.025* | |
O5 | 0.2547 (4) | 0.26556 (17) | 0.72251 (17) | 0.0172 (6) | |
H5O | 0.3275 | 0.2139 | 0.7158 | 0.021* | |
O6 | 0.0154 (4) | 0.08534 (18) | 0.71468 (16) | 0.0171 (6) | |
H6O | 0.0145 | 0.0671 | 0.7687 | 0.021* | |
O7 | −0.4163 (4) | 0.13234 (17) | 0.70110 (18) | 0.0188 (6) | |
H7O | −0.3906 | 0.0696 | 0.7028 | 0.023* | |
N4A | 0.0594 (4) | 0.5401 (2) | 0.6052 (2) | 0.0136 (7) | |
N8A | −0.1842 (4) | 0.3606 (2) | 0.5991 (2) | 0.0149 (7) | |
C1 | −0.1007 (5) | 0.5273 (3) | 0.4517 (2) | 0.0143 (8) | |
H1 | −0.0582 | 0.4555 | 0.4394 | 0.017* | |
C2 | 0.0541 (5) | 0.6012 (3) | 0.4148 (2) | 0.0134 (8) | |
H2 | −0.0005 | 0.6721 | 0.4181 | 0.016* | |
C3 | 0.2473 (6) | 0.5964 (3) | 0.4683 (2) | 0.0150 (8) | |
H3 | 0.3099 | 0.5278 | 0.4603 | 0.018* | |
C4 | 0.2039 (6) | 0.6142 (2) | 0.5678 (2) | 0.0159 (8) | |
H4A | 0.3303 | 0.6094 | 0.6020 | 0.019* | |
H4B | 0.1506 | 0.6841 | 0.5758 | 0.019* | |
C5 | 0.0836 (5) | 0.2572 (2) | 0.6656 (2) | 0.0129 (8) | |
H5 | 0.1248 | 0.2305 | 0.6055 | 0.016* | |
C6 | −0.0675 (5) | 0.1857 (2) | 0.7072 (2) | 0.0148 (8) | |
H6 | −0.0980 | 0.2109 | 0.7691 | 0.018* | |
C7 | −0.2591 (5) | 0.1850 (3) | 0.6542 (2) | 0.0149 (8) | |
H7 | −0.2360 | 0.1518 | 0.5946 | 0.018* | |
C8 | −0.3350 (5) | 0.2933 (3) | 0.6401 (3) | 0.0153 (8) | |
H8A | −0.4544 | 0.2913 | 0.6010 | 0.018* | |
H8B | −0.3757 | 0.3221 | 0.6988 | 0.018* | |
C9 | 0.1461 (5) | 0.4365 (2) | 0.6120 (2) | 0.0145 (8) | |
H9A | 0.2693 | 0.4389 | 0.6487 | 0.017* | |
H9B | 0.1817 | 0.4114 | 0.5514 | 0.017* | |
C9A | −0.0033 (5) | 0.3642 (3) | 0.6551 (2) | 0.0130 (8) | |
H9 | −0.0396 | 0.3910 | 0.7158 | 0.016* | |
C10 | −0.2718 (5) | 0.4641 (3) | 0.5941 (2) | 0.0164 (8) | |
H10A | −0.3102 | 0.4862 | 0.6553 | 0.020* | |
H10B | −0.3946 | 0.4614 | 0.5572 | 0.020* | |
C10A | −0.1298 (5) | 0.5425 (3) | 0.5540 (2) | 0.0137 (8) | |
H10 | −0.1909 | 0.6114 | 0.5630 | 0.016* |
U11 | U22 | U33 | U12 | U13 | U23 | |
O1 | 0.0139 (14) | 0.0215 (14) | 0.0245 (15) | 0.0016 (12) | −0.0068 (13) | −0.0025 (12) |
O2 | 0.0211 (14) | 0.0140 (11) | 0.0163 (13) | −0.0033 (12) | 0.0031 (13) | 0.0039 (11) |
O3 | 0.0162 (15) | 0.0168 (12) | 0.0302 (16) | −0.0035 (13) | 0.0046 (14) | 0.0023 (12) |
O5 | 0.0114 (13) | 0.0154 (13) | 0.0249 (14) | 0.0027 (12) | −0.0021 (13) | 0.0017 (12) |
O6 | 0.0198 (14) | 0.0139 (12) | 0.0177 (14) | 0.0032 (12) | 0.0043 (13) | 0.0039 (11) |
O7 | 0.0139 (14) | 0.0115 (11) | 0.0308 (15) | −0.0006 (12) | 0.0041 (13) | 0.0027 (12) |
N4A | 0.0107 (15) | 0.0117 (14) | 0.0184 (16) | −0.0019 (14) | 0.0016 (14) | 0.0004 (13) |
N8A | 0.0121 (15) | 0.0135 (15) | 0.0191 (15) | −0.0024 (14) | −0.0005 (14) | 0.0026 (14) |
C1 | 0.0094 (18) | 0.0135 (17) | 0.0199 (18) | −0.0002 (17) | −0.0018 (17) | 0.0003 (15) |
C2 | 0.015 (2) | 0.0111 (17) | 0.0141 (18) | −0.0007 (16) | −0.0002 (16) | 0.0021 (15) |
C3 | 0.0138 (19) | 0.0105 (17) | 0.0208 (19) | 0.0002 (18) | −0.0004 (17) | 0.0039 (16) |
C4 | 0.017 (2) | 0.0126 (17) | 0.0180 (19) | −0.0034 (17) | −0.0022 (18) | 0.0012 (15) |
C5 | 0.0101 (17) | 0.0167 (17) | 0.0119 (17) | 0.0023 (17) | −0.0033 (16) | −0.0002 (15) |
C6 | 0.0179 (19) | 0.0105 (16) | 0.0161 (18) | 0.0002 (17) | 0.0007 (17) | −0.0001 (15) |
C7 | 0.0147 (19) | 0.0144 (17) | 0.0158 (18) | −0.0017 (18) | 0.0015 (16) | −0.0006 (15) |
C8 | 0.0088 (18) | 0.0172 (19) | 0.0197 (19) | −0.0019 (16) | 0.0008 (16) | −0.0001 (17) |
C9 | 0.0127 (19) | 0.0138 (18) | 0.0170 (19) | −0.0010 (16) | 0.0003 (16) | 0.0006 (15) |
C9A | 0.0137 (18) | 0.0128 (16) | 0.0126 (17) | 0.0008 (16) | −0.0021 (16) | −0.0001 (15) |
C10 | 0.0140 (19) | 0.0177 (19) | 0.0175 (19) | 0.0010 (18) | 0.0027 (18) | 0.0005 (17) |
C10A | 0.0107 (19) | 0.0140 (18) | 0.0164 (19) | 0.0031 (16) | −0.0005 (16) | −0.0002 (15) |
O1—C1 | 1.446 (4) | C2—H2 | 1.0000 |
O1—H1O | 0.8400 | C3—C4 | 1.528 (5) |
O2—C2 | 1.434 (4) | C3—H3 | 1.0000 |
O2—H2O | 0.8400 | C4—H4A | 0.9900 |
O3—C3 | 1.431 (4) | C4—H4B | 0.9900 |
O3—H3O | 0.8400 | C5—C6 | 1.512 (5) |
O5—C5 | 1.431 (4) | C5—C9A | 1.526 (4) |
O5—H5O | 0.8400 | C5—H5 | 1.0000 |
O6—C6 | 1.432 (4) | C6—C7 | 1.508 (5) |
O6—H6O | 0.8400 | C6—H6 | 1.0000 |
O7—C7 | 1.440 (4) | C7—C8 | 1.521 (5) |
O7—H7O | 0.8400 | C7—H7 | 1.0000 |
N4A—C4 | 1.480 (4) | C8—H8A | 0.9900 |
N4A—C9 | 1.480 (4) | C8—H8B | 0.9900 |
N4A—C10A | 1.480 (4) | C9—C9A | 1.520 (5) |
N8A—C9A | 1.472 (4) | C9—H9A | 0.9900 |
N8A—C8 | 1.473 (4) | C9—H9B | 0.9900 |
N8A—C10 | 1.479 (4) | C9A—H9 | 1.0000 |
C1—C2 | 1.522 (5) | C10—C10A | 1.523 (5) |
C1—C10A | 1.548 (5) | C10—H10A | 0.9900 |
C1—H1 | 1.0000 | C10—H10B | 0.9900 |
C2—C3 | 1.522 (5) | C10A—H10 | 1.0000 |
C1—O1—H1O | 109.5 | O6—C6—C7 | 111.4 (3) |
C2—O2—H2O | 109.5 | O6—C6—C5 | 109.9 (3) |
C3—O3—H3O | 109.5 | C7—C6—C5 | 111.1 (3) |
C5—O5—H5O | 109.5 | O6—C6—H6 | 108.1 |
C6—O6—H6O | 109.5 | C7—C6—H6 | 108.1 |
C7—O7—H7O | 109.5 | C5—C6—H6 | 108.1 |
C4—N4A—C9 | 111.7 (3) | O7—C7—C6 | 111.8 (3) |
C4—N4A—C10A | 110.7 (3) | O7—C7—C8 | 105.6 (3) |
C9—N4A—C10A | 113.0 (3) | C6—C7—C8 | 110.5 (3) |
C9A—N8A—C8 | 110.5 (3) | O7—C7—H7 | 109.6 |
C9A—N8A—C10 | 109.0 (3) | C6—C7—H7 | 109.6 |
C8—N8A—C10 | 107.3 (3) | C8—C7—H7 | 109.6 |
O1—C1—C2 | 109.3 (3) | N8A—C8—C7 | 112.7 (3) |
O1—C1—C10A | 107.2 (3) | N8A—C8—H8A | 109.1 |
C2—C1—C10A | 111.1 (3) | C7—C8—H8A | 109.1 |
O1—C1—H1 | 109.7 | N8A—C8—H8B | 109.1 |
C2—C1—H1 | 109.7 | C7—C8—H8B | 109.1 |
C10A—C1—H1 | 109.7 | H8A—C8—H8B | 107.8 |
O2—C2—C1 | 107.8 (3) | N4A—C9—C9A | 110.0 (3) |
O2—C2—C3 | 110.9 (3) | N4A—C9—H9A | 109.7 |
C1—C2—C3 | 111.4 (3) | C9A—C9—H9A | 109.7 |
O2—C2—H2 | 108.9 | N4A—C9—H9B | 109.7 |
C1—C2—H2 | 108.9 | C9A—C9—H9B | 109.7 |
C3—C2—H2 | 108.9 | H9A—C9—H9B | 108.2 |
O3—C3—C2 | 109.6 (3) | N8A—C9A—C9 | 108.9 (3) |
O3—C3—C4 | 109.2 (3) | N8A—C9A—C5 | 110.1 (3) |
C2—C3—C4 | 109.9 (3) | C9—C9A—C5 | 111.3 (3) |
O3—C3—H3 | 109.4 | N8A—C9A—H9 | 108.8 |
C2—C3—H3 | 109.4 | C9—C9A—H9 | 108.8 |
C4—C3—H3 | 109.4 | C5—C9A—H9 | 108.8 |
N4A—C4—C3 | 112.9 (3) | N8A—C10—C10A | 113.0 (3) |
N4A—C4—H4A | 109.0 | N8A—C10—H10A | 109.0 |
C3—C4—H4A | 109.0 | C10A—C10—H10A | 109.0 |
N4A—C4—H4B | 109.0 | N8A—C10—H10B | 109.0 |
C3—C4—H4B | 109.0 | C10A—C10—H10B | 109.0 |
H4A—C4—H4B | 107.8 | H10A—C10—H10B | 107.8 |
O5—C5—C6 | 110.0 (3) | N4A—C10A—C10 | 108.6 (3) |
O5—C5—C9A | 107.3 (3) | N4A—C10A—C1 | 113.3 (3) |
C6—C5—C9A | 110.8 (3) | C10—C10A—C1 | 112.2 (3) |
O5—C5—H5 | 109.6 | N4A—C10A—H10 | 107.5 |
C6—C5—H5 | 109.6 | C10—C10A—H10 | 107.5 |
C9A—C5—H5 | 109.6 | C1—C10A—H10 | 107.5 |
O1—C1—C2—O2 | −67.9 (4) | C4—N4A—C9—C9A | 177.1 (3) |
C10A—C1—C2—O2 | 174.0 (3) | C10A—N4A—C9—C9A | −57.3 (4) |
O1—C1—C2—C3 | 170.2 (3) | C8—N8A—C9A—C9 | −178.4 (3) |
C10A—C1—C2—C3 | 52.1 (4) | C10—N8A—C9A—C9 | −60.8 (3) |
O2—C2—C3—O3 | 65.4 (4) | C8—N8A—C9A—C5 | 59.2 (4) |
C1—C2—C3—O3 | −174.6 (3) | C10—N8A—C9A—C5 | 176.9 (3) |
O2—C2—C3—C4 | −174.6 (3) | N4A—C9—C9A—N8A | 60.1 (4) |
C1—C2—C3—C4 | −54.6 (4) | N4A—C9—C9A—C5 | −178.4 (3) |
C9—N4A—C4—C3 | 70.0 (4) | O5—C5—C9A—N8A | −178.4 (3) |
C10A—N4A—C4—C3 | −56.8 (4) | C6—C5—C9A—N8A | −58.3 (4) |
O3—C3—C4—N4A | 177.7 (3) | O5—C5—C9A—C9 | 60.8 (4) |
C2—C3—C4—N4A | 57.5 (4) | C6—C5—C9A—C9 | −179.2 (3) |
O5—C5—C6—O6 | −62.9 (4) | C9A—N8A—C10—C10A | 59.5 (4) |
C9A—C5—C6—O6 | 178.7 (3) | C8—N8A—C10—C10A | 179.2 (3) |
O5—C5—C6—C7 | 173.4 (3) | C4—N4A—C10A—C10 | 179.2 (3) |
C9A—C5—C6—C7 | 55.0 (4) | C9—N4A—C10A—C10 | 53.0 (4) |
O6—C6—C7—O7 | 67.6 (4) | C4—N4A—C10A—C1 | 53.7 (4) |
C5—C6—C7—O7 | −169.5 (3) | C9—N4A—C10A—C1 | −72.4 (4) |
O6—C6—C7—C8 | −175.1 (3) | N8A—C10—C10A—N4A | −54.2 (4) |
C5—C6—C7—C8 | −52.2 (4) | N8A—C10—C10A—C1 | 71.8 (4) |
C9A—N8A—C8—C7 | −58.0 (4) | O1—C1—C10A—N4A | −171.4 (3) |
C10—N8A—C8—C7 | −176.7 (3) | C2—C1—C10A—N4A | −52.1 (4) |
O7—C7—C8—N8A | 175.3 (3) | O1—C1—C10A—C10 | 65.1 (4) |
C6—C7—C8—N8A | 54.1 (4) |
Experimental details
Crystal data | |
Chemical formula | C12H22N2O6 |
Mr | 290.32 |
Crystal system, space group | Orthorhombic, P212121 |
Temperature (K) | 173 |
a, b, c (Å) | 6.702 (2), 13.099 (5), 14.893 (3) |
V (Å3) | 1307.5 (7) |
Z | 4 |
Radiation type | Mo Kα |
µ (mm−1) | 0.12 |
Crystal size (mm) | 0.42 × 0.30 × 0.15 |
Data collection | |
Diffractometer | Siemens/Nicolet R3m 4-circle diffractometer |
Absorption correction | – |
No. of measured, independent and observed [I > 2σ(I)] reflections | 1608, 1504, 1146 |
Rint | 0.039 |
(sin θ/λ)max (Å−1) | 0.615 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.046, 0.094, 0.98 |
No. of reflections | 1504 |
No. of parameters | 187 |
H-atom treatment | H-atom parameters constrained |
Δρmax, Δρmin (e Å−3) | 0.23, −0.24 |
Computer programs: SHELXTL (Siemens, 1983), SHELXTL, SHELXS86 (Sheldrick, 1990), SHELXL97 (Sheldrick, 1997), ORTEP-3 for Windows (Farrugia, 1997), SHELXL97.
N4A—C4 | 1.480 (4) | N4A—C10A | 1.480 (4) |
N4A—C9 | 1.480 (4) | N8A—C9A | 1.472 (4) |
C9—N4A—C10A | 113.0 (3) | C8—N8A—C10 | 107.3 (3) |
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The title compound, (II), which is a condensation dimer of deoxynojirimycin, (I) (1-deoxy-D-glucopyranose having nitrogen in place of oxygen as the ring atom), was formed in low yield as a by-product on reaction of the latter compound with 2-bromobenzoylchloride in the presence of base. Presumably, the primary hydroxyl groups of the starting material were selectively esterified and the nitrogen nucleophiles of pairs of the product molecules then displaced the acyloxy groups to generate the central ring of the dimeric product.
The bond lengths and angles in (II) (Fig. 1) are normal (Table 1). The crystal lattice is bound tightly by five intermolecular O—H···O bonds and one O—H···N hydrogen bond, which involve all the hydroxyl H atoms [e.g. O3—H3O···O1(1 + x, y, z) with O···O = 2.782 (4) Å and O—H···O 162°; Spek, 1990].
There are no reported crystal structures of perhydrodiazaanthracene ring systems with ring fusion through the N atoms; the closest relatives are two sugar-derived fused-ring pyridopyrimidine compounds, with the former ring carrying three equatorial hydroxyl groups (Berges et al., 1999, and references therein). There are a few reported structures of piperazine compounds in which the N atoms are linked via aliphatic carbon chains [e.g. 1,7(1,4)-bis(2,5-diphenylpiperizina)dodecacyclophane; Fuji et al., 1996].
The six-membered rings of (II) adopt chair conformations and the ring fusion is unusual in being trans-cisoid-cis. This is also observed in a perhydroanthracene derivative with one N atom at a ring-junction position, a structure that occurs in the Veratrum alkaloids (Brambilla et al., 1982). The structures of perhydroanthracenes with the cis-cisoid-cis (van Koningsveld et al., 1984) and cis-transoid-cis (Hjortaas, 1967) configurations have also been reported.