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In the title molecule, C
20H
19NO
3, the piperidine ring adopts a chair conformation. The phenyl and furyl rings have equatorial orientations. Molecules are linked by C—H
O hydrogen bonds.
Supporting information
CCDC reference: 651444
Key indicators
- Single-crystal X-ray study
- T = 160 K
- Mean (C-C) = 0.003 Å
- Disorder in main residue
- R factor = 0.071
- wR factor = 0.226
- Data-to-parameter ratio = 14.5
checkCIF/PLATON results
No syntax errors found
Alert level A
PLAT220_ALERT_2_A Large Non-Solvent C Ueq(max)/Ueq(min) ... 5.82 Ratio
| Author Response: ... atom disorder
|
PLAT222_ALERT_3_A Large Non-Solvent H Ueq(max)/Ueq(min) ... 10.00 Ratio
| Author Response: ... atom disorder
|
PLAT241_ALERT_2_A Check High Ueq as Compared to Neighbors for C64
| Author Response: ... atom disorder
|
Alert level B
PLAT241_ALERT_2_B Check High Ueq as Compared to Neighbors for O62
| Author Response: ... atom disorder
|
PLAT242_ALERT_2_B Check Low Ueq as Compared to Neighbors for C63
PLAT242_ALERT_2_B Check Low Ueq as Compared to Neighbors for C65A
PLAT242_ALERT_2_B Check Low Ueq as Compared to Neighbors for C65B
PLAT366_ALERT_2_B Short? C(sp?)-C(sp?) Bond C63 - C64 ... 1.28 Ang.
PLAT411_ALERT_2_B Short Inter H...H Contact H6 .. H65A .. 2.05 Ang.
PLAT415_ALERT_2_B Short Inter D-H..H-X H1 .. H65B .. 1.98 Ang.
Alert level C
PLAT153_ALERT_1_C The su's on the Cell Axes are Equal (x 100000) 500 Ang.
PLAT301_ALERT_3_C Main Residue Disorder ......................... 4.00 Perc.
PLAT353_ALERT_3_C Long N-H Bond (0.87A) N1 - H1 ... 1.02 Ang.
PLAT420_ALERT_2_C D-H Without Acceptor N1 - H1 ... ?
Alert level G
PLAT793_ALERT_1_G Check the Absolute Configuration of C2 = ... R
PLAT793_ALERT_1_G Check the Absolute Configuration of C3 = ... S
PLAT793_ALERT_1_G Check the Absolute Configuration of C6 = ... S
3 ALERT level A = In general: serious problem
7 ALERT level B = Potentially serious problem
4 ALERT level C = Check and explain
3 ALERT level G = General alerts; check
4 ALERT type 1 CIF construction/syntax error, inconsistent or missing data
10 ALERT type 2 Indicator that the structure model may be wrong or deficient
3 ALERT type 3 Indicator that the structure quality may be low
0 ALERT type 4 Improvement, methodology, query or suggestion
0 ALERT type 5 Informative message, check
A mixture of ammonium acetate (38.5 g, 0.5 mol), furfuraldehyde (82.84 ml, 1 mol) and benzyl acetone (38.5 ml, 0.5 mol) in distilled ethanol was heated
first to boiling. After cooling, the viscous liquid obtained was dissolved in
ether (200 ml) and shaken with 10 ml of concentrated hydrochloric acid. The
precipitated hydrochloride of 3-benzyl-2,6-di-furylpiperidin-4-one was removed
by filtration and washed first with 40 ml mixture of ethanol and ether (1:1)
and then with ether to remove most of the coloured impurities. The base was
liberated from an alcoholic solution by adding aqueous ammonia and then
diluted with water. It was recrystallized from mixture of petroleum ether. The
yield of the compound was 70%.
Atom H1 at N1 was located in a difference Fourier map and refined isotropically.
Remaining H atoms were positioned geometrically and allowed to ride on their
parent atoms with C–H = 0.93–1.00 Å and Uiso =
1.2Ueq(parent atom). The furyl ring at position 6 is disordered. The
site occupancy of the two atom positions C65A and C65B were refined
(0.604:0.396).
Structure description
top
Piperidine heterocycles play an important role in the field of medicinal
Chemistry (Balamurugan et al., 2006,2007). In the title compound, (I),
N1 shows a pyramidal geometry (Fig. 1). The piperidine ring adopts a chair
conformation. The phenyl group at C3 and the furyl rings at C2 and C6 are in
equatorial positions. In the solid state, the symmetry-related molecules are
linked by C23—H23···O4 (x + 1, -y + 1/2, z - 1/2)
hydrogen bonds to form chains along the c axis (Fig. 2).
For related literature, see: Balamurugan et al. (2006, 2007).
Data collection: COLLECT (Nonius, 2000); cell refinement: DENZO-SMN (Otwinowski & Minor, 1997); data reduction: DENZO-SMN and SCALEPACK (Otwinowski & Minor, 1997); program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: ORTEP-3 (Farrugia,1997); software used to prepare material for publication: PLATON (Spek, 2003).
t-3-Benzyl-r-2,c-6-di-2-furylpiperidin-4-one
top
Crystal data top
C20H19NO3 | F(000) = 680 |
Mr = 321.36 | Dx = 1.297 Mg m−3 |
Monoclinic, P21/c | Melting point: 463 K |
Hall symbol: -P 2ybc | Mo Kα radiation, λ = 0.71073 Å |
a = 5.443 (5) Å | Cell parameters from 3346 reflections |
b = 21.437 (5) Å | θ = 2.0–26.0° |
c = 14.108 (5) Å | µ = 0.09 mm−1 |
β = 91.037 (5)° | T = 160 K |
V = 1645.9 (17) Å3 | Platelike, light-brown |
Z = 4 | 0.25 × 0.25 × 0.13 mm |
Data collection top
Nonius KappaCCD area-detector diffractometer | 2182 reflections with I > 2σ(I) |
Radiation source: Nonius FR590 sealed tube generator | Rint = 0.086 |
Horizontally mounted graphite crystal monochromator | θmax = 26.0°, θmin = 2.4° |
Detector resolution: 9 pixels mm-1 | h = −6→6 |
φ and ω scans with κ offsets | k = −26→26 |
30100 measured reflections | l = −17→17 |
3254 independent reflections | |
Refinement top
Refinement on F2 | Secondary atom site location: difference Fourier map |
Least-squares matrix: full | Hydrogen site location: inferred from neighbouring sites |
R[F2 > 2σ(F2)] = 0.071 | H-atom parameters constrained |
wR(F2) = 0.226 | w = 1/[σ2(Fo2) + (0.1215P)2 + 1.0322P] where P = (Fo2 + 2Fc2)/3 |
S = 1.06 | (Δ/σ)max < 0.001 |
3254 reflections | Δρmax = 0.49 e Å−3 |
225 parameters | Δρmin = −0.50 e Å−3 |
0 restraints | Extinction correction: SHELXL97, Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4 |
Primary atom site location: structure-invariant direct methods | Extinction coefficient: 0.040 (6) |
Crystal data top
C20H19NO3 | V = 1645.9 (17) Å3 |
Mr = 321.36 | Z = 4 |
Monoclinic, P21/c | Mo Kα radiation |
a = 5.443 (5) Å | µ = 0.09 mm−1 |
b = 21.437 (5) Å | T = 160 K |
c = 14.108 (5) Å | 0.25 × 0.25 × 0.13 mm |
β = 91.037 (5)° | |
Data collection top
Nonius KappaCCD area-detector diffractometer | 2182 reflections with I > 2σ(I) |
30100 measured reflections | Rint = 0.086 |
3254 independent reflections | |
Refinement top
R[F2 > 2σ(F2)] = 0.071 | 0 restraints |
wR(F2) = 0.226 | H-atom parameters constrained |
S = 1.06 | Δρmax = 0.49 e Å−3 |
3254 reflections | Δρmin = −0.50 e Å−3 |
225 parameters | |
Special details top
Experimental. Solvent used: petroleum ether Cooling Device: Oxford Cryosystems Cryostream 700
Crystal mount: glued on a glass fibre Mosaicity (°.): 0.421 (1) Frames
collected: 637 Seconds exposure per frame: 15 Degrees rotation per frame: 1.0
Crystal-Detector distance (mm): 35.0 |
Geometry. Bond distances, angles etc. have been calculated using the rounded
fractional coordinates. All su's are estimated from the variances of the
(full) variance-covariance matrix. The cell e.s.d.'s are taken into account in
the estimation of distances, angles and torsion angles |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor
wR and goodness of fit S are based on F2, conventional
R-factors R are based on F, with F set to zero for
negative F2. The threshold expression of F2 >
σ(F2) is used only for calculating R-factors(gt) etc.
and is not relevant to the choice of reflections for refinement.
R-factors based on F2 are statistically about twice as large
as those based on F, and R- factors based on ALL data will be
even larger. |
Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top | x | y | z | Uiso*/Ueq | Occ. (<1) |
O4 | −0.3321 (4) | 0.26535 (11) | 0.53493 (16) | 0.0545 (9) | |
O22 | 0.2807 (3) | 0.31977 (9) | 0.25411 (13) | 0.0342 (7) | |
O62 | 0.4497 (5) | 0.40526 (14) | 0.6315 (2) | 0.0796 (11) | |
N1 | 0.1558 (4) | 0.38238 (11) | 0.43396 (16) | 0.0326 (8) | |
C2 | −0.0170 (5) | 0.34803 (13) | 0.37281 (19) | 0.0309 (9) | |
C3 | −0.0465 (5) | 0.27982 (13) | 0.40998 (19) | 0.0318 (9) | |
C4 | −0.1353 (6) | 0.28604 (14) | 0.5105 (2) | 0.0384 (10) | |
C5 | 0.0277 (6) | 0.32360 (15) | 0.5754 (2) | 0.0437 (10) | |
C6 | 0.0689 (5) | 0.38847 (14) | 0.53178 (19) | 0.0337 (9) | |
C21 | 0.0650 (5) | 0.34981 (13) | 0.27285 (19) | 0.0290 (8) | |
C23 | 0.3166 (5) | 0.32621 (14) | 0.1585 (2) | 0.0348 (9) | |
C24 | 0.1344 (5) | 0.35883 (14) | 0.11844 (19) | 0.0350 (9) | |
C25 | −0.0293 (5) | 0.37395 (14) | 0.1926 (2) | 0.0359 (10) | |
C31 | −0.2129 (5) | 0.23934 (14) | 0.3473 (2) | 0.0351 (9) | |
C61 | 0.2441 (5) | 0.42625 (17) | 0.5899 (2) | 0.0410 (12) | |
C63 | 0.5666 (6) | 0.45457 (16) | 0.6754 (2) | 0.0424 (10) | |
C64 | 0.4392 (7) | 0.50353 (18) | 0.6585 (4) | 0.085 (2) | |
C65A | 0.2486 (2) | 0.48141 (5) | 0.57868 (8) | 0.0265 (17) | 0.604 (11) |
C311 | −0.1902 (2) | 0.17066 (5) | 0.36974 (8) | 0.0291 (8) | |
C312 | 0.0109 (2) | 0.13637 (5) | 0.33918 (8) | 0.0325 (9) | |
C313 | 0.0333 (2) | 0.07361 (5) | 0.35848 (8) | 0.0387 (10) | |
C314 | −0.1458 (2) | 0.04334 (5) | 0.40948 (8) | 0.0424 (11) | |
C315 | −0.3433 (2) | 0.07662 (5) | 0.44198 (8) | 0.0419 (11) | |
C316 | −0.3665 (2) | 0.13937 (5) | 0.42228 (8) | 0.0360 (9) | |
C65B | 0.2195 (2) | 0.49251 (5) | 0.62338 (8) | 0.0146 (19) | 0.396 (11) |
H1 | 0.19817 | 0.42561 | 0.40918 | 0.14 (2)* | |
H3 | 0.12038 | 0.25992 | 0.41242 | 0.043 (8)* | |
H5A | −0.04851 | 0.32791 | 0.63815 | 0.042 (8)* | |
H2 | −0.18116 | 0.36889 | 0.37523 | 0.026 (7)* | |
H6 | −0.09249 | 0.41072 | 0.52994 | 0.046 (9)* | |
H23 | 0.45350 | 0.30988 | 0.12556 | 0.060 (10)* | |
H24 | 0.11708 | 0.36973 | 0.05344 | 0.041 (9)* | |
H25 | −0.17804 | 0.39655 | 0.18610 | 0.055 (10)* | |
H31A | −0.17119 | 0.24592 | 0.28005 | 0.044 (9)* | |
H31B | −0.38559 | 0.25222 | 0.35555 | 0.038 (8)* | |
H63 | 0.71196 | 0.45263 | 0.71091 | 0.0511* | |
H64 | 0.45432 | 0.54271 | 0.68633 | 0.1024* | |
H65A | 0.16234 | 0.50540 | 0.53437 | 0.29 (9)* | 0.604 (11) |
H312 | 0.13517 | 0.15671 | 0.30425 | 0.044 (9)* | |
H313 | 0.17167 | 0.05110 | 0.33673 | 0.049 (9)* | |
H314 | −0.13247 | −0.00008 | 0.42201 | 0.050 (10)* | |
H315 | −0.46468 | 0.05620 | 0.47832 | 0.053 (10)* | |
H316 | −0.50465 | 0.16163 | 0.44485 | 0.045 (9)* | |
H5B | 0.18809 | 0.30210 | 0.58442 | 0.054 (10)* | |
H65B | 0.08362 | 0.51877 | 0.61995 | 0.019 (16)* | 0.396 (11) |
Atomic displacement parameters (Å2) top | U11 | U22 | U33 | U12 | U13 | U23 |
O4 | 0.0649 (16) | 0.0520 (14) | 0.0476 (15) | −0.0018 (12) | 0.0306 (12) | 0.0033 (11) |
O22 | 0.0327 (11) | 0.0453 (12) | 0.0247 (11) | 0.0100 (9) | 0.0041 (8) | 0.0015 (9) |
O62 | 0.0713 (19) | 0.0724 (19) | 0.094 (2) | 0.0224 (15) | −0.0269 (16) | −0.0344 (16) |
N1 | 0.0429 (14) | 0.0321 (13) | 0.0230 (12) | 0.0010 (10) | 0.0083 (10) | 0.0038 (10) |
C2 | 0.0322 (15) | 0.0348 (16) | 0.0259 (15) | 0.0072 (12) | 0.0064 (12) | 0.0055 (12) |
C3 | 0.0361 (15) | 0.0335 (15) | 0.0261 (15) | 0.0085 (12) | 0.0056 (12) | 0.0072 (12) |
C4 | 0.0517 (19) | 0.0335 (16) | 0.0305 (17) | 0.0105 (14) | 0.0155 (14) | 0.0087 (13) |
C5 | 0.065 (2) | 0.0458 (19) | 0.0206 (15) | 0.0083 (16) | 0.0096 (14) | 0.0061 (13) |
C6 | 0.0369 (16) | 0.0420 (17) | 0.0225 (15) | 0.0067 (13) | 0.0059 (12) | 0.0040 (12) |
C21 | 0.0281 (14) | 0.0330 (15) | 0.0262 (15) | 0.0054 (11) | 0.0072 (11) | 0.0040 (12) |
C23 | 0.0375 (16) | 0.0439 (18) | 0.0234 (15) | −0.0011 (13) | 0.0088 (12) | −0.0045 (12) |
C24 | 0.0419 (17) | 0.0415 (17) | 0.0217 (15) | −0.0032 (13) | 0.0028 (12) | 0.0023 (12) |
C25 | 0.0341 (16) | 0.0457 (18) | 0.0279 (16) | 0.0047 (13) | 0.0027 (12) | 0.0073 (13) |
C31 | 0.0354 (16) | 0.0421 (17) | 0.0279 (15) | 0.0070 (13) | 0.0026 (12) | 0.0111 (13) |
C61 | 0.0250 (15) | 0.076 (3) | 0.0220 (15) | 0.0042 (15) | 0.0013 (12) | 0.0074 (15) |
C63 | 0.0353 (16) | 0.056 (2) | 0.0358 (18) | −0.0001 (15) | −0.0048 (13) | −0.0097 (15) |
C64 | 0.047 (2) | 0.036 (2) | 0.173 (6) | −0.0051 (17) | 0.005 (3) | 0.004 (3) |
C65A | 0.029 (3) | 0.014 (3) | 0.036 (3) | 0.0025 (18) | −0.011 (2) | −0.003 (2) |
C311 | 0.0268 (14) | 0.0384 (16) | 0.0221 (14) | 0.0012 (11) | −0.0026 (11) | 0.0024 (12) |
C312 | 0.0315 (15) | 0.0425 (17) | 0.0233 (14) | −0.0001 (12) | −0.0019 (12) | −0.0007 (12) |
C313 | 0.0393 (17) | 0.0424 (18) | 0.0339 (17) | 0.0089 (14) | −0.0119 (13) | −0.0063 (13) |
C314 | 0.052 (2) | 0.0369 (18) | 0.0376 (18) | −0.0052 (14) | −0.0155 (15) | 0.0016 (13) |
C315 | 0.0428 (18) | 0.0457 (19) | 0.0371 (18) | −0.0079 (14) | −0.0024 (14) | 0.0074 (14) |
C316 | 0.0304 (15) | 0.0434 (18) | 0.0341 (16) | −0.0007 (13) | 0.0004 (12) | 0.0033 (13) |
C65B | 0.015 (3) | 0.011 (3) | 0.018 (4) | −0.001 (2) | 0.007 (3) | −0.002 (2) |
Geometric parameters (Å, º) top
O4—C4 | 1.215 (4) | C3—H3 | 1.0000 |
O22—C21 | 1.369 (3) | C5—H5A | 0.9900 |
O22—C23 | 1.373 (4) | C5—H5B | 0.9900 |
O62—C61 | 1.333 (4) | C6—H6 | 1.0000 |
O62—C63 | 1.375 (5) | C23—H23 | 0.9500 |
N1—C2 | 1.464 (4) | C24—H24 | 0.9500 |
N1—C6 | 1.473 (4) | C25—H25 | 0.9500 |
N1—H1 | 1.0200 | C31—H31B | 0.9900 |
C2—C21 | 1.487 (4) | C31—H31A | 0.9900 |
C2—C3 | 1.563 (4) | C63—H63 | 0.9300 |
C3—C4 | 1.512 (4) | C64—H64 | 0.9300 |
C3—C31 | 1.525 (4) | C65A—H65A | 0.9300 |
C4—C5 | 1.498 (5) | C65B—H65B | 0.9300 |
C5—C6 | 1.539 (5) | C311—C312 | 1.393 (2) |
C6—C61 | 1.486 (4) | C311—C316 | 1.395 (2) |
C21—C25 | 1.339 (4) | C312—C313 | 1.378 (2) |
C23—C24 | 1.331 (4) | C313—C314 | 1.384 (2) |
C24—C25 | 1.424 (4) | C314—C315 | 1.376 (2) |
C31—C311 | 1.511 (3) | C315—C316 | 1.379 (2) |
C61—C65A | 1.193 (4) | C312—H312 | 0.9500 |
C61—C65B | 1.504 (4) | C313—H313 | 0.9500 |
C63—C64 | 1.278 (5) | C314—H314 | 0.9500 |
C64—C65A | 1.590 (5) | C315—H315 | 0.9500 |
C64—C65B | 1.308 (4) | C316—H316 | 0.9500 |
C2—H2 | 1.0000 | | |
| | | |
O4···C311 | 3.196 (4) | H1···H65Aiv | 2.5900 |
O4···C316 | 3.137 (4) | H1···C64viii | 2.6800 |
O4···C23i | 3.266 (5) | H1···C65Biv | 2.9000 |
O22···N1 | 2.960 (4) | H2···H6 | 2.4000 |
O62···N1 | 3.226 (5) | H2···H64iv | 2.5500 |
O4···H5Bii | 2.8300 | H2···C65Biv | 2.9800 |
O4···H23i | 2.3800 | H2···H65Biv | 2.4700 |
O4···H316 | 2.7200 | H3···C312 | 2.9000 |
O4···H31B | 2.5600 | H3···O22 | 2.7300 |
O22···H3 | 2.7300 | H5A···H312x | 2.5500 |
O22···H31Biii | 2.7100 | H5A···C312x | 2.9500 |
O62···H5B | 2.7100 | H5B···O4iii | 2.8300 |
O62···H6iii | 2.9000 | H5B···O62 | 2.7100 |
N1···O22 | 2.960 (4) | H5B···C23x | 3.0200 |
N1···O62 | 3.226 (5) | H6···C65Aiv | 2.8900 |
N1···H65Biv | 2.5900 | H6···H65Aiv | 2.0500 |
C2···C65Biv | 3.592 (4) | H6···H65A | 2.4600 |
C23···O4v | 3.266 (5) | H6···O62ii | 2.9000 |
C65A···C65Aiv | 3.560 (4) | H6···C63ii | 2.9500 |
C65B···C2iv | 3.592 (4) | H6···H2 | 2.4000 |
C2···H65Biv | 2.8800 | H6···C65Biv | 3.0700 |
C6···H65Biv | 3.0300 | H23···O4v | 2.3800 |
C6···H65Aiv | 2.7500 | H24···C313vi | 3.0300 |
C21···H31A | 2.5700 | H24···C314vi | 3.0900 |
C23···H5Bvi | 3.0200 | H24···C312vi | 3.0700 |
C24···H314vii | 3.0800 | H31A···H312 | 2.5600 |
C63···H6iii | 2.9500 | H31A···C21 | 2.5700 |
C64···H1viii | 2.6800 | H31B···O4 | 2.5600 |
C65A···H6iv | 2.8900 | H31B···O22ii | 2.7100 |
C65A···H65Aiv | 2.7400 | H31B···H316 | 2.4100 |
C65A···H1 | 2.6800 | H63···C312xii | 3.0800 |
C65B···H1iv | 2.9000 | H63···C313xii | 2.7500 |
C65B···H2iv | 2.9800 | H63···C314xii | 2.8900 |
C65B···H6iv | 3.0700 | H64···H2iv | 2.5500 |
C311···O4 | 3.196 (4) | H64···H1viii | 2.4400 |
C312···C316iii | 3.566 (4) | H65A···H1 | 2.4700 |
C313···C315iii | 3.572 (4) | H65A···H6iv | 2.0500 |
C314···C314ix | 3.514 (4) | H65A···H65Aiv | 2.0100 |
C315···C313ii | 3.572 (4) | H65A···C6iv | 2.7500 |
C316···C312ii | 3.566 (4) | H65A···C65Aiv | 2.7400 |
C316···O4 | 3.137 (4) | H65A···H6 | 2.4600 |
C312···H5Avi | 2.9500 | H65A···H1iv | 2.5900 |
C312···H24x | 3.0700 | H65B···C6iv | 3.0300 |
C312···H316iii | 3.0500 | H65B···H1iv | 1.9800 |
C312···H3 | 2.9000 | H65B···N1iv | 2.5900 |
C312···H63xi | 3.0800 | H65B···C2iv | 2.8800 |
C313···H63xi | 2.7500 | H65B···H2iv | 2.4700 |
C313···H24x | 3.0300 | H312···H31A | 2.5600 |
C314···H63xi | 2.8900 | H312···H5Avi | 2.5500 |
C314···H314ix | 2.9500 | H313···C315iii | 3.0500 |
C314···H24x | 3.0900 | H314···C314ix | 2.9500 |
C315···H313ii | 3.0500 | H314···C24xiii | 3.0800 |
H1···C65A | 2.6800 | H315···H315xiv | 2.5200 |
H1···H65A | 2.4700 | H316···H31B | 2.4100 |
H1···H65Biv | 1.9800 | H316···O4 | 2.7200 |
H1···H64viii | 2.4400 | H316···C312ii | 3.0500 |
| | | |
C21—O22—C23 | 106.3 (2) | C6—C5—H5B | 110.00 |
C61—O62—C63 | 108.5 (3) | H5A—C5—H5B | 108.00 |
C2—N1—C6 | 112.5 (2) | N1—C6—H6 | 108.00 |
C2—N1—H1 | 114.00 | C5—C6—H6 | 108.00 |
C6—N1—H1 | 109.00 | C61—C6—H6 | 108.00 |
C3—C2—C21 | 112.1 (2) | O22—C23—H23 | 125.00 |
N1—C2—C3 | 110.0 (2) | C24—C23—H23 | 125.00 |
N1—C2—C21 | 110.2 (2) | C25—C24—H24 | 127.00 |
C2—C3—C4 | 105.6 (2) | C23—C24—H24 | 127.00 |
C2—C3—C31 | 113.7 (2) | C24—C25—H25 | 126.00 |
C4—C3—C31 | 113.4 (2) | C21—C25—H25 | 126.00 |
O4—C4—C3 | 122.2 (3) | C3—C31—H31B | 109.00 |
C3—C4—C5 | 115.1 (3) | C311—C31—H31A | 109.00 |
O4—C4—C5 | 122.6 (3) | C311—C31—H31B | 109.00 |
C4—C5—C6 | 109.3 (2) | H31A—C31—H31B | 108.00 |
N1—C6—C61 | 110.6 (2) | C3—C31—H31A | 109.00 |
C5—C6—C61 | 111.6 (2) | C64—C63—H63 | 126.00 |
N1—C6—C5 | 110.3 (2) | O62—C63—H63 | 126.00 |
C2—C21—C25 | 134.0 (3) | C63—C64—H64 | 128.00 |
O22—C21—C2 | 116.4 (2) | C65A—C64—H64 | 128.00 |
O22—C21—C25 | 109.6 (2) | C65B—C64—H64 | 113.00 |
O22—C23—C24 | 110.6 (2) | C61—C65A—H65A | 129.00 |
C23—C24—C25 | 106.2 (2) | C64—C65A—H65A | 129.00 |
C21—C25—C24 | 107.3 (2) | C61—C65B—H65B | 129.00 |
C3—C31—C311 | 112.8 (2) | C64—C65B—H65B | 129.00 |
O62—C61—C65B | 105.0 (2) | C31—C311—C316 | 121.71 (14) |
O62—C61—C6 | 125.8 (3) | C31—C311—C312 | 120.74 (14) |
O62—C61—C65A | 112.0 (3) | C312—C311—C316 | 117.55 (10) |
C6—C61—C65B | 128.9 (2) | C311—C312—C313 | 121.42 (10) |
C6—C61—C65A | 118.8 (3) | C312—C313—C314 | 120.01 (10) |
O62—C63—C64 | 107.6 (3) | C313—C314—C315 | 119.49 (10) |
C63—C64—C65B | 114.3 (3) | C314—C315—C316 | 120.53 (10) |
C63—C64—C65A | 103.4 (3) | C311—C316—C315 | 120.99 (10) |
C61—C65A—C64 | 102.5 (2) | C311—C312—H312 | 119.00 |
C61—C65B—C64 | 101.8 (2) | C313—C312—H312 | 119.00 |
C21—C2—H2 | 108.00 | C312—C313—H313 | 120.00 |
N1—C2—H2 | 109.00 | C314—C313—H313 | 120.00 |
C3—C2—H2 | 108.00 | C315—C314—H314 | 120.00 |
C4—C3—H3 | 108.00 | C313—C314—H314 | 120.00 |
C2—C3—H3 | 108.00 | C314—C315—H315 | 120.00 |
C31—C3—H3 | 108.00 | C316—C315—H315 | 120.00 |
C4—C5—H5A | 110.00 | C315—C316—H316 | 119.00 |
C4—C5—H5B | 110.00 | C311—C316—H316 | 120.00 |
C6—C5—H5A | 110.00 | | |
| | | |
C23—O22—C21—C2 | 178.7 (2) | C31—C3—C4—C5 | 177.9 (2) |
C23—O22—C21—C25 | −0.1 (3) | C2—C3—C31—C311 | 165.7 (2) |
C21—O22—C23—C24 | 0.3 (3) | C4—C3—C31—C311 | −73.6 (3) |
C63—O62—C61—C6 | 177.6 (3) | O4—C4—C5—C6 | −120.3 (3) |
C63—O62—C61—C65A | 19.2 (3) | C3—C4—C5—C6 | 55.3 (3) |
C61—O62—C63—C64 | −1.7 (4) | C4—C5—C6—N1 | −52.6 (3) |
C6—N1—C2—C3 | −62.6 (3) | C4—C5—C6—C61 | −175.9 (2) |
C6—N1—C2—C21 | 173.3 (2) | N1—C6—C61—O62 | −82.1 (4) |
C2—N1—C6—C5 | 58.8 (3) | N1—C6—C61—C65A | 74.9 (3) |
C2—N1—C6—C61 | −177.2 (2) | C5—C6—C61—O62 | 41.0 (4) |
N1—C2—C3—C4 | 58.3 (3) | C5—C6—C61—C65A | −161.9 (2) |
N1—C2—C3—C31 | −176.8 (2) | O22—C21—C25—C24 | −0.2 (3) |
C21—C2—C3—C4 | −178.7 (2) | C2—C21—C25—C24 | −178.6 (3) |
C21—C2—C3—C31 | −53.8 (3) | O22—C23—C24—C25 | −0.4 (3) |
N1—C2—C21—O22 | 65.6 (3) | C23—C24—C25—C21 | 0.3 (3) |
N1—C2—C21—C25 | −116.1 (4) | C3—C31—C311—C312 | −76.9 (2) |
C3—C2—C21—O22 | −57.3 (3) | C3—C31—C311—C316 | 102.4 (2) |
C3—C2—C21—C25 | 121.1 (3) | O62—C61—C65A—C64 | −24.5 (3) |
C2—C3—C4—O4 | 118.6 (3) | C6—C61—C65A—C64 | 175.5 (3) |
C2—C3—C4—C5 | −57.0 (3) | O62—C63—C64—C65A | −11.4 (4) |
C31—C3—C4—O4 | −6.5 (4) | C63—C64—C65A—C61 | 22.7 (4) |
Symmetry codes: (i) x−1, −y+1/2, z+1/2; (ii) x−1, y, z; (iii) x+1, y, z; (iv) −x, −y+1, −z+1; (v) x+1, −y+1/2, z−1/2; (vi) x, −y+1/2, z−1/2; (vii) −x, y+1/2, −z+1/2; (viii) −x+1, −y+1, −z+1; (ix) −x, −y, −z+1; (x) x, −y+1/2, z+1/2; (xi) x−1, −y+1/2, z−1/2; (xii) x+1, −y+1/2, z+1/2; (xiii) −x, y−1/2, −z+1/2; (xiv) −x−1, −y, −z+1. |
Hydrogen-bond geometry (Å, º) top
D—H···A | D—H | H···A | D···A | D—H···A |
C23—H23···O4v | 0.95 | 2.38 | 3.266 (5) | 155 |
Symmetry code: (v) x+1, −y+1/2, z−1/2. |
Experimental details
Crystal data |
Chemical formula | C20H19NO3 |
Mr | 321.36 |
Crystal system, space group | Monoclinic, P21/c |
Temperature (K) | 160 |
a, b, c (Å) | 5.443 (5), 21.437 (5), 14.108 (5) |
β (°) | 91.037 (5) |
V (Å3) | 1645.9 (17) |
Z | 4 |
Radiation type | Mo Kα |
µ (mm−1) | 0.09 |
Crystal size (mm) | 0.25 × 0.25 × 0.13 |
|
Data collection |
Diffractometer | Nonius KappaCCD area-detector |
Absorption correction | – |
No. of measured, independent and observed [I > 2σ(I)] reflections | 30100, 3254, 2182 |
Rint | 0.086 |
(sin θ/λ)max (Å−1) | 0.618 |
|
Refinement |
R[F2 > 2σ(F2)], wR(F2), S | 0.071, 0.226, 1.06 |
No. of reflections | 3254 |
No. of parameters | 225 |
H-atom treatment | H-atom parameters constrained |
Δρmax, Δρmin (e Å−3) | 0.49, −0.50 |
Hydrogen-bond geometry (Å, º) top
D—H···A | D—H | H···A | D···A | D—H···A |
C23—H23···O4i | 0.95 | 2.38 | 3.266 (5) | 155 |
Symmetry code: (i) x+1, −y+1/2, z−1/2. |
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Piperidine heterocycles play an important role in the field of medicinal Chemistry (Balamurugan et al., 2006,2007). In the title compound, (I), N1 shows a pyramidal geometry (Fig. 1). The piperidine ring adopts a chair conformation. The phenyl group at C3 and the furyl rings at C2 and C6 are in equatorial positions. In the solid state, the symmetry-related molecules are linked by C23—H23···O4 (x + 1, -y + 1/2, z - 1/2) hydrogen bonds to form chains along the c axis (Fig. 2).