Supporting information
Crystallographic Information File (CIF) https://doi.org/10.1107/S160053680705667X/bi2254sup1.cif | |
Structure factor file (CIF format) https://doi.org/10.1107/S160053680705667X/bi2254Isup2.hkl |
CCDC reference: 672903
Key indicators
- Single-crystal X-ray study
- T = 295 K
- Mean (C-C) = 0.003 Å
- R factor = 0.039
- wR factor = 0.088
- Data-to-parameter ratio = 12.5
checkCIF/PLATON results
No syntax errors found
Alert level C PLAT062_ALERT_4_C Rescale T(min) & T(max) by ..................... 0.99
0 ALERT level A = In general: serious problem 0 ALERT level B = Potentially serious problem 1 ALERT level C = Check and explain 0 ALERT level G = General alerts; check 0 ALERT type 1 CIF construction/syntax error, inconsistent or missing data 0 ALERT type 2 Indicator that the structure model may be wrong or deficient 0 ALERT type 3 Indicator that the structure quality may be low 1 ALERT type 4 Improvement, methodology, query or suggestion 0 ALERT type 5 Informative message, check
For general literature concerning 8-hydroxyquinolines, see: Chen & Shi (1998).
Sodium carbonate (0.01 mol) and 2-(quinolin-8-yloxy)acetyl chloride (0.014 mol) were added to a solution of 2-(quinolin-8-yloxy)acetohydrazide (0.01 mol) in tetrahydrofuran (20 ml) and water (20 ml). The solution was stirred at 313 K for 10 h, then poured into water (100 ml). The precipitated solid was filtered and recrystallized from ethanol (m.p. 368 K). Elemental analysis calculated: C 60.26, H 5.06, N 12.77%; found: C 60.24, H 5.08, N 12.76%. Crystals suitable for single-crystal X-ray analysis were selected directly from the sample after recrystallization.
All H atoms were placed in idealized positions (C—H = 0.93–0.97 Å, O—H = 0.85 Å, N—H = 0.87 Å) and refined as riding atoms. For those bound to C, Uiso(H) = 1.2Ueq(C). while for those bound to O or N, an isotropic displacement parameter was refined.
Data collection: SMART (Siemens, 1996); cell refinement: SAINT (Siemens, 1996); data reduction: SAINT (Siemens, 1996); program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: SHELXTL (Bruker, 1997); software used to prepare material for publication: SHELXTL (Bruker, 1997.
C22H18N4O4·2H2O | F(000) = 920 |
Mr = 438.44 | Dx = 1.413 Mg m−3 |
Monoclinic, C2/c | Melting point: 368 K |
Hall symbol: -c 2yc | Mo Kα radiation, λ = 0.71073 Å |
a = 21.687 (3) Å | Cell parameters from 1050 reflections |
b = 8.3203 (11) Å | θ = 2.7–23.7° |
c = 13.8618 (17) Å | µ = 0.11 mm−1 |
β = 124.528 (2)° | T = 295 K |
V = 2060.7 (5) Å3 | Block, colourless |
Z = 4 | 0.29 × 0.25 × 0.22 mm |
Bruker SMART CCD diffractometer | 1824 independent reflections |
Radiation source: fine-focus sealed tube | 1263 reflections with I > 2σ(I) |
Graphite monochromator | Rint = 0.032 |
ϕ and ω scans | θmax = 25.1°, θmin = 2.3° |
Absorption correction: multi-scan (SADABS; Sheldrick, 1996) | h = −22→25 |
Tmin = 0.970, Tmax = 0.988 | k = −8→9 |
5251 measured reflections | l = −16→16 |
Refinement on F2 | Secondary atom site location: difference Fourier map |
Least-squares matrix: full | Hydrogen site location: inferred from neighbouring sites |
R[F2 > 2σ(F2)] = 0.039 | H-atom parameters constrained |
wR(F2) = 0.088 | w = 1/[σ2(Fo2) + (0.0279P)2 + 1.2115P] where P = (Fo2 + 2Fc2)/3 |
S = 1.00 | (Δ/σ)max < 0.001 |
1824 reflections | Δρmax = 0.17 e Å−3 |
146 parameters | Δρmin = −0.14 e Å−3 |
0 restraints | Extinction correction: SHELXL, Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4 |
Primary atom site location: structure-invariant direct methods | Extinction coefficient: 0.0018 (4) |
C22H18N4O4·2H2O | V = 2060.7 (5) Å3 |
Mr = 438.44 | Z = 4 |
Monoclinic, C2/c | Mo Kα radiation |
a = 21.687 (3) Å | µ = 0.11 mm−1 |
b = 8.3203 (11) Å | T = 295 K |
c = 13.8618 (17) Å | 0.29 × 0.25 × 0.22 mm |
β = 124.528 (2)° |
Bruker SMART CCD diffractometer | 1824 independent reflections |
Absorption correction: multi-scan (SADABS; Sheldrick, 1996) | 1263 reflections with I > 2σ(I) |
Tmin = 0.970, Tmax = 0.988 | Rint = 0.032 |
5251 measured reflections |
R[F2 > 2σ(F2)] = 0.039 | 0 restraints |
wR(F2) = 0.088 | H-atom parameters constrained |
S = 1.00 | Δρmax = 0.17 e Å−3 |
1824 reflections | Δρmin = −0.14 e Å−3 |
146 parameters |
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | ||
N1 | 0.24176 (8) | 0.20341 (19) | 0.30918 (12) | 0.0450 (4) | |
N2 | 0.03903 (8) | 0.0311 (2) | 0.28690 (13) | 0.0485 (4) | |
H11 | 0.0611 | 0.0808 | 0.2592 | 0.058* | |
O1 | 0.18629 (6) | 0.04914 (16) | 0.41376 (10) | 0.0442 (4) | |
O2 | 0.03928 (7) | −0.1099 (2) | 0.42604 (12) | 0.0648 (5) | |
O3 | 0.08291 (7) | 0.20984 (19) | 0.16292 (11) | 0.0654 (5) | |
H12 | 0.1305 | 0.2125 | 0.2074 | 0.098* | |
H13 | 0.0732 | 0.1821 | 0.0966 | 0.098* | |
C1 | 0.26269 (9) | 0.0511 (2) | 0.47287 (14) | 0.0371 (4) | |
C2 | 0.31124 (10) | −0.0184 (2) | 0.57907 (15) | 0.0472 (5) | |
H2 | 0.2928 | −0.0705 | 0.6170 | 0.057* | |
C3 | 0.38840 (11) | −0.0123 (3) | 0.63189 (18) | 0.0605 (6) | |
H3 | 0.4204 | −0.0610 | 0.7044 | 0.073* | |
C4 | 0.41744 (11) | 0.0627 (3) | 0.57978 (18) | 0.0604 (6) | |
H4 | 0.4690 | 0.0652 | 0.6161 | 0.073* | |
C5 | 0.36924 (10) | 0.1372 (2) | 0.47012 (16) | 0.0461 (5) | |
C6 | 0.39571 (12) | 0.2199 (3) | 0.41171 (19) | 0.0596 (6) | |
H6 | 0.4468 | 0.2252 | 0.4446 | 0.071* | |
C7 | 0.34666 (13) | 0.2913 (3) | 0.3079 (2) | 0.0623 (6) | |
H7 | 0.3635 | 0.3473 | 0.2690 | 0.075* | |
C8 | 0.27014 (12) | 0.2799 (3) | 0.25997 (18) | 0.0555 (6) | |
H8 | 0.2371 | 0.3298 | 0.1884 | 0.067* | |
C9 | 0.29094 (9) | 0.1327 (2) | 0.41529 (14) | 0.0385 (4) | |
C10 | 0.15646 (9) | −0.0393 (2) | 0.46586 (15) | 0.0426 (5) | |
H10A | 0.1736 | 0.0080 | 0.5411 | 0.051* | |
H10B | 0.1749 | −0.1488 | 0.4795 | 0.051* | |
C11 | 0.07242 (10) | −0.0411 (2) | 0.39007 (16) | 0.0439 (5) |
U11 | U22 | U33 | U12 | U13 | U23 | |
N1 | 0.0467 (9) | 0.0482 (10) | 0.0398 (8) | −0.0047 (8) | 0.0243 (8) | −0.0014 (8) |
N2 | 0.0291 (8) | 0.0727 (12) | 0.0425 (9) | −0.0036 (8) | 0.0196 (7) | 0.0027 (8) |
O1 | 0.0308 (7) | 0.0596 (9) | 0.0409 (7) | −0.0028 (6) | 0.0196 (6) | 0.0066 (6) |
O2 | 0.0462 (8) | 0.0922 (12) | 0.0624 (9) | −0.0092 (8) | 0.0346 (8) | 0.0119 (8) |
O3 | 0.0474 (8) | 0.0945 (12) | 0.0508 (8) | 0.0049 (8) | 0.0257 (7) | 0.0052 (8) |
C1 | 0.0303 (10) | 0.0417 (11) | 0.0372 (9) | −0.0058 (8) | 0.0178 (8) | −0.0070 (8) |
C2 | 0.0395 (11) | 0.0552 (13) | 0.0417 (11) | −0.0051 (10) | 0.0198 (9) | 0.0028 (10) |
C3 | 0.0385 (12) | 0.0743 (17) | 0.0482 (12) | −0.0027 (11) | 0.0122 (10) | 0.0075 (11) |
C4 | 0.0320 (11) | 0.0773 (17) | 0.0592 (13) | −0.0040 (11) | 0.0182 (10) | 0.0008 (12) |
C5 | 0.0396 (11) | 0.0490 (13) | 0.0517 (11) | −0.0101 (10) | 0.0271 (10) | −0.0102 (10) |
C6 | 0.0516 (13) | 0.0716 (16) | 0.0660 (14) | −0.0215 (12) | 0.0397 (12) | −0.0167 (13) |
C7 | 0.0758 (16) | 0.0670 (16) | 0.0645 (14) | −0.0253 (13) | 0.0520 (13) | −0.0134 (12) |
C8 | 0.0706 (15) | 0.0541 (14) | 0.0480 (11) | −0.0118 (12) | 0.0373 (11) | −0.0014 (10) |
C9 | 0.0377 (10) | 0.0390 (11) | 0.0392 (10) | −0.0060 (8) | 0.0220 (9) | −0.0081 (9) |
C10 | 0.0388 (10) | 0.0505 (12) | 0.0402 (10) | −0.0041 (9) | 0.0233 (9) | −0.0007 (9) |
C11 | 0.0383 (11) | 0.0537 (13) | 0.0432 (11) | −0.0039 (10) | 0.0253 (9) | −0.0053 (10) |
N1—C8 | 1.313 (2) | C3—C4 | 1.351 (3) |
N1—C9 | 1.367 (2) | C3—H3 | 0.930 |
N2—C11 | 1.325 (2) | C4—C5 | 1.409 (3) |
N2—N2i | 1.396 (3) | C4—H4 | 0.930 |
N2—H11 | 0.870 | C5—C6 | 1.409 (3) |
O1—C1 | 1.3704 (19) | C5—C9 | 1.414 (2) |
O1—C10 | 1.418 (2) | C6—C7 | 1.349 (3) |
O2—C11 | 1.224 (2) | C6—H6 | 0.930 |
O3—H12 | 0.850 | C7—C8 | 1.398 (3) |
O3—H13 | 0.850 | C7—H7 | 0.930 |
C1—C2 | 1.361 (2) | C8—H8 | 0.930 |
C1—C9 | 1.424 (2) | C10—C11 | 1.502 (2) |
C2—C3 | 1.396 (3) | C10—H10A | 0.970 |
C2—H2 | 0.930 | C10—H10B | 0.970 |
C8—N1—C9 | 117.26 (16) | C7—C6—C5 | 119.74 (19) |
C11—N2—N2i | 119.00 (16) | C7—C6—H6 | 120.1 |
C11—N2—H11 | 126.3 | C5—C6—H6 | 120.1 |
N2i—N2—H11 | 114.7 | C6—C7—C8 | 118.9 (2) |
C1—O1—C10 | 116.58 (13) | C6—C7—H7 | 120.5 |
H12—O3—H13 | 104.3 | C8—C7—H7 | 120.5 |
C2—C1—O1 | 125.01 (16) | N1—C8—C7 | 124.4 (2) |
C2—C1—C9 | 119.59 (16) | N1—C8—H8 | 117.8 |
O1—C1—C9 | 115.40 (15) | C7—C8—H8 | 117.8 |
C1—C2—C3 | 120.95 (18) | N1—C9—C5 | 122.26 (16) |
C1—C2—H2 | 119.5 | N1—C9—C1 | 119.16 (15) |
C3—C2—H2 | 119.5 | C5—C9—C1 | 118.58 (16) |
C4—C3—C2 | 121.31 (19) | O1—C10—C11 | 111.84 (14) |
C4—C3—H3 | 119.3 | O1—C10—H10A | 109.2 |
C2—C3—H3 | 119.3 | C11—C10—H10A | 109.2 |
C3—C4—C5 | 119.64 (18) | O1—C10—H10B | 109.2 |
C3—C4—H4 | 120.2 | C11—C10—H10B | 109.2 |
C5—C4—H4 | 120.2 | H10A—C10—H10B | 107.9 |
C6—C5—C4 | 122.68 (18) | O2—C11—N2 | 124.29 (17) |
C6—C5—C9 | 117.40 (18) | O2—C11—C10 | 118.66 (17) |
C4—C5—C9 | 119.92 (17) | N2—C11—C10 | 117.04 (16) |
C10—O1—C1—C2 | −3.3 (3) | C8—N1—C9—C1 | 178.83 (17) |
C10—O1—C1—C9 | 176.44 (15) | C6—C5—C9—N1 | 0.7 (3) |
O1—C1—C2—C3 | 178.99 (18) | C4—C5—C9—N1 | 179.78 (18) |
C9—C1—C2—C3 | −0.8 (3) | C6—C5—C9—C1 | −179.47 (18) |
C1—C2—C3—C4 | 0.2 (3) | C4—C5—C9—C1 | −0.4 (3) |
C2—C3—C4—C5 | 0.2 (3) | C2—C1—C9—N1 | −179.35 (17) |
C3—C4—C5—C6 | 178.9 (2) | O1—C1—C9—N1 | 0.9 (2) |
C3—C4—C5—C9 | −0.1 (3) | C2—C1—C9—C5 | 0.9 (3) |
C4—C5—C6—C7 | −178.7 (2) | O1—C1—C9—C5 | −178.91 (16) |
C9—C5—C6—C7 | 0.3 (3) | C1—O1—C10—C11 | −176.56 (15) |
C5—C6—C7—C8 | −0.7 (3) | N2i—N2—C11—O2 | 0.4 (3) |
C9—N1—C8—C7 | 1.0 (3) | N2i—N2—C11—C10 | 179.43 (14) |
C6—C7—C8—N1 | 0.0 (3) | O1—C10—C11—O2 | −178.11 (18) |
C8—N1—C9—C5 | −1.4 (3) | O1—C10—C11—N2 | 2.8 (2) |
Symmetry code: (i) −x, y, −z+1/2. |
D—H···A | D—H | H···A | D···A | D—H···A |
O3—H13···O2ii | 0.85 | 2.13 | 2.9745 (19) | 175 |
O3—H12···N1 | 0.85 | 1.99 | 2.840 (1) | 176 |
N2—H11···O3 | 0.87 | 1.97 | 2.815 (2) | 164 |
Symmetry code: (ii) x, −y, z−1/2. |
Experimental details
Crystal data | |
Chemical formula | C22H18N4O4·2H2O |
Mr | 438.44 |
Crystal system, space group | Monoclinic, C2/c |
Temperature (K) | 295 |
a, b, c (Å) | 21.687 (3), 8.3203 (11), 13.8618 (17) |
β (°) | 124.528 (2) |
V (Å3) | 2060.7 (5) |
Z | 4 |
Radiation type | Mo Kα |
µ (mm−1) | 0.11 |
Crystal size (mm) | 0.29 × 0.25 × 0.22 |
Data collection | |
Diffractometer | Bruker SMART CCD diffractometer |
Absorption correction | Multi-scan (SADABS; Sheldrick, 1996) |
Tmin, Tmax | 0.970, 0.988 |
No. of measured, independent and observed [I > 2σ(I)] reflections | 5251, 1824, 1263 |
Rint | 0.032 |
(sin θ/λ)max (Å−1) | 0.596 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.039, 0.088, 1.00 |
No. of reflections | 1824 |
No. of parameters | 146 |
H-atom treatment | H-atom parameters constrained |
Δρmax, Δρmin (e Å−3) | 0.17, −0.14 |
Computer programs: SMART (Siemens, 1996), SAINT (Siemens, 1996), SHELXS97 (Sheldrick, 1997), SHELXL97 (Sheldrick, 1997), SHELXTL (Bruker, 1997), SHELXTL (Bruker, 1997.
D—H···A | D—H | H···A | D···A | D—H···A |
O3—H13···O2i | 0.85 | 2.13 | 2.9745 (19) | 175.2 |
O3—H12···N1 | 0.85 | 1.99 | 2.840 (1) | 176.2 |
N2—H11···O3 | 0.87 | 1.97 | 2.815 (2) | 164.4 |
Symmetry code: (i) x, −y, z−1/2. |
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8-Hydroxyquinoline and its derivatives are amongst the most extensively investigated ligands in coordination chemistry (Chen & Shi, 1998). In the course of our studies on 8-hydroxyquinoline derivatives, the title compound was synthesized and its crystal structure determined.
In the crystal, the hydrazine molecule lies across a twofold rotation axis (Fig. 1). The mean planes of the two quinoline rings make a dihedral angle of 64.1 (2)°. The hydrazine molecules and the two water molecules are linked into infinite chains by O—H···O, O—H···N and N—H···O hydrogen bonds (Fig. 2).