Supporting information
Crystallographic Information File (CIF) https://doi.org/10.1107/S1600536807029613/bg2066sup1.cif | |
Structure factor file (CIF format) https://doi.org/10.1107/S1600536807029613/bg2066Isup2.hkl |
CCDC reference: 655040
Key indicators
- Single-crystal X-ray study
- T = 100 K
- Mean (C-C) = 0.003 Å
- R factor = 0.029
- wR factor = 0.072
- Data-to-parameter ratio = 13.0
checkCIF/PLATON results
No syntax errors found
Alert level C PLAT153_ALERT_1_C The su's on the Cell Axes are Equal (x 100000) 100 Ang. PLAT180_ALERT_3_C Check Cell Rounding: # of Values Ending with 0 = 4 PLAT720_ALERT_4_C Number of Unusual/Non-Standard Label(s) ........ 13
Alert level G REFLT03_ALERT_4_G Please check that the estimate of the number of Friedel pairs is correct. If it is not, please give the correct count in the _publ_section_exptl_refinement section of the submitted CIF. From the CIF: _diffrn_reflns_theta_max 72.32 From the CIF: _reflns_number_total 4772 Count of symmetry unique reflns 3016 Completeness (_total/calc) 158.22% TEST3: Check Friedels for noncentro structure Estimate of Friedel pairs measured 1756 Fraction of Friedel pairs measured 0.582 Are heavy atom types Z>Si present yes PLAT791_ALERT_1_G Confirm the Absolute Configuration of C1' = . S PLAT791_ALERT_1_G Confirm the Absolute Configuration of C2' = . R PLAT791_ALERT_1_G Confirm the Absolute Configuration of C3A = . R PLAT791_ALERT_1_G Confirm the Absolute Configuration of C3B = . S PLAT791_ALERT_1_G Confirm the Absolute Configuration of C4' = . R PLAT791_ALERT_1_G Confirm the Absolute Configuration of C11A = . S PLAT860_ALERT_3_G Note: Number of Least-Squares Restraints ....... 1
0 ALERT level A = In general: serious problem 0 ALERT level B = Potentially serious problem 3 ALERT level C = Check and explain 8 ALERT level G = General alerts; check 7 ALERT type 1 CIF construction/syntax error, inconsistent or missing data 0 ALERT type 2 Indicator that the structure model may be wrong or deficient 2 ALERT type 3 Indicator that the structure quality may be low 2 ALERT type 4 Improvement, methodology, query or suggestion 0 ALERT type 5 Informative message, check
The preparation of adduct I was previously described in detail (Aversa et al., 2001). Crystals suitable for X-ray analysis were obtained by spontaneous slow evaporation of the chromatographic column eluent (petrol/EtOAc 7:3).
H atom on O4 was located in the difference Fourier map and refined freely. All other H atoms were clearly observable but were placed at ideal positions (C—H3: 0.96 (1) Å, C—H2: 0.97 (1) Å, C—H: 0.98 (1) Å, and allowed to ride with U(H) = 1.2 × Ueq(Host) for C—H2 and C—H and U(H) = 1.5 × Ueq(Host) for C—H3.
The Diels–Alder (DA) reaction is one of the best examined and well appreciated complexity-generating reactions. Some of us (Aversa et al., 2001) have described the synthesis of enantiopure 4-[1-(alkyl sulfinyl)vinyl]-1,2-dihydronaphthalenes and their DA reactions with N-phenyl maleimide (NPM). The main product (I) of the NPM cycloaddition to (1S,2R,4R)-1-{[(R)-[1-(3,4-dihydro-6-methoxy-1- naphthalenyl)ethenyl]sulfinyl]methyl}-7,7-dimethylbicyclo[2.2.1]heptan-2-ol is easily separated from their diastereomers and obtained as crystals suitable for X-ray analysis, which allows the assignment of (R), (S) and (S) configurations respectively to the new stereogenic centres 3a, 3 b and 11a, generated during the DA cycloaddition. The results here reported confirm the structure previously assigned to adduct (I) just through comparison with an analogous compound which structure had been determined by X-ray studies (Aversa et al., 2001). On the basis of our recent studies (Aversa et al., 2005) an unquestionable confirmation of structure (I) appeared to be desiderable, and this has been possible with the low temperature data set presented herein. A strong intramolecular hydrogen bond is formed (O4–HO4···O2, Fig 1 and Table 1) and this may be an important factor in determining the preferred face of approach by the dienophile and thus the corresponding configurations of the new stereogenic centres. The most important intermolecular interaction is a C—H···π one where the hydrogen atom H11c points to the geometrical centroid of the [C13—C18]i phenyl ring, i: -x + 2;y + 0,5;-z + 2 (Fig 2), with a H···Ct(Ph) distance of 2.81 Å and a C11a—H11c–Ct(Ph) angle of 142°.
For related literature, see: Aversa et al. (2001, 2005).
Data collection: CrysAlis CCD (Oxford Diffraction, 2006); cell refinement: CrysAlis CCD; data reduction: CrysAlis RED (Oxford Diffraction, 2006); program(s) used to solve structure: SIR97 (Altomare et al., 1999); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: ORTEP (Farrugia, 1997); software used to prepare material for publication: SHELXL97.
C33H37NO5S | F(000) = 596 |
Mr = 559.70 | Dx = 1.320 Mg m−3 |
Monoclinic, P21 | Cu Kα radiation, λ = 1.54178 Å |
Hall symbol: P 2yb | Cell parameters from 13765 reflections |
a = 11.271 (1) Å | θ = 3.9–72.2° |
b = 7.137 (1) Å | µ = 1.37 mm−1 |
c = 17.513 (1) Å | T = 100 K |
β = 91.620 (1)° | Prismatic, light yellow |
V = 1408.2 (2) Å3 | 0.28 × 0.21 × 0.16 mm |
Z = 2 |
Oxford Diffraction Excalibur PX Ultra CCD diffractometer | 4772 independent reflections |
Radiation source: Enhance (Cu) X-ray Source | 4326 reflections with I > 2σ(I) |
Oxford Diffraction, Enhance ULTRA assembly monochromator | Rint = 0.034 |
Detector resolution: 8.1241 pixels mm-1 | θmax = 72.3°, θmin = 3.9° |
ω scans | h = −13→13 |
Absorption correction: multi-scan (CrysAlis RED; Oxford Diffraction, 2006) | k = −8→6 |
Tmin = 0.710, Tmax = 0.803 | l = −21→20 |
20509 measured reflections |
Refinement on F2 | Secondary atom site location: difference Fourier map |
Least-squares matrix: full | Hydrogen site location: difference Fourier map |
R[F2 > 2σ(F2)] = 0.029 | H atoms treated by a mixture of independent and constrained refinement |
wR(F2) = 0.072 | w = 1/[σ2(Fo2) + (0.0521P)2] where P = (Fo2 + 2Fc2)/3 |
S = 1.04 | (Δ/σ)max = 0.001 |
4772 reflections | Δρmax = 0.15 e Å−3 |
368 parameters | Δρmin = −0.29 e Å−3 |
1 restraint | Absolute structure: Flack (1983) |
Primary atom site location: structure-invariant direct methods | Absolute structure parameter: −0.002 (11) |
C33H37NO5S | V = 1408.2 (2) Å3 |
Mr = 559.70 | Z = 2 |
Monoclinic, P21 | Cu Kα radiation |
a = 11.271 (1) Å | µ = 1.37 mm−1 |
b = 7.137 (1) Å | T = 100 K |
c = 17.513 (1) Å | 0.28 × 0.21 × 0.16 mm |
β = 91.620 (1)° |
Oxford Diffraction Excalibur PX Ultra CCD diffractometer | 4772 independent reflections |
Absorption correction: multi-scan (CrysAlis RED; Oxford Diffraction, 2006) | 4326 reflections with I > 2σ(I) |
Tmin = 0.710, Tmax = 0.803 | Rint = 0.034 |
20509 measured reflections |
R[F2 > 2σ(F2)] = 0.029 | H atoms treated by a mixture of independent and constrained refinement |
wR(F2) = 0.072 | Δρmax = 0.15 e Å−3 |
S = 1.04 | Δρmin = −0.29 e Å−3 |
4772 reflections | Absolute structure: Flack (1983) |
368 parameters | Absolute structure parameter: −0.002 (11) |
1 restraint |
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. |
x | y | z | Uiso*/Ueq | ||
S1 | 0.81555 (3) | 0.41507 (5) | 0.70796 (2) | 0.01779 (9) | |
N2 | 1.13302 (12) | 0.2560 (2) | 0.92663 (8) | 0.0216 (3) | |
O1 | 0.97546 (11) | 0.4534 (2) | 0.94801 (7) | 0.0343 (3) | |
O2 | 0.83893 (11) | 0.60772 (17) | 0.74147 (7) | 0.0261 (3) | |
O3 | 1.24918 (12) | 0.0105 (2) | 0.88840 (8) | 0.0332 (3) | |
O4 | 0.61320 (13) | 0.76651 (19) | 0.74012 (8) | 0.0318 (3) | |
O5 | 1.18741 (11) | 0.27852 (19) | 0.45217 (7) | 0.0265 (3) | |
C1 | 1.01297 (15) | 0.3044 (3) | 0.92662 (9) | 0.0240 (4) | |
C3 | 1.15251 (16) | 0.0808 (3) | 0.89372 (9) | 0.0234 (4) | |
C3A | 1.03364 (15) | −0.0007 (3) | 0.86789 (10) | 0.0225 (4) | |
H3A | 1.0231 | −0.1239 | 0.8941 | 0.027* | |
C3B | 1.01803 (15) | −0.0319 (2) | 0.78048 (9) | 0.0203 (4) | |
H3B | 0.9472 | −0.1154 | 0.7742 | 0.024* | |
C4 | 1.11951 (15) | −0.1389 (2) | 0.74457 (10) | 0.0228 (4) | |
H4A | 1.1247 | −0.2667 | 0.7664 | 0.027* | |
H4B | 1.1956 | −0.0740 | 0.7559 | 0.027* | |
C5 | 1.09750 (15) | −0.1504 (2) | 0.65824 (10) | 0.0224 (4) | |
H5A | 1.1608 | −0.2255 | 0.6349 | 0.027* | |
H5B | 1.0205 | −0.2127 | 0.6470 | 0.027* | |
C5A | 1.09625 (14) | 0.0440 (2) | 0.62493 (9) | 0.0177 (3) | |
C6 | 1.14288 (14) | 0.0803 (3) | 0.55369 (9) | 0.0206 (3) | |
H6 | 1.1762 | −0.0195 | 0.5254 | 0.025* | |
C7 | 1.14154 (14) | 0.2594 (3) | 0.52332 (9) | 0.0199 (3) | |
C8 | 1.09805 (13) | 0.4080 (3) | 0.56590 (8) | 0.0181 (3) | |
H8 | 1.0993 | 0.5320 | 0.5462 | 0.022* | |
C9 | 1.05288 (13) | 0.3728 (2) | 0.63736 (9) | 0.0181 (3) | |
H9 | 1.0260 | 0.4747 | 0.6671 | 0.022* | |
C9A | 1.04601 (13) | 0.1914 (2) | 0.66660 (9) | 0.0163 (3) | |
C9B | 0.98456 (14) | 0.1480 (2) | 0.73786 (9) | 0.0170 (3) | |
C10 | 0.89132 (14) | 0.2434 (2) | 0.76548 (9) | 0.0177 (3) | |
C11 | 0.84265 (15) | 0.1932 (3) | 0.84179 (9) | 0.0226 (4) | |
H11A | 0.7862 | 0.0877 | 0.8355 | 0.027* | |
H11B | 0.7988 | 0.3016 | 0.8621 | 0.027* | |
C11A | 0.94198 (15) | 0.1377 (3) | 0.89859 (9) | 0.0231 (4) | |
H11C | 0.9046 | 0.0785 | 0.9437 | 0.028* | |
C12 | 1.20323 (16) | 0.4640 (3) | 0.42401 (10) | 0.0276 (4) | |
H12A | 1.1266 | 0.5291 | 0.4221 | 0.041* | |
H12B | 1.2351 | 0.4585 | 0.3726 | 0.041* | |
H12C | 1.2588 | 0.5319 | 0.4580 | 0.041* | |
C13 | 1.22603 (15) | 0.3608 (3) | 0.96544 (9) | 0.0227 (4) | |
C14 | 1.25390 (16) | 0.5396 (3) | 0.94238 (10) | 0.0260 (4) | |
H14 | 1.2117 | 0.5963 | 0.9007 | 0.031* | |
C15 | 1.34454 (16) | 0.6360 (3) | 0.98083 (11) | 0.0306 (4) | |
H15 | 1.3644 | 0.7594 | 0.9655 | 0.037* | |
C16 | 1.40612 (16) | 0.5528 (3) | 1.04146 (11) | 0.0316 (4) | |
H16 | 1.4691 | 0.6183 | 1.0669 | 0.038* | |
C17 | 1.37598 (16) | 0.3747 (3) | 1.06485 (10) | 0.0302 (4) | |
H17 | 1.4176 | 0.3187 | 1.1069 | 0.036* | |
C18 | 1.28532 (16) | 0.2770 (3) | 1.02726 (10) | 0.0265 (4) | |
H18 | 1.2641 | 0.1548 | 1.0435 | 0.032* | |
C1' | 0.57486 (14) | 0.4506 (2) | 0.67893 (9) | 0.0185 (3) | |
C2' | 0.58386 (15) | 0.6673 (3) | 0.67131 (10) | 0.0232 (4) | |
H2' | 0.6426 | 0.6992 | 0.6316 | 0.028* | |
C3' | 0.45756 (16) | 0.7237 (3) | 0.64210 (11) | 0.0289 (4) | |
H3'1 | 0.4163 | 0.7994 | 0.6806 | 0.035* | |
H3'2 | 0.4607 | 0.7956 | 0.5939 | 0.035* | |
C4' | 0.39582 (15) | 0.5338 (3) | 0.62942 (10) | 0.0242 (4) | |
H4' | 0.3074 | 0.5414 | 0.6244 | 0.029* | |
C5' | 0.45540 (16) | 0.4398 (3) | 0.56100 (10) | 0.0296 (4) | |
H5'1 | 0.4645 | 0.5292 | 0.5183 | 0.036* | |
H5'2 | 0.4093 | 0.3299 | 0.5425 | 0.036* | |
C6' | 0.57822 (15) | 0.3798 (3) | 0.59575 (9) | 0.0253 (4) | |
H6'1 | 0.5879 | 0.2420 | 0.5941 | 0.030* | |
H6'2 | 0.6438 | 0.4391 | 0.5681 | 0.030* | |
C7' | 0.44189 (13) | 0.4178 (3) | 0.69833 (9) | 0.0228 (3) | |
C8' | 0.40543 (17) | 0.4955 (4) | 0.77559 (11) | 0.0366 (5) | |
H8'1 | 0.4343 | 0.6244 | 0.7813 | 0.055* | |
H8'2 | 0.4399 | 0.4178 | 0.8167 | 0.055* | |
H8'3 | 0.3187 | 0.4940 | 0.7784 | 0.055* | |
C9' | 0.40350 (17) | 0.2118 (3) | 0.69455 (13) | 0.0370 (5) | |
H9'1 | 0.3173 | 0.2034 | 0.6997 | 0.056* | |
H9'2 | 0.4432 | 0.1419 | 0.7361 | 0.056* | |
H9'3 | 0.4255 | 0.1583 | 0.6454 | 0.056* | |
C10' | 0.66464 (13) | 0.3585 (2) | 0.73332 (9) | 0.0197 (4) | |
H10A | 0.6536 | 0.2209 | 0.7318 | 0.024* | |
H10B | 0.6509 | 0.4015 | 0.7861 | 0.024* | |
HO4 | 0.685 (2) | 0.737 (4) | 0.7490 (14) | 0.045 (7)* |
U11 | U22 | U33 | U12 | U13 | U23 | |
S1 | 0.01489 (17) | 0.0198 (2) | 0.01866 (17) | −0.00013 (16) | 0.00063 (13) | 0.00070 (17) |
N2 | 0.0214 (7) | 0.0257 (8) | 0.0176 (7) | 0.0045 (6) | −0.0016 (5) | −0.0007 (6) |
O1 | 0.0288 (7) | 0.0459 (9) | 0.0279 (7) | 0.0129 (6) | −0.0060 (5) | −0.0163 (6) |
O2 | 0.0236 (6) | 0.0199 (7) | 0.0345 (7) | −0.0041 (5) | −0.0025 (5) | −0.0017 (6) |
O3 | 0.0254 (7) | 0.0359 (8) | 0.0377 (8) | 0.0110 (6) | −0.0074 (5) | −0.0087 (6) |
O4 | 0.0296 (7) | 0.0253 (7) | 0.0400 (8) | 0.0047 (6) | −0.0070 (6) | −0.0128 (6) |
O5 | 0.0313 (7) | 0.0279 (7) | 0.0207 (6) | 0.0029 (5) | 0.0089 (5) | 0.0025 (5) |
C1 | 0.0237 (9) | 0.0365 (11) | 0.0117 (8) | 0.0061 (8) | −0.0005 (6) | 0.0003 (8) |
C3 | 0.0278 (9) | 0.0241 (9) | 0.0182 (8) | 0.0038 (8) | −0.0019 (6) | 0.0011 (7) |
C3A | 0.0238 (8) | 0.0235 (9) | 0.0200 (8) | 0.0024 (7) | −0.0008 (7) | 0.0049 (7) |
C3B | 0.0219 (8) | 0.0195 (9) | 0.0195 (8) | −0.0027 (6) | −0.0005 (6) | 0.0026 (6) |
C4 | 0.0260 (8) | 0.0186 (9) | 0.0239 (9) | 0.0025 (7) | −0.0015 (7) | 0.0032 (7) |
C5 | 0.0247 (9) | 0.0167 (8) | 0.0258 (9) | 0.0019 (7) | 0.0013 (7) | −0.0007 (7) |
C5A | 0.0149 (7) | 0.0170 (8) | 0.0212 (8) | −0.0004 (6) | −0.0017 (6) | −0.0012 (7) |
C6 | 0.0182 (8) | 0.0217 (9) | 0.0220 (8) | 0.0025 (7) | 0.0019 (6) | −0.0032 (7) |
C7 | 0.0160 (7) | 0.0271 (9) | 0.0166 (7) | −0.0013 (7) | 0.0016 (6) | −0.0006 (7) |
C8 | 0.0160 (7) | 0.0174 (8) | 0.0209 (7) | −0.0010 (7) | −0.0004 (6) | 0.0043 (8) |
C9 | 0.0131 (7) | 0.0205 (9) | 0.0207 (8) | 0.0005 (6) | 0.0002 (6) | −0.0019 (6) |
C9A | 0.0143 (7) | 0.0177 (8) | 0.0168 (8) | −0.0024 (6) | −0.0003 (6) | −0.0005 (6) |
C9B | 0.0162 (7) | 0.0168 (8) | 0.0179 (8) | −0.0018 (6) | −0.0024 (6) | −0.0002 (7) |
C10 | 0.0175 (7) | 0.0197 (9) | 0.0159 (7) | −0.0027 (7) | −0.0012 (6) | 0.0002 (7) |
C11 | 0.0184 (8) | 0.0307 (10) | 0.0187 (8) | −0.0010 (7) | 0.0008 (6) | 0.0031 (7) |
C11A | 0.0217 (8) | 0.0309 (10) | 0.0167 (8) | 0.0024 (7) | 0.0015 (6) | 0.0046 (7) |
C12 | 0.0264 (9) | 0.0332 (11) | 0.0234 (9) | 0.0041 (7) | 0.0060 (7) | 0.0095 (8) |
C13 | 0.0198 (8) | 0.0318 (10) | 0.0165 (8) | 0.0044 (7) | 0.0006 (6) | −0.0051 (7) |
C14 | 0.0249 (9) | 0.0340 (11) | 0.0192 (8) | 0.0052 (8) | 0.0030 (7) | −0.0001 (8) |
C15 | 0.0283 (9) | 0.0327 (11) | 0.0314 (10) | −0.0017 (8) | 0.0080 (8) | −0.0025 (9) |
C16 | 0.0220 (9) | 0.0436 (12) | 0.0294 (10) | −0.0001 (8) | 0.0020 (7) | −0.0104 (9) |
C17 | 0.0266 (9) | 0.0403 (12) | 0.0233 (9) | 0.0085 (8) | −0.0043 (7) | −0.0033 (8) |
C18 | 0.0265 (9) | 0.0308 (10) | 0.0222 (9) | 0.0054 (8) | −0.0019 (7) | 0.0010 (8) |
C1' | 0.0151 (7) | 0.0200 (9) | 0.0204 (8) | 0.0013 (6) | 0.0021 (6) | −0.0021 (7) |
C2' | 0.0230 (9) | 0.0212 (9) | 0.0253 (9) | 0.0008 (7) | −0.0003 (7) | −0.0009 (7) |
C3' | 0.0263 (9) | 0.0239 (9) | 0.0363 (10) | 0.0062 (8) | −0.0041 (8) | 0.0003 (8) |
C4' | 0.0181 (8) | 0.0265 (10) | 0.0280 (9) | 0.0053 (7) | −0.0019 (7) | −0.0021 (8) |
C5' | 0.0252 (9) | 0.0367 (11) | 0.0265 (9) | 0.0060 (8) | −0.0068 (7) | −0.0059 (9) |
C6' | 0.0201 (8) | 0.0327 (11) | 0.0229 (8) | 0.0055 (7) | −0.0016 (6) | −0.0074 (8) |
C7' | 0.0136 (7) | 0.0268 (9) | 0.0281 (8) | −0.0001 (8) | 0.0023 (6) | 0.0028 (9) |
C8' | 0.0228 (9) | 0.0575 (14) | 0.0300 (10) | 0.0061 (9) | 0.0098 (8) | 0.0031 (9) |
C9' | 0.0211 (9) | 0.0320 (11) | 0.0576 (13) | −0.0065 (8) | −0.0051 (9) | 0.0112 (10) |
C10' | 0.0155 (7) | 0.0223 (9) | 0.0214 (8) | 0.0000 (6) | 0.0010 (6) | −0.0010 (7) |
S1—O2 | 1.5151 (13) | C12—H12A | 0.9800 |
S1—C10 | 1.7879 (17) | C12—H12B | 0.9800 |
S1—C10' | 1.8156 (16) | C12—H12C | 0.9800 |
N2—C1 | 1.396 (2) | C13—C14 | 1.377 (3) |
N2—C3 | 1.397 (2) | C13—C18 | 1.391 (2) |
N2—C13 | 1.442 (2) | C14—C15 | 1.390 (3) |
O1—C1 | 1.208 (2) | C14—H14 | 0.9500 |
O3—C3 | 1.206 (2) | C15—C16 | 1.386 (3) |
O4—C2' | 1.428 (2) | C15—H15 | 0.9500 |
O4—HO4 | 0.85 (3) | C16—C17 | 1.381 (3) |
O5—C7 | 1.3695 (19) | C16—H16 | 0.9500 |
O5—C12 | 1.426 (2) | C17—C18 | 1.388 (3) |
C1—C11A | 1.509 (3) | C17—H17 | 0.9500 |
C3—C3A | 1.518 (2) | C18—H18 | 0.9500 |
C3A—C11A | 1.537 (2) | C1'—C10' | 1.519 (2) |
C3A—C3B | 1.552 (2) | C1'—C6' | 1.543 (2) |
C3A—H3A | 1.0000 | C1'—C2' | 1.556 (3) |
C3B—C4 | 1.526 (2) | C1'—C7' | 1.564 (2) |
C3B—C9B | 1.527 (2) | C2'—C3' | 1.552 (2) |
C3B—H3B | 1.0000 | C2'—H2' | 1.0000 |
C4—C5 | 1.527 (2) | C3'—C4' | 1.537 (3) |
C4—H4A | 0.9900 | C3'—H3'1 | 0.9900 |
C4—H4B | 0.9900 | C3'—H3'2 | 0.9900 |
C5—C5A | 1.505 (2) | C4'—C7' | 1.541 (2) |
C5—H5A | 0.9900 | C4'—C5' | 1.543 (2) |
C5—H5B | 0.9900 | C4'—H4' | 1.0000 |
C5A—C6 | 1.392 (2) | C5'—C6' | 1.556 (2) |
C5A—C9A | 1.408 (2) | C5'—H5'1 | 0.9900 |
C6—C7 | 1.384 (3) | C5'—H5'2 | 0.9900 |
C6—H6 | 0.9500 | C6'—H6'1 | 0.9900 |
C7—C8 | 1.394 (2) | C6'—H6'2 | 0.9900 |
C8—C9 | 1.387 (2) | C7'—C8' | 1.529 (3) |
C8—H8 | 0.9500 | C7'—C9' | 1.534 (3) |
C9—C9A | 1.395 (2) | C8'—H8'1 | 0.9800 |
C9—H9 | 0.9500 | C8'—H8'2 | 0.9800 |
C9A—C9B | 1.477 (2) | C8'—H8'3 | 0.9800 |
C9B—C10 | 1.353 (2) | C9'—H9'1 | 0.9800 |
C10—C11 | 1.502 (2) | C9'—H9'2 | 0.9800 |
C11—C11A | 1.529 (2) | C9'—H9'3 | 0.9800 |
C11—H11A | 0.9900 | C10'—H10A | 0.9900 |
C11—H11B | 0.9900 | C10'—H10B | 0.9900 |
C11A—H11C | 1.0000 | ||
O2—S1—C10 | 109.18 (8) | H12B—C12—H12C | 109.5 |
O2—S1—C10' | 105.12 (7) | C14—C13—C18 | 121.20 (17) |
C10—S1—C10' | 98.37 (8) | C14—C13—N2 | 120.73 (16) |
C1—N2—C3 | 112.66 (15) | C18—C13—N2 | 118.06 (16) |
C1—N2—C13 | 124.26 (15) | C13—C14—C15 | 119.15 (17) |
C3—N2—C13 | 122.55 (14) | C13—C14—H14 | 120.4 |
C2'—O4—HO4 | 103.1 (17) | C15—C14—H14 | 120.4 |
C7—O5—C12 | 117.49 (14) | C16—C15—C14 | 120.3 (2) |
O1—C1—N2 | 124.44 (18) | C16—C15—H15 | 119.8 |
O1—C1—C11A | 127.48 (16) | C14—C15—H15 | 119.8 |
N2—C1—C11A | 108.04 (15) | C17—C16—C15 | 119.96 (18) |
O3—C3—N2 | 123.88 (17) | C17—C16—H16 | 120.0 |
O3—C3—C3A | 127.56 (17) | C15—C16—H16 | 120.0 |
N2—C3—C3A | 108.55 (15) | C16—C17—C18 | 120.39 (17) |
C3—C3A—C11A | 104.23 (15) | C16—C17—H17 | 119.8 |
C3—C3A—C3B | 115.05 (14) | C18—C17—H17 | 119.8 |
C11A—C3A—C3B | 112.23 (14) | C17—C18—C13 | 118.96 (18) |
C3—C3A—H3A | 108.4 | C17—C18—H18 | 120.5 |
C11A—C3A—H3A | 108.4 | C13—C18—H18 | 120.5 |
C3B—C3A—H3A | 108.4 | C10'—C1'—C6' | 114.61 (13) |
C4—C3B—C9B | 113.40 (13) | C10'—C1'—C2' | 116.10 (14) |
C4—C3B—C3A | 114.38 (14) | C6'—C1'—C2' | 103.96 (14) |
C9B—C3B—C3A | 112.42 (14) | C10'—C1'—C7' | 115.12 (13) |
C4—C3B—H3B | 105.2 | C6'—C1'—C7' | 101.84 (13) |
C9B—C3B—H3B | 105.2 | C2'—C1'—C7' | 103.44 (14) |
C3A—C3B—H3B | 105.2 | O4—C2'—C3' | 109.75 (14) |
C3B—C4—C5 | 109.41 (14) | O4—C2'—C1' | 115.75 (15) |
C3B—C4—H4A | 109.8 | C3'—C2'—C1' | 102.98 (14) |
C5—C4—H4A | 109.8 | O4—C2'—H2' | 109.4 |
C3B—C4—H4B | 109.8 | C3'—C2'—H2' | 109.4 |
C5—C4—H4B | 109.8 | C1'—C2'—H2' | 109.4 |
H4A—C4—H4B | 108.2 | C4'—C3'—C2' | 103.08 (14) |
C5A—C5—C4 | 109.48 (14) | C4'—C3'—H3'1 | 111.1 |
C5A—C5—H5A | 109.8 | C2'—C3'—H3'1 | 111.1 |
C4—C5—H5A | 109.8 | C4'—C3'—H3'2 | 111.1 |
C5A—C5—H5B | 109.8 | C2'—C3'—H3'2 | 111.1 |
C4—C5—H5B | 109.8 | H3'1—C3'—H3'2 | 109.1 |
H5A—C5—H5B | 108.2 | C3'—C4'—C7' | 102.67 (14) |
C6—C5A—C9A | 119.57 (16) | C3'—C4'—C5' | 106.87 (15) |
C6—C5A—C5 | 121.28 (15) | C7'—C4'—C5' | 103.31 (14) |
C9A—C5A—C5 | 119.15 (14) | C3'—C4'—H4' | 114.2 |
C7—C6—C5A | 121.05 (15) | C7'—C4'—H4' | 114.2 |
C7—C6—H6 | 119.5 | C5'—C4'—H4' | 114.2 |
C5A—C6—H6 | 119.5 | C4'—C5'—C6' | 102.58 (13) |
O5—C7—C6 | 116.20 (15) | C4'—C5'—H5'1 | 111.3 |
O5—C7—C8 | 123.95 (16) | C6'—C5'—H5'1 | 111.3 |
C6—C7—C8 | 119.83 (15) | C4'—C5'—H5'2 | 111.3 |
C9—C8—C7 | 119.24 (16) | C6'—C5'—H5'2 | 111.3 |
C9—C8—H8 | 120.4 | H5'1—C5'—H5'2 | 109.2 |
C7—C8—H8 | 120.4 | C1'—C6'—C5' | 103.51 (13) |
C8—C9—C9A | 121.65 (15) | C1'—C6'—H6'1 | 111.1 |
C8—C9—H9 | 119.2 | C5'—C6'—H6'1 | 111.1 |
C9A—C9—H9 | 119.2 | C1'—C6'—H6'2 | 111.1 |
C9—C9A—C5A | 118.40 (14) | C5'—C6'—H6'2 | 111.1 |
C9—C9A—C9B | 122.45 (14) | H6'1—C6'—H6'2 | 109.0 |
C5A—C9A—C9B | 119.12 (15) | C8'—C7'—C9' | 107.64 (17) |
C10—C9B—C9A | 125.76 (15) | C8'—C7'—C4' | 113.91 (16) |
C10—C9B—C3B | 115.58 (14) | C9'—C7'—C4' | 113.12 (15) |
C9A—C9B—C3B | 118.28 (14) | C8'—C7'—C1' | 114.91 (15) |
C9B—C10—C11 | 120.33 (15) | C9'—C7'—C1' | 113.89 (15) |
C9B—C10—S1 | 120.45 (12) | C4'—C7'—C1' | 93.06 (13) |
C11—C10—S1 | 118.95 (12) | C7'—C8'—H8'1 | 109.5 |
C10—C11—C11A | 111.20 (13) | C7'—C8'—H8'2 | 109.5 |
C10—C11—H11A | 109.4 | H8'1—C8'—H8'2 | 109.5 |
C11A—C11—H11A | 109.4 | C7'—C8'—H8'3 | 109.5 |
C10—C11—H11B | 109.4 | H8'1—C8'—H8'3 | 109.5 |
C11A—C11—H11B | 109.4 | H8'2—C8'—H8'3 | 109.5 |
H11A—C11—H11B | 108.0 | C7'—C9'—H9'1 | 109.5 |
C1—C11A—C11 | 112.28 (15) | C7'—C9'—H9'2 | 109.5 |
C1—C11A—C3A | 105.38 (14) | H9'1—C9'—H9'2 | 109.5 |
C11—C11A—C3A | 115.21 (14) | C7'—C9'—H9'3 | 109.5 |
C1—C11A—H11C | 107.9 | H9'1—C9'—H9'3 | 109.5 |
C11—C11A—H11C | 107.9 | H9'2—C9'—H9'3 | 109.5 |
C3A—C11A—H11C | 107.9 | C1'—C10'—S1 | 111.24 (11) |
O5—C12—H12A | 109.5 | C1'—C10'—H10A | 109.4 |
O5—C12—H12B | 109.5 | S1—C10'—H10A | 109.4 |
H12A—C12—H12B | 109.5 | C1'—C10'—H10B | 109.4 |
O5—C12—H12C | 109.5 | S1—C10'—H10B | 109.4 |
H12A—C12—H12C | 109.5 | H10A—C10'—H10B | 108.0 |
C3—N2—C1—O1 | −175.54 (17) | O1—C1—C11A—C3A | 171.81 (17) |
C13—N2—C1—O1 | 12.7 (3) | N2—C1—C11A—C3A | −10.36 (17) |
C3—N2—C1—C11A | 6.54 (18) | C10—C11—C11A—C1 | 73.88 (19) |
C13—N2—C1—C11A | −165.26 (15) | C10—C11—C11A—C3A | −46.8 (2) |
C1—N2—C3—O3 | −179.26 (16) | C3—C3A—C11A—C1 | 10.09 (17) |
C13—N2—C3—O3 | −7.3 (3) | C3B—C3A—C11A—C1 | −115.05 (15) |
C1—N2—C3—C3A | 0.23 (19) | C3—C3A—C11A—C11 | 134.44 (16) |
C13—N2—C3—C3A | 172.19 (14) | C3B—C3A—C11A—C11 | 9.3 (2) |
O3—C3—C3A—C11A | 172.82 (17) | C1—N2—C13—C14 | −66.1 (2) |
N2—C3—C3A—C11A | −6.65 (18) | C3—N2—C13—C14 | 122.91 (18) |
O3—C3—C3A—C3B | −63.9 (2) | C1—N2—C13—C18 | 113.06 (19) |
N2—C3—C3A—C3B | 116.67 (16) | C3—N2—C13—C18 | −58.0 (2) |
C3—C3A—C3B—C4 | 50.4 (2) | C18—C13—C14—C15 | 1.3 (2) |
C11A—C3A—C3B—C4 | 169.37 (14) | N2—C13—C14—C15 | −179.61 (16) |
C3—C3A—C3B—C9B | −80.78 (18) | C13—C14—C15—C16 | 0.1 (3) |
C11A—C3A—C3B—C9B | 38.17 (19) | C14—C15—C16—C17 | −1.2 (3) |
C9B—C3B—C4—C5 | −45.98 (19) | C15—C16—C17—C18 | 0.9 (3) |
C3A—C3B—C4—C5 | −176.70 (14) | C16—C17—C18—C13 | 0.4 (3) |
C3B—C4—C5—C5A | 62.43 (18) | C14—C13—C18—C17 | −1.6 (3) |
C4—C5—C5A—C6 | 143.70 (15) | N2—C13—C18—C17 | 179.29 (15) |
C4—C5—C5A—C9A | −36.8 (2) | C10'—C1'—C2'—O4 | −37.7 (2) |
C9A—C5A—C6—C7 | 0.5 (2) | C6'—C1'—C2'—O4 | −164.56 (14) |
C5—C5A—C6—C7 | −179.98 (15) | C7'—C1'—C2'—O4 | 89.37 (16) |
C12—O5—C7—C6 | −171.10 (15) | C10'—C1'—C2'—C3' | −157.47 (14) |
C12—O5—C7—C8 | 7.1 (2) | C6'—C1'—C2'—C3' | 75.70 (15) |
C5A—C6—C7—O5 | −178.65 (14) | C7'—C1'—C2'—C3' | −30.38 (17) |
C5A—C6—C7—C8 | 3.0 (2) | O4—C2'—C3'—C4' | −128.89 (15) |
O5—C7—C8—C9 | 179.66 (14) | C1'—C2'—C3'—C4' | −5.09 (18) |
C6—C7—C8—C9 | −2.2 (2) | C2'—C3'—C4'—C7' | 39.58 (17) |
C7—C8—C9—C9A | −2.3 (2) | C2'—C3'—C4'—C5' | −68.77 (17) |
C8—C9—C9A—C5A | 5.8 (2) | C3'—C4'—C5'—C6' | 73.14 (18) |
C8—C9—C9A—C9B | −172.02 (14) | C7'—C4'—C5'—C6' | −34.75 (19) |
C6—C5A—C9A—C9 | −4.8 (2) | C10'—C1'—C6'—C5' | 161.04 (15) |
C5—C5A—C9A—C9 | 175.66 (15) | C2'—C1'—C6'—C5' | −71.19 (17) |
C6—C5A—C9A—C9B | 173.03 (14) | C7'—C1'—C6'—C5' | 36.08 (18) |
C5—C5A—C9A—C9B | −6.5 (2) | C4'—C5'—C6'—C1' | −1.26 (19) |
C9—C9A—C9B—C10 | 29.3 (2) | C3'—C4'—C7'—C8' | 63.04 (18) |
C5A—C9A—C9B—C10 | −148.51 (17) | C5'—C4'—C7'—C8' | 174.07 (16) |
C9—C9A—C9B—C3B | −158.17 (15) | C3'—C4'—C7'—C9' | −173.62 (15) |
C5A—C9A—C9B—C3B | 24.0 (2) | C5'—C4'—C7'—C9' | −62.58 (18) |
C4—C3B—C9B—C10 | 177.05 (14) | C3'—C4'—C7'—C1' | −55.98 (15) |
C3A—C3B—C9B—C10 | −51.26 (19) | C5'—C4'—C7'—C1' | 55.05 (16) |
C4—C3B—C9B—C9A | 3.7 (2) | C10'—C1'—C7'—C8' | 62.0 (2) |
C3A—C3B—C9B—C9A | 135.43 (15) | C6'—C1'—C7'—C8' | −173.41 (17) |
C9A—C9B—C10—C11 | −175.47 (15) | C2'—C1'—C7'—C8' | −65.73 (19) |
C3B—C9B—C10—C11 | 11.8 (2) | C10'—C1'—C7'—C9' | −62.9 (2) |
C9A—C9B—C10—S1 | 10.6 (2) | C6'—C1'—C7'—C9' | 61.76 (18) |
C3B—C9B—C10—S1 | −162.16 (12) | C2'—C1'—C7'—C9' | 169.43 (16) |
O2—S1—C10—C9B | −111.63 (14) | C10'—C1'—C7'—C4' | −179.85 (14) |
C10'—S1—C10—C9B | 139.08 (14) | C6'—C1'—C7'—C4' | −55.23 (15) |
O2—S1—C10—C11 | 74.32 (14) | C2'—C1'—C7'—C4' | 52.45 (15) |
C10'—S1—C10—C11 | −34.97 (15) | C6'—C1'—C10'—S1 | 65.08 (17) |
C9B—C10—C11—C11A | 37.0 (2) | C2'—C1'—C10'—S1 | −56.24 (17) |
S1—C10—C11—C11A | −148.90 (13) | C7'—C1'—C10'—S1 | −177.27 (12) |
O1—C1—C11A—C11 | 45.6 (2) | O2—S1—C10'—C1' | 81.13 (12) |
N2—C1—C11A—C11 | −136.53 (14) | C10—S1—C10'—C1' | −166.30 (12) |
D—H···A | D—H | H···A | D···A | D—H···A |
O4—HO4···O2 | 0.85 (3) | 1.97 (3) | 2.7847 (19) | 161 (2) |
C11A—H11C···Ct(Ph) | 1.00 | 2.81 | 3.645 (1) | 142 |
Experimental details
Crystal data | |
Chemical formula | C33H37NO5S |
Mr | 559.70 |
Crystal system, space group | Monoclinic, P21 |
Temperature (K) | 100 |
a, b, c (Å) | 11.271 (1), 7.137 (1), 17.513 (1) |
β (°) | 91.620 (1) |
V (Å3) | 1408.2 (2) |
Z | 2 |
Radiation type | Cu Kα |
µ (mm−1) | 1.37 |
Crystal size (mm) | 0.28 × 0.21 × 0.16 |
Data collection | |
Diffractometer | Oxford Diffraction Excalibur PX Ultra CCD |
Absorption correction | Multi-scan (CrysAlis RED; Oxford Diffraction, 2006) |
Tmin, Tmax | 0.710, 0.803 |
No. of measured, independent and observed [I > 2σ(I)] reflections | 20509, 4772, 4326 |
Rint | 0.034 |
(sin θ/λ)max (Å−1) | 0.618 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.029, 0.072, 1.04 |
No. of reflections | 4772 |
No. of parameters | 368 |
No. of restraints | 1 |
H-atom treatment | H atoms treated by a mixture of independent and constrained refinement |
Δρmax, Δρmin (e Å−3) | 0.15, −0.29 |
Absolute structure | Flack (1983) |
Absolute structure parameter | −0.002 (11) |
Computer programs: CrysAlis CCD (Oxford Diffraction, 2006), CrysAlis CCD, CrysAlis RED (Oxford Diffraction, 2006), SIR97 (Altomare et al., 1999), SHELXL97 (Sheldrick, 1997), ORTEP (Farrugia, 1997), SHELXL97.
D—H···A | D—H | H···A | D···A | D—H···A |
O4—HO4···O2 | 0.85 (3) | 1.97 (3) | 2.7847 (19) | 161 (2) |
C11A—H11C···Ct(Ph) | 1.00 | 2.81 | 3.645 (1) | 142 |
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The Diels–Alder (DA) reaction is one of the best examined and well appreciated complexity-generating reactions. Some of us (Aversa et al., 2001) have described the synthesis of enantiopure 4-[1-(alkyl sulfinyl)vinyl]-1,2-dihydronaphthalenes and their DA reactions with N-phenyl maleimide (NPM). The main product (I) of the NPM cycloaddition to (1S,2R,4R)-1-{[(R)-[1-(3,4-dihydro-6-methoxy-1- naphthalenyl)ethenyl]sulfinyl]methyl}-7,7-dimethylbicyclo[2.2.1]heptan-2-ol is easily separated from their diastereomers and obtained as crystals suitable for X-ray analysis, which allows the assignment of (R), (S) and (S) configurations respectively to the new stereogenic centres 3a, 3 b and 11a, generated during the DA cycloaddition. The results here reported confirm the structure previously assigned to adduct (I) just through comparison with an analogous compound which structure had been determined by X-ray studies (Aversa et al., 2001). On the basis of our recent studies (Aversa et al., 2005) an unquestionable confirmation of structure (I) appeared to be desiderable, and this has been possible with the low temperature data set presented herein. A strong intramolecular hydrogen bond is formed (O4–HO4···O2, Fig 1 and Table 1) and this may be an important factor in determining the preferred face of approach by the dienophile and thus the corresponding configurations of the new stereogenic centres. The most important intermolecular interaction is a C—H···π one where the hydrogen atom H11c points to the geometrical centroid of the [C13—C18]i phenyl ring, i: -x + 2;y + 0,5;-z + 2 (Fig 2), with a H···Ct(Ph) distance of 2.81 Å and a C11a—H11c–Ct(Ph) angle of 142°.