Supporting information
Crystallographic Information File (CIF) https://doi.org/10.1107/S1600536807039499/bq2031sup1.cif | |
Structure factor file (CIF format) https://doi.org/10.1107/S1600536807039499/bq2031Isup2.hkl |
CCDC reference: 662412
1.41 g (10 mmole) of o-chlorobenzaldehyde was disolved in an equivalent amount (1.10 g) of neat dimethylphosphonate in the presence of an equal mixture (2.5 g + 2.5 g) of KF and ψ-Al2O3. The mixture was kept at room temperature for 48 h. The product was extracted twice with 20 ml portions of a dichloromethane-methanol mixture (1:1). After the evaporation of the solvant on a rotary evaporator, the oily residue was redisolved in a mixture of diethyl ether and acetone (3:1) and recrystallized in this medium. M·P: (83–86 °C); yield: 40 percent %.
H atoms to the C-atoms of the phenyl ring were bonded geometrically 0.930 Å, while the H-atom attached to C7 is at a distance of 0.98 Å. Thermal parameter of all these H atoms was taken 1.2 times of the corresponding atoms. The thermal parameter of H-atoms geometrically bonded to CH3 groups [0.960 Å] and H-atom of OH [0.80 Å] was taken 1.5 times of the corresponding atom. Regarding data: Some reflections could not be recovered from flopy at back back home and also zero track of used hard disk damaged.
α-Hydroxy phosphonates are a subject of increasing interest because these compounds inhibit various enzymes like renin (Patel et al., 1990) and HIV protease (Stowasser et al., 1992).
To our surprise various samples of (I) obtained in different batches have had some optical activity indicating that either the mechanism favours one conformer, or, two optical isomers prefer to crystallize separately in unequal proportions. Hence, we determined the crystal structure.
As can be seen on ORTEP diagram (Fig. 1.) the crystal investigated contains only the R-isomer. The P-atom adopts a distorted tetrahedral configuration: the bond angles aroud it being in the range 101.76 (15)°-116.18 (17)°. These values are closer to ideal like reported earlier (Fang et al., 2006) than those of dimethyl[α-(benzylamino)-p-chlorobenzyl]phosphonate (Liu et al., 1995). The geometry about P-atom is exactly similar to (Fang et al., 2006), however, all the bond distances around P-atom are all larger. The bond distance P1—C7 [1.822 (3) Å] is smaller compared to the value [1.860 (4) Å], in our reported structure (Tahir et al., 1996). There exist a strong inter-molecular hydrogen bonding between O1—H1 (hydroxy group) and O2i(x + 1/2, -y + 1/2, -z). Another inter-molecular hydrogen bonding exists between C7—H7 and O1(x + 1/2, -y + 1/2, -z) which forms eight membered group (C7,O1,H1,O2i,P1i,C7i,O1i,H7). There also exists an intre-molecular hydrogen bonding between C7—H7···Cl1. Due to inter-molecular hydrogen bonding one-dimensional polymeric network is formed extending to crystallographic b axis (Fig. 2). The closest approach between polymeric chains is among C6 and C9 (x, y + 1, z) [3.387 (6) Å]. The Flack parameter -0.13 (17) [Flack, 1983] clearly indicates the R-configuration of the title compound.
For related literature, see: Fang et al. (2006); Liu et al. (1995); Patel et al. (1990); Stowasser et al. (1992); Tahir et al. (1996).
Data collection: CAD-4 EXPRESS (Enraf–Nonius, 1992); data reduction: MolEN (Fair, 1990); program(s) used to solve structure: SHELXS86 (Sheldrick, 1985); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: ORTEP-3 for Windows (Farrugia, 1997) and PLATON (Spek, 2003); software used to prepare material for publication: WinGX (Version 1.70.01; Farrugia, 1999).
C9H12ClO4P | Dx = 1.458 Mg m−3 |
Mr = 250.61 | Melting point = 83–86 K |
Orthorhombic, P212121 | Mo Kα radiation, λ = 0.71073 Å |
Hall symbol: P 2ac 2ab | Cell parameters from 25 reflections |
a = 7.5670 (12) Å | θ = 10.6–18.5° |
b = 7.9230 (13) Å | µ = 0.47 mm−1 |
c = 19.0420 (12) Å | T = 295 K |
V = 1141.6 (3) Å3 | Prism, colourless |
Z = 4 | 0.25 × 0.2 × 0.15 mm |
F(000) = 520 |
Enraf–Nonius CAD-4 diffractometer | Rint = 0.012 |
ω/2θ scans | θmax = 26.3°, θmin = 2.8° |
Absorption correction: empirical (using intensity measurements) via ψ scans (molEN; Fair, 1990) | h = 0→9 |
Tmin = 0.885, Tmax = 0.954 | k = 0→9 |
1361 measured reflections | l = −23→23 |
1314 independent reflections | 3 standard reflections every 120 min |
1119 reflections with I > 2σ(I) | intensity decay: −2.5% |
Refinement on F2 | Secondary atom site location: difference Fourier map |
Least-squares matrix: full | H-atom parameters constrained |
R[F2 > 2σ(F2)] = 0.039 | w = 1/[σ2(Fo2) + (0.0418P)2] where P = (Fo2 + 2Fc2)/3 |
wR(F2) = 0.113 | (Δ/σ)max < 0.001 |
S = 1.10 | Δρmax = 0.40 e Å−3 |
1314 reflections | Δρmin = −0.24 e Å−3 |
137 parameters | Absolute structure: Flack (1983), number of Friedel pairs? |
0 restraints | Absolute structure parameter: −0.13 (17) |
Primary atom site location: structure-invariant direct methods |
C9H12ClO4P | V = 1141.6 (3) Å3 |
Mr = 250.61 | Z = 4 |
Orthorhombic, P212121 | Mo Kα radiation |
a = 7.5670 (12) Å | µ = 0.47 mm−1 |
b = 7.9230 (13) Å | T = 295 K |
c = 19.0420 (12) Å | 0.25 × 0.2 × 0.15 mm |
Enraf–Nonius CAD-4 diffractometer | 1119 reflections with I > 2σ(I) |
Absorption correction: empirical (using intensity measurements) via ψ scans (molEN; Fair, 1990) | Rint = 0.012 |
Tmin = 0.885, Tmax = 0.954 | 3 standard reflections every 120 min |
1361 measured reflections | intensity decay: −2.5% |
1314 independent reflections |
R[F2 > 2σ(F2)] = 0.039 | H-atom parameters constrained |
wR(F2) = 0.113 | Δρmax = 0.40 e Å−3 |
S = 1.10 | Δρmin = −0.24 e Å−3 |
1314 reflections | Absolute structure: Flack (1983), number of Friedel pairs? |
137 parameters | Absolute structure parameter: −0.13 (17) |
0 restraints |
Experimental. the structure was solved by Patterson method using SHELX86. The whole molecule was recognized. |
Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes. |
x | y | z | Uiso*/Ueq | ||
Cl1 | 0.56770 (15) | 0.23649 (19) | 0.17150 (7) | 0.0795 (4) | |
P1 | 0.17377 (12) | 0.01006 (12) | 0.04711 (5) | 0.0473 (3) | |
O1 | 0.1972 (4) | 0.3210 (3) | 0.00635 (13) | 0.0574 (7) | |
H1 | 0.2771 | 0.3722 | −0.0135 | 0.086* | |
O2 | −0.0201 (3) | 0.0013 (3) | 0.04521 (15) | 0.0598 (7) | |
O3 | 0.2678 (4) | −0.0579 (5) | −0.02068 (17) | 0.0851 (11) | |
O4 | 0.2591 (4) | −0.0924 (3) | 0.10882 (16) | 0.0677 (8) | |
C1 | 0.2247 (5) | 0.2842 (4) | 0.13248 (18) | 0.0435 (8) | |
C2 | 0.3483 (5) | 0.2960 (5) | 0.18634 (19) | 0.0503 (8) | |
C3 | 0.3055 (7) | 0.3590 (6) | 0.2521 (2) | 0.0681 (12) | |
H3 | 0.3909 | 0.3647 | 0.2871 | 0.082* | |
C4 | 0.1361 (7) | 0.4132 (6) | 0.2651 (2) | 0.0711 (13) | |
H4 | 0.1068 | 0.4575 | 0.3087 | 0.085* | |
C5 | 0.0103 (6) | 0.4015 (6) | 0.2133 (2) | 0.0678 (11) | |
H5 | −0.1051 | 0.4353 | 0.2226 | 0.081* | |
C6 | 0.0532 (5) | 0.3401 (5) | 0.1477 (2) | 0.0551 (9) | |
H6 | −0.0330 | 0.3357 | 0.1130 | 0.066* | |
C7 | 0.2690 (5) | 0.2188 (4) | 0.06033 (16) | 0.0442 (7) | |
H7 | 0.3977 | 0.2127 | 0.0550 | 0.053* | |
C8 | 0.1895 (8) | −0.1584 (7) | −0.0722 (3) | 0.0854 (15) | |
H8A | 0.2745 | −0.1832 | −0.1082 | 0.128* | |
H8B | 0.0911 | −0.0993 | −0.0924 | 0.128* | |
H8C | 0.1489 | −0.2618 | −0.0514 | 0.128* | |
C9 | 0.2136 (6) | −0.2659 (6) | 0.1212 (3) | 0.0752 (13) | |
H9A | 0.2786 | −0.3072 | 0.1610 | 0.113* | |
H9B | 0.2425 | −0.3318 | 0.0805 | 0.113* | |
H9C | 0.0892 | −0.2745 | 0.1305 | 0.113* |
U11 | U22 | U33 | U12 | U13 | U23 | |
Cl1 | 0.0526 (6) | 0.1012 (9) | 0.0848 (7) | 0.0123 (7) | −0.0213 (5) | 0.0012 (7) |
P1 | 0.0411 (5) | 0.0440 (4) | 0.0568 (5) | −0.0009 (4) | 0.0001 (4) | −0.0005 (4) |
O1 | 0.0495 (15) | 0.0652 (16) | 0.0574 (14) | −0.0111 (13) | −0.0051 (13) | 0.0206 (12) |
O2 | 0.0424 (13) | 0.0495 (13) | 0.0875 (17) | −0.0030 (12) | −0.0028 (13) | 0.0068 (17) |
O3 | 0.0605 (19) | 0.108 (3) | 0.087 (2) | −0.0166 (19) | 0.0124 (17) | −0.044 (2) |
O4 | 0.0700 (19) | 0.0418 (13) | 0.0913 (19) | 0.0008 (14) | −0.0206 (16) | 0.0101 (13) |
C1 | 0.0437 (19) | 0.0368 (15) | 0.0501 (17) | −0.0043 (14) | −0.0008 (15) | 0.0088 (14) |
C2 | 0.050 (2) | 0.0448 (18) | 0.0564 (19) | −0.0040 (16) | −0.0059 (16) | 0.0091 (16) |
C3 | 0.081 (3) | 0.069 (3) | 0.055 (2) | −0.009 (3) | −0.009 (2) | 0.0008 (19) |
C4 | 0.092 (4) | 0.065 (2) | 0.057 (2) | −0.011 (3) | 0.011 (2) | −0.010 (2) |
C5 | 0.061 (3) | 0.062 (2) | 0.081 (3) | 0.002 (2) | 0.016 (2) | −0.004 (2) |
C6 | 0.048 (2) | 0.0504 (19) | 0.067 (2) | −0.0044 (17) | 0.0004 (19) | −0.0005 (17) |
C7 | 0.0416 (17) | 0.0436 (16) | 0.0474 (17) | −0.0051 (15) | −0.0010 (14) | 0.0031 (15) |
C8 | 0.084 (3) | 0.091 (3) | 0.081 (3) | 0.000 (3) | −0.008 (3) | −0.034 (3) |
C9 | 0.066 (3) | 0.054 (2) | 0.106 (3) | 0.003 (2) | 0.002 (3) | 0.019 (2) |
Cl1—C2 | 1.748 (4) | C3—H3 | 0.9300 |
P1—O2 | 1.469 (3) | C4—C5 | 1.374 (7) |
P1—O4 | 1.568 (3) | C4—H4 | 0.9300 |
P1—O3 | 1.569 (3) | C5—C6 | 1.379 (6) |
P1—C7 | 1.822 (3) | C5—H5 | 0.9300 |
O1—C7 | 1.417 (4) | C6—H6 | 0.9300 |
O1—H1 | 0.8200 | C7—H7 | 0.9800 |
O3—C8 | 1.396 (5) | C8—H8A | 0.9600 |
O4—C9 | 1.436 (5) | C8—H8B | 0.9600 |
C1—C2 | 1.392 (5) | C8—H8C | 0.9600 |
C1—C6 | 1.401 (5) | C9—H9A | 0.9600 |
C1—C7 | 1.506 (5) | C9—H9B | 0.9600 |
C2—C3 | 1.386 (6) | C9—H9C | 0.9600 |
C3—C4 | 1.374 (7) | ||
O2—P1—O4 | 113.93 (18) | C6—C5—H5 | 119.7 |
O2—P1—O3 | 114.62 (18) | C5—C6—C1 | 121.1 (4) |
O4—P1—O3 | 104.59 (19) | C5—C6—H6 | 119.4 |
O2—P1—C7 | 116.18 (17) | C1—C6—H6 | 119.4 |
O4—P1—C7 | 101.76 (15) | O1—C7—C1 | 112.3 (3) |
O3—P1—C7 | 104.22 (17) | O1—C7—P1 | 105.5 (2) |
C7—O1—H1 | 109.5 | C1—C7—P1 | 110.5 (2) |
C8—O3—P1 | 125.5 (3) | O1—C7—H7 | 109.5 |
C9—O4—P1 | 121.3 (3) | C1—C7—H7 | 109.5 |
C2—C1—C6 | 116.7 (3) | P1—C7—H7 | 109.5 |
C2—C1—C7 | 123.1 (3) | O3—C8—H8A | 109.5 |
C6—C1—C7 | 120.2 (3) | O3—C8—H8B | 109.5 |
C3—C2—C1 | 122.2 (4) | H8A—C8—H8B | 109.5 |
C3—C2—Cl1 | 117.7 (3) | O3—C8—H8C | 109.5 |
C1—C2—Cl1 | 120.1 (3) | H8A—C8—H8C | 109.5 |
C4—C3—C2 | 119.6 (4) | H8B—C8—H8C | 109.5 |
C4—C3—H3 | 120.2 | O4—C9—H9A | 109.5 |
C2—C3—H3 | 120.2 | O4—C9—H9B | 109.5 |
C5—C4—C3 | 119.8 (4) | H9A—C9—H9B | 109.5 |
C5—C4—H4 | 120.1 | O4—C9—H9C | 109.5 |
C3—C4—H4 | 120.1 | H9A—C9—H9C | 109.5 |
C4—C5—C6 | 120.7 (4) | H9B—C9—H9C | 109.5 |
C4—C5—H5 | 119.7 | ||
O2—P1—O3—C8 | −16.2 (5) | C4—C5—C6—C1 | 1.6 (7) |
O4—P1—O3—C8 | 109.3 (5) | C2—C1—C6—C5 | −0.8 (6) |
C7—P1—O3—C8 | −144.3 (4) | C7—C1—C6—C5 | −179.5 (4) |
O2—P1—O4—C9 | 51.0 (4) | C2—C1—C7—O1 | −134.9 (3) |
O3—P1—O4—C9 | −74.9 (4) | C6—C1—C7—O1 | 43.8 (4) |
C7—P1—O4—C9 | 176.8 (3) | C2—C1—C7—P1 | 107.6 (3) |
C6—C1—C2—C3 | 0.2 (5) | C6—C1—C7—P1 | −73.7 (4) |
C7—C1—C2—C3 | 178.9 (3) | O2—P1—C7—O1 | −55.4 (3) |
C6—C1—C2—Cl1 | −177.7 (3) | O4—P1—C7—O1 | −179.7 (2) |
C7—C1—C2—Cl1 | 1.0 (5) | O3—P1—C7—O1 | 71.8 (3) |
C1—C2—C3—C4 | −0.4 (6) | O2—P1—C7—C1 | 66.3 (3) |
Cl1—C2—C3—C4 | 177.6 (4) | O4—P1—C7—C1 | −58.1 (3) |
C2—C3—C4—C5 | 1.1 (7) | O3—P1—C7—C1 | −166.6 (2) |
C3—C4—C5—C6 | −1.7 (7) |
D—H···A | D—H | H···A | D···A | D—H···A |
O1—H1···O2i | 0.82 | 1.93 | 2.743 (4) | 171 |
C7—H7···Cl1 | 0.98 | 2.57 | 3.100 (4) | 114 |
C7—H7···O1i | 0.98 | 2.56 | 3.494 (5) | 159 |
Symmetry code: (i) x+1/2, −y+1/2, −z. |
Experimental details
Crystal data | |
Chemical formula | C9H12ClO4P |
Mr | 250.61 |
Crystal system, space group | Orthorhombic, P212121 |
Temperature (K) | 295 |
a, b, c (Å) | 7.5670 (12), 7.9230 (13), 19.0420 (12) |
V (Å3) | 1141.6 (3) |
Z | 4 |
Radiation type | Mo Kα |
µ (mm−1) | 0.47 |
Crystal size (mm) | 0.25 × 0.2 × 0.15 |
Data collection | |
Diffractometer | Enraf–Nonius CAD-4 |
Absorption correction | Empirical (using intensity measurements) via ψ scans (MolEN; Fair, 1990) |
Tmin, Tmax | 0.885, 0.954 |
No. of measured, independent and observed [I > 2σ(I)] reflections | 1361, 1314, 1119 |
Rint | 0.012 |
(sin θ/λ)max (Å−1) | 0.623 |
Refinement | |
R[F2 > 2σ(F2)], wR(F2), S | 0.039, 0.113, 1.10 |
No. of reflections | 1314 |
No. of parameters | 137 |
H-atom treatment | H-atom parameters constrained |
Δρmax, Δρmin (e Å−3) | 0.40, −0.24 |
Absolute structure | Flack (1983), number of Friedel pairs? |
Absolute structure parameter | −0.13 (17) |
Computer programs: CAD-4 EXPRESS (Enraf–Nonius, 1992), MolEN (Fair, 1990), SHELXS86 (Sheldrick, 1985), SHELXL97 (Sheldrick, 1997), ORTEP-3 for Windows (Farrugia, 1997) and PLATON (Spek, 2003), WinGX (Version 1.70.01; Farrugia, 1999).
Cl1—C2 | 1.748 (4) | O1—C7 | 1.417 (4) |
P1—O2 | 1.469 (3) | O3—C8 | 1.396 (5) |
P1—O4 | 1.568 (3) | O4—C9 | 1.436 (5) |
P1—O3 | 1.569 (3) | C1—C7 | 1.506 (5) |
P1—C7 | 1.822 (3) | ||
O2—P1—O4 | 113.93 (18) | O2—P1—C7 | 116.18 (17) |
O2—P1—O3 | 114.62 (18) | O4—P1—C7 | 101.76 (15) |
O4—P1—O3 | 104.59 (19) | O3—P1—C7 | 104.22 (17) |
D—H···A | D—H | H···A | D···A | D—H···A |
O1—H1···O2i | 0.82 | 1.93 | 2.743 (4) | 171 |
C7—H7···Cl1 | 0.98 | 2.57 | 3.100 (4) | 114 |
C7—H7···O1i | 0.98 | 2.56 | 3.494 (5) | 159 |
Symmetry code: (i) x+1/2, −y+1/2, −z. |
α-Hydroxy phosphonates are a subject of increasing interest because these compounds inhibit various enzymes like renin (Patel et al., 1990) and HIV protease (Stowasser et al., 1992).
To our surprise various samples of (I) obtained in different batches have had some optical activity indicating that either the mechanism favours one conformer, or, two optical isomers prefer to crystallize separately in unequal proportions. Hence, we determined the crystal structure.
As can be seen on ORTEP diagram (Fig. 1.) the crystal investigated contains only the R-isomer. The P-atom adopts a distorted tetrahedral configuration: the bond angles aroud it being in the range 101.76 (15)°-116.18 (17)°. These values are closer to ideal like reported earlier (Fang et al., 2006) than those of dimethyl[α-(benzylamino)-p-chlorobenzyl]phosphonate (Liu et al., 1995). The geometry about P-atom is exactly similar to (Fang et al., 2006), however, all the bond distances around P-atom are all larger. The bond distance P1—C7 [1.822 (3) Å] is smaller compared to the value [1.860 (4) Å], in our reported structure (Tahir et al., 1996). There exist a strong inter-molecular hydrogen bonding between O1—H1 (hydroxy group) and O2i(x + 1/2, -y + 1/2, -z). Another inter-molecular hydrogen bonding exists between C7—H7 and O1(x + 1/2, -y + 1/2, -z) which forms eight membered group (C7,O1,H1,O2i,P1i,C7i,O1i,H7). There also exists an intre-molecular hydrogen bonding between C7—H7···Cl1. Due to inter-molecular hydrogen bonding one-dimensional polymeric network is formed extending to crystallographic b axis (Fig. 2). The closest approach between polymeric chains is among C6 and C9 (x, y + 1, z) [3.387 (6) Å]. The Flack parameter -0.13 (17) [Flack, 1983] clearly indicates the R-configuration of the title compound.