3D electron diffraction (3DED) was used to elucidate the structure of a new ninth polymorph of indomethacin from an amorphous solid dispersion, which are product formulations used to improve the dissolution performance of active pharmaceutical ingredients with poor aqueous solubility. Insights from the structure solution allowed for a simpler crystallization route for this polymorph to be deduced, demonstrating the relevance of 3DED within drug development.

The crystal structure of the important bioactive flavonoid Oroxylin A (6-meth­oxy­chrysin) is reported for the first time and com­pared to those of its regioisomers Negletein and Wogonin. The latter crystallizes as a monohydrate from ethanol or as a sesquihydrate from di­chloro­methane or methanol.

The under-oil crystallization method was successfully adopted for the crystallization of organic salts. Compared with the previously reported vapour-diffusion-based nano-crystallization technique, the under-oil method generated single crystals of more different salts for all studied compounds.

Bubble-induced crystal growth of indomethacin polymorphs not only depends on the interface created by the bubble but also strongly correlates with the true cavitation of the bubble.

The rich solid-state chemistry of olanzapine uncovered during the development of this blockbuster drug has inspired the development and application of new tools and techniques for understanding molecular assembly during crystallization.

Fiber growth of nimesulide, a precursor of glass-to-crystal growth in supercooled liquid, is reported.

An understanding of protein stability is essential for optimizing the expression, purification and crystallization of proteins. In this review, discussion will focus on factors affecting protein stability on a somewhat practical level, particularly from the view of a protein crystallographer.

In order to form a solid solution with its prodrug cortisone, hydrocortisone (cortisol) must violate Etter's rule of hydrogen bonding. The preparation of a uniform product with the desired composition, which is hindered under a thermodynamic regime, can be achieved by supercritical assisted spray drying. The new phase enables fine-tuning of the phase's composition as well as a higher dissolution rate for hydrocortisone.

Pharmaceutical cocrystals of the antituberculosis drug pyrazinamide with substituted hy­droxy­acids (2,4-di­hydroxy­benzoic acid; 2,6-di­hydroxy­benzoic acid; 3,5-di­hydroxy­benzoic acid and ferulic acid) and a molecular salt with p-toluene­sulfonic acid have been synthesized using both mechanical grinding as well as solution crystallization. This is the first report of the pyrazinamide salt.

A novel drug–drug salt of furosemide (a rapid-acting diuretic) with triamterene (a potassium-sparing diuretic) was successfully synthesized. This dual pharmaceutical salt was comprehensively characterized using single-crystal/powder X-ray diffraction, thermal analysis and vibrational spectroscopy.