A fixed-target 3D-printed mesh-holder optimized for sample handling for serial synchrotron crystallography was implemented. This allows rapid data collection from microcrystals. Data are analyzed and structures determined using a high-performance computing pipeline.

In this work, serial crystallography is applied to a drug discovery target and the room-temperature ligand-bound complexes are used to explore temperature-dependent structural differences.

Strategies for sample delivery of macromolecular crystals at X-ray free-electron lasers are reviewed, covering injection methods, fixed-target approaches and hybrid methods.

Presented here are 3D printed sample delivery devices for precise control over fluids and the generation of micrometre-sized gas-focused liquid jets, high-viscosity streams and near-monodisperse droplets suitable for X-ray scattering experiments on X-ray free-electron laser (XFEL) instruments.

A fixed path length sample holder for cryoSAXS was microfabricated and tested. The holder has superior scattering properties, holds sub-microlitre sample volumes and solves many of the issues associated with previous non-fixed path length sample holders for cryoSAXS.

Two modulators have been designed, assembled, magnetically tested and installed at SwissFEL in order to implement laser-based seeding at the soft X-ray beamline Athos.

A microfluidic platform has been developed for the capture and X-ray analysis of protein microcrystals, affording a means to improve the efficiency of XFEL and synchrotron experiments.

Electron spectroscopy in laser-pump/X-ray probe experiments is used to characterize electron dynamics, with an emphasis on space-charge acceleration.

A new open-source Python-based library for data acquisition, device manipulation and scan routines is presented.

The temporal variation of the surface morphology of Ta₂O₅ films on Si substrates has been measured using X-ray reflectivity at a fixed angle during radio-frequency magnetron sputtering. During an early stage of growth of polycrystalline Ta₂O₅, the variation of surface roughness revealed a morphology of island nucleation and island coalescence.