The title compound represents a symmetrically substituted 4-cyano pyrazole with two phenyl groups, which is a precursor for the scorpionate ligand.

The synthesis, crystal structure, and some spectroscopic details for the phenyl­pyrazole-based insecticide N-{3-cyano-1-[2,6-di­chloro-4- (tri­fluoro­meth­yl)phen­yl]-4-(ethyl­sulfan­yl)-1H-pyrazol-5-yl}-2,2,2- tri­fluoro­acetamide (C₁₅H₈N₄Cl₂F₆OS) are presented.

The title compound represents the first symmetrically substituted 4-cyano­pyrazole. The 4-cyano group lies in the plane of the pyrazole ring and has a linear C—CN bond angle of 179.2 (1)°. In the crystal, mol­ecules are linked via N—HN hydrogen bonds, forming inversion dimers with an (6) ring motif.

In the structure of the title co-crystal, C₃H₃N₃O₂·C₅H₈N₂, the components are linked by a set of directional O—HN, N—HO, N—HN and C—HO hydrogen bonds to yield a two-dimensional mono-periodic arrangement. The structure propagates in the third dimension by extensive π–π stacking inter­actions of nearly parallel mol­ecules of the two components, following an alternating sequence. The primary structure-defining inter­action is very strong oxime-OH donor to pyrazole-N acceptor hydrogen bond [ON = 2.587 (2) Å], while the significance of weaker hydrogen bonds and π–π stacking inter­actions is comparable.

The synthesis and structure are reported of Tp^Ph,4CNNi(NO₃)(EtOH), an octa­hedral complex containing a tridentate cyano­scorpionate ligand, a bidentate nitrate ligand and a neutral ethanol ligand.

In the title mol­ecule, the five- and six-membered rings are oriented at a dihedral angle of 75.88 (8)°. In the crystal, N—HN hydrogen bonds form chains of mol­ecules extending along the c-axis direction that are connected by inversion-related pairs of O—HN into ribbons. The ribbons are linked by C—Hπ(ring) inter­actions, forming layers parallel to the ab plane.

The crystal structure of the phenyl­pyrazole insecticide ethiprole is presented along with a step-by-step overview of the model building and refinement process.

Biologically relevant spiro­[indolin-2-one-3,4′-pyrano[2,3-c]pyrazoles] derivatives were synthesized by a simple, energy-efficient and chemically sustainable method under ambient conditions with excellent yields, and the molecules were fully studied with regard to their detailed spectral and X-ray crystallographic behavior.

The crystal structures of ruxolitinib and its dihydrate and phos­phate are described in detail and com­pared through the analysis of both Hirshfeld surfaces and fingerprint plots.

In each of two isostructural 3-(5-ar­yloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-1-(thio­phen-2-yl)prop-2-en-1-ones, the thio­phene unit is disordered over two sets of atomic sites and a combination of C—HN and C—HO hydrogen bonds link the mol­ecules into sheets.