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22 citations found for Murphy, M
Search for Murphy, M in the World Directory of Crystallographers
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The bacterial cell wall is a polymeric structure that determines the overall shape of the cell and undergoes constant remodelling during cell growth, requiring enzymes that cleave the existing peptidoglycan structure. Csd4 is an enzyme important for cell shape as deleting it in Helicobacter pylori causes the helical-shaped cells to become rod-like. Csd4 is a zinc carboxypeptidase that can cleave the tripeptide moiety found in peptidoglycan (i.e. L-Ala-γ-D-Glu-m-DAP) to release meso-diaminopimelic acid (mDAP). Structures of Csd4 were solved by X-ray crystallography up to 1.75 Å resolution in space group P212121 with zinc and substrate/product bound and contain the same unit cell dimensions. Csd4 is a monomeric enzyme with three domains: an N-terminal M14-family carboxypeptidase domain followed by two smaller domains likely important in protein-protein or protein-peptidoglycan interactions. Key interactions are observed between the protein and substrate in the active site, supporting specific substrate recognition by Csd4. A water or hydroxide molecule, which is required for catalytic activity, is also observed bound to the zinc and is poised to interact with the substrate molecule upon activation.
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organic compounds
Molecules of 4-hydroxyisophthalic acid, C8H6O5, are disordered over two equally occupied orientations across a mirror plane. Each molecule contains an O-HO intramolecular hydrogen bond, and both carboxylic acid groups are involved in R22(8) intermolecular hydrogen bonding. The crystal structure is further supported by --stacking interactions.
research papers
A structure of a copper-containing nitrite reductase from Geobacillus thermodenitrificans (GtNIR) was determined using an anaerobically manipulated crystal. Furthermore, a peroxide-bound structure of GtNIR was determined.
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research communications
The large C-terminal domain of the C. crescentus surface-layer protein RsaA has been crystallized. Initial RsaA crystals have been shown to diffract to ∼2.5 Å resolution.
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research papers
This freely available set of hardware-independent programs produces photorealistic figures for publication or lecture presentation.
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research papers (metal-organic compounds)
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