The title compound, C₂₉H₃₆O₁₀·2C₂H₆OS, forms a monoclinic crystal containing two hydrogen-bonded di­methyl sulfoxide mol­ecules per 10-de­acetyl baccatin III. The lattice is further stabilized by two additional hydrogen bonds and a dipole-dipole interaction. A comparison of 10-de­acetyl baccatin III with the structurally similar docetaxel reveals differences primarily in the benzoyl moiety, while comparisons to baccatin III identify relative differences principally in the cyclo­octane- and cyclo­hexane-ring conformations.