Tomatinase, a saponin-detoxifying enzyme belonging to family 3 of the glycosyl hydrolases from the fungal tomato pathogen S. lycopersici, has been purified from culture medium and crystallized. The crystals belong to space group P2₁2₁2 are predicted to contain 46% solvent and diffract to at least 3.0 Å resolution.

The successful synthesis, characterization and analysis of inter­molecular inter­actions of aryl­sul­fon­amide Schiff bases have been achieved, alongside their evaluation for inhibitory effects on tankyrase poly(ADP-ribose) polymerase in the context of colon cancer, through in-silico testing.

The synthesis and characterization, crystal structures and DNA docking studies of a tetra­cyclic iso­quinolino­benzo­thia­diazine and its two precursors are reported.

Three o-nitro­sul­fonamides and three N-cyclo­amino-o-sul­fan­il­amides have been successfully synthesized and characterized, and the intermolecular interactions analysed, as well as being tested in silico for carbonic anhydrase II (4iwz) and IX (5fl4) inhibitory activities. The results obtained from crystal packing and DFT analysis suggest that the mol­ecules are held together by forces such as hydro­gen bonding and π–π inter­actions.