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A low-temperature structure of ginkgolide A monohydrate, (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-dimethylethyl)-hexa­hydro-4,7b-di­hydroxy-8-methyl-9H-1,7a-epoxymethano-1H,6aH-cyclo­penta­[c]­furo­[2,3-b]­furo­[3′,2′:3,4]­cyclopenta­[1,2-d]­furan-5,9,12(4H)-trione monohydrate, C20H24O9·H2O, obtained from Mo Kα data, is a factor of three more precise than the previous room-temperature determination. A refinement of the ginkgolide A monohydrate structure with Cu Kα data has allowed the assignment of the absolute configuration of the series of compounds. Ginkgolide C sesquihydrate, (1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11S,11aR)-3-(1,1-di­methyl­ethyl)-hexa­hydro-2,4,7b,11-tetrahydroxy-8-methyl-9H-1,7a-epoxy­methano-1H,6aH-cyclopenta­[c]­furo­[2,3-b]­furo­[3′,2′:3,4]­cyclo­penta­[1,2-d]­furan-5,9,12(4H)-trione sesquihydrate, C20H24O11·1.5H2O, has two independent diterpene mol­ecules, both of which exhibit intramolecular hydrogen bonding between OH groups. Ginkgolide J dihydrate, (1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-di­methyl­ethyl)-hexa­hydro-2,4,7b-tri­hydroxy-8-methyl-9H-1,7a-epoxy­methano-1H,6aH-cyclo­penta­[c]­furo­[2,3-b]furo[3′,2′:3,4]­cyclo­penta­[1,2-d]­furan-5,9,12(4H)-trione dihydrate, C20H24O10·2H2O, has the same basic skeleton as the other ginkgolides, with its three OH groups having the same configurations as those in ginkgolide C. The conformations of the six five-membered rings are quite similar across ­ginkgolides A–C and J, except for the A and F rings of ginkgolide A.

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