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Acta Cryst. (2016). F72, 636-641
https://doi.org/10.1107/S2053230X16009778

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Crystal structure of the antigen-binding fragment of a monoclonal antibody specific for the multidrug-resistance-linked ABC transporter human P-glycoprotein

L. Esser, S. Shukla, F. Zhou, S. V. Ambudkar and D. Xia

The monoclonal antibody UIC2 binds specifically to the extracellular region of the human P-glycoprotein in a conformationally sensitive manner. The crystal structure of the Fab fragment of UIC2 is reported.

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