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In the title compound, C24H20N6O, the pyridin-3-yl groups on the ethyl­ene fragment are found in a trans conformation with a C(py)—C(e)—C(e)—C(py) (py = pyridine, e = ethylene) torsion angle of 179.2 (3)°. The dihedral angle between the pyridine rings is 3.5 (1)°. In the crystal, N—H...N and C—H...O=C inter­actions form a layer arrangement parallel to the bc plane. The compound displays disorder of the ethyl­ene fragment over two positions with an occupancy ratio of 0.676 (7) to 0.324 (7) that extends into the amide section of the nicotinamide moiety.
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