Cinnarizinium fumarate

In the title salt {systematic name: 4-diphenyl­methyl-1-[(E)-3-phenyl­prop-2-en-1-yl]piperazin-1-ium (2Z)-3-carb­oxy­prop-2-enoate}, C₂₆H₂₉N₂⁺·C₄H₃O₄⁻, the piperazine ring in the cation adopts a distorted chair conformation and contains a positively charged N atom with quaternary character. The dihedral angle between the mean planes of the phenyl rings of the diphenyl­methyl group is 74.2 (7)° and those between these rings and the phenyl ring of the 3-phenyl­prop-2-en-1-yl group are 12.7 (9) and 80.6 (8)°. In the crystal, N—H...O and O—H...O hydrogen bonds form chains along [001]. Weak C—H...O inter­actions connect parallel chains along [010], forming layers perpendicular to the a-axis direction.

Olanzapinium dipicrate

The asymmetric unit of the title salt [systematic name: 2-methyl-4-(4-methyl­piperazin-4-ium-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepinium bis­(2,4,6-trinitro­phenolate)], C₁₇H₂₂N₄S²⁺·2C₆H₂N₃O₇⁻, consists of a diprotonated olanzapinium cation and two independent picrate anions. In the cation, the piperazine ring adopts a distorted chair conformation and contains a positively charged N atom with quaternary character and the N atom in the seven-membered 1,5-diazepine ring, which adopts a boat configuration, is also protonated. The dihedral angle between the benzene and thiene rings flanking the diazepine ring is 58.8 (1)°. In one of the picrate anions, a nitro group is disordered over two sets of sites in a 0.748 (5):0.252 (5) ratio, and the benzene ring has a flat envelope conformation with the O⁻ C atom displaced from the mean plane of the other five C atoms [maximum deviation 0.0151 (14) Å] by 0.1449 (14) Å. In the crystal, N—H...O hydrogen bonds and weak inter­molecular C—H...S and C—H...O inter­actions link the components, forming a three-dimensional network.

4-[Bis(4-fluoro­phen­yl)meth­yl]-1-[(2E)-3-phenyl­prop-2-en-1-yl]piperazin-1-ium 3-carb­oxy­propano­ate

In the title salt, C₂₆H₂₇F₂N₂⁺·C₄H₅O₄⁻, the piperazine N atom bearing the vinylic substituent is protonated. The piperazine ring adopts a chair conformation. In ther crystal, the succinate monoanions are connected via short O—H...O hydrogen bonds between the carb­oxy­lic acid and carboxyl­ate groups into undulating chains extending along [001] and the flunarizinium monocations are attached to these chains via N⁺—H...O⁻ hydrogen bonds. C—H...O inter­actions connect these chains into a three-dimensional network. The shortest centroid–centroid distance of 3.7256 (10) Å was found between one of the fluorinated benzene rings and the non-fluorinated phenyl ring in the neighbouring mol­ecule related by a glide plane.

Cinnarizinium bis­(p-toluene­sulfonate) dihydrate

The asymmetric unit of the title salt [systematic name: 1-benzhydryl-4-cinnamylpiperazine-1,4-diium bis­(p-toluene­sulfonate) dihydrate], C₂₆H₃₀N₂²⁺·2C₇H₇O₃S⁻·2H₂O, consists of a diprotonated cinnarizinium cation hydrogen bonded through two water mol­ecules to two independent p-toluene­sulfonate anions, one which is disordered over two sets of sites in a 0.793 (3):0.207 (3) ratio. In the cation, the piperazine ring adopts a chair configuration and contains two positively charged N atoms with quarternery character. The dihedral angle between the two benzene rings in the benzhydr­yl group is 71.8 (1)°. The benzene ring flanked opposite the piperazine ring is twisted by 75.9 (9) and 8.8 (3)° from these two benzene rings. In the crystal, the [N—H...O_water—H...O([pdbond]S)]₂ hydrogen-bonded asymmetric unit is connected by further O—H...O hydrogen bonds linking the components into chains along [100].

Flunarizinium hydrogen maleate

In the cation of the title salt {systematic name: 4-[bis­(4-fluoro­phen­yl)meth­yl]-1-[(2E)-3-phenyl­prop-2-en-1-yl]piperazin-1-ium hydrogen maleate}, C₂₆H₂₇F₂N₂⁺·C₄H₃O₄⁻, the protonated piperazine ring is in a chair conformation. The dihedral angle between the 4-fluoro­phenyl rings is 68.2 (2)°. An intra­molecular O—H...O hydrogen bond occurs in the anion. In the crystal, N—H...O, C—H...O and C—H...F inter­actions are observed, which link the ions into [001] chains.

Bis{4-[(1,3-benzodioxol-5-yl)meth­yl]piperazin-1-yl}methane

In the title compound, C₂₅H₃₂N₄O₄, both piperazine rings adopt a chair conformation. One of dioxolane ring systems is essentially planar [dihedral angle = 0.9 (2)°] while the other adopts a slightly disordered envelope conformation, the mean plane of the dioxolane ring being twisted by 3.6 (2)° from that of the benzene ring. The dihedral angle between the benzene rings is 69.9 (5)°. No classical hydrogen bonds were observed.

1-[4-(4-Hy­droxy­phen­yl)piperazin-1-yl]ethanone

In the title compound, C₁₂H₁₆N₂O₂, the piperazine ring has a chair conformation. The dihedral angle between the mean planes of the benzene ring and the acetyl group is 48.7 (1)°. In the crystal, mol­ecules are linked via O—H...O hydrogen bonds, forming chains propagating along [010].

4-Methyl-N-(4-nitro­benzyl­idene)piperazin-1-amine

In the title compound, C₁₂H₁₆N₄O₂, the piperazine ring is in a slightly distorted chair conformation. In the mol­ecule, the mean plane of the nitro group is twisted by 8.0 (3)° from that of the benzene ring. Also, the mean plane of the 2-nitro­benzyl ring is twisted slightly from that of the piperazine ring, with an N—N=C—C torsion angle of −176.24 (11)°. In the crystal, pairs of weak C—H...O inter­actions link the mol­ecules into dimers approximately along [010].

N-(1H-Indol-3-yl­methyl­idene)-4-methyl­piperazin-1-amine

In the title compound, C₁₄H₁₈N₄, the piperazine ring is in a slightly distorted chair conformation. The indole ring system is twisted from the piperazine ring, making a dihedral angle of 7.27 (11)°. In the crystal, N—H...N hydrogen bonds link mol­ecules into chains along [10-1].