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In each of ethyl N-{2-amino-5-formyl-6-[meth­yl(phen­yl)amino]­pyrimidin-4-yl}glycinate, C16H19N5O3, (I), N-{2-amino-5-formyl-6-[meth­yl(phen­yl)amino]­pyrimidin-4-yl}glycin­amide, C14H16N6O2, (II), and ethyl 3-amino-N-{2-amino-5-formyl-6-[meth­yl(phen­yl)amino]­pyrimidin-4-yl}propionate, C17H21N5O3, (III), the pyrimidine ring is effectively planar, but in each of methyl N-{2-amino-6-[benz­yl(meth­yl)amino]-5-formyl­pyrimidin-4-yl}glycinate, C16H19N5O3, (IV), ethyl 3-amino-N-{2-amino-6-[benz­yl(meth­yl)amino]-5-formylpyrimidin-4-yl}propionate, C18H23N5O3, (V), and ethyl 3-amino-N-[2-amino-5-formyl-6-(piperidin-4-yl)pyrimidin-4-yl]propionate, C15H23N5O3, (VI), the pyrimidine ring is folded into a boat conformation. The bond lengths in each of (I)-(VI) provide evidence for significant polarization of the electronic structure. The mol­ecules of (I) are linked by paired N-H...N hydrogen bonds to form isolated dimeric aggregates, and those of (III) are linked by a combination of N-H...N and N-H...O hydrogen bonds into a chain of edge-fused rings. In the structure of (IV), mol­ecules are linked into sheets by means of two hydrogen bonds, both of N-H...O type, in the structure of (V) by three hydrogen bonds, two of N-H...N type and one of C-H...O type, and in the structure of (VI) by four hydrogen bonds, all of N-H...O type. Mol­ecules of (II) are linked into a three-dimensional framework structure by a combination of three N-H...O hydrogen bonds and one C-H...O hydrogen bond.

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(2R,4S)-2-(3-Methyl­thio­phen-2-yl)-2,3,4,5-tetra­hydro-1,4-ep­oxy­naphtho­[1,2-b]azepine, C19H17NOS, (I), crystallizes with a single enanti­omer in each crystal, whereas its geometrical isomer (2RS,4SR)-2-(5-methyl­thio­phen-2-yl)-2,3,4,5-tetra­hy­dro-1,4-ep­oxy-naphtho­[1,2-b]azepine, (II), and (2RS,4SR)-2-(5-bromo­thio­phen-2-yl)-2,3,4,5-tetra­hydro-1,4-ep­oxy­naphtho­[1,2-b]azepine, C18H14BrNOS, (III), both crystallize as racemic mixtures. A combination of one C-H...O hydrogen bond and two C-H...[pi](arene) hydrogen bonds links the mol­ecules of (I) into a three-dimensional framework; the mol­ecules of (II) are linked into a C(4)C(4)[R22(7)] chain of rings by a combination of C-H...N and C-H...O hydrogen bonds; and in (III), where Z' = 2, a combination of four C-H...[pi](arene) hydrogen bonds and two C-H...[pi](thien­yl) hydrogen bonds links the mol­ecules into complex sheets. Comparisons are made with the assembly patterns in some aryl-substituted 1,4-ep­oxy­naphtho[1,2-b]azepines.

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(2RS,4SR)-7-Bromo-2-(2-methyl­phenyl)-2,3,4,5-tetra­hydro-1H-naphtho­[1,2-b]azepin-4-ol, C21H20BrNO, (I), and (2RS,4SR)-2-(3-methyl­thio­phen-2-yl)-2,3,4,5-tetra­hydro-1H-naphtho­[1,2-b]azepin-4-ol, C19H19NOS, (II), both crystallize with Z' = 2 in the space groups P21/c and Cc, respectively; compound (II) crystallizes as a nonmerohedral twin, with twin fractions 0.183 (2) and 0.817 (2). The mol­ecules of (I) are linked by O-H...O and O-H...N hydrogen bonds to form a cyclic centrosymmetric R44(16) tetra­mer. The mol­ecules of (II) are linked by O-H...O hydrogen bonds to form a C22(4) chain and these chains are weakly linked by a single C-H...[pi](thienyl) inter­action to form a three-dimensional array. Comparisons are made with some related compounds.
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