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The asymmetric unit of the title compound, 2C15H16N6O3·C3H7NO·H2O, contains two independent ethyl 6-methyl-2-oxo-4-[4-(1H-tetra­zol-5-yl)phen­yl]-1,2,3,4-tetra­hydro­pyrim­id­ine-5-carboxyl­ate mol­ecules, in which the dihedral angles between the tetra­zole and benzene rings are 20.54 (12) and 12.13 (12)°. An intra­molecular C—H...O hydrogen bond occurs in each mol­ecule. In the crystal, N—H...O, N—H...N, O—H...O and O—H...N hydrogen bonds, as well as weak C—H...O and C—H...N hydrogen bonds, link the mol­ecules into a three-dimensional supra­molecular architecture. π–π stacking is also observed between parallel tetra­zole rings of adjacent mol­ecules, the centroid–centroid distance being 3.482 (6) Å.

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In the title compound, C16H10N4O2·0.17H2O, prepared by the one-step condensation reaction of isatin with hydrazine hydrate under microwave irradiation, the complete organic mol­ecule is generated by crystallographic inversion symmetry and therefore exists in an S-trans conformation. In the crystal, mol­ecules are linked by N—H...O hydrogen bonds, generating a three-dimensional framework with [001] channels, which are occupied by the disordered water mol­ecules.

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In the title mol­ecule, C14H18ClN5O2S, the six atoms of the 1,6-di­hydro­pyridazine ring are essentially coplanar (r.m.s. deviation = 0.008 Å), and the dihedral angle between this and the 1,3,4-thia­diazole ring is 62.06 (10)°. In the crystal, centrosymmetrically related mol­ecules are linked by inter­molecular C-H-O hydrogen bonding to form a supra­molecular dimer. The terminal ethyl group is statistically disordered over two positions.
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