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The asymmetric unit of the title compound, 2C15H16N6O3·C3H7NO·H2O, contains two independent ethyl 6-methyl-2-oxo-4-[4-(1H-tetra­zol-5-yl)phen­yl]-1,2,3,4-tetra­hydro­pyrim­id­ine-5-carboxyl­ate mol­ecules, in which the dihedral angles between the tetra­zole and benzene rings are 20.54 (12) and 12.13 (12)°. An intra­molecular C—H...O hydrogen bond occurs in each mol­ecule. In the crystal, N—H...O, N—H...N, O—H...O and O—H...N hydrogen bonds, as well as weak C—H...O and C—H...N hydrogen bonds, link the mol­ecules into a three-dimensional supra­molecular architecture. π–π stacking is also observed between parallel tetra­zole rings of adjacent mol­ecules, the centroid–centroid distance being 3.482 (6) Å.
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