The co-crystal N,N′-bis­[(pyridin-1-ium-2-yl)meth­yl]ethane­dithio­amide bis­(2,6-di­nitro­benzoate)–2,6-di­nitro­benzoic acid (1/4)

The asymmetric unit of title co-crystal, C₁₄H₁₆N₄S₂²⁺·2C₇H₃N₂O₆⁻·4C₇H₄N₂O₆, comprises a centrosymmetric dipyridinium dication, a 2,6-di­nitro­benzoate anion and two independent 2,6-di­nitro­benzoic acid mol­ecules. The pyridin­ium rings are each approximately perpendicular to the central di­thio­amide unit [dihedral angle = 80.67 (12)°]. The carboxyl­ate/carb­oxy­lic acid groups are approximately perpendicular to the benzene ring to which they are attached [dihedral angles = 78.85 (16), 81.46 (19) and 71.28 (15)°]. By contrast, the major twist exhibited by a nitro group is manifested in a dihedral angle of 32.66 (17)°. The most prominent feature of the crystal packing is linear supra­molecular chains along [1-10], featuring O—H...O(carboxyl­ate) and pyridinium-N—H...O hydrogen bonds. These are consolidated into a three-dimensional architecture by thio­amide–nitro N—H...O, C—H...O and π–π [inter-centroid distance = 3.524 (2) Å] inter­actions. One of the nitro O atoms was refined over two sites; the major site was 0.65 (7) occupied.

tert-Butyl 4-{[2-amino-4-(2-hy­droxy­phen­yl)pyrimidin-5-yl]meth­yl}piperazine-1-carboxyl­ate

In the title compound, C₂₀H₂₇N₅O₃, the central piperazine ring adopts a chair conformation, with the N-bound carboxyl­ate and methyl­ene substituents occupying bis­ectional and equatorial orientations, respectively. A twist is evident between the aromatic rings [dihedral angle = 25.61 (9)°] but an intra­molecular O—H...N hydrogen bond persists between these. Supra­molecular tapes along [1-10] are formed in the crystal packing through N(amino)—H...O(hydrox­yl) and N(amino)—H...N(pyrimidin­yl) hydrogen bonds, and these are linked into layers in the ab plane by π–π inter­actions [inter-centroid distance between pyrimidinyl rings = 3.5919 (9) Å].