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In the title compound, C24H18N2OS, the pyridine and the two phenyl rings are oriented at dihedral angles of 10.1 (5), 71.7 (6) and 68.7 (5)°, respectively, to the central thio­phene ring. In the crystal, pairs of weak C—H...O hydrogen bonds link inversion-related mol­ecules, forming dimers. The dimers are linked by further weak C—H...O hydrogen bonds, forming chains running along the a-axis direction.

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In the title mol­ecule, C22H22N2O4, the eth­oxy­phenyl rings are oriented at dihedral angles of 69.31 (13) and 75.90 (13)° to the nitro­phenyl ring and are twisted to each other, making a dihedral angle of 78.55 (13)°. In the crystal, weak C—H...O hydrogen bonds and C—H...π inter­action link the mol­ecules into a three-dimensional supra­molecular architecture.
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