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Radiation-induced structural changes which can be explained by hydrogen abstraction were observed in a high-resolution X-ray diffraction study on cyclosporine A.

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Complementary techniques greatly aid the interpretation of macromolecule structures to yield functional information, and can also help to track radiation-induced changes. A new on-axis spectrometer being integrated into the macromolecular crystallography beamlines of the Swiss Light Source is presented.
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