Acta Crystallographica Section D
Acta Crystallographica
Section D
STRUCTURAL BIOLOGY
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Acta Cryst.
(2012).
D
68
,
680-685
https://doi.org/10.1107/S0907444912007457
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Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1
D. Li
,
T.-M. Fu
,
J. Nan
,
C. Liu
,
L.-F. Li
and
X.-D. Su
The crystal structure of human RSK1 C-terminal kinase domain (CTKD) is reported at 2.7 Å resolution. The structure indicates that the autoinhibition of the CTKD is caused by an α-helix occupying the substrate-binding groove.
Keywords:
RSK1
;
cancer
;
p90 ribosomal S6 kinase
;
autoinhibition
.
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