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In the title compound, [Cu2(SO4)2(C20H36N8)(H2O)2]·6H2O, the dinuclear molecule lies across an inversion centre and contains square-pyramidal CuII ions separated by 7.5709 (18) Å. Symmetry-related molecules are linked together by hydrogen bonds between the coordinated water mol­ecules and the sulfate ligands. They are further linked by a framework of fused cyclic water tetra­meric and pseudo-hexa­gonal units in a three-dimensional hydrogen-bonded network involving both coordinated and uncoordinated water mol­ecules, as well as sulfate ligands. While the tetra­meric units are purely composed of water mol­ecules, the pseudo-hexa­gonal units involve O atoms from the sulfate. Further hydrogen bonding also involves the NH group from the imidazole in addition to the above-mentioned units.
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