Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA

Crystal structures were determined of the extracellular part of glutamate carboxypeptidase II (GCPII; amino-acid residues 44-750) in complex with two potent inhibitors, quisqualate and 2-PMPA (the most potent GCPII inhibitor to date), at resolutions of 3.0 and 2.2 Å, respectively.