The β-propeller domain of the trilobed protease from Pyrococcus furiosus reveals an open Velcro topology

A high-molecular-weight protease complex called trilobed protease (TLP) was recently discovered in the archaeon P. furiosus. The crystal structure of the N-terminal β-propeller domain of the trilobed protease at 2 Å resolution shows that the trilobed protease utilizes this accessory domain to control substrate access to the active site.