Feasibility study of propagation-based phase-contrast X-ray lung imaging on the Imaging and Medical beamline at the Australian Synchrotron

The feasibility of propagation-based X-ray phase-contrast imaging of small animal lungs has been investigated at the Imaging and Medical beamline (IMBL) of the Australian Synchrotron, including computed tomography and X-ray velocimetry. Excellent contrast of the lung phantoms indicates that live animal lung imaging can readily be achieved at the IMBL.

Tracking extended mucociliary transport activity of individual deposited particles: longitudinal synchrotron X-ray imaging in live mice

Synchrotron phase-contrast X-ray imaging is well suited to non-invasive live imaging in small-animal models such as mice. However, due to the radiation dose delivered, the use of longitudinal studies has not previously been reported. In this report the post-deposition mucociliary transit behaviour of deposited particulates in the trachea of live mice is examined using a longitudinal study design incorporating repeat imaging at periods of 3, 9 or 25 h.