Structure of dNTP-inducible dNTP triphosphohydrolase: insight into broad specificity for dNTPs and triphosphohydrolase-type hydrolysis

Here, the crystal structure of Tt-dNTPase has been determined at 2.2 Å resolution, representing the first report of the tertiary structure of a dNTPase homologue belonging to the HD superfamily, a diverse group of metal-dependent phosphohydrolases that includes a variety of uncharacterized proteins.

Structure of archaeal glyoxylate reductase from Pyrococcus horikoshii OT3 complexed with nicotinamide adenine dinucleotide phosphate

The crystal structure of glyoxylate reductase from the hyperthermophilic archaeon P. horikoshii OT3 complexed with NADP(H) was solved at 1.7 Å resolution. The present study revealed its cofactor-recognition and thermostability mechanisms.

Structure of the AlaX-M trans-editing enzyme from Pyrococcus horikoshii

The crystal structure of the AlaX-M trans-editing enzyme revealed that the conserved glycine-rich loop in the N-terminal domain is located near the catalytic site in the C-terminal domain.

Structure of an archaeal TYW1, the enzyme catalyzing the second step of wye-base biosynthesis

The crystal structure of P. horikoshii TYW1 is described.

Structure of the human Tim44 C-terminal domain in complex with pentaethylene glycol: ligand-bound form

Familial oncocytic thyroid carcinoma is associated with a missense mutation, P308Q, in the C-terminal domain of Tim44. Here, the crystal structure of the human Tim44 C-terminal domain in complex with pentaethylene glycol at 1.9 Å resolution is reported.