Design of specific peptide inhibitors of phospholipase A₂: structure of a complex formed between Russell's viper phospholipase A₂ and a designed peptide Leu-Ala-Ile-Tyr-Ser (LAIYS)

V. Chandra, J. Jasti, P. Kaur, S. Dey, A. Srinivasan, Ch. Betzel and T. P. Singh

The structure of the complex formed between Russell's viper phospholipase A₂ and a designed peptide LAIYS has been determined at 2.0 Å resolution. The peptide binds to phospholipase A₂ specifically and fills the hydrophobic channel completely.

Keywords: phospholipase A₂; peptide inhibition; asymmetric dimers.

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Design of specific peptide inhibitors of phospholipase A2: structure of a complex formed between Russell's viper phospholipase A2 and a designed peptide Leu-Ala-Ile-Tyr-Ser (LAIYS)

Design of specific peptide inhibitors of phospholipase A₂: structure of a complex formed between Russell's viper phospholipase A₂ and a designed peptide Leu-Ala-Ile-Tyr-Ser (LAIYS)