Download citation
Download citation

link to html
The expression, purification, crystallization and preliminary crystallographic characterization of the diterpene cyclooctatin synthase (CYC) from Streptomyces sp. LZ35 are reported.

Download citation
Download citation

link to html
BMN 673, a novel PARP1/2 inhibitor in clinical development with substantial tumor cytotoxicity, forms extensive hydrogen-bonding and π-stacking in the nicotinamide pocket, with its unique disubstituted scaffold extending towards the less conserved edges of the pocket. These interactions might provide structural insight into the ability of BMN 673 to both inhibit catalysis and affect DNA-binding activity.
Follow Acta Cryst. F
Sign up for e-alerts
Follow Acta Cryst. on Twitter
Follow us on facebook
Sign up for RSS feeds