D. W. Banner,
B. Gsell,
J. Benz,
J. Bertschinger,
D. Burger,
S. Brack,
S. Cuppuleri,
M. Debulpaep,
A. Gast,
D. Grabulovski,
M. Hennig,
H. Hilpert,
W. Huber,
A. Kuglstatter,
E. Kusznir,
T. Laeremans,
H. Matile,
C. Miscenic,
A. C. Rufer,
D. Schlatter,
J. Steyaert,
M. Stihle,
R. Thoma,
M. Weber and
A. Ruf Surface-residue mutagenesis and cocrystallization with Fab fragments, Fynomers or Xaperones were used to obtain the first high-resolution crystal structures of BACE2. These map the conformational space accessible to this potential drug target.