An enzyme with a deep trefoil knot for the active-site architecture

O. Nureki, M. Shirouzu, K. Hashimoto, R. Ishitani, T. Terada, M. Tamakoshi, T. Oshima, M. Chijimatsu, K. Takio, D. G. Vassylyev, T. Shibata, Y. Inoue, S. Kuramitsu and S. Yokoyama

The crystal structure of a hypothetical RNA 2'-O-ribose methyltransferase from T. thermophilus (RrmA) has been determined at 2.4 Å resolution and a deep trefoil knot has been found for the first time.

Keywords: knots in polypeptide; methyltransferases; Thermus thermophilus HB8.

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