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The two new isomorphous structures [3-methyl-4-(4-methyl­phen­yl)-1-phenyl-6-trifluoro­methyl-1H-pyrazolo­[3,4-b]pyri­din-5-yl](thio­phen-2-yl)methanone, C26H18F3N3OS, (I), and [4-(4-chloro­phen­yl)-3-methyl-1-phenyl-6-trifluoro­methyl-1H-pyrazolo­[3,4-b]pyridin-5-yl](thio­phen-2-yl)methanone, C25H15ClF3N3OS, (II), are shown to obey the chlorine-methyl exchange rule. Both structures show extensive disorder, treatment of which greatly improves the quality of the description of the structures. In addition, it is worth noting that the presence of extensive disorder may make it difficult to detect the isomorphism automatically during data-mining procedures (such as searches of the Cambridge Structural Database).

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Proline (Pro) exists in its neutral form in N-acetyl-L-proline monohydrate and is zwitterionic in N-benzyl-L-proline. The presence of a water molecule in the neutral form and the difference in the ionization states between the two forms have effected significant changes in the respective intermolecular schemes.
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