Towards a high-throughput system for high-pressure cooling of cryoprotectant-free biological crystals

P. van der Linden, F. Dobias, H. Vitoux, U. Kapp, J. Jacobs, S. Mc Sweeney, C. Mueller-Dieckmann and P. Carpentier

A high-pressure system for cooling cryoprotectant-free biological crystals has been designed for automated data collection on synchrotrons. The apparatus and the method have been validated with a series of test samples.

Keywords: protein crystallography; high-pressure crystallography; cryocrystallography; cryoprotection.

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